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"Chih-Chang Chang"

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The Quantitative Evaluation of Automatic Segmentation in Lumbar Magnetic Resonance Images
Neurospine. 2024;21(2):665-675.   Published online June 30, 2024
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The Quantitative Evaluation of Automatic Segmentation in Lumbar Magnetic Resonance Images
Neurospine. 2024;21(2):665-675.   Published online June 30, 2024
Close
Objective
This study aims to overcome challenges in lumbar spine imaging, particularly lumbar spinal stenosis, by developing an automated segmentation model using advanced techniques. Traditional manual measurement and lesion detection methods are limited by subjectivity and inefficiency. The objective is to create an accurate and automated segmentation model that identifies anatomical structures in lumbar spine magnetic resonance imaging scans.
Methods
Leveraging a dataset of 539 lumbar spinal stenosis patients, the study utilizes the residual U-Net for semantic segmentation in sagittal and axial lumbar spine magnetic resonance images. The model, trained to recognize specific tissue categories, employs a geometry algorithm for anatomical structure quantification. Validation metrics, like Intersection over Union (IOU) and Dice coefficients, validate the residual U-Net’s segmentation accuracy. A novel rotation matrix approach is introduced for detecting bulging discs, assessing dural sac compression, and measuring yellow ligament thickness.
Results
The residual U-Net achieves high precision in segmenting lumbar spine structures, with mean IOU values ranging from 0.82 to 0.93 across various tissue categories and views. The automated quantification system provides measurements for intervertebral disc dimensions, dural sac diameter, yellow ligament thickness, and disc hydration. Consistency between training and testing datasets assures the robustness of automated measurements.
Conclusion
Automated lumbar spine segmentation with residual U-Net and deep learning exhibits high precision in identifying anatomical structures, facilitating efficient quantification in lumbar spinal stenosis cases. The introduction of a rotation matrix enhances lesion detection, promising improved diagnostic accuracy, and supporting treatment decisions for lumbar spinal stenosis patients.

Citations

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  • External validation of SpineNetv2 deep learning system for automated lumbar spine MRI analysis: A multi-pathology diagnostic agreement study
    Xingkai Wu, Qianbo Song, Jiaxiang Zhou, Zhiyu Zhou, Guangru Cao, Kebing Jin, Qian Du
    European Spine Journal.2026; 35(3): 1238.     CrossRef
  • Enhancing lumbar disc herniation classification through region-of-interest guidance and geometric shape features
    Cong Zhang, Kunjin He, Wei Xu, Xiaoqing Gu, Zhengming Chen, Yiping Weng
    Biomedical Physics & Engineering Express.2026; 12(1): 015038.     CrossRef
  • Deep learning for lumbar spine segmentation in magnetic resonance imaging—A systematic review
    Diogo Mendes, João Manuel R.S. Tavares
    Biomedical Signal Processing and Control.2026; 118: 109700.     CrossRef
  • Clinical Application of Deep Learning for Spine MRI Interpretation: A Multicenter Evaluation of Artificial-Intelligence-Assisted versus Manual Reading on Diagnostic Agreement with the Reference Standard
    Xing Cheng, Maoping Zhang, Zhenxiao Ren, Tang Tang, Xiaolin Meng, Zhong Huang, Hongwei Bran Li, Weiguo Li, Qiuchan Yan, Haixiong Chen, Jie Jia, Ce Wang, Cheng Li, Chunshan Yang, Guifeng Shi, Guohua Li, Kaixin Zeng, Wei Chen, Haoxuan Gao, Xiaobo Wang, Xin
    Research.2026;[Epub]     CrossRef
  • Anatomy-Aware Text-Visual Fusion with Dual-Perspective Prompts for Fine-Grained Lumbar Spine Segmentation
    Sheng Lian, Jianlong Cai, Dengfeng Pan, Guang-Yong Chen, Hao Xu, Fan Zhang, Guodong Fan, Jialun Pei, Shuo Li
    International Journal of Computer Vision.2026;[Epub]     CrossRef
  • Automated Quantitative Analysis of the Lumbar Spine: a Comprehensive Approach
    Purushottam Kumar, Suyash Singh, Bunil Kumar Balabantaray, Rajashree Nayak
    Journal of Imaging Informatics in Medicine.2025; 39(1): 229.     CrossRef
  • Taiwan’s Smart Healthcare Value Chain: AI Innovation from R&D to Industry Deployment
    Tzu-Min Lin, Hui-Wen Yang, Ching-Cheng Han, Chih-Sheng Lin
    Healthcare.2025; 14(1): 23.     CrossRef
  • 8,254 View
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  • 8 Web of Science
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Comparison of Cortical Bone Trajectory to Pedicle-Based Dynamic Stabilization: An Analysis of 291 Patients
Neurospine. 2023;20(1):308-316.   Published online March 31, 2023
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Comparison of Cortical Bone Trajectory to Pedicle-Based Dynamic Stabilization: An Analysis of 291 Patients
Neurospine. 2023;20(1):308-316.   Published online March 31, 2023
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Objective
Pedicle-based dynamic stabilization (DS) has gained popularity outside of America. Although pedicle screw (PS) loosening has always been a concern, it is reportedly innocuous. Cortical bone trajectory (CBT) screw is an emerging option with less invasiveness and similar effectiveness to PS in short-segment lumbar fusion. This study aimed to verify the use of CBT for DS by comparing the outcomes between pedicle- and CBT-based DS.
Methods
Consecutive patients with lumbar spondylosis or low-grade spondylolisthesis who underwent 1- or 2-level DS between L3–5 with a minimum follow-up of 24 months were reviewed. Screw loosening was determined by computed tomography and the incidences were compared.
Results
A total of 291 patients who underwent Dynesys DS (235 pedicle- and 56 CBT-based, respectively) were compared. The demographics and preoperative conditions were similar. All the clinical outcomes improved at 24-month postoperation, while the CBT-based group had less operation time and blood loss than the pedicle-based group. The rates of screw loosening were lower in the CBT-based (5.4% per screw and 12.5% per patient) than the pedicle-based group (9% per screw and 26.4% per patient). Furthermore, there were no differences in the clinical outcomes and complication profiles.
Conclusion
The CBT-based DS for 1- or 2-level lumbar degeneration demonstrated equivalent clinical improvement as the pedicle-based DS. The adaption of CBT-based screws for DS could be a less invasive approach (shorter operation time and less blood loss), with lower chances of screw loosening than the conventional PS-based DS.

Citations

Citations to this article as recorded by  Crossref logo
  • Comparative CT-Based Bone Density of Traditional Pedicle Screw Trajectory, Cortical Bone Trajectory, and Modified Cortical Bone Trajectory — Radiographic Analysis of 3500 Simulated Pedicle-Screw Trajectories in 1750 Lumbar Vertebrae
    Sathish Muthu, Kavya Priyadharshini Natarajan, Vibhu Krishnan Viswanathan, Dhibin Vikash Kolarpatti Ponnusamy, Sathish Kumar Rajappan Chandra, Khan Sharun
    Global Spine Journal.2026;[Epub]     CrossRef
  • The Effect of Osteopenia and Osteoporosis on Screw Loosening in MIS-TLIF and Dynamic Stabilization
    Hsuan-Kan Chang, Chih-Chang Chang, Yu-Wen Cheng, Ching-Lan Wu, Tsung-Hsi Tu, Jau-Ching Wu, Wen-Cheng Huang
    Global Spine Journal.2025; 15(4): 2209.     CrossRef
  • Comparative Analysis Between Cortical Bone Trajectory (CBT) Screw Fixation and Traditional Pedicle Screw Fixation in Lumbar Spine Surgery: A Systematic Review and Meta-Analysis
    Vivek Sanker, Amr Badary, Aliza Asad, Barabara Buccilli, Ahed H Kattaa, David J Park, Steven D. Chang, Atman Desai, Harminder Singh
    Cureus.2025;[Epub]     CrossRef
  • Robot-assisted cortical bone trajectory versus traditional pedicle screws in the treatment of lumbar spinal stenosis with osteoporosis: A retrospective cohort study
    Ruizhao Zhao, Yuyu Fan, Junjie Qiao, Lixiang Ding, Wei Qu, Xiutong Fang
    Asian Journal of Surgery.2025; 48(10): 6062.     CrossRef
  • Screening patients requiring secondary lumbar surgery for degenerative lumbar spine diseases: a nationwide sample cohort study
    Hangeul Park, Juhee Lee, Yunhee Choi, Jun-Hoe Kim, Sum Kim, Young-Rak Kim, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Chi Heon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Comparative Biomechanical Stability of the Fixation of Different Miniplates in Restorative Laminoplasty after Laminectomy: A Finite Element Study
    Guoyin Liu, Weiqian Huang, Nannan Leng, Peng He, Xin Li, Muliang Lin, Zhonghua Lian, Yong Wang, Jianmin Chen, Weihua Cai
    Bioengineering.2024; 11(5): 519.     CrossRef
  • Clinical study on freehand of bicortical sacral screw fixation with the assistance of torque measurement device
    Guozheng Jiang, Luchun Xu, Yukun Ma, Jianbin Guan, Ningning Feng, Ziye Qiu, Shibo Zhou, Wenhao Li, Yongdong Yang, Yi Qu, He Zhao, Zeyu Li, Xing Yu
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • Expert consensus on the clinical application of cortical bone trajectory for lumbar pedicle screws: results from a modified Delphi study
    Yiqi Zhang, Jingwei Liu, Honghao Yang, Qiang Wang, Yong Hai, Yuzeng Liu
    Asian Spine Journal.2024; 18(5): 690.     CrossRef
  • Diabetes‐related Screw Loosening: The Distinction of Surgical Sites and the Relationship among Diabetes, Implant Stabilization and Clinical Outcomes
    Tianji Wang, Jing Wang, Xiaofan Hu, Kaili Hao, Geng Xiang, Zixiang Wu, Zhensheng Ma, Tianqing Li, Yu Chen, Xiong Zhao, Yang Zhang, Tiancheng Ma, Jingjuan Ren, Wei Lei, Yafei Feng
    Orthopaedic Surgery.2023; 15(12): 3136.     CrossRef
  • 8,584 View
  • 208 Download
  • 8 Web of Science
  • 9 Crossref

CSRS Special Issue

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Measurement of Deformity at the Craniovertebral Junction: Correlation of Triangular Area and Myelopathy
Neurospine. 2022;19(4):889-895.   Published online December 31, 2022
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Measurement of Deformity at the Craniovertebral Junction: Correlation of Triangular Area and Myelopathy
Neurospine. 2022;19(4):889-895.   Published online December 31, 2022
Close
Objective
Diseases of the craniovertebral junction (CVJ) are commonly associated with deformity, malalignment, and subsequent myelopathy. The misaligned CVJ might cause compression of neuronal tissues and subsequently clinical symptoms. The triangular area (TA), measured by magnetic resonance imaging/images (MRI/s), is a novel measurement for quantification of the severity of compression to the brain stem. This study aimed to assess the normal and pathological values of TA by a comparison of patients with CVJ disease to age- and sex-matched controls. Moreover, postoperative TAs were correlated with outcomes.
Methods
Consecutive patients who underwent surgery for CVJ disease were included for comparison to an age- and sex-matched cohort of normal CVJ persons as controls. The demographics, perioperative information, and pre- and postoperative 2-year cervical MRIs were collected for analysis. Cervical TAs were measured and compared.
Results
A total of 201 patients, all of whom had pre- or postoperative MRI, were analyzed. The TA of the CVJ deformity group was larger than the healthy control group (1.62 ± 0.57 cm2 vs. 1.01 ± 0.18 cm2, p < 0.001). Moreover, patients who had combined anterior odontoidectomy and posterior laminectomy with fixation had the greatest reduction in the TA (1.18 ± 0.58 cm2).
Conclusion
In CVJ deformity, the measurement of the cervical TA could indicate the severity of brain stem compression. After surgery, the TA had a varying degree of improvement, which could represent the efficacy of surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • 3D printing enabled biomechanical evaluation of a novel expandable wedge spacer for atlantoaxial reduction
    Chih-Chang Chang, Shao-Fu Huang, Rong-Chen Lin, Chun-Li Lin
    3D Printing in Medicine.2026;[Epub]     CrossRef
  • Prognostic Factors in Craniocervical Realignment for Craniovertebral Junction Kyphosis With Negative Cervical Imbalance: A Comprehensive Study
    Dong Hun Kim, Jae Taek Hong, Jin Young Kim, Kang Bin Koo, Dae Hee Lee, Jung Woo Hur, Ho Jin Lee, Il Sup Kim
    Neurospine.2025; 22(3): 725.     CrossRef
  • Evaluation of Cervicomedullary Compression Around the Craniovertebral Junction: Commentary on “Measurement of Deformity at the Craniovertebral Junction: Correlation of Triangular Area and Myelopathy”
    Jae Taek Hong
    Neurospine.2022; 19(4): 896.     CrossRef
  • 6,543 View
  • 229 Download
  • 3 Web of Science
  • 3 Crossref

Editorial

APCSS special Topic-Craniovertebral Junction Surgery

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The Nuances of Occipitocervical Instability and Stenosis in Patients With Basilar Invagination and Atlantoaxial Dislocation
Neurospine. 2019;16(2):255-256.   Published online June 30, 2019
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The Nuances of Occipitocervical Instability and Stenosis in Patients With Basilar Invagination and Atlantoaxial Dislocation
Neurospine. 2019;16(2):255-256.   Published online June 30, 2019
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  • 8,559 View
  • 137 Download

Review Article

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The Option of Motion Preservation in Cervical Spondylosis: Cervical Disc Arthroplasty Update
Neurospine. 2018;15(4):296-305.   Published online December 14, 2018
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The Option of Motion Preservation in Cervical Spondylosis: Cervical Disc Arthroplasty Update
Neurospine. 2018;15(4):296-305.   Published online December 14, 2018
Close
Cervical disc arthroplasty (CDA), or total disc replacement, has emerged as an option in the past two decades for the management of 1- and 2-level cervical disc herniation and spondylosis causing radiculopathy, myelopathy, or both. Multiple prospective randomized controlled trials have demonstrated CDA to be as safe and effective as anterior cervical discectomy and fusion, which has been the standard of care for decades. Moreover, CDA successfully preserved segmental mobility in the majority of surgical levels for 5–10 years. Although CDA has been suggested to have long-term efficacy for the reduction of adjacent segment disease in some studies, more data are needed on this topic. Surgery for CDA is more demanding for decompression, because indirect decompression by placement of a tall bone graft is not possible in CDA. The artificial discs should be properly sized, centered, and installed to allow movement of the vertebrae, and are commonly 6 mm high or less in most patients. The key to successful CDA surgery includes strict patient selection, generous decompression of the neural elements, accurate sizing of the device, and appropriately centered implant placement.

Citations

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  • The Total Disc Replacement Osteolysis Grading Scale – a simple, reliable and quantifiable tool for assessing, managing and reporting osteolysis after cervical total disc replacement
    Alana Celenza, Jessica Gaff, Moreica Pabbruwe, Juan Amaya, Ashik Amlani, Andrew Berg, Sonja Häckel, Michael Kern, Andrew Miles, Paul Taylor, Gregory Cunningham
    European Spine Journal.2026; 35(4): 1706.     CrossRef
  • A review of combined anterior cervical discectomy and fusion with cervical disc replacement for multilevel cervical disc disease
    Jeffrey Weinreb, Claire van Ekdom, Diarra Oden, Joseph O’Brien
    Current Orthopaedic Practice.2026;[Epub]     CrossRef
  • Clinical and Radiological Outcomes of Skip-Level Cervical Disk Arthroplasty
    Chao-Hung Kuo, Ching‐Ying Wang, Yin-Sheng Chen, Yi-Hsuan Kuo, Chih-Chang Chang, Chin-Lan Wu, Li-Yu Fay, Tsung-Hsi Tu, Wen-Cheng Huang, Jau-Ching Wu
    Neurosurgery.2026;[Epub]     CrossRef
  • History of Trauma Preceding Cervical Disc Replacement Leads to Worse Postoperative Patient Reported Outcomes: A Matched Cohort Analysis
    Sereen Halayqeh, Chad Z. Simon, Annika Bay, Eric Mai, Cole T. Kwas, Tomoyuki Asada, Andrea Pezzi, Adrian T. H. Lui, Atahan Durbas, Olivia C. Tuma, Nicholas J. Giattino, Anthony R. Lewis, James E. Dowdell, Kyle W. Morse, James Farmer, Russel C. Huang, Todd
    Global Spine Journal.2026;[Epub]     CrossRef
  • Comparison of Hybrid Surgery and Two-Level ACDF in Treating Consecutive Cervical Degenerative Disc Disease: A Systematic Review and Meta-Analysis
    Yihan Yang, Weishi Liang, Duan Sun, Bo Han, Zhangfu Li, Yeqiu Xu, Peng Yin, Xianjun Qu, Yong Hai
    Global Spine Journal.2025; 15(8): 3953.     CrossRef
  • Menor síndrome adyacente superior y menor tasa de reoperación. Resultados a mediano y largo plazo de la artroplastia cervical frente a la artrodesis cervical anterior: revisión sistemática y metaanálisis de ensayos clínicos aleatorizados
    J.H. Núñez, B. Escudero, J.D. Montenegro, M.J. Jiménez-Jiménez, J. Martínez-Peña, M. Surroca, D. Bosch-García
    Revista Española de Cirugía Ortopédica y Traumatología.2024; 68(2): 168.     CrossRef
  • [Translated article] Less superior adjacent syndrome and lower reoperation rate. Medium- and long-term results of cervical arthroplasty versus anterior cervical arthrodesis: Systematic review and meta-analysis of randomized clinical trials
    J.H. Núñez, B. Escudero, J.D. Montenegro, M.J. Jiménez-Jiménez, J. Martínez-Peña, M. Surroca, D. Bosch-García
    Revista Española de Cirugía Ortopédica y Traumatología.2024; 68(2): T168.     CrossRef
  • Revolutionizing Relief: Cervical Radiculopathy With Neurological Deficits Rescued by Cervical Disc Replacement
    Rahul Singh, Sohael Khan, Ratnakar E Ambade, Kashyap Kanani, Vipul Agrawal, Siddharth K Patel
    Cureus.2024;[Epub]     CrossRef
  • Clinical management of bone loss in cervical total disc arthroplasty: literature review and treatment recommendations
    Hannah Spece, Armen Khachatryan, Frank M. Phillips, Todd H. Lanman, Gunnar B. J. Andersson, Grant E. Garrigues, Hyun Bae, Joshua J. Jacobs, Steven M. Kurtz
    European Spine Journal.2024; 33(8): 2969.     CrossRef
  • The Efficacy of Second-Generation Cervical Spine Arthroplasty: A 5-Year Perspective
    David Bosch-García, Rodrigo Luna Gutiérrez, Berta Escudero Cisneros, Carlos García Cardona, Juan Diego Montenegro, Jorge H. Núñez
    Journal of Minimally Invasive Spine Surgery and Technique.2024; 9(Suppl 2): S117.     CrossRef
  • A Decreasing National Trend in Lumbar Disc Arthroplasty
    Emily S. Mills, Tara Shelby, Gabriel J. Bouz, Raymond J. Hah, Jeffrey C. Wang, Ram K. Alluri
    Global Spine Journal.2023; 13(8): 2271.     CrossRef
  • Incidence and Risk Factor of Implant Dislocation After Cervical Disk Arthroplasty: A Retrospective Cohort Analysis of 756 Patients
    Chin-Chu Ko, Bo-Kai Feng, Yi-Hsuan Kuo, Chao-Hung Kuo, Tsung-Hsi Tu, Chih-Chang Chang, Henrich Cheng, Wen-Cheng Huang, Jau-Ching Wu
    Neurosurgery.2023; 93(2): 330.     CrossRef
  • Multilevel Cervical Disk Arthroplasty
    Aditya Muralidharan, Davin Gong, Joshua D. Piche, Neil Al-Saidi, Hwee Weng Dennis Hey, Ilyas Aleem
    Clinical Spine Surgery.2023; 36(9): 363.     CrossRef
  • Range of motion after 1, 2, and 3 level cervical disc arthroplasty
    Todd H. Lanman, Jason M. Cuellar, Nicole Mottole, Michael Wernke, Elizabeth Carruthers, Antonio Valdevit
    North American Spine Society Journal (NASSJ).2023; 16: 100294.     CrossRef
  • Cervical and Lumbar Disc Arthroplasty: A Review of Current Implant Design and Outcomes
    Ian J. Wellington, Cameron Kia, Ergin Coskun, Barrett B. Torre, Christopher L. Antonacci, Michael R. Mancini, John P. Connors, Sean M. Esmende, Heeren S. Makanji
    Bioengineering.2022; 9(5): 227.     CrossRef
  • Outcomes of cervical disc replacement in patients with neck pain greater than arm pain
    Pratyush Shahi, Avani S. Vaishnav, Ryan Lee, Eric Mai, Michael E. Steinhaus, Russel Huang, Todd Albert, Sravisht Iyer, Evan D. Sheha, James E. Dowdell, Sheeraz A. Qureshi
    The Spine Journal.2022; 22(9): 1481.     CrossRef
  • Outcomes of cervical arthroplasty versus anterior cervical arthrodesis: a systematic review and meta-analysis of randomized clinical trials with a minimum follow-up of 7-year
    Jorge H. Núñez, Berta Escudero, Irene Omiste, Judith Martínez-Peñas, Maria Surroca, Francisco Alonzo-González, David Bosch-García
    European Journal of Orthopaedic Surgery & Traumatology.2022; 33(5): 1875.     CrossRef
  • Letter to the Editor Regarding “Anterior Bone Loss in Cervical Disk Arthroplasty Correlates with Increased Cervical Lordosis”
    Ioannis Siasios, Kalliopi Tsoleka, Ethymia Samara, Theodosis Birbilis
    World Neurosurgery.2022; 166: 288.     CrossRef
  • Safety and Validity of Anterior Cervical Disc Replacement for Single-level Cervical Disc Disease: Initial Two-year Follow-up of the Prospective Observational Post-marketing Surveillance Study for Japanese Patients
    Toshihiro TAKAMI, Takeshi HARA, Masahito HARA, Toshihiko INUI, Kiyoshi ITO, Izumi KOYANAGI, Junichi MIZUNO, Masaki MIZUNO, Hiroyuki NAKASE, Nobuyuki SHIMOKAWA, Taku SUGAWARA, Shinsuke SUZUKI, Toshiyuki TAKAHASHI, Masakazu TAKAYASU, Satoshi TANI, Kazutoshi
    Neurologia medico-chirurgica.2022; 62(11): 489.     CrossRef
  • Does the sizing of current cervical disc arthroplasty systems match Chinese cervical anatomic dimensions?
    Lu Wang, Meng Bai, Xing-Bin Li, Zhao-Rui Wang, Bang Wang, Ai-Bing Huang
    Frontiers in Bioengineering and Biotechnology.2022;[Epub]     CrossRef
  • Multilevel cervical disc arthroplasty: a review of optimal surgical management and future directions
    Tsung-Hsi Tu, Ching-Ying Wang, Yu-Chun Chen, Jau-Ching Wu
    Journal of Neurosurgery: Spine.2022; : 1.     CrossRef
  • Cervical disc arthroplasty for Klippel-Feil syndrome
    Chu-Yi Lee, Ching-Lan Wu, Hsuan-Kan Chang, Jau-Ching Wu, Wen-Cheng Huang, Henrich Cheng, Tsung-Hsi Tu
    Clinical Neurology and Neurosurgery.2021; 209: 106934.     CrossRef
  • Cervical disc arthroplasty: What we know in 2020 and a literature review
    Jun Jae Shin, Kwang-Ryeol Kim, Dong Wuk Son, Dong Ah Shin, Seong Yi, Keung-Nyun Kim, Do-Heum Yoon, Yoon Ha, K Daniel Riew
    Journal of Orthopaedic Surgery.2021;[Epub]     CrossRef
  • Late complication of cervical disc arthroplasty: heterotopic ossification causing myelopathy after 10 years. Illustrative case
    Che-Han Hsu, Yi-Hsuan Kuo, Chao-Hung Kuo, Chin-Chu Ko, Jau-Ching Wu, Wen-Cheng Huang
    Journal of Neurosurgery: Case Lessons.2021;[Epub]     CrossRef
  • Cervical disc arthroplasty at C2–3: illustrative case
    Jason Ku, Johnson Ku, Hsuan-Kan Chang, Jau-Ching Wu
    Journal of Neurosurgery: Case Lessons.2021;[Epub]     CrossRef
  • Cervical Disc Replacement
    Jeremy Steinberger, Sheeraz Qureshi
    Neurosurgery Clinics of North America.2020; 31(1): 73.     CrossRef
  • Comparison of cervical disc arthroplasty and anterior cervical discectomy and fusion for the treatment of cervical disc degenerative diseases on the basis of more than 60 months of follow-up: a systematic review and meta-analysis
    Yijian Zhang, Nanning Lv, Fan He, Bin Pi, Hao Liu, Angela Carley Chen, Huilin Yang, Mingming Liu, Xuesong Zhu
    BMC Neurology.2020;[Epub]     CrossRef
  • Letter to the Editor. Indolent clinical and radiological effects of cervical disc arthroplasty
    Wen-Cheng Huang, Yu-Chun Chen, Tsung-Hsi Tu, Hsuan-Kan Chang, Chao-Hung Kuo
    Journal of Neurosurgery: Spine.2020; 32(6): 984.     CrossRef
  • Letter to the Editor. Cervical spondylotic myelopathy
    Atul Goel
    Journal of Neurosurgery: Spine.2020; 32(4): 631.     CrossRef
  • Letter to the Editor. The need for research prioritization in cervical myelopathy
    Oliver Daniel Mowforth, Michelle Louise Starkey, Mark Reinhard Kotter, Benjamin Marshall Davies
    Journal of Neurosurgery: Spine.2020; 32(5): 777.     CrossRef
  • Segmental Motion of the Cervical Spine After Total Disc Replacement Using ActivC Versus Discectomy and Fusion Using Stand-alone Cage
    Bum-Joon Kim, Se-Hoon Kim, Seung-Hwan Lee, Sung-Kon Ha, Sang-Dae Kim, Dong-Jun Lim
    World Neurosurgery.2019; 126: e1228.     CrossRef
  • Cervical disc arthroplasty for less-mobile discs
    Tsung-Hsi Tu, Chu-Yi Lee, Chao-Hung Kuo, Jau-Ching Wu, Hsuan-Kan Chang, Li-Yu Fay, Wen-Cheng Huang, Henrich Cheng
    Journal of Neurosurgery: Spine.2019; 31(3): 310.     CrossRef
  • Recent advances in the management of cervical spondylotic myelopathy: bibliometric analysis and surgical perspectives
    Yu-Chun Chen, Chao-Hung Kuo, Chieh-Ming Cheng, Jau-Ching Wu
    Journal of Neurosurgery: Spine.2019; 31(3): 299.     CrossRef
  • Anterior Cervical Disc Replacement : Current Status and Future Perspective in Japan
    Toshihiro Takami, Kentaro Naito, Kenji Ohata
    Spinal Surgery.2019; 33(2): 144.     CrossRef
  • Effect of Myelopathy on Early Clinical Improvement After Cervical Disc Replacement: A Study of a Local Patient Cohort and a Large National Cohort
    Andre M. Samuel, Harold G. Moore, Avani S. Vaishnav, Steven McAnany, Todd Albert, Sravisht Iyer, Yoshihiro Katsuura, Catherine Himo Gang, Sheeraz A. Qureshi
    Neurospine.2019; 16(3): 563.     CrossRef
  • Preservation Versus Elimination of Segmental Motion in Anterior Cervical Spine Surgery
    Wen-Cheng Huang, Jau-Ching Wu
    Neurospine.2019; 16(3): 576.     CrossRef
  • 17,142 View
  • 265 Download
  • 36 Web of Science
  • 36 Crossref

Original Article

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A Hybrid Dynamic Stabilization and Fusion System in Multilevel Lumbar Spondylosis
Neurospine. 2018;15(3):231-241.   Published online August 22, 2018
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A Hybrid Dynamic Stabilization and Fusion System in Multilevel Lumbar Spondylosis
Neurospine. 2018;15(3):231-241.   Published online August 22, 2018
Close
Objective
The Dynesys-Transition-Optima (DTO) hybrid system was designed to achieve arthrodesis and stabilization in patients with lumbar degeneration. Satisfactory outcomes were demonstrated previously. However, no study has evaluated the effects of using the DTO system in patients with lumbar spondylolisthesis or stenosis.
Methods
This retrospective study included 35 consecutive patients with multilevel lumbar degeneration with or without spondylolisthesis who underwent surgery using the DTO system. Imaging studies included pre- and postoperative radiography, magnetic resonance imaging, and computed tomography. The clinical outcomes were measured by Japanese Orthopedic Association (JOA) scores, Oswestry Disability Index (ODI) scores, and a visual analogue scale (VAS) for back and leg pain.
Results
Thirty patients (85.7%) with a mean age of 61.9 years completed the follow-up, with a mean duration of 35.1 months. There were 21 patients in the spondylolisthesis group and 9 in the stenosis group. The spondylolisthesis group had worse functional scores than the stenosis group preoperatively. After DTO surgery, all patients showed significant improvements in clinical outcomes, including VAS for back and leg pain, ODI, and JOA scores (p < 0.05). There were no significant differences in clinical outcomes between the 2 groups. At a 2-year follow-up, lumbar alignment was well maintained in both groups (p = 0.116). There were no significant differences in lumbar alignment between the 2 groups.
Conclusion
During a follow-up period of over 2 years, both patients with spondylolisthesis and those with stenosis showed improvements and similar disability and pain scores after surgery using the DTO system. Lumbar alignment was also well maintained.

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