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Neurospine provides spine clinicians and researchers with peer-reviewed articles on both basic and clinical investigations of the spine and spinal cord, aimed at enhancing patient management, education, research, and professionalism.
The journal welcomes submissions covering the entire spine, from the craniocervical to the lumbosacral regions, including the following areas: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, and rehabilitation of spinal, spinal cord and peripheral nerve diseases.

Original Article

June 30, 2025


Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway
Yuan-Huan Ma, Hong-Ying Chen, Qing-Shuai Wei, Li-Zhi Peng, Ke-Jun Zhang, Qing-Wen Deng, Lai-Jian Wang, Zhou Liu, Bi-Qin Lai, Ying Ding, et al.
Neurospine. 2025;22(2):311-328.

Original Article

June 30, 2025


The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study
Jun Jae Shin, Sun Joon Yoo, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, et al.
Neurospine. 2025;22(2):337-348.

Original Article

June 30, 2025


Proximal Thoracic Alignment Change Influences Cervical Sagittal Alignment After Correction Surgery in Patients With Lenke Type 2 Adolescent Idiopathic Scoliosis
Xi Lin, Satoshi Suzuki, Kazuki Takeda, Takahito Iga, Toshiki Okubo, Masahiro Ozaki, Osahiko Tsuji, Narihito Nagoshi, Morio Matsumoto, Masaya Nakamura, et al.
Neurospine. 2025;22(2):354-363.

Original Article

June 30, 2025


Evidence-Based Clinical Practice Guidelines for Patients With Lumbar Disc Herniation With Radiculopathy in South Korea
Jong Joo Lee, Min Cheol Chang, Dong Ah Shin, Jin Hoon Park, Miyoung Choi, Hyung-Youl Park, In Soo Kim, Jung-Kil Lee, Chung-Kee Chough, Seung Hwan Yoon, et al.
Neurospine. 2025;22(2):366-383.

Review Article

June 30, 2025


A Systematic Review of Treatment Guidelines for Lumbar Disc Herniation
Haiyue Jin, Alexander M. Lopez, Flor Garza Romero, Ryan Hoang, Ashish Ramesh, Hansen C. Bow
Neurospine. 2025;22(2):389-402.

Review Article

June 30, 2025


Narrative Review on Postoperative Pain Management Following Spine Surgery
Crystal Yu, Michael Madsen, Olutola Akande, Michael Y. Oh, Ryan Mattie, David W. Lee
Neurospine. 2025;22(2):403-420.

Review Article

June 30, 2025


Advances in Therapeutic Applications of CRISPR Genome Editing for Spinal Pain Management
Chan Young Kang, Kyung Wook Been, Myoung-Hee Kang, Myung Su Choi, Rae Hee Kang, Junseok W. Hur, Junho K. Hur
Neurospine. 2025;22(2):421-440.

Original Article

June 30, 2025


Effectiveness of a Facet Joint Block Versus a Medial Branch Block in Spinal Pain Management: A Systematic Review and Meta-Analysis
Sung Hyeon Noh, Kyoung-Tae Kim, Dong Ah Shin, Je Hwi Yun, Pyung Goo Cho, Sang Hyun Kim
Neurospine. 2025;22(2):441-450.

Original Article

June 30, 2025


Preoperative Opioid Misuse Associations With Delayed Opioid Cessation, Pain, and Negative Affect After Spine Surgery
Jennifer M. Hah, Shana C. Levine, Saneel Khairnar, Luke Pirrotta, Alma Rechav Ben-Natan, Emily Tse, Gabrielle Hettie, Todd Alamin, Anand Veeravagu, Serena Hu, et al.
Neurospine. 2025;22(2):451-464.

Original Article

June 30, 2025


Evaluating the Technical Specifications and Clinical Performance of Different Percutaneous Epidural Neuroplasty Catheters
Ji Young Jang, Songrit Vuttipongkul, Dong Soon Jang, Min Cheol Chang
Neurospine. 2025;22(2):465-472.

Original Article

December 23, 2024


Precision Nanotherapy for Spinal Cord Injury: Modulating SLC16A3 With Methylprednisolone-Loaded Nanoparticles
Jianwei Lv, Shibo Ma, Duo Shan
Neurospine. 2025;22(2):478-499.

Original Article

April 16, 2025


Surgical Strategy Analysis of Chiari Malformation With or Without Type II Basilar Invagination According to the Morphological Types of the Atlanto-Occipital Joint: A Retrospective Study of 212 Patients
Qinguo Huang, Junhua Ye, Yanyu Wu, Qiang Zhou, Hong Li, Lin Peng, Yuntao Lu
Neurospine. 2025;22(2):500-513.

Original Article

June 30, 2025


Optimization of Paravertebral Foramen Screw Placement: A Stepwise Approach Considering O-arm Navigation Errors: Technical Note and Case Series
Yu Yamamoto, Yusuke Nishimura, Motonori Ishii, Nobuhisa Fukaya, Eisuke Tsukamoto, Ryuta Saito, Masahito Hara, Masakazu Takayasu
Neurospine. 2025;22(2):514-522.

Original Article

June 30, 2025


Rates, Causes, and Predictive Factors of Hospital Readmissions After Spine Surgery for Lumbar Spinal Stenosis: A Nationwide Retrospective Cohort Study
Lingxiao Chen, Jiaming Ding, Zhuo Chen, David B. Anderson, Maja R. Radojčić, Ruiyuan Zheng, Qingyu Sun, Wenjian Yuan, Jiuxiao Sun, Runhan Fu, et al.
Neurospine. 2025;22(2):523-539.

Original Article

June 30, 2025


Endoscopic Transnasal Approach to Atlantoaxial Decompression and C1–2 Fixation in Basilar Invagination of Adults: A Feasibility Study
Jiahai Ding, Shao Xie, Yuliang Chen, Runchuan Zhou, Syed Matiullah Azizi, Xiaoya Huang, Yang Xiong, Yuancheng Yao, Yushun Zhang, Yong Liu, et al.
Neurospine. 2025;22(2):543-555.

Original Article

June 30, 2025


Biportal Endoscopic Decompression for Degenerative Lumbar Spondylolisthesis With Stenosis
Wongthawat Liawrungrueang, Ho-Jin Lee, Sang Bum Kim, Sang-Min Park, Hyun-Jin Park
Neurospine. 2025;22(2):556-565.

Original Article

April 30, 2025


Endoscopic Decompression Combined With Percutaneous Pedicle Screw Fixation for AOSpine A3 or A4 Thoracolumbar Fractures With Neurological Deficits: A Retrospective Cohort Study
Huiming Yang, Junxian Miao, Jiangtao Wang, Dan Han, Yuhang Wang, Liang Yan, Biao Wang, Dingjun Hao
Neurospine. 2025;22(2):571-582.

Original Article

June 30, 2025


Intra-, Epidural And Intracranial Pressure Changes During Interlaminar Endoscopy, With and Without Dural Tear
Mazda Farshad, Jana Felicitas Schader, Alexandra Stauffer, Carl Moritz Zipser, Najmeh Kheram, José Miguel Spirig, Marie-Rosa Fasser, Jonas Widmer, Vincent Hagel
Neurospine. 2025;22(2):583-591.

Original article

April 16, 2025


Development and Validation of a Nomogram for Predicting Adjacent Vertebral Fracture After Osteoporotic Vertebral Compression Fracture Surgery: A Multicenter Retrospective Cohort Study
Hanwen Cheng, Huilong Wen, Yong Ma, Zhuojie Liu, Haoyu Wu, Lajing Luowu, Yong Xiao, Lianbin Liang, Fanjie Kong, Longyi Xiao, et al.
Neurospine. 2025;22(2):592-602.

Original Article

April 15, 2025


Anterior Corpectomy Versus Posterior Pedicle Screw Fixation With 5.5-mm Rods for Metastatic Spinal Tumor Located in the Cervicothoracic Junction
Sun Woo Jang, Hong Kyung Shin, Sang Ryong Jeon, Sung Woo Roh, Danbi Park, Chongman Kim, Jin Hoon Park
Neurospine. 2025;22(2):603-612.

From the Editor-in-Chief: Featured Articles in the June 2025 Issue
Inbo Han
Neurospine. 2025;22(2):309-310.

Editorial

June 30, 2025

Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway  
Yuan-Huan Ma, Hong-Ying Chen, Qing-Shuai Wei, Li-Zhi Peng, Ke-Jun Zhang, Qing-Wen Deng, Lai-Jian Wang, Zhou Liu, Bi-Qin Lai, Ying Ding, et al.
Neurospine. 2025;22(2):311-328.

Original Article

June 30, 2025

A Commentary on “Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway”
Wu Xue, Anyuan Dai, Qinyi Liu
Neurospine. 2025;22(2):329-331.

Commentary

June 30, 2025

Establishing a Standardized Fellowship Curriculum for Advanced Minimally Invasive Spine Interventions: A Multidisciplinary Approach to Training and Competency
Denis Patterson, Joseph Chang, David Lee, Eric Lee, Jennifer Lee, Ramana Naidu, Lawrence Poree, Jeffrey Roh, Peter Staats, Michael Y. Oh
Neurospine. 2025;22(2):332-334.

Editorial

June 30, 2025

A Commentary on “Establishing a Standardized Fellowship Curriculum for Advanced Minimally Invasive Spine Interventions: A Multidisciplinary Approach to Training and Competency”
Gyu Yeul Ji
Neurospine. 2025;22(2):335-336.

Commentary

June 30, 2025

The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study
Jun Jae Shin, Sun Joon Yoo, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, et al.
Neurospine. 2025;22(2):337-348.

Original Article

June 30, 2025

A Commentary on “The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study”
John H. Chi
Neurospine. 2025;22(2):349-350.

Commentary

June 30, 2025

Beyond the K Line - A Commentary on “The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study”
Fabrizio Russo, Gianluca Vadalà, Vincenzo Denaro
Neurospine. 2025;22(2):351-353.

Commentary

June 30, 2025

Proximal Thoracic Alignment Change Influences Cervical Sagittal Alignment After Correction Surgery in Patients With Lenke Type 2 Adolescent Idiopathic Scoliosis
Xi Lin, Satoshi Suzuki, Kazuki Takeda, Takahito Iga, Toshiki Okubo, Masahiro Ozaki, Osahiko Tsuji, Narihito Nagoshi, Morio Matsumoto, Masaya Nakamura, et al.
Neurospine. 2025;22(2):354-363.

Original Article

June 30, 2025

A Commentary on “Proximal Thoracic Alignment Change Influences Cervical Sagittal Alignment After Correction Surgery in Patients With Lenke Type 2 Adolescent Idiopathic Scoliosis”
Seung Woo Suh
Neurospine. 2025;22(2):364-365.

Commentary

June 30, 2025

Evidence-Based Clinical Practice Guidelines for Patients With Lumbar Disc Herniation With Radiculopathy in South Korea
Jong Joo Lee, Min Cheol Chang, Dong Ah Shin, Jin Hoon Park, Miyoung Choi, Hyung-Youl Park, In Soo Kim, Jung-Kil Lee, Chung-Kee Chough, Seung Hwan Yoon, et al.
Neurospine. 2025;22(2):366-383.

Original Article

June 30, 2025

A Commentary on “Evidence-Based Clinical Practice Guidelines for Patients With Lumbar Disc Herniation With Radiculopathy in South Korea”
Alexander M. Lopez, Michael Y. Oh
Neurospine. 2025;22(2):384-386.

Commentary

June 30, 2025

The Inaugural Milestone in International Partnership: A Commentary on the KNPS–PSPS (Korean Neuro-Pain Society–Pacific Spine and Pain Society) Special Issue in Neurospine
Dong Ah Shin
Neurospine. 2025;22(2):387-388.

Editorial

June 30, 2025

A Systematic Review of Treatment Guidelines for Lumbar Disc Herniation
Haiyue Jin, Alexander M. Lopez, Flor Garza Romero, Ryan Hoang, Ashish Ramesh, Hansen C. Bow
Neurospine. 2025;22(2):389-402.

Review Article

June 30, 2025

Narrative Review on Postoperative Pain Management Following Spine Surgery
Crystal Yu, Michael Madsen, Olutola Akande, Michael Y. Oh, Ryan Mattie, David W. Lee
Neurospine. 2025;22(2):403-420.

Review Article

June 30, 2025

Advances in Therapeutic Applications of CRISPR Genome Editing for Spinal Pain Management
Chan Young Kang, Kyung Wook Been, Myoung-Hee Kang, Myung Su Choi, Rae Hee Kang, Junseok W. Hur, Junho K. Hur
Neurospine. 2025;22(2):421-440.

Review Article

June 30, 2025

Effectiveness of a Facet Joint Block Versus a Medial Branch Block in Spinal Pain Management: A Systematic Review and Meta-Analysis
Sung Hyeon Noh, Kyoung-Tae Kim, Dong Ah Shin, Je Hwi Yun, Pyung Goo Cho, Sang Hyun Kim
Neurospine. 2025;22(2):441-450.

Original Article

June 30, 2025

Preoperative Opioid Misuse Associations With Delayed Opioid Cessation, Pain, and Negative Affect After Spine Surgery
Jennifer M. Hah, Shana C. Levine, Saneel Khairnar, Luke Pirrotta, Alma Rechav Ben-Natan, Emily Tse, Gabrielle Hettie, Todd Alamin, Anand Veeravagu, Serena Hu, et al.
Neurospine. 2025;22(2):451-464.

Original Article

June 30, 2025

Evaluating the Technical Specifications and Clinical Performance of Different Percutaneous Epidural Neuroplasty Catheters
Ji Young Jang, Songrit Vuttipongkul, Dong Soon Jang, Min Cheol Chang
Neurospine. 2025;22(2):465-472.

Original Article

June 30, 2025

Artificial Intelligence (AI) Agents Versus Agentic AI: What’s the Effect in Spine Surgery?
Wongthawat Liawrungrueang
Neurospine. 2025;22(2):473-477.

Editorial

June 30, 2025

Precision Nanotherapy for Spinal Cord Injury: Modulating SLC16A3 With Methylprednisolone-Loaded Nanoparticles
Jianwei Lv, Shibo Ma, Duo Shan
Neurospine. 2025;22(2):478-499.

Original Article

December 23, 2024

Surgical Strategy Analysis of Chiari Malformation With or Without Type II Basilar Invagination According to the Morphological Types of the Atlanto-Occipital Joint: A Retrospective Study of 212 Patients
Qinguo Huang, Junhua Ye, Yanyu Wu, Qiang Zhou, Hong Li, Lin Peng, Yuntao Lu
Neurospine. 2025;22(2):500-513.

Original Article

April 16, 2025

Optimization of Paravertebral Foramen Screw Placement: A Stepwise Approach Considering O-arm Navigation Errors: Technical Note and Case Series
Yu Yamamoto, Yusuke Nishimura, Motonori Ishii, Nobuhisa Fukaya, Eisuke Tsukamoto, Ryuta Saito, Masahito Hara, Masakazu Takayasu
Neurospine. 2025;22(2):514-522.

Original Article

June 30, 2025

Rates, Causes, and Predictive Factors of Hospital Readmissions After Spine Surgery for Lumbar Spinal Stenosis: A Nationwide Retrospective Cohort Study
Lingxiao Chen, Jiaming Ding, Zhuo Chen, David B. Anderson, Maja R. Radojčić, Ruiyuan Zheng, Qingyu Sun, Wenjian Yuan, Jiuxiao Sun, Runhan Fu, et al.
Neurospine. 2025;22(2):523-539.

Original Article

June 30, 2025

Changing the Learning Experience and Learning Outcomes of the Unilateral Biportal Endoscopic Spine Surgery Based on Applying a Competency Task Analysis
Siravich Suvithayasiri, Piya Chavalparit, Win Boonsirikamchai, Borriwat Santipas, Michael Piccirillo, Jin-Sung Kim
Neurospine. 2025;22(2):540-542.

Editorial

June 30, 2025

Endoscopic Transnasal Approach to Atlantoaxial Decompression and C1–2 Fixation in Basilar Invagination of Adults: A Feasibility Study
Jiahai Ding, Shao Xie, Yuliang Chen, Runchuan Zhou, Syed Matiullah Azizi, Xiaoya Huang, Yang Xiong, Yuancheng Yao, Yushun Zhang, Yong Liu, et al.
Neurospine. 2025;22(2):543-555.

Original Article

June 30, 2025

Biportal Endoscopic Decompression for Degenerative Lumbar Spondylolisthesis With Stenosis
Wongthawat Liawrungrueang, Ho-Jin Lee, Sang Bum Kim, Sang-Min Park, Hyun-Jin Park
Neurospine. 2025;22(2):556-565.

Original Article

June 30, 2025

Advancing Endoscopic Decompression in Degenerative Lumbar Spondylolisthesis – A Commentary on “Biportal Endoscopic Decompression for Degenerative Lumbar Spondylolisthesis With Stenosis”
Jin-Sung Kim
Neurospine. 2025;22(2):566-570.

Commentary

June 30, 2025

Endoscopic Decompression Combined With Percutaneous Pedicle Screw Fixation for AOSpine A3 or A4 Thoracolumbar Fractures With Neurological Deficits: A Retrospective Cohort Study
Huiming Yang, Junxian Miao, Jiangtao Wang, Dan Han, Yuhang Wang, Liang Yan, Biao Wang, Dingjun Hao
Neurospine. 2025;22(2):571-582.

Original Article

April 30, 2025

Intra-, Epidural And Intracranial Pressure Changes During Interlaminar Endoscopy, With and Without Dural Tear
Mazda Farshad, Jana Felicitas Schader, Alexandra Stauffer, Carl Moritz Zipser, Najmeh Kheram, José Miguel Spirig, Marie-Rosa Fasser, Jonas Widmer, Vincent Hagel
Neurospine. 2025;22(2):583-591.

Original Article

June 30, 2025

Development and Validation of a Nomogram for Predicting Adjacent Vertebral Fracture After Osteoporotic Vertebral Compression Fracture Surgery: A Multicenter Retrospective Cohort Study
Hanwen Cheng, Huilong Wen, Yong Ma, Zhuojie Liu, Haoyu Wu, Lajing Luowu, Yong Xiao, Lianbin Liang, Fanjie Kong, Longyi Xiao, et al.
Neurospine. 2025;22(2):592-602.

Original article

April 16, 2025

Anterior Corpectomy Versus Posterior Pedicle Screw Fixation With 5.5-mm Rods for Metastatic Spinal Tumor Located in the Cervicothoracic Junction
Sun Woo Jang, Hong Kyung Shin, Sang Ryong Jeon, Sung Woo Roh, Danbi Park, Chongman Kim, Jin Hoon Park
Neurospine. 2025;22(2):603-612.

Original Article

April 15, 2025

A Commentary on “Deep Learning-Enhanced Hand Grip and Release Test for Degenerative Cervical Myelopathy: Shortening Assessment Duration to 6 Seconds”
Renyi Lu, Tian Gao
Neurospine. 2025;22(2):613-614.

Letter to the Editor

June 30, 2025

Clinical Utility and Actionability of Failure to Rescue Prediction Model for Thoracolumbar Fusion: A Focus on Variable Relevance – A Commentary on “A Predictive Model of Failure to Rescue After Thoracolumbar Fusion”
Seyed Amirhossein Tabatabaei, Mohammad Reza Cheraghi
Neurospine. 2025;22(2):615-616.

Letter to the Editor

June 30, 2025

Reply Letter: A Commentary on “A Predictive Model of Failure to Rescue After Thoracolumbar Fusion”
Joanna M. Roy, Aaron C. Segura, Michael M. Covell, Christian A. Bowers
Neurospine. 2025;22(2):617-618.

Letter to the Editor

June 30, 2025

Author Correction: Augmented Reality to Improve Surgical Workflow in Minimally Invasive Transforaminal Lumbar Interbody Fusion – A Feasibility Study With Case Series
Fabian Sommer, Ibrahim Hussain, Sertac Kirnaz, Jacob L. Goldberg, Rodrigo Navarro-Ramirez, Lynn B. McGrath Jr, Franziska A. Schmidt, Branden Medary, Pravesh Shankar Gadjradj, Roger Härtl
Neurospine. 2025;22(2):619-619.
Corrects: Neurospine 2022;19(3):574

Correction

May 28, 2025

Author Correction: Integrated Optical and Magnetic Navigation for Simplified Percutaneous Transforaminal Endoscopic Lumbar Discectomy: A Novel Approach
Xing-Chen Yao, Jun-Peng Liu, Xin-Ru Du, Li Guan, Jincai Yang, Yong Hai, Aixing Pan
Neurospine. 2025;22(2):620-620.
Corrects: Neurospine 2025;22(1):297

Correction

May 28, 2025


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