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Funding/Support
This work is supported by the University Nature Scientific Research Project of Anhui Province (grant number 2022AH051159); and Program for Anhui Provincial Institute of Translational Medicine (2022zhyx-C19).
Author Contribution
Conceptualization: BZ, RJZ, CLS; Data curation: BZ, LPZ, XLZ, DL; Formal analysis: BZ, LPZ; Funding acquisition: RJZ, CLS; Methodology: BZ, LPZ, JQW; Project administration: CYJ, HQZ, LK, RJZ, CLS; Visualization: CYJ, HQZ, LK, RJZ; Writing - original draft: BZ, LPZ; Writing - review & editing: RJZ, CLS.
Characteristic | Fracture (n = 78) | Control (n = 78) | t/Z/χ²† | p-value |
---|---|---|---|---|
Female sex | 57 (73) | 62 (79) | 0.886 | 0.347 |
Age (yr) | 68.0 ± 7.2 | 67.0 ± 6.6 | -0.639 | 0.523 |
BMI (kg/m2) | 23.6 ± 3.5 | 24.5 ± 3.1 | -1.955 | 0.051 |
Smoker | 9 (12) | 7 (9) | 0.279 | 0.598 |
Diabetes | 6 (8) | 12 (15) | 2.261 | 0.133 |
Hypertension | 33 (42) | 34 (44) | 0.026 | 0.872 |
CHD | 5 (6) | 5 (6) | 0.000 | > 0.999 |
Fracture | Control | t/Z/χ²† | p-value | |
---|---|---|---|---|
HU | ||||
L1 | 84.83 ± 26.44 | 115.45 ± 32.91 | -4.825 | < 0.001 |
L2 | 65.60 ± 27.40 | 111.16 ± 31.59 | -7.010 | < 0.001 |
L3 | 59.28 ± 29.21 | 101.11 ± 33.53 | -6.654 | < 0.001 |
L4 | 61.80 ± 27.61 | 108.9 ± 34.28 | -7.240 | < 0.001 |
L1–4 | 64.59 ± 26.43 | 108.29 ± 30.88 | -7.824 | < 0.001 |
VBQ | ||||
L1 | 3.48 ± 0.57 | 3.28 ± 0.53 | -1.769 | 0.077 |
L2 | 3.60 ± 0.75 | 3.29 ± 0.61 | -2.521 | 0.012 |
L3 | 3.38 ± 0.68 | 3.23 ± 0.58 | -1.232 | 0.218 |
L4 | 3.50 ± 0.66 | 3.28 ± 0.57 | -1.984 | 0.047 |
L1–4 | 3.50 ± 0.66 | 3.27 ± 0.57 | -2.194 | 0.028 |
BMD | ||||
L1 | 0.76 ± 0.20 | 0.87 ± 0.12 | -3.824 | < 0.001 |
L2 | 0.75 ± 0.16 | 0.94 ± 0.17 | -5.640 | < 0.001 |
L3 | 0.81 ± 0.18 | 1.01 ± 0.18 | -6.293 | < 0.001 |
L4 | 0.84 ± 0.16 | 1.09 ± 0.20 | -7.206 | < 0.001 |
L1–4 | 0.79 ± 0.16 | 0.98 ± 0.16 | -6.749 | < 0.001 |
HU (L1–4) | BMD (L1–4) | VBQ (L1–4) | |
---|---|---|---|
No. of thoracolumbar fragility fractures | |||
r | -0.639 | -0.554 | 0.160 |
p-value | < 0.001 | < 0.001 | 0.045 |
Variable | Threshold | Sensitivity (%) | Specificity (%) | AUC | p-value |
---|---|---|---|---|---|
HU | 87.50 | 85.53 | 72.50 | 0.848 | 0.001 |
VBQ | 3.30 | 67.11 | 67.50 | 0.641 | 0.002 |