| Clinical Applications of Human Bone Marrow Progenitors for augmenting Spinal Fusion |
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Jae Young Choi, M.D., Jong Baeck Lim, M.D.†, and Kyeong Hoon Sung, M.D. |
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Department of Neurosurgery, 21st Centry Hospital, Seoul, Korea, †Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea |
| Clinical Applications of Human Bone Marrow Progenitors for augmenting Spinal Fusion |
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Jae Young Choi, M.D., Jong Baeck Lim, M.D.†, and Kyeong Hoon Sung, M.D. |
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| Abstract |
Most bone substitutes are osteoconductors that lack osteoinductive properties. Therefore, these substitutes can only promote bone fusion when the bone environment at the implantation site provides these osteoinductive factors. These osteoinductive factors include the osteoblast progenitor cells. The most abundant and readily available source is the bone marrow. Bone marrow-derived mononucleated cells including connective tissue progenitors can be concentrated rapidly from bone marrow aspirates. Concentration of cells in this way to produce an enriched autologous cancellous bone chips mixed with mononucleated cells improves graft efficacy.
We believe the enhanced concentration of bone marrow derived mononucleated cells may augment spinal fusion and obviate the need for autologous graft harvest. The procedures and its clinical applications about bone marrow aspirates are described and discussed. |
| Keywords:
Bone marrow․Mononucleated cells, Connective tissue progenitors, Fusion |
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