The purpose of this study is to evaluate clinical and radiological outcomes analysis of the laminoplasty in the elderly patients, and to compare with the non-elderly patients.
Methods
A retrospective study of the short term result in patients who had treated with the laminoplasty for cervical spondylotic myelopathy (CSM) was performed. From January 2008 to December 2012, total 62 patients were operated with single open-door technique because of CSM; 28 patients were the elderly and 34 patients were the non-elderly. We evaluated some factors including sex, symptom duration, estimated blood loss during operation, operation time, hospitalization day, complications, pre- and postoperative modified Japanese Orthopedic Association (mJOA) score, recovery rate of mJOA score, achieved mJOA score, mean cervical canal width and expansion ratio of antero-posterior diameter in order to identify difference between the two group. Clinical outcomes were calculated with the recovery rate of mJOA score at the time of one year after operation.
Results
Mean age were 71.9 in the elderly group and 52.9 in the non-elderly group. Although postoperative mJOA score in the elderly group was lower than that of the non-elderly group, achieved mJOA score was statistically same between the two groups. Other clinical and radiological outcomes were also statistically same.
Conclusion
We conclude that the laminoplasty also assures good clinical outcomes in the elderly patients with CSM, same as in the non-elderly group.
CSM is a neurologic disorder which is caused by narrow spinal canal due to degenerative changes in the cervical spine. Degenerative changes include herniation of cervical intervertebral discs, ossification of vertebral ligaments, hypertrophic changes in the vertebral bodies or facet joints and so on5,14). CSM may presents various clinical symptoms such as gait disturbance, decreased motor functions, sensory changes of the trunk or limbs, and abnormal responses of the pathologic ref lexes. Owing to the natural course of this disease entity, surgical interventions have been considered in order to prevent the neurologic deterioration.
Nowadays, it is widely accepted that the laminoplasty can achieve satisfactory clinical results for CSM, and there are a lot of studies about satisfactory outcomes, surgical techniques and so on. However, efficacies of laminoplasty for the elderly patients with CSM were still controversial. Additionally, several authors have reported that the elderly patients can't recover adequately comparing with the non-elderly patients within the laminoplasty15,17,19).
The purpose of this study aimed to analyze clinical and radiological outcomes of the laminoplasty in the elderly patients and compare with that of the non-elderly patients.
MATERIALS AND METHODS1. Patient Series
This is a retrospective study of the short term result after the laminoplasty. From January 2008 to December 2012, 89 patients were treated with the laminoplasty. 27 patients with traumatic cervical myelopathy, cerebral palsy, previous cervical surgery and spinal cord infarction were excluded. Thus, total 62 patients with CSM were included in this study. This study was consisted of 44 men and 18 women; the mean age was 61.5 years (range, 37-84 years). All patients had typical symptoms such as gait disturbance, limb weakness, pathologic reflexes and numbness.
These patients were divided into the following 2 groups by age as the elderly group (≥65 years) and the non-elderly group (<65 years); 28 patients were the elderly and 34 patients were the non-elderly. All of these patients were followed up at least one year, and this study focused on the short term clinical and radiological outcomes. The characters of the both groups are summarized with Table 1.
2. Surgical Procedures
In this study, all patients were operated by single open-door laminoplasty with Hirabayashi's method9). The spinous processes and laminae were exposed as much as possible and the paraspinal muscles were preserved so far as possible. We also separated the posterior ligament complex of upper and lower margins of the lesion. Using a high-speed pneumatic drill, a trough was drilled down to the ligamentum flavum on the open-door side. We drilled all the way through the laminae and made a very thin remnant of laminae. This thin rim and associated ligament were then removed with a Kerrison punch. And then, a second trough was drilled on the hinge side. We took care of making a trough without cutting the whole depth of laminae of hinge side, keeping the width of the slot 3-4mm in the hinge side. The opening on the open side was then gently expanded, thus lifting the lamina off the spinal cord and expanding the canal. While operator gently expanded the opening with a Penfield dissector or Raney clip applier, an assistant carefully rotated the lamina toward the hinge side. The door were kept open by placing the anchors (Centerpiece™ plate fixation system, Medtronic, Minnesota, USA) and fasten the door to the lateral mass. And then a drainage tube was inserted and the paraverterbral muscles and the skin were closed layer by layer. All patients equipped the Philadelphia neck brace at least one month in order to stabilize the cervical vertebrae and the paraverterbral muscles.
3. Analysis of Clinical Outcomes
Severity of myelopathy was evaluated at the times of admission date as preoperatively and one year after operation as postoperatively with a scoring system proposed by the Benzel et al.'s modified Japanese Orthopaedic Association Scale for cervical myelopathy (mJOA score)3). The mJOA score quantifies neurological impairment by evaluating upper extremity motor dysfunction with a range of 0 to 5, lower extremity motor dysfunction with a range of 0 to 7, sensory disturbance with a range of 0 to 3, and sphincter dysfunction with a range of 0 to 3 (Table 2). The recovery rate (RR) of mJOA score was evaluated using a formula suggested by Hirabayashi et al.9), and achieved mJOA score was also evaluated (Table 3).
Other clinical outcomes such as estimated blood loss during operation, operation time, hospitalization day and postoperative complications were also assessed.
4. Analysis of Radiological Outcomes
All cases had been routinely examined at the admission date or preoperative work up period for the operation with cervical spine plain films, cervical computed tomography (CT) and magnetic resonance imaging (MRI). Postoperative radiological examinations were also taken several times at our outpatient department, we set the images at the one year after operation as short term result.
Mean canal width of antero-posterior diameter was measured at operated levels with cervical plain films as average of pre- and postoperative numerical values. We calculated the expansion ratio with followed formula; [expansion ratio=(postoperative value-preoperative value)/preoperative value×100%] (Fig. 1).
All of radiological examination analysis was performed by independent observers with three times repeating in order to induce accuracy.
5. Statistical Analysis
Statistical analysis were performed using PASW stastistics 18.0 (SPSS Inc, Hong Kong) software. All values are expressed as the mean±standard deviation. The Mann-Whitney U test and chi-square distribution test were performed for analyzing the differences between two groups. The p value of <0.05 was considered statistically significant.
RESULTS
9 patients had double segments with the location being (C3-C5) in 6 cases and (C4-C6) in 2 cases and (C5-C7) in 1 case. 28 patients had triple segments with the location being (C2-C5) in 2 cases (C3-C6) in 21 cases and (C4-C7) in 5 cases. 25 patients had quadruple or more segments with the location being (C2-C6) in 5 cases and (C2-C7) in 7 cases and (C3-C7) in 13 cases.
The mean symptom duration was 9.5 months (range, 1-50 months). The mean preoperative modified JOA score was 12.2±2.2 (range, 7-16) and the mean postoperative modified JOA score was 15.3±1.3 (range, 12-17). The mean modified JOA recovery rate (RR) was 53.6±15.3%(range, 20.0-81.8%). The mean achieved modified JOA score was 3.11±1.6 (range, 1-9). The mean preoperative cervical canal width of antero-posterior diameter was 14.3±1.8mm(range, 10.1-18.6mm) and the mean postoperative cervical canal width of antero-posterior diameter was 20.2±1.8mm(range, 16.2-25.0mm). The mean cervical canal expansion ratio was 42.9±10.9% (range, 20.4-72.0%).
The mean symptom duration were 10.1±12.4 months in the elderly patients and 9.1±11.2 months in the non-elderly patients. The mean preoperative modified JOA score were 11.8±2.2 in the elderly patients and 12.6±2.1 in the non-elderly patients. The mean postoperative modified JOA score were 14.9±1.5 in the elderly patients and 15.7±1.0 in the non-elderly patients. In this study, the elderly patients group showed lower mJOA recovery rate and significantly lower postoperative mJOA scores (p<0.05) than the non-elderly group. However, there was no statistical difference of mJOA recovery rate between the elderly group and the non-elderly group. The mean mJOA recovery rate (RR) were 50.7±15.1% in the elderly patients and 55.9±14.8 in the non-elderly patients. Furthermore, the mean achieved mJOA score were statistically same between the two groups (Fig. 2, 3). The mean achieved mJOA score were 3.1±1.3 in the elderly patients and 3.1±1.8 in the non-elderly patients.
In radiologic outcomes, the mean preoperative cervical canal width of antero-posterior diameter were 14.3±1.9mm in the elderly patients and 14.2±1.7 in the non-elderly patients. The mean postoperative cervical canal width of antero-posterior diameter were 20.4±2.0mm in the elderly patients and 20.1±1.6 in the non-elderly patients. The mean cervical canal expansion ratio were 43.4±11.0% in the elderly patients and 42.4±10.9% in the non-elderly patients.
There were postoperative infection of 2 cases, delirium of 1 case and C5 palsy of 1 case happened in the elderly group while postoperative infection of 1 case and hematoma collection in operation site of 1 case occurred in the non-elderly group. Although more complication cases were reported in the elderly group, it didn't have any significant distinction between the two groups. Estimated blood loss, operation time and hospitalization day were also statistically same in this study.
DISCUSSION
Since Hirabayashi et al. reported the cervical open-door laminoplasty for CSM in 198310), there were some studies which announced for comparisons of clinical outcomes between the elderly group and the non-elderly group those who had underwent cervical decompression for CSM in Japan8,14,15,16,17,19,21). Some authors divided patients into two groups as non-elderly and elderly, and another authors divided patients into three groups or more. However, their conclusions were still controversial, whether being divided into two or three groups is not the point. Like our study, some authors found no significant difference in JOA recovery rates between different age group, on the contrary, others reported that JOA recovery rates tended to decrease with aging. Latter authors supposed that age-related changes in the spinal cord might explain the reasons why the elderly patients usually don't recover adequately after lamoniplasty those in the non-elderly patients15,16). However, all authors identified that cervical decompression has enough effectiveness for the elderly patients with CSM.
In case of Japan, some authors had concluded that patient age influences on the clinical outcome of the laminoplasty5,22). In this study, although preoperative modified JOA score was statistically same between the elderly group and the non-elderly group, postoperative modified JOA score was different between the two groups. However, modified JOA recovery rate and achieved modified JOA score were statistically same. Clinical outcomes such as modified JOA recovery rate or achieved modified JOA score in the elderly group were comparable with those in the non-elderly group. According to this result, the laminoplasty for CSM was also effective in the elderly patients. Thus, if the patient is in good physical condition, old age alone is not a contraindication to this surgical treatment for CSM. Yoon et al. had reviewed 433 previous citations which had designed a systematic-review to evaluate potential predictive factors of the laminoplasty for CSM23). 12 studies of them were related to age which is predictive factors affecting outcome after the laminoplasty. Like our study, authors also found out that increased age is not a strong predictor of clinical outcomes after the laminoplasty, therefore age by itself should not preclude the laminoplasty for CSM.
Meanwhile, JOA recovery rate is a simple and useful parameter to compare clinical outcomes quantitatively. However, the usage of this score may be unreasonable. As JOA recovery rate can be alterable due to preoperative JOA score even if the same achieved JOA score were taken. Machino et al. announced a large-scale study of the surgical outcome for CSM from a single operative procedure with double-door laminoplasty in 520 elderly patients14). They pointed out that actual surgical outcome in patients with the same recovery rate may differ due to the preoperative JOA scores. For example, if someone gets same point of achieved JOA score after operation, recovery rate is changed due to the preoperative JOA score. Therefore, they concluded that surgeons should consider JOA recovery rate as well as achieved JOA score in order to evaluate clinical outcomes appropriately.
In the aspect of measuring for assessment of CSM, Kalsi-Ryan et al. had reviewed related articles for identifying the most suitable measurement of the scoring systems for CSM13). The goal of their review was to establish the most reliable, valid, responsive, sensitive and quantitative measurement of CSM. Their review was consisted of 3 steps. First step, they defined the measurements which are currently used in the literatures. In their review, Nurick scale18), modified JOA scale3), visual analogue scale (VAS) for pain, Short-form 36 health survey (SF-36)7), neck disability index (NDI)1), the myelopathy disability index (MDI)6) and european myelopathy scale (EMS) were in order of citation times. They also analyzed validity, reliability and responsiveness of these measurements. Second step, they pointed out that these measurements don't objectively quantify the physical findings of the individual. And they made the criteria which are consist of six outcome measurements in terms of ancillary measurements. QuickDASH2,11), Berg balance scale4), 30-meter walk test (30MWT)20), graded redefined assessment of strength sensibility and prehension (GRASSP)12), grip strength (dynamometer) and GAITRite analysis (computerized walkway system) were included in their criteria. Third step, they focused on the literature about these ancillary measurements, and they also introduce that how these ancillary measurements can be useful in clinical practices. In conclusion, they recognized that it can't define with a single score on a single outcome measurement for CSM because of its heterogeneity. Thus, they suggested that clinician can obtain more reliable, valid, responsive and quantitative information in the CSM population using these ancillary measurements.
Our study has several limitations. First, it is often difficult for the elderly patients to assess their neurological functions exactly because some of them don't have enough communicative competence to express their symptoms. Secondly, this study may contain a selection bias. If a patient have serious comorbidity, surgeons can't operate them or anesthesiologists refuse to anesthetize that patient. And most patients with CSM were considered for operation, so an adequate number of control groups who had underwent conservative therapy could not be obtained. Thirdly, we set up one year follow up as the point of times for evaluating clinical outcomes. However, these data are just short-term follow up data, so there is a possibility that these data don't reflect on the natural course of postoperative recovery. Therefore, it is necessary that long-term follow up or final follow up analysis should be reinforced for further work-up.
CONCLUSION
In the present study, the elderly patients treated with laminoplasty for CSM showed favorable clinical and radiological outcomes, same as the non-elderly patients. Additionally, incidence of postoperative complications was not significantly increased.
We conclude that the laminoplasty for the elderly patients with CSM assures satisfactory clinical and radiological results.
BartelsRHVerbeekALBenzelECFehlingsMGGuiotBHValidation of a translated version of the modified Japanese orthopaedic association score to assess outcomes in cervical spondylotic myelopathy: an approach to globalize outcomes assessment toolsNeurosurgery2010661013101620404709BeatonDEWrightJGKatzJNUpper Extremity Collaborative GDevelopment of the QuickDASH: comparison of three itemreduction approachesJ Bone Joint Surg Am2005871038104615866967BenzelECLanconJKestersonLHaddenTCervical laminectomy and dentate ligament section for cervical spondylotic myelopathyJ Spinal Disord199142862951802159BergKOWood-DauphineeSLWilliamsJIMakiBMeasuring balance in the elderly: validation of an instrumentCan J Public Health199283Suppl 2S7S111468055BernhardtMHynesRABlumeHWWhiteAA3rdCervical spondylotic myelopathyJ Bone Joint Surg Am1993751191288419381CaseyATBlandJMCrockardHADevelopment of a functional scoring system for rheumatoid arthritis patients with cervical myelopathyAnn Rheum Dis1996559019069014584GuilfoyleMRSeeleyHLaingRJThe Short Form 36 health survey in spine disease--validation against condition-specific measuresBr J Neurosurg20092340140519637011HandaYKubotaTIshiiHSatoKTsuchidaAAraiYEvaluation of prognostic factors and clinical outcome in elderly patients in whom expansive laminoplasty is performed for cervical myelopathy due to multisegmental spondylotic canal stenosis. A retrospective comparison with younger patientsJ Neurosurg20029617317912450280HirabayashiKSatomiKOperative procedure and results of expansive open-door laminoplastySpine (Phila Pa 1976)1988138708763143157HirabayashiKWatanabeKWakanoKSuzukiNSatomiKIshiiYExpansive open-door laminoplasty for cervical spinal stenotic myelopathySpine (Phila Pa 1976)198386936996420895HudakPLAmadioPCBombardierCThe Upper Extremity Collaborative Group (UECG)Development of an upper extremity outcome measure: the DASH(disabilities of the arm, shoulder and hand) [corrected]Am J Ind Med1996296026088773720Kalsi-RyanSCurtAVerrierMCFehlingsMGDevelopment of the Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP): reviewing measurement specific to the upper limb in tetraplegiaJ Neurosurg Spine201217657622985372Kalsi-RyanSSinghAMassicotteEMArnoldPMBrodkeDSNorvellDCAncillary outcome measures for assessment of individuals with cervical spondylotic myelopathySpine (Phila Pa 1976)201338S111S12223963009MachinoMYukawaYHidaTItoKNakashimaHKanbaraSCan elderly patients recover adequately after laminoplasty?: a comparative study of 520 patients with cervical spondylotic myelopathySpine20123766767121912325MatsudaYShibataTOkiSKawataniYMashimaNOishiHOutcomes of surgical treatment for cervical myelopathy in patients more than 75 years of ageSpine (Phila Pa 1976)19992452953410101815NagashimaHDokaiTHashiguchiHIshiiHKameyamaYKataeYClinical features and surgical outcomes of cervical spondylotic myelopathy in patients aged 80 years or older: a multi-center retrospective studyEur Spine J20112024024621197553NagashimaHMorioYYamashitaHYamaneKTeshimaRClinical features and surgical outcomes of cervical myelopathy in the elderlyClin Orthop Relat Res200644414014516446592NurickSThe pathogenesis of the spinal cord disorder associated with cervical spondylosisBrain197295871005023093SatomiKOgawaJIshiiYHirabayashiKShort-term complications and long-term results of expansive open-door laminoplasty for cervical stenotic myelopathySpine J20011263014588365SinghACrockardHAQuantitative assessment of cervical spondylotic myelopathy by a simple walking testLancet199935437037310437865TanakaJSekiNTokimuraFDoiKInoueSOperative results of canal-expansive laminoplasty for cervical spondylotic myelopathy in elderly patientsSpine (Phila Pa 1976)1999242308231210586453WangLFZhangYZShenYSuYLXuJXDingWYUsing the T2-weighted magnetic resonance imaging signal intensity ratio and clinical manifestations to assess the prognosis of patients with cervical ossification of the posterior longitudinal ligamentJ Neurosurg Spine20101331932320809723YoonSTRaichAHashimotoRERiewKDShaffreyCIRheeJMPredictive factors affecting outcome after cervical laminoplastySpine (Phila Pa 1976)201338S232S25223962999
Mean canal width of antero-posterior diameter was measured at operated levels with cervical plain films as average of data of pre- and post-operative numerical values.
Pre- and postoperative modified JOA score in the both groups. Pre- and postoperative modified JOA score of the elderly group tend to show lower numerical values than those of the non-elderly group. Moreover, postoperative modified JOA score has statistical difference between the both groups (p<0.05).
Recovery rate of mJOA (A) and achieved JOA score (B) are statistically same in both groups (p>0.05). In this study, we cautiously conclude that the elderly patients can recover as well as the non-elderly patients.
Summary for characters of the two groups
Elderly
Non-elderly
p-value
Cases
28
34
Age, years
71.9±5.1
52.9±7.7
Sex (female), %
32.1
26.5
NS
Symptom duration, months
10.1±12.4
9.1±11.2
NS (0.864)
Estimated blood loss, cc
205±89
188±83
NS (0.435)
Operation time, minutes
161±25
169±22
NS (0.215)
Hospitalization day
16.3±3.9
16.9±4.4
NS (0.605)
Complication, cases
4/28 (14.3%)
2/34 (5.9%)
NS (0.265)
Preoperative modified JOA scores
11.8±2.2
12.6±2.1
NS (0.153)
Postoperative modified JOA scores
14.9±1.5
15.7±1.0
0.013 (p<0.05)
JOA recovery rate, %
50.7±15.1
55.9±14.8
NS (0.127)
Achieved JOA scores
3.1±1.3
3.1±1.8
NS (0.602)
Preoperative mean canal width, mm
14.3±1.9
14.2±1.7
NS (0.783)
Postoperative mean canal width, mm
20.4±2.0
20.1±1.6
NS (0.276)
Canal expansion ratio, %
43.4±11.0
42.4±10.9
NS (0.515)
*JOA score indicates Japanese Orthopaedic Association score for CSM
*NS: no siginificant difference
Benzel et al.’s modified Japanese Orthopaedic Association scale3)
A. Motor dysfunction score of the upper extremities
0: inability to move hands
1: inability to eat with a spoon but able to move hands
2: inability to button shirt but able to eat with a spoon
3: able to button shirt with great difficulty
4: able to button shirt with slight difficulty
5: no dysfunction
B. Motor dysfunction score of the lower extremities
0: complete loss of motor and sensory function
1: sensory preservation without ability to move legs
2: able to move legs but unable to walk
3: able to walk on flat floor with a walking aid
4: able to walk up and/or down stairs with hand rail
5: moderate to significant lack of stability but able to walk up and/or down stairs without hand rail
6: mild lack of stability but walk unaided with smooth reciprocation
7: no dysfunction
C. Sensation
0: complete loss of hand sensation
1: severe sensory loss or pain
2: mild sensory loss
3: no sensory loss
D. Sphincter dysfunction score
0: inability to micturate voluntarily
1: marked difficulty with micturition
2: mild to moderate difficulty with micturition
3: normal micturition
*JOA score indicates Japanese Orthopaedic Association score for CSM
Recovery rate of the modified JOA score (Hirabayashi method) and Achieved JOA score
Recovery rate of the modified JOA score (Hirabayashi method)9)