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Lordosis Distribution Index in Short-Segment Lumbar Spine Fusion – Can Ideal Lordosis Reduce Revision Surgery and Iatrogenic Deformity?
Neurospine. 2021;18(3):543-553.   Published online September 30, 2021
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Lordosis Distribution Index in Short-Segment Lumbar Spine Fusion – Can Ideal Lordosis Reduce Revision Surgery and Iatrogenic Deformity?
Neurospine. 2021;18(3):543-553.   Published online September 30, 2021
Close
Objective
The demand for spinal fusion is increasing, with concurrent reports of iatrogenic adult spinal deformity (flatback deformity) possibly due to inappropriate lordosis distribution. This distribution is assessed using the lordosis distribution index (LDI) which describes the upper and lower arc lordosis ratio. Maldistributed LDI has been associated to adjacent segment disease following interbody fusion, although correlation to later-stage deformity is yet to be assessed. We therefore aimed to investigate if hypolordotic lordosis maldistribution was associated to radiographic deformity-surrogates or revision surgery following instrumented lumbar fusion.
Methods
All patients undergoing fusion surgery ( ≤ 4 vertebra) for degenerative lumbar diseases were retrospectively included at a single center. Patients were categorized according to their postoperative LDI as: “normal” (LDI 50–80), “hypolordotic” (LDI < 50), or “hyperlordotic” (LDI > 80).
Results
We included 149 patients who were followed for 21 ± 14 months. Most attained a normally distributed lordosis (62%). The hypolordotic group had increased postoperative pelvic tilt (PT) (p < 0.001), pelvic incidence minus lumbar lordosis (PI–LL) mismatch (p < 0.001) and decreased global lordosis (p = 0.007) compared to the normal group. Survival analyses revealed a significant difference in revision surgery (p = 0.03), and subsequent multivariable logistic regression showed increased odds of 1-year revision in the hypolordotic group (p = 0.04). There was also a negative, linear correlation between preoperative pelvic incidence (PI) and postoperative LDI (p < 0.001).
Conclusion
In patients undergoing instrumented lumbar fusion surgery, hypolordotic lordosis maldistribution (LDI < 50) was associated to increased risk of revision surgery, increased postoperative PT and PI–LL mismatch. Lordosis distribution should be considered prior to spinal fusion, especially in high PI patients.

Citations

Citations to this article as recorded by  Crossref logo
  • The Use of a Wilson Kyphosis Frame Results in Minimal Loss of Lordosis Correction after Single Level Minimally Invasive TLIF at L4-5 or L5-S1
    Mitchell S. Fourman, Keith Lyons, Kasra Araghi, J. Manuel Sarmiento, Sidhant Dalal, Dan Shinn, Junho Song, Pratyush Shahi, Dimitra Melissaridou, Evan Sheha, Sravisht Iyer, James Dowdell, Sheeraz Qureshi
    Global Spine Journal.2026; 16(3): 1509.     CrossRef
  • Can proximal junctional failure be predicted after adult spinal deformity surgery by experienced deformity surgeons based on patient, surgical and radiographic parameters?
    Marc Khalifé, Ayman Mohamed, David Ben-Israel, Joshua T. Bunch, Alan H. Daniels, Bassel G. Diebo, Robert Eastlack, Richard G. Fessler, Munish C. Gupta, Kojo Hamilton, Richard Hostin, Han Jo Kim, Eric O. Klineberg, Lawrence G. Lenke, Jeffrey Mullin, Pravee
    European Spine Journal.2026; 35(5): 2295.     CrossRef
  • Standalone Anterior Lumbar Interbody Fusion L5-S1 for Single-Level Degenerative Disc Disease: Implant Parameters Influencing Radiological Results
    Pierre Barthes, André Boché, Richard Lacroix, Cécile Swennen, Mathieu Severyns, Clément Giraud, Tanguy Vendeuvre
    Cureus.2026;[Epub]     CrossRef
  • Distal lordotic angle independent of pelvic incidence to reduce the risk of adjacent segment degeneration following L4–S1 posterior lumbar interbody fusion: A retrospective study
    Young-Gook Gwak, Myung-Hoon Shin
    Medicine.2026; 105(4): e47329.     CrossRef
  • Association between lumbar lordosis and proximal junctional failure following adult spinal deformity surgery: a systematic review and meta-analysis
    Abdullah M. Alharran, AbdulMuhsen AlQallaf, Mohammad Mohammad, Mohammad Salem Alajmi, Mohammad Alkaak, Salem Y. Alenezi, Fahad Mohammad, Ahmad Al Ahmad, Nizar Algarni, Yousef Marwan
    Spine Deformity.2026;[Epub]     CrossRef
  • How Does the Lordosis Apex, Lordosis Arcs, and Inflection Point According to Roussouly Predict Outcomes After Adult Spinal Deformity Surgery?
    Harsh Jain, Advith Sarikonda, Hani Chanbour, Iyan Younus, Tyler Zeoli, Adam M. Wegner, Amir M. Abtahi, Byron F. Stephens, Scott L. Zuckerman
    Spine.2026; 51(8): 542.     CrossRef
  • The impact of preoperative lordosis distribution index on postoperative sagittal alignment and outcomes after lumbar fusion surgery for degenerative spine disease
    Jonathan Dalton, Robert Oris, Joydeep Baidya, Mitchell Ng, Joshua Mathew, Yunsoo Lee, Olivia Opara, William Green, Yulia Lee, Yasmine Eichbaum, Morgan Hitchner, Gregorio Baek, Matthew Meade, Adam Kohring, Abbey Glover, Emily Ducaji, Julian Takagi-Stewart,
    European Spine Journal.2026;[Epub]     CrossRef
  • Radiographic assessment of immediate postoperative lumbar lordosis redistribution after pedicle subtraction osteotomy with pre-contoured rods: A retrospective study
    Thomas Chevillotte, Théo Cojean, Pierre Grobost, Alice Darnis, Timothée Dautel, Clément Silvestre
    Orthopaedics & Traumatology: Surgery & Research.2026; : 104729.     CrossRef
  • L3-L4 Hyperlordosis and Decreased Lower Lumbar Lordosis Following Short-Segment L4-L5 Lumbar Fusion Surgery is Associated With L3-L4 Revision Surgery for Adjacent Segment Stenosis
    Brandon J. Herrington, Renan R. Fernandes, Jennifer C. Urquhart, Parham Rasoulinejad, Fawaz Siddiqi, Christopher S. Bailey
    Global Spine Journal.2025; 15(2): 382.     CrossRef
  • Distal Lumbar Lordosis is Associated With Reoperation for Adjacent Segment Disease After Lumbar Fusion for Degenerative Conditions
    Ragavan Manoharan, Ahmed Cherry, Aditya Raj, Nisaharan Srikandarajah, Mark Xu, Carlo Iorio, Christopher J. Nielsen, Yoga Raja Rampersaud, Stephen J. Lewis
    Global Spine Journal.2025; 15(1): 143.     CrossRef
  • One-Level Versus Two-Level Anterior Lumbar Interbody Fusion (ALIF) From L4 to S1
    Manjot Singh, Ashley Knebel, Michael J. Kuharski, Joseph E. Nassar, Tucker Callanan, Bryce A. Basques, Eren O. Kuris, Bassel G. Diebo, Alan H. Daniels
    Spine.2025; 50(4): 271.     CrossRef
  • Impact of spinal alignment on adjacent segment disease and degeneration after short-segment lumbosacral fusion
    Giuseppe Loggia, Mazda Farshad, Moritz Jokeit, Jonas Widmer, Stefani Dossi, Marco D. Burkhard
    The Spine Journal.2025; 25(11): 2461.     CrossRef
  • Assessment of lumbosacral spinal curvatures before and after surgery using 3D posturography
    Karol Łosiński, Aleksandra Bryndal, Agnieszka Grochulska, Wojciech Nawos-Wysocki, Sebastian Glowinski
    Scientific Reports.2025;[Epub]     CrossRef
  • Sagittal plane optimization with prone transpsoas lateral interbody fusion (PTP LIF)
    Zachary NaPier
    Seminars in Spine Surgery.2025; : 101181.     CrossRef
  • Impact of Segmental Lordosis Restoration During Degenerative Spinal Fusion on Two-year Adjacent Segment Disease and Revision Rates
    Manjot Singh, Michael J. Kuharski, Hazem Abdel-Megid, Mariah Balmaceno-Criss, Ashley Knebel, Mohammad Daher, Joseph E. Nassar, Bryce Basques, Eren O. Kuris, Bassel G. Diebo, Alan H. Daniels
    Spine.2025; 50(17): 1219.     CrossRef
  • Principles of Level Selection for Instrumentation in Adult Thoracolumbar Spinal Deformity Surgery
    Zeeshan M. Sardar, Josephine R. Coury, Katherine Dong, Anson G. Bautista, Lawrence G. Lenke, Justin L. Reyes
    Journal of Bone and Joint Surgery.2025; 107(20): 2322.     CrossRef
  • Utility of the L1 pelvic angle (L1PA) for assessment of sagittal alignment of the lumbar spine following short segment fusion: Comparison to segmental measures
    Zvipo M. Chisango, Catherine B. Hurley, Gabriel A. Gonzalez, Michael J. Farias, Nicolas L. Carayannopoulos, Joseph P. Carroll, Manjot Singh, Jinseong Kim, Bryce A. Basques, Bassel G. Diebo, Alan H. Daniels
    North American Spine Society Journal (NASSJ).2025; 24: 100798.     CrossRef
  • Personalized Spine Surgery in Adult Deformity: Reoperation Rates and Mechanical Complications Following Customized Planning and Interbody Implant Use
    Justin S. Smith, Chun-Po Yen, Roland Kent, Sigurd Berven, Gregory M. Mundis, Robert Robinson, Rodrigo J. Nicolau, Joseph A. Osorio, Jahangir Asghar, J. Rush Fisher, Kelli M. Howell, Mark Tantorski, Donald Blaskiewicz, Jeffrey P. Mullin, Joseph Gjolaj, Joh
    Global Spine Journal.2025;[Epub]     CrossRef
  • Pelvic position significantly influences the segmental lumbar lordosis: a cross-sectional study in asymptomatic population
    SiYu Zhou, YuDong Zhao, Yi Zhao, ZhiQian Luo, HongBin He, JunJie Ma, WeiPeng Qiu, GengYu Han, ZhuoRan Sun, Weishi Li
    European Spine Journal.2025;[Epub]     CrossRef
  • The Significance of Odontoid Incidence in Patients With Cervical Spondylotic Myelopathy
    Hongyu Qin, Weiyou Chen, Longao Huang, Xin Xiao, Qinghua Yang, Hua Jiang
    Global Spine Journal.2024; 14(8): 2374.     CrossRef
  • Single position L5-S1 lateral ALIF with simultaneous robotic posterior fixation is safe and improves regional alignment and lordosis distribution index
    Nicholas S. Hernandez, L. Daniel Diaz-Aguilar, Martin H. Pham
    European Spine Journal.2024; 33(9): 3583.     CrossRef
  • Long-term comparison of anterior (ALIF) versus transforaminal (TLIF) lumbar interbody fusion: a propensity score-matched register-based study
    Ole Kristian Alhaug, Filip C. Dolatowski, Anette Moltu Thyrhaug, Sverre Mjønes, Joao André Barroso Pereira Roque Dos Reis, Ivar Austevoll
    European Spine Journal.2024; 33(3): 1109.     CrossRef
  • Postoperative lordosis distribution index, patient reported outcome measures, and revision surgery following transforaminal lumbar interbody fusion
    Anders Schack, Tanvir Johanning Bari, Martin Gehrchen, Benny Dahl, Rachid Bech-Azeddine
    World Neurosurgery: X.2024; 21: 100251.     CrossRef
  • Validation of Roussouly classification in predicting the occurrence of adjacent segment disease after short-level lumbar fusion surgery
    Muyi Wang, Xin Wang, Hao Wang, Yifei Shen, Yong Qiu, Xu Sun, Dong Zhou, Yuqing Jiang
    Journal of Orthopaedics and Traumatology.2024;[Epub]     CrossRef
  • Sagittal Alignment in the Degenerative Lumbar Spine
    Bassel G. Diebo, Mariah Balmaceno-Criss, Renaud Lafage, Christopher L. McDonald, Daniel Alsoof, Sereen Halayqeh, Kevin J. DiSilvestro, Eren O. Kuris, Virginie Lafage, Alan H. Daniels
    Journal of Bone and Joint Surgery.2024; 106(5): 445.     CrossRef
  • Limited Intervention in Adult Scoliosis—A Systematic Review
    Zuhair Jameel Mohammed, John Worley, Luke Hiatt, Sakthivel Rajan Rajaram Manoharan, Steven Theiss
    Journal of Clinical Medicine.2024; 13(4): 1030.     CrossRef
  • Lumbar lordosis and sacral slope do not differ in two types of postoperative lumbar disc re-herniation: a cross-sectional observational study
    Zhijia Shen, Wenhao Wang, Li Ni, Hongcheng Zhao, Lianda Yang, Huilin Yang, Linlin Zhang
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • Modified S1 Pedicle Subtraction Osteotomy
    Precious C. Oyem, Jacob K. Greenberg, Colin R. Rhoads, Alexander Spiessberger
    Clinical Spine Surgery.2024; 37(6): 252.     CrossRef
  • Reciprocal Changes in Sagittal Spinal Alignment After L5-S1 Anterior Lumbar Interbody Fusion
    James J. Zhou, S. Harrison Farber, Nima Alan, Kathleen S. Moore, Charuta G. Furey, Luke K. O'Neill, Juan P. Giraldo, Zaman Mirzadeh, Jay D. Turner, Juan S. Uribe
    World Neurosurgery.2024; 188: e64.     CrossRef
  • Predictive Value of Bolster Supine X-Ray for the Correction of Segmental Deformity After Thoracolumbar Fusion Surgery
    Sang Hyub Lee, Dong-Hwan Kim, Jin Hoon Park, Dong Ho Kang
    Neurosurgery.2024; 95(5): 1046.     CrossRef
  • Restoring L4-S1 Lordosis Shape in Severe Sagittal Deformity: Impact of Correction Techniques on Alignment and Complication Profile
    Manjot Singh, Mariah Balmaceno-Criss, Mohammad Daher, Renaud Lafage, D. Kojo Hamilton, Justin S. Smith, Robert K. Eastlack, Richard G. Fessler, Jeffrey L. Gum, Munish C. Gupta, Richard Hostin, Khaled M. Kebaish, Eric O. Klineberg, Stephen J. Lewis, Breton
    World Neurosurgery.2024; 189: e219.     CrossRef
  • Evaluating the biomechanical effects of pedicle subtraction osteotomy at different lumbar levels: a finite element investigation
    Niloufar Shekouhi, Sudharshan Tripathi, Alekos Theologis, Muzammil Mumtaz, Hassan Serhan, Robert McGuire, Vijay K. Goel, Joseph M. Zavatsky
    The Spine Journal.2024; 24(11): 2191.     CrossRef
  • Lumbar Apex Position as an Independent Risk Factor for Adjacent Segment Diseases in Patients Undergoing Short-Level Transforaminal Lumbar Interbody Fusion
    Muyi Wang, Xin Wang, Jingbin Wu, Yifei Shen, Yong Qiu, Xu Sun, Dong Zhou, Yuqing Jiang
    Spine.2024; 49(20): 1435.     CrossRef
  • L4 Pedicle Subtraction Osteotomy in a Patient With Multiple Previous Revisions: A Case Report
    Alejandro J Quinonez, Austin H Carroll, Fred Mo
    Cureus.2024;[Epub]     CrossRef
  • Therapeutic and diagnostic classification of degenerative spondylolisthesis: validation and multiple-center inter-observer agreement
    E.S. Baykov, A.G. Nazarenko, N.A. Konovalov, A.I. Vasiliev, A.V. Evsyukov, D.M. Kozlov, A.S. Nikitin, R.M. Nanaev, A.G. Martikyan, Yu.M. Poluektov, E.S. Brinyuk, S.N. Makarov, A.A. Kuleshov, A.I. Kokorev, A.V. Krutko
    Burdenko's Journal of Neurosurgery.2024; 88(6): 13.     CrossRef
  • Pelvic Incidence–Lumbar Lordosis Mismatch Is Predisposed to Adjacent Segment Degeneration After Single-Level Anterior Lumbar Interbody Fusion: A Retrospective Case-Control Study
    Sun Geon Yoon, Hyung Chang Lee, Sang-Min Lee
    Neurospine.2023; 20(1): 301.     CrossRef
  • Spinal Canal Remodeling and Indirect Decompression of Contralateral Foraminal Stenosis After Endoscopic Posterolateral Transforaminal Lumbar Interbody Fusion
    Pang Hung Wu, Eugene Tze-Chun Lau, Hyeun-Sung Kim, Giovanni Grasso, Il-Tae Jang
    Neurospine.2023; 20(1): 99.     CrossRef
  • Commentary: Risk Factors for Adjacent Segment Disease in Short Segment Lumbar Interbody Fusion—A Case Series
    Hani Chanbour, Iyan Younus, Scott L. Zuckerman
    Operative Neurosurgery.2023; 25(2): e64.     CrossRef
  • Does pelvic incidence tell us the risk of proximal junctional kyphosis in adult spinal deformity surgery?
    Abdul Fettah Buyuk, John M. Dawson, Stefan Yakel, Eduardo C. Beauchamp, Amir A. Mehbod, Ensor E. Transfeldt, Pierre Roussouly
    European Spine Journal.2022; 31(6): 1438.     CrossRef
  • L5–S1 nonunion occurrence even after anterior column support combined with iliac screw fixation in long fusion for adult spinal deformity: CT-based analysis at 2-year follow-up
    Se-Jun Park, Chong-Suh Lee, Jin-Sung Park, Tae-Hoon Yum, Tae Soo Shin, Ji-Woo Chang, Keun-Ho Lee
    Journal of Neurosurgery: Spine.2022; 37(3): 420.     CrossRef
  • The Standing and Sitting Spino‐Pelvic Sagittal Alignment in Patients with Instrumented Lumbar Fusion Might Correlate with Adjacent Segment Degeneration
    Siyu Zhou, Woquan Zhong, Zhuoran Sun, Yang Guo, Yi Zhao, Wei Li, Weishi Li
    Orthopaedic Surgery.2022; 14(12): 3313.     CrossRef
  • 12,181 View
  • 251 Download
  • 49 Web of Science
  • 41 Crossref

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A Comparison of Mortality and Morbidity Between Complex and Degenerative Spine Surgery in Prospectively Collected Data From 2,280 Procedures
Neurospine. 2021;18(3):524-532.   Published online March 22, 2021
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A Comparison of Mortality and Morbidity Between Complex and Degenerative Spine Surgery in Prospectively Collected Data From 2,280 Procedures
Neurospine. 2021;18(3):524-532.   Published online March 22, 2021
Close
Objective
The reported incidence of complications and/or adverse events (AEs) following spine surgery varies greatly. A validated, systematic, reproducible reporting system to quantify AEs was used in 2 prospective cohorts, from 2 spine surgery centers, conducting either complex or purely degenerative spine surgery; in a comparative fashion. The aim was to highlight the differences between 2 distinctly different prospective cohorts with patients from the same background population.
Methods
AEs were registered according to the predefined AE variables in the SAVES (Spine AdVerse Events Severity) system which was used to record all intra- and perioperative AEs. Additional outcomes, including mortality, length of stay, wound infection requiring revision, readmission, and unplanned revision surgery during the index admission, were also registered.
Results
A total of 593 complex and 1,687 degenerative procedures were consecutively included with 100% data completion. There was a significant difference in morbidity when comparing the total number of AEs between the 2 groups (p < 0.001): with a mean number of 1.42 AEs per patient (n = 845) in the complex cohort, and 0.97 AEs per patient (n = 1,630) in the degenerative cohort.
Conclusion
In this prospective study comparing 2 cohorts, we report the rates of AEs related to spine surgery using a validated reproducible grading system for registration. The rates of morbidity and mortality were significantly higher following complex spine surgery compared to surgery for degenerative spine disease.

Citations

Citations to this article as recorded by  Crossref logo
  • Protocol for the development of enhanced recovery after surgery (ERAS) recommendations for individuals undergoing surgery for degenerative cervical myelopathy
    Caroline A. Treanor, David B. Anderson, Benjamin M. Davies, Harvinder S. Chhabra, Mike Hutton, Laskhmikumar Venkatraghavan, Jed S. Lazarus, Anoushka Singh, Kieran J. Smith, Daniel J. Stubbs, Aditya Vedantam, Juan J. Zamorano, Carl M. Zipser, Thomas W. Wai
    Spinal Cord.2025; 63(12): 674.     CrossRef
  • Independent Prognostic Factors Associated With Improved Patient-Reported Outcomes in the Prospective Evaluation of Elderly Deformity Surgery (PEEDS) Study
    Fthimnir M. Hassan, Lawrence G. Lenke, Sigurd H. Berven, Michael P. Kelly, Justin S. Smith, Christopher I. Shaffrey, Benny T. Dahl, Marinus de Kleuver, Maarten Spruit, Ferran Pellise, Kenneth M. C Cheung, Ahmet Alanay, David W. Polly, Jonathan Sembrano, Y
    Global Spine Journal.2024; 14(8): 2298.     CrossRef
  • Comparative analysis of patient demographics, perioperative outcomes, and adverse events after lumbar spinal fusion between urban and rural hospitals: an analysis of the National Inpatient Sample (NIS) database
    Justin Im, Mohamed A.R. Soliman, Esteban Quiceno, Ahmed M. Elbayomy, Alexander O. Aguirre, Cathleen C. Kuo, Evan M. Sood, Asham Khan, Hannon W. Levy, Moleca M. Ghannam, John Pollina, Jeffrey P. Mullin
    Clinical Neurology and Neurosurgery.2024; 243: 108375.     CrossRef
  • Development of a COX-2-Selective Fluorescent Probe for the Observation of Early Intervertebral Disc Degeneration
    Cheol Ho Heo, Eun Ji Roh, Jaehee Kim, Hyemin Choi, Ho Yeon Jang, Giseong Lee, Chang Su Lim, Inbo Han
    Journal of Functional Biomaterials.2023; 14(4): 192.     CrossRef
  • First clinical experience with posterior lumbar interbody fusion using a thermal-sprayed silver-containing hydroxyapatite-coated cage
    Tadatsugu Morimoto, Masatsugu Tsukamoto, Katsuhiro Aita, Nobuyuki Fujita, Masaaki Mawatari
    Journal of Orthopaedic Surgery and Research.2023;[Epub]     CrossRef
  • Screw Insertional Torque Measurement in Spine Surgery: Correlation With Bone Mineral Density and Hounsfield Unit
    Byeong Ho Oh, Jee Yong Kim, Jong Beom Lee, Jae Taek Hong, Jae Hoon Sung, Khoi D. Than, Ho Jin Lee, Il Sup Kim
    Neurospine.2023; 20(4): 1177.     CrossRef
  • 10,329 View
  • 205 Download
  • 6 Web of Science
  • 6 Crossref

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Use of Opioids and Other Analgesics Before and After Primary Surgery for Adult Spinal Deformity: A 10-Year Nationwide Study
Neurospine. 2020;17(1):237-245.   Published online July 24, 2019
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Use of Opioids and Other Analgesics Before and After Primary Surgery for Adult Spinal Deformity: A 10-Year Nationwide Study
Neurospine. 2020;17(1):237-245.   Published online July 24, 2019
Close
Objective
To report the 1-year pre and postoperative analgesic use in patients undergoing primary surgery for adult spinal deformity (ASD) and assess risk factors for chronic postoperative opioid use.
Methods
Patients > 18 years undergoing primary instrumented surgery for ASD in Denmark between 2006 and 2016 were identified in the Danish National Patient Registry. Information on analgesic use were obtained from the Danish National Health Service Prescription Database. Use of analgesics was calculated one year before and after surgery for each patient, per quarter (-Q4 to -Q1 before and Q1 to Q4 after). Users were defined as patient with one or more prescriptions in the given quarter.
Results
We identified 892 patients. Preoperatively, 28% (n = 246) of patients were opioid users in -Q4 and 33% (n = 295) in -Q1. Postoperatively, 85% (n = 756) of patients were opioid users in Q1 and 31% (n = 280) in Q4. Proportions of users of other analgesics (paracetamol, antidepressants, and anticonvulsants) were stable before and after surgery. Use of nonsteroidal anti-inflammatory drug decreased postoperatively by 40% (-Q1 vs. Q4). 26% of patients had chronic preoperative opioid use (one or more prescriptions in each -Q2 and -Q1) and 24% had chronic postoperative use (prescription each of Q1–Q4). Multivariate logistic regression analysis showed age increment per 10 years and preoperative chronic opioid use as risk factors for chronic postoperative opioid use.
Conclusion
One year after ASD surgery, opioid use was not reduced compared to preoperative usage.

Citations

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  • Purchases of analgesics before and after spine surgery – register based study of 152,829 Finnish patients with 15-year follow-up
    Henri Mononen, Reijo Sund, Jukka Huopio, Heikki Kröger, Antti Malmivaara, Jyrki Salmenkivi, Timo Nyyssönen, Ville Turppo, Joonas Sirola
    European Spine Journal.2026; 35(5): 2945.     CrossRef
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    Justin Mathew, Jeffrey L. Gum, Leah Y. Carreon, Benjamin C. Sampedro, Jennifer Harpe-Bates, Bren P. Hines, Morgan E. Brown, Christy L. Daniels, Tino Mkorombindo, Steven D. Glassman
    Spine.2025; 50(12): 804.     CrossRef
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    Alexandra C. Dionne, Kurt Holuba, Riley Sevensky, Justin L. Reyes, Roy Miller, Fthimnir M. Hassan, Josephine R. Coury, Joseph M. Lombardi, Lawrence G. Lenke, Zeeshan M. Sardar
    Journal of Craniovertebral Junction and Spine.2025; 16(3): 320.     CrossRef
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    Kadir Abul, Caglar Yilgor, Altug Yucekul, Nezih Arin Alanay, Yasemin Yavuz, Tais Zulemyan, Louis Boissiere, Anouar Bourghli, Ibrahim Obeid, Javier Pizones, Frank Kleinstueck, Francisco J.S. Perez-Grueso, Ferran Pellise, Ahmet Alanay
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    Aladine A. Elsamadicy, Mani Ratnesh S. Sandhu, Benjamin C. Reeves, Josiah J.Z. Sherman, Samuel Craft, Mica Williams, John H. Shin, Daniel M. Sciubba
    Clinical Neurology and Neurosurgery.2023; 224: 107532.     CrossRef
  • Peri-operative optimization in adult spinal deformity surgery
    Bilal B. Butt, Jetan H. Badhiwala, Jason W. Savage
    Seminars in Spine Surgery.2023; 35(2): 101026.     CrossRef
  • Optimizing Preoperative Chronic Pain Management in Elective Spine Surgery Patients
    Emily Arciero, Josephine R. Coury, Alexandra Dionne, Justin Reyes, Joseph M. Lombardi, Zeeshan M. Sardar
    JBJS Reviews.2023;[Epub]     CrossRef
  • A national database propensity score-matched comparison of minimally invasive and open colectomy for long-term opioid use
    Amir L. Bastawrous, Kara K. Brockhaus, Melissa I. Chang, Gediwon Milky, I.-Fan Shih, Yanli Li, Robert K. Cleary
    Surgical Endoscopy.2022; 36(1): 701.     CrossRef
  • Baseline Risk Factors for Prolonged Opioid Use Following Spine Surgery: Systematic Review and Meta-Analysis
    Shruthi Mohan, Conor P. Lynch, Elliot D.K. Cha, Kevin C. Jacob, Madhav R. Patel, Cara E. Geoghegan, Michael C. Prabhu, Nisheka N. Vanjani, Hanna Pawlowski, Kern Singh
    World Neurosurgery.2022; 159: 179.     CrossRef
  • Opioid use prior to surgery is associated with worse preoperative and postoperative patient reported quality of life and decreased surgical cost effectiveness for symptomatic adult spine deformity; A matched cohort analysis
    Breton Line, Shay Bess, Jeffrey L. Gum, Richard Hostin, Khaled Kebaish, Christopher Ames, Douglas Burton, Gregory Mundis, Robert Eastlack, Munish Gupta, Eric Klineberg, Virgine Lafage, Renaud Lafage, Frank Schwab, Christopher Shaffrey, Justin S. Smith
    North American Spine Society Journal (NASSJ).2022; 9: 100096.     CrossRef
  • Preoperative opioids before adult spinal deformity surgery associated with increased reoperations and high rates of chronic postoperative opioid use at 3-year follow-up
    Andre M. Samuel, Kyle W. Morse, Yuri A. Pompeu, Avani S. Vaishnav, Catherine Himo Gang, Han Jo Kim, Sheeraz A. Qureshi
    Spine Deformity.2022; 10(3): 615.     CrossRef
  • Opioid and Analgesic Use Before and After Revision Knee Arthroplasty for the Indications “Pain Without Loosening” Versus “Aseptic Loosening” – A Danish Nationwide Study
    Kristine Bollerup Arndt, Henrik M. Schrøder, Anders Troelsen, Martin Lindberg-Larsen
    The Journal of Arthroplasty.2022; 37(8): 1618.     CrossRef
  • Preoperative duration of pain is associated with chronic opioid use after adult spinal deformity surgery
    Kevin C. Mo, Rahul Sachdev, Bo Zhang, Amar Vadhera, Mark Ren, Nicholas S. Andrade, Khaled M. Kebaish, Richard L. Skolasky, Brian J. Neuman
    Spine Deformity.2022; 10(6): 1393.     CrossRef
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  • 9,245 View
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Towards Guideline-Based Management of Tethered Cord Syndrome in Spina Bifida: A Global Health Paradigm Shift in the Era of Prenatal Surgery
Neurospine. 2019;16(4):715-727.   Published online July 8, 2019
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Towards Guideline-Based Management of Tethered Cord Syndrome in Spina Bifida: A Global Health Paradigm Shift in the Era of Prenatal Surgery
Neurospine. 2019;16(4):715-727.   Published online July 8, 2019
Close
An estimated 60% of the world’s population lives in Asia, where the incidence of neural tube defects is high. Aware that tethered cord syndrome (TCS) is an important comorbidity, the purpose of this systematic review was to explore the treatment of TCS among individuals living with spina bifida (SB) in Asia. MEDLINE and Embase databases were searched for relevant studies published from January 2000 to June 2018. Search terms such as ‘spinal dysraphism,’ ‘spinabifida,’ ‘diastematomyelia,’ ‘lipomeningocele,’ ‘lypomyelomeningocele,’ ‘meningomyelocele,’ and ‘tethered cord syndrome’ were used in diverse combinations. Of the 1,290 articles that were identified in accordance with PRISMA (Preferred Items for Systematic Reviews and Meta-Analyses) guidelines, 15 Asia-based studies met the inclusion criteria. Significant differences in the diagnostic criteria and management of TCS were documented. As the surgical techniques for prenatal closure of the spinal defect continue to evolve, their adoption internationally is likely to continue. In this setting, a clear and evidence-based approach to the definition and management of TCS is essential. The recent publication by the Spina Bifida Association of America of their updated care guidelines may serve as a tool used to promote a systematized approach to diagnosing and treating TCS among individuals with SB in the region, as well as globally.

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    Sheena Ali, Samer K. Elbabaa
    Journal of Spinal Surgery.2026; 13(1): 35.     CrossRef
  • Surgical outcomes of tethered cord syndrome in patients with normal conus medullaris and filum terminale without urologic symptoms
    Alper Tabanli, Emrah Akcay, Hakan Yilmaz, Seymen Ozdemir, Mesut Mete, Mehmet Selcuki
    Child's Nervous System.2025;[Epub]     CrossRef
  • The Effect of Detethering Surgery on the Bladder Function and Psychology of Children with Primary Tethered Cord Syndrome
    Shuai Yang, Zhaokai Zhou, Xingchen Liu, Zhan Wang, Yanping Zhang, He Zhang, Lei Lv, Yibo Wen, Qingwei Wang, Wei Jia, Jinhua Hu, Jian Guo Wen
    International braz j urol.2025;[Epub]     CrossRef
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    Hepu Lin, Hui Su, Cuicui Li, Pengfei Zhang, Bo Xiu, Yunjing Bai, Ruxiang Xu
    Frontiers in Surgery.2024;[Epub]     CrossRef
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    Sheena Ali, Chandrashekhar Deopujari, Uday Andar, Samer K. Elbabaa
    Wadia Journal of Women and Child Health.2024; 2: 121.     CrossRef
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    Hangeul Park, Jun-Hoe Kim, Chang-Hyun Lee, Sum Kim, Young-Rak Kim, Kyung-Tae Kim, Ji-hoon Kim, John M. Rhee, Woo-Young Jo, Hyongmin Oh, Hee-Pyoung Park, Chi Heon Kim, Barry Kweh
    PLOS ONE.2024; 19(7): e0305694.     CrossRef
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    Talia Collier, Jonathan Castillo, Lisa Thornton, Santiago Vallasciani, Heidi Castillo
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    Continence.2023; 7: 100784.     CrossRef
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    Mandana Behbahani, Nathan Shlobin, Colleen Rosen, Elizabeth Yerkes, Vineeta Swaroop, Sandi Lam, Robin Bowman
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  • 16,106 View
  • 256 Download
  • 13 Web of Science
  • 16 Crossref

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Neural Axis Abnormalities in Patients With Adolescent Idiopathic Scoliosis: Is Routine Magnetic Resonance Imaging Indicated Irrespective of Curve Severity?
Neurospine. 2019;16(2):339-346.   Published online October 15, 2018
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Neural Axis Abnormalities in Patients With Adolescent Idiopathic Scoliosis: Is Routine Magnetic Resonance Imaging Indicated Irrespective of Curve Severity?
Neurospine. 2019;16(2):339-346.   Published online October 15, 2018
Close
Objective
Magnetic resonance imaging (MRI)-verified neural axis abnormalities (NAAs) have been described in adolescent idiopathic scoliosis (AIS), and several risk factors have been associated with the presence of NAAs in AIS patients. However, the clinical significance of these findings is unclear. The purpose of the present study was to determine the prevalence of NAAs in a large consecutive cohort of AIS patients and to evaluate the clinical significance of previously proposed risk factors.
Methods
We prospectively included AIS patients referred to a tertiary facility for evaluation. Full-spine MRI scans were performed on all included patients irrespective of curve magnitude or proposed treatment modality. MRI scans were prospectively analyzed by a neuroradiologist and the pathologic findings were confirmed by a second independent radiologist.
Results
NAA was observed in 34 of the 381 patients (8.9%): 32 patients had a syrinx, 1 patient had an arachnoid cyst, and 1 patient had a Chiari malformation. Four patients were referred for a neurosurgical evaluation but none received any neurosurgical treatment. No statistically significant difference was observed between the NAA and non-NAA groups in terms of sex, major curve size, thoracic kyphosis, left thoracic curve, curve convexity, curve progression, or level of pain (p>0.05).
Conclusion
In this prospective study examining the risk factors for NAA in AIS patients, we found that previously proposed risk factors could not predict the MRI outcomes. The finding of an NAA had no clinical implications and we do not support MRI scans as a routine diagnostic modality in all AIS patients.

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Choice of Rods in Surgical Treatment of Adolescent Idiopathic Scoliosis: What Are the Clinical Implications of Biomechanical Properties? – A Review of the Literature
Neurospine. 2018;15(2):123-130.   Published online June 19, 2018
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Choice of Rods in Surgical Treatment of Adolescent Idiopathic Scoliosis: What Are the Clinical Implications of Biomechanical Properties? – A Review of the Literature
Neurospine. 2018;15(2):123-130.   Published online June 19, 2018
Close
The surgical treatment of adolescent idiopathic scoliosis (AIS) involves 3-dimensional curve correction with multisegmental pedicle screws attached to contoured bilateral rods. The substantial corrective forces exert a high level of stress on the rods, and the ability of the rod to withstand these forces without undergoing permanent deformation relies on its biomechanical properties. These properties, in turn, are dependent on the material, diameter, and shape of the rod. The surgical treatment of AIS is characterized by the requirement for a special biomechanical profile that may differ substantially from what is needed for adult deformity surgery. This overview summarizes the current knowledge of rod biomechanics in frequently used rod constructs, with a particular focus on translational research between biomechanical studies and clinical applicability in AIS patients.

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