Skip to main navigation Skip to main content
  • E-Submission
  • Contact us

NS : Neurospine

OPEN ACCESS
Search
Advanced Search
ABOUT
BROWSE ARTICLES
FOR CONTRIBUTORS

Page Path

18
results for

"Dae-Chul Cho"

Article category

More +

Publication year

More +

Keywords

More +

Authors

More +

Funded articles

More +

"Dae-Chul Cho"

Original Article

Trauma

Impact of Fracture Deficit Volume on Fusion Success in Anterior Odontoid Screw Fixation
JinWoo Jung, Young San Ko, Yu Sung Yoon, Dae-Chul Cho
Neurospine 2025;22(3):859-869.   Published online September 30, 2025
DOI: https://doi.org/10.14245/ns.2550536.268

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Impact of Fracture Deficit Volume on Fusion Success in Anterior Odontoid Screw Fixation
Neurospine. 2025;22(3):859-869.   Published online September 30, 2025
DOI: https://doi.org/10.14245/ns.2550536.268
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Impact of Fracture Deficit Volume on Fusion Success in Anterior Odontoid Screw Fixation
Neurospine. 2025;22(3):859-869.   Published online September 30, 2025
DOI: https://doi.org/10.14245/ns.2550536.268
Close
Objective
Anterior odontoid screw fixation (AOSF) has several advantages over posterior C1–2 fusion for Grauer type II and shallow type III odontoid fractures. However, the risk factors for fusion failure, particularly in terms of 3-dimensional (3D) measurements, remain unclear. This study investigated the impact of fracture deficit volume (FDV), a novel 3D measurement, on fusion outcomes in patients undergoing AOSF.
Methods
We enrolled 44 patients with Grauer type II or shallow type III odontoid fractures treated with AOSF at a single institution. Radiological assessments included preoperative and postoperative measurements of the fracture gap and fracture displacement on computed tomography (CT) scans. FDV was calculated through 3D CT reconstruction of preoperative and immediate postoperative CT to quantify the spatial gap between the edges of the fractures. Fusion outcomes were defined as solid union, fibrous union, or nonunion. Logistic regression and a generalized additive model (GAM) were used to identify risk factors for fusion failure after AOSF.
Results
Solid fusion was achieved in 77.3% of patients. A reduction in the FDV with respect to the preoperative value was significantly associated with successful fusion (p=0.028), whereas patients presenting an increased FDV postoperatively were more likely to exhibit fusion failure (p=0.006). Age≥65 years, a fracture gap≥2 mm, and an increased FDV postoperatively were significant risk factors for fusion failure. GAM analysis revealed a linear relationship between a reduced FDV and improved fusion rates (adjusted R2=0.186, p=0.018).
Conclusion
The risk of fusion failure is greater in elderly patients, those with a fracture gap greater than 2 mm, and those with an increased FDV postoperatively. Among the modifiable risk factors, FDV had the greatest impact on fusion outcomes after AOSF.
  • 3,793 View
  • 56 Download

Commentary

Commentary on “Comparison of the Clinical Efficacy of Anabolic Agents and Bisphosphonates in the Patients With Osteoporotic Vertebral Fracture: Systematic Review and Meta-analysis of Randomized Controlled Trials”
Dae-Chul Cho
Neurospine 2024;21(2):430-431.   Published online June 30, 2024
DOI: https://doi.org/10.14245/ns.2448592.296

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Commentary on “Comparison of the Clinical Efficacy of Anabolic Agents and Bisphosphonates in the Patients With Osteoporotic Vertebral Fracture: Systematic Review and Meta-analysis of Randomized Controlled Trials”
Neurospine. 2024;21(2):430-431.   Published online June 30, 2024
DOI: https://doi.org/10.14245/ns.2448592.296
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Commentary on “Comparison of the Clinical Efficacy of Anabolic Agents and Bisphosphonates in the Patients With Osteoporotic Vertebral Fracture: Systematic Review and Meta-analysis of Randomized Controlled Trials”
Neurospine. 2024;21(2):430-431.   Published online June 30, 2024
DOI: https://doi.org/10.14245/ns.2448592.296
Close
  • 4,204 View
  • 80 Download
  • 1 Web of Science

Review Article

Special Issue on AI & Robotics

Navigation-Guided/Robot-Assisted Spinal Surgery: A Review Article
Young-Seok Lee, Dae-Chul Cho, Kyoung-Tae Kim
Neurospine 2024;21(1):8-17.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2347184.592

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Navigation-Guided/Robot-Assisted Spinal Surgery: A Review Article
Neurospine. 2024;21(1):8-17.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2347184.592
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Navigation-Guided/Robot-Assisted Spinal Surgery: A Review Article
Neurospine. 2024;21(1):8-17.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2347184.592
Close
The development of minimally invasive spinal surgery utilizing navigation and robotics has significantly improved the feasibility, accuracy, and efficiency of this surgery. In particular, these methods provide improved accuracy of pedicle screw placement, reduced radiation exposure, and shortened learning curves for surgeons. However, research on the clinical outcomes and cost-effectiveness of navigation and robot-assisted spinal surgery is still in its infancy. Therefore, there is limited available evidence and this makes it difficult to draw definitive conclusions regarding the long-term benefits of these technologies. In this review article, we provide a summary of the current navigation and robotic spinal surgery systems. We concluded that despite the progress that has been made in recent years, and the clear advantages these methods can provide in terms of clinical outcomes and shortened learning curves, cost-effectiveness remains an issue. Therefore, future studies are required to consider training costs, variable initial expenses, maintenance and service fees, and operating costs of these advanced platforms so that they are feasible for implementation in standard clinical practice.

Citations

Citations to this article as recorded by  Crossref logo
  • Digital Twin Framework for Spine Surgery Considering Respiratory Motions: Methodology and Proof-of-Concept Validation
    Ashkan Ghorbanian, Borhan Beigzadeh
    IEEE Access.2026; : 1.     CrossRef
  • Obstacles to Spine Surgery in Limited-Resource Environments
    Amer Sebaaly, Mohammad Daher, Joseph E. Nassar, Gaby Kreichati, Khalil Kharrat, Alan H. Daniels
    Journal of Bone and Joint Surgery.2026; 108(7): 477.     CrossRef
  • Novel 3D-navigated screw corridors for posterior pelvic ring stabilization: a finite element analysis
    Eftychios Bolierakis, Maximilian Praster, Hatem Alabdulrahman, Ulf Krister Hofmann, Christian Herren, Roman Michalik, Michel Teuben, Hans-Christoph Pape, Frank Hildebrand, Till Berk
    European Journal of Trauma and Emergency Surgery.2026;[Epub]     CrossRef
  • Preoperative Surgical Planning for Lumbar Spine Pedicle Screw Placement Using PointNet
    Seokbin Hwang, Suk-Joong Lee, Sungmin Kim
    Electronics.2026; 15(2): 468.     CrossRef
  • Robotics in Cervical Spine Surgery: The Current Scenario
    S. Vidyadhara, Abhishek Soni, T. Balamurugan, H. S. Chhabra
    Indian Spine Journal.2026; 9(1): 12.     CrossRef
  • Robotic Thoracolumbar Pedicle Screw Fixation: A Comprehensive Narrative Review
    Anuj Mundra, Sachin Sharma, Vishal Singh, S. Vidyadhara, Harvinder Singh Chhabra
    Indian Spine Journal.2026; 9(1): 61.     CrossRef
  • Three-dimensional Printing in Spine Surgery: A Comprehensive Review of Current Applications, Outcomes, and Future Directions
    Manish Gupta, Bhavuk Garg
    Indian Spine Journal.2026; 9(1): 72.     CrossRef
  • AI-Driven Robotics has Optimized Motion Control, Decision-Making, and Real-Time Adaptability in Minimally Invasive Surgeries: A Systematic Review
    Mary Little Flower Thomas, Christopher Ezhil Singh Sreedharan, Glan Devadhas George, T. Jaya, Sridharan Ponnusamy, Jerril Gilda Sreedharan, Jerril Gilda, K. G. Jaya Christiyan, M. P. Muhsin
    Premier Journal of Science.2026;[Epub]     CrossRef
  • Mini-review on human-centered assurance in robot-assisted orthopedics and neurosurgery
    Sue Min Cho, Xinrui Zou, Laura Fleig, Mathias Unberath
    Frontiers in Robotics and AI.2026;[Epub]     CrossRef
  • Spinale Robotik vs. Cone-Beam-Navigation
    Patrick Strube, Alexander Hölzl, Anna-Maria Vogel, Georg Matziolis, Chris Lindemann
    Die Orthopädie.2026;[Epub]     CrossRef
  • Safety and accuracy of robot-assisted pedicle screw fixation: a randomized controlled trial
    Yawen Jiang, Jikui Qian, Ling Zhang, Yan Yu, Liming Cheng, Jinwu Wang, Ying Yao, Shaobai Wang
    International Journal of Surgery.2026; 112(4): 9770.     CrossRef
  • Budget impact analysis of robot-assisted versus conventional spine surgery in Spain
    Rubén Martín Láez, Fernando Álvarez-Sala Walther, Julen Monje, María Álvarez, Mehdi Zahra, Sofía De Pedro, Paula Castro Albarrán, Miguel Ángel Casado, José A. Fernández Alén
    Journal of Robotic Surgery.2026;[Epub]     CrossRef
  • O‐Arm Navigation Enhances Facet Preservation Without Compromising Clinical Outcomes in UBE Decompression for Radiographically Stable Adult Degenerative Scoliosis: A Single‐Center Comparative Study
    Yi Liu, Yiwei Xie, Zhibao Chen, Ruijun Xu, Haojie Chen, Xiaojian Ye, Jiangming Yu
    Orthopaedic Surgery.2026;[Epub]     CrossRef
  • Posterior and Transforaminal Lumbar Interbody Fusion
    Arpan A. Patel, Shaarada Srivatsa, Mark A. Davison, Michael P. Steinmetz
    Neurosurgery Clinics of North America.2025; 36(1): 11.     CrossRef
  • Robotics in orthopaedic surgery: The end of surgery or its future?
    Felix C. Oettl, Bálint Zsidai, Jacob F. Oeding, Mazda Farshad, Michael T. Hirschmann, Kristian Samuelsson
    Knee Surgery, Sports Traumatology, Arthroscopy.2025; 33(3): 793.     CrossRef
  • Application of 3D visualization virtual surgery system in percutaneous transforaminal endoscopic discectomy
    Chen Gong, Min Zhang, Jianming Wu, Zhiwei Shi, Xiangyang Liu, Yahui Niu
    Technology and Health Care.2025; 33(2): 744.     CrossRef
  • Computer-aided robotics for applications in fracture reduction surgery: Advances, challenges, and opportunities
    Xianzheng Zhou, Yimiao Chen, Genyuan Miao, Yanchao Guo, Qinhe Zhang, Jianping Bi
    iScience.2025; 28(1): 111509.     CrossRef
  • A systematic review and meta-analysis of radiation exposure in spinal surgeries: Comparing C-Arm, CT navigation, and O-Arm techniques
    Kamran Shirbache, Melika Heidarzadeh, Reihane Qahremani, Amin Karami, Shaghayegh Karami, Elham Madreseh, Julio J. Jauregui, Ebrahim Najafzadeh, Ali Kazemi, Mohammad Hossein Nabian
    Journal of Medical Imaging and Radiation Sciences.2025; 56(2): 101831.     CrossRef
  • S8 Navigation system combined with an ultrasonic osteotome for three-dimensional real-time dynamic visualization decompression to reduce postoperative neurological deterioration in thoracic ossification of the ligamentum flavum
    Shuai Li, Jinpeng Du, Xiaohui Wang, Yunfei Huang, Yansheng Huang, Zhen Chang, Liang Yan, Xuefang Zhang, Zhengwei Shi, Zhigang Zhao, Lin Gao, Songchuan Zhao, Baorong He
    European Spine Journal.2025; 34(3): 1004.     CrossRef
  • Robotic pedicle screw placement for minimal invasive thoracolumbar spine surgery: a technical note
    Luthfi Gatam, Phedy Phedy, Syafruddin Husin, Harmantya Mahadhipta, Asrafi Rizki Gatam, Mitchel Mitchel, Karina Sylvana Gani, Erica Kholinne
    Frontiers in Surgery.2025;[Epub]     CrossRef
  • How Do Robotics and Navigation Facilitate Minimally Invasive Spine Surgery? A Case Series and Narrative Review
    Esteban Quiceno, Mohamed A. R. Soliman, Asham Khan, Jeffrey P. Mullin, John Pollina
    Neurosurgery.2025; 96(3S): S84.     CrossRef
  • Robotic Systems in Spinal Surgery: A Review of Accuracy, Radiation Exposure, Hospital Readmission Rate, Cost, and Adverse Events
    Nadia V. Haik, Alison E. Burgess, Norris C. Talbot, Patrick Luther, James R. Bridges, Michael Folse, Elizabeth Jee, Jamie Toms
    World Neurosurgery.2025; 195: 123721.     CrossRef
  • Optimizing Single-Position Prone Lateral Lumbar Interbody Fusion with Exoscopic Technology: A Review of Key Innovations
    Christian Quinones, John Preston Wilson, Deepak Kumbhare, Bharat Guthikonda, Stanley Hoang
    Journal of Clinical Medicine.2025; 14(4): 1132.     CrossRef
  • Letter to the Editor Regarding “Robotic Systems in Spinal Surgery: A Review of Accuracy, Radiation Exposure, Hospital Readmission Rate, Cost, and Adverse Events”
    Yuxuan Dai, Yu Chen, Bing Wang, Jiao Zhang, Bo Chen
    World Neurosurgery.2025; 196: 123838.     CrossRef
  • Optimizing the clinical adoption of total joint replacement of the lumbar spine through imaging, robotics and artificial intelligence
    S. Craig Humphreys, Jon E. Block, Ahilan Sivaganesan, Louis J. Nel, Marc Peterman, Scott D. Hodges
    Expert Review of Medical Devices.2025; 22(5): 405.     CrossRef
  • Integrated Optical and Magnetic Navigation for Simplified Percutaneous Transforaminal Endoscopic Lumbar Discectomy: A Novel Approach
    Xing-Chen Yao, Jun-Peng Liu, Xin-Ru Du, Li Guan, Yong Hai, Jincai Yang, Aixing Pan
    Neurospine.2025; 22(1): 297.     CrossRef
  • Advancements in robotic-assisted spine surgery: A literature review and technology comparison
    Jonathan Hammond, Stefano Priola
    Interdisciplinary Neurosurgery.2025; 40: 102056.     CrossRef
  • Automated labeling using tracked ultrasound imaging: Application in tracking vertebrae during spine surgery
    Debarghya China, Luke J. MacLean, Jinchi Wei, Nicholas Theodore, Norbert Johnson, Neil Crawford, Kai Ding, Ali Uneri
    Medical Image Analysis.2025; 105: 103672.     CrossRef
  • Optimizing TLIF Approach Selection: An Algorithmic Framework with Illustrative Cases
    Alyssa M. Bartlett, Summer Shabana, Caroline C. Folz, Mounica Paturu, Christoper I. Shaffrey, Parastou Quist, Olumide Danisa, Khoi D. Than, Peter Passias, Muhammad M. Abd-El-Barr
    Journal of Clinical Medicine.2025; 14(12): 4209.     CrossRef
  • Japanese 2021 nationwide survey on complications from spine surgery
    Sadayuki Ito, Shiro Imagama, Hiroaki Nakashima, Masaaki Machino, Toshinori Sakai, Toshimi Aizawa, Hideyuki Arima, Hideaki Hamanaka, Yuyu Ishimoto, Satoshi Kato, Yoshiharu Kawaguchi, Hiroaki Konishi, Naohisa Miyakoshi, Hideki Murakami, Yukitaka Nagamoto, K
    European Spine Journal.2025; 34(8): 3095.     CrossRef
  • The feasibility of robotic navigation in single position oblique lateral spine surgery. A technical note and a retrospective study
    Asrafi Rizki Gatam, Luthfi Gatam, Ajiantoro Ajiantoro, Omar Luthfi, Phedy Phedy, Harmantya Mahadhipta, Syafruddin Husin, Karina Sylvana Gani, Mitchel Mitchel, Erica Kholinne
    Frontiers in Surgery.2025;[Epub]     CrossRef
  • Comprehensive workflow with optical navigation in minimally invasive transforaminal lumbar interbody fusion: a retrospective study
    Kangheng Niu, Zhenzhen Tao, Le Cheng, Zhong Wei, Hui Kang, Tanjun Wei, Biwang Huang, Feng Xu, Chengjie Xiong
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Utility of Enabling Technologies in Spinal Deformity Surgery: Optimizing Surgical Planning and Intraoperative Execution to Maximize Patient Outcomes
    Nora C. Kim, Eli Johnson, Christopher DeWald, Nathan Lee, Timothy Y. Wang
    Journal of Clinical Medicine.2025; 14(15): 5377.     CrossRef
  • Complications and Errors With Spinal Robotics and Navigation
    Trice A. Pickens, Cade F. Bennett, Daniel E. Herrera, Wellington K. Hsu, Srikanth N. Divi, Alpesh A. Patel
    Contemporary Spine Surgery.2025; 26(9): 1.     CrossRef
  • Whole-Workflow Robotic-Assisted Percutaneous Endoscopic Lumbar Discectomy via a Two-Step Access Method: Technical Report and Preliminary Results
    Wenjie Zheng, Junlong Wu, Wen Xia, Rui Zuo, Xian Chang, Hong Yin, Changqing Li, Chao Zhang
    Journal of Pain Research.2025; Volume 18: 4361.     CrossRef
  • The Role of Robotic-Assisted Surgery in Orthopedic Practice: A Comprehensive Review of Opportunities, Challenges, and Future Directions
    Ahmed Elkohail, Ahmed M Khalifa, Ali Soffar, Ibrahim Omar, Mostafa Abdulaziz, Ahmed Elsaket, Ahmed Elnewishy, Momen Abdelglil, Siddhartha Murhekar, Ahmed Swealem
    Cureus.2025;[Epub]     CrossRef
  • The application of robotic and artificial intelligence technologies in spinal surgery: a review focused on prospects in remote areas of China
    Zhibin Liu, Junlong Huang, Hao Zhang, Shuzhuo Zhang, Honghao Dai, Yuexin Jiang, Hongtao Bi, Zhongshu Shan
    Journal of Robotic Surgery.2025;[Epub]     CrossRef
  • Intelligence Architectures and Machine Learning Applications in Contemporary Spine Care
    Rahul Kumar, Conor Dougherty, Kyle Sporn, Akshay Khanna, Puja Ravi, Pranay Prabhakar, Nasif Zaman
    Bioengineering.2025; 12(9): 967.     CrossRef
  • Threshold-Anchored Mechanomyography Metrics for Patient Stratification in Spinal Decompression: Associations with Early Pain Outcomes
    Muwaffak Abdulhak, Ross Jones, David Nay, Christopher Wybo
    Journal of Personalized Medicine.2025; 15(12): 564.     CrossRef
  • Preliminary evaluation of mixed reality navigation with single-vertebra registration in spinal surgery
    Zhongjie Shi, Zirui Su, Lingling Yang, Xin Gao, Deyong Xiao, Yilong Peng, Xiaojun Li, JianFeng Guo, Shujie Sun, Zhanxiang Wang
    European Journal of Medical Research.2025;[Epub]     CrossRef
  • Whole process navigated percutaneous endoscopic lumbar discectomy guided by a novel X-ray instant navigation: a technical report and preliminary clinical outcomes
    Wenjie Zheng, Wen Xia, Chao Liu, Zhengyang Wu, Minghan Liu, Rui Zuo, Linfeng Mo, Yue Zhou, Changqing Li, Chao Zhang
    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
  • From complexity to clarity: A perspective on personalized spine care through genetic, psychosocial, and technological advancements
    Favour Tope Adebusoye, Rohan S. Mane, Liyana Nithya Paaramee Priyankara, Mohammed Ahmed, Shubham Gaikwad, Jovan Ilic, Yash J. Pal, Brandon Lucke-Wold, Julie L. Chan, Daniel J. Hoh, Matthew Decker, Steven G. Roth, Daryl Pinion Fields, Paul R. Krafft
    Journal of Craniovertebral Junction and Spine.2025; 16(4): 379.     CrossRef
  • Impact of Navigation Assistance on Perioperative Outcomes in Sacroiliac Joint Arthrodesis: A Comparative Study
    Attila Sarkadi, Adolf Mueller, Vitaly Sokotukhin , Stephan Lackermair, Eric O Sarpong, Hannes Egermann
    Cureus.2025;[Epub]     CrossRef
  • Hospitalizations and surgical management of lumbar disc degeneration in Italy: a 22-Year nationwide retrospective study
    Fabrizio Russo, Bruna Maria Rondinone, Giuseppe Francesco Papalia, Gianluca Vadalà, Rocco Papalia, Vincenzo Denaro, Sergio Iavicoli
    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
  • Accuracy of Robotic-Guided Pedicular Screw Insertion in Thoracolumbar Spinal Surgery
    Ignacio Dominguez, Rafael Luque, Angela Carrascosa, Juan Pablo Castaño, Alicia Collado, Pedro Alonso Lera, Fernando Marco
    Journal of Clinical Medicine.2025; 14(23): 8425.     CrossRef
  • Effectiveness and reliability of AI in diagnosis and robot-assisted spinal and cranial surgery: efficient outcomes and ethical worries
    Iqra Shahid, Ahmed Raza, Inshrah Qureshi, Umaima Cheema, Siraj Ul Muneer, Ayesha Sehar, Maryam Aqeel, Saleha Azeem, Ahmad Hussain, Calvin R. Wei, Samuel Mbabazi, Fabrice Kibukila, Dieudonné Kakusu, Aymar Akilimali
    Annals of Medicine & Surgery.2025; 87(11): 7280.     CrossRef
  • Bibliometric analysis of robotic-assisted hepatobiliary and pancreaticosplenic surgery
    Tao Liu, Kunming Zhao, Heqi Tai, Xiaofeng Tian
    Journal of Robotic Surgery.2025;[Epub]     CrossRef
  • Biomechanical optimization of pedicle screw trajectories in osteoporotic lumbar fusion: finite element analysis and validation of robotic-assisted implementation
    Cheng Zhong, Zhe Han
    Journal of Robotic Surgery.2025;[Epub]     CrossRef
  • Commentary on “Navigation-Guided/Robot-Assisted Spinal Surgery: A Review Article”
    John R. Adler Jr
    Neurospine.2024; 21(1): 18.     CrossRef
  • Knee Arthroscopy in the Era of Precision Medicine: A Comprehensive Review of Tailored Approaches and Emerging Technologies
    Vinit Rathod, Milind R Gharpinde , Sandeep Shrivastav
    Cureus.2024;[Epub]     CrossRef
  • Commentary on “The Utility and Feasibility of Smart Glasses in Spine Surgery: Minimizing Radiation Exposure During Percutaneous Pedicle Screw Insertion”
    Wongthawat Liawrungrueang
    Neurospine.2024; 21(2): 440.     CrossRef
  • Efficacy and safety of navigation robot-assisted versus conventional oblique lateral lumbar interbody fusion with internal fixation in the treatment of lumbar degenerative diseases: A retrospective study
    Min Tong, Siping Zhang, Wenhao Zhang, Limin Mou, Zhenyu Dong, Rong Wang, Shida Li, Yifei Huang
    Medicine.2024; 103(32): e39261.     CrossRef
  • Overcoming the Learning Curve in Robot-Assisted Spinal Surgery—How Does It Compare to O-Arm Navigation?
    Pirateb Paramasivam Meenakshi Sundaram, Mun Chun Lai, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh
    Surgeries.2024; 5(4): 896.     CrossRef
  • Mid-term efficacy of non-contact orthopedic robot navigation in the treatment of lumbar spondylolisthesis
    XiaoPeng Gu, SongOu Zhang, YongTao Liu, JunLiang Qi, YueQuan Gu, WeiHu Ma
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • Letter to the editor regarding "Level-specific comparison of 3D navigated and robotic arm-guided screw placement: an accuracy assessment of 1210 pedicle screws in lumbar surgery" by Asada et al
    Sanaa Hameed, Fauziyya Muhammad, Lance M Villeneuve, Zachary A Smith
    The Spine Journal.2024; 24(12): 2428.     CrossRef
  • Evaluation of Pedicle Screw Position on Computerized Tomography Using Three-Dimensional Reconstruction Software
    Jiwon Park, Jin S. Yeom, Yeonho Kim, Yoonjoong Hwang, Namkug Kim, Sang-Min Park
    Medicina.2024; 60(12): 2040.     CrossRef
  • Does Robotic Spine Surgery Add Value to Surgical Practice over Navigation-Based Systems? A Study on Operating Room Efficiency
    Pirateb Paramasivam Meenakshi Sundaram, Daniel Yang Yao Peh, Jane Wenjin Poh, Guna Pratheep Kalanchiam, Wayne Ming Quan Yap, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh
    Medicina.2024; 60(12): 2112.     CrossRef
  • 23,435 View
  • 417 Download
  • 53 Web of Science
  • 57 Crossref

Editorial

Bone Biology and Osteoporosis Special Issue

Optimal Strategies for the Treatment of Osteoporotic Spinal Diseases
Dae-Chul Cho
Neurospine 2023;20(4):1095-1096.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2347328.664

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Optimal Strategies for the Treatment of Osteoporotic Spinal Diseases
Neurospine. 2023;20(4):1095-1096.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2347328.664
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Optimal Strategies for the Treatment of Osteoporotic Spinal Diseases
Neurospine. 2023;20(4):1095-1096.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2347328.664
Close

Citations

Citations to this article as recorded by  Crossref logo
  • Lumbar fusion surgery in the era of an aging society: analysis of a nationwide population cohort with minimum 8-year follow-up
    Woo-Keun Kwon, Alekos A. Theologis, Joo Han Kim, Hong Joo Moon
    The Spine Journal.2024; 24(8): 1378.     CrossRef
  • 3,453 View
  • 177 Download
  • 1 Web of Science
  • 1 Crossref

Original Articles

Bone Biology and Osteoporosis Special Issue

Fusion Assessment of Oblique Lumbar Interbody Fusion Using Demineralized Bone Matrix: A 2-Year Prospective Study
Sangseok Lee, Jin Woo Jung, Sang-Woo Lee, Kyoung-Tae Kim, Heum-Dai Kwon, Subum Lee, Young San Ko, Pius Kim, Dae-Chul Cho
Neurospine 2023;20(4):1205-1216.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2347032.516

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Fusion Assessment of Oblique Lumbar Interbody Fusion Using Demineralized Bone Matrix: A 2-Year Prospective Study
Neurospine. 2023;20(4):1205-1216.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2347032.516
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Fusion Assessment of Oblique Lumbar Interbody Fusion Using Demineralized Bone Matrix: A 2-Year Prospective Study
Neurospine. 2023;20(4):1205-1216.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2347032.516
Close
Objective
Although several studies have reported successful fusion rates after oblique lumbar interbody fusion (OLIF) using allografts or dimerized bone matrix (DBM) instead of autografts, whether OLIF can achieve satisfactory solid fusion without the use of autografts remains unclear. This study investigated the real fusion rates after OLIF using allografts and DBM, which were evaluated using both dynamic radiographs and computed tomography scans.
Methods
We enrolled 79 consecutive patients who underwent minimally invasive OLIF followed by percutaneous pedicle screw fixation. All patients were treated with OLIF between L2 and L5 and underwent radiographic and clinical follow-ups at 12, 18, and 24 months after surgery. Radiographic assessment of fusion was performed using the modified BrantigaSteffee-Fraser (mBSF) scale, which was categorized as follows: grades I (radiographic pseudoarthrosis), II (indeterminate fusion), and III (solid radiographic fusion). Other radiologic and clinical outcomes were evaluated using the following parameters: vertebral slippage distance, disc height, subsidence, Oswestry Disability Index (ODI), and visual analogue scale (VAS).
Results
Clinical outcomes demonstrated significant improvements in the VAS scores for back pain, leg pain, and ODI after surgery. Subsidence was present in 34 cases (35.4%) at 12 months postoperatively, which increased to 47.9% and reached 50.0% at 1.5 years and 2 years after surgery, respectively. The solid fusion rate after OLIF was 32.3% at 1 year, increased to 58.3% at 1.5 years, and reached 72.9% at 2 years. Radiographic pseudoarthrosis was 24.0% at 1 year, which decreased to 6.3% at 1.5 years and 3.1% at 2 years.
Conclusion
OLIF is a safe and effective surgical procedure for the treatment of degenerative lumbar diseases. The mBSF scale, which simultaneously evaluates both dynamic angles and bone bridge formation, offers great reliability for the radiological assessment of fusion. Moreover, OLIF using allografts and DBM, which is performed on one or 2 levels at L2–5, can achieve satisfactory fusion rates within 2 years after surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • Oblique lateral interbody fusion: role of the elastic modulus of the cage material in mechanically induced osteogenesis
    Teng Lu, Zhongwei Sun, Xijing He
    Computer Methods and Programs in Biomedicine.2026; 276: 109242.     CrossRef
  • CT Evaluation of Lumbar Interbody Fusion: A Comprehensive Review with an Integrated Framework for Principle-Based Interpretation
    Szu-Hsiang Peng, Jwo-Luen Pao
    Diagnostics.2026; 16(1): 140.     CrossRef
  • Understanding Spine Biologics: A Systematic Review of Demineralized Bone Matrix in Spinal Fusion From 2014-2024
    Molly Butler, Blake Martin, Christopher Carr, Muhsin Quraishi, Alexander F. Post, Fernando L. Vale
    Global Spine Journal.2026;[Epub]     CrossRef
  • Incidence and Risk Factors of Postoperative Ileus in Oblique Lumbar Interbody Fusion Surgery: A Retrospective Study
    Young-Seok Lee, Myeong Jin Ko, Seung Won Park
    Neurospine.2025; 22(1): 222.     CrossRef
  • Reduction-First Technique of Unilateral Biportal Endoscopy Lumbar Interbody Fusion for Spondylolisthesis
    JinWoo Jung, Man-Kyu Park, Yong Jin Park, Dae-Chul Cho, Young San Ko
    World Neurosurgery.2025; 198: 124005.     CrossRef
  • Comparative efficacy of autologous iliac bone versus allogeneic demineralized bone matrix in lateral lumbar interbody fusion using a novel minimally invasive iliac bone retrieval tool: a self-controlled study
    Jiaqi Li, Shaorong Li, Shuowen Zhang, Lin Liu, Weijian Wang, Han Wu, Qiang Yang, Wei Zhang
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • 7,190 View
  • 231 Download
  • 6 Web of Science
  • 6 Crossref

Spinal Cord Injury INTS-Neurospine Special Issue

Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury
Dongwoo Yu, Seul Ah Mun, Sang Woo Kim, Dae-Chul Cho, Chi Heon Kim, Inbo Han, Subum Lee, Sang-Woo Lee, Kyoung-Tae Kim
Neurospine 2022;19(3):737-747.   Published online September 30, 2022
DOI: https://doi.org/10.14245/ns.2244410.205

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury
Neurospine. 2022;19(3):737-747.   Published online September 30, 2022
DOI: https://doi.org/10.14245/ns.2244410.205
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury
Neurospine. 2022;19(3):737-747.   Published online September 30, 2022
DOI: https://doi.org/10.14245/ns.2244410.205
Close
Objective
Neuropathic pain is a common secondary complication of spinal cord injury (SCI). N-methyl-D-aspartate (NMDA) receptor activation is critical for hypersensitivity in neuropathic pain. This activation requires the binding of both glutamate and the D-serine co-agonist to the NMDA glycine site. We evaluated the effects of D-serine on neuropathic pain after SCI and explored the underlying molecular mechanisms.
Methods
Anesthetized rats underwent T9 spinal cord contusion (130 kdyn). D-serine (500 and 1,000 mg/kg) and MK-801 hydrogen maleate (2.0 mg/kg) were injected daily for 2 weeks, starting the day after SCI. Functional outcomes were assessed according to the Basso, Beattie, and Bresnahan scale, while histological outcomes were evaluated based on lesion volume and spared tissue area. Mechanical allodynia and thermal hyperalgesia were evaluated by measuring the withdrawal threshold of a von Frey filament and hot/cold plate latency. Western blotting was performed to determine the expression levels of Trpv1, Nav1.9, calcitonin gene-related peptide (CGRP), and β-actin in damaged tissue.
Results
The withdrawal threshold values and latency of the D-serine group were significantly lower than those of the noninjection group. The MK-801 group showed higher threshold values and latencies than the other groups. Western blotting showed increased Nav1.9 and Trpv1 levels and lower CGRP levels in the D-serine group, whereas the MK-801 group showed the opposite results.
Conclusion
D-serine increases neuropathic pain after traumatic SCI by mediating the NMDA receptor. NMDA receptor antagonists alleviate neuropathic pain after traumatic SCI.

Citations

Citations to this article as recorded by  Crossref logo
  • Astrocytic α7-nicotinic acetylcholine receptors mediate pain information processing and perception
    Teng Teng, Shaofan Yang, Jin Li, Haoyu Wang, Fengjuan Wu, Yong He, Jihua Fan, Hongwei Shi, Mingzhu Huang, Xiang Zhou, Ying Liu, Mingyue Gong, Chuanyan Yang, Huiquan Wang, Zhenlu Cai, Hongli Li, Kuan Zhang
    Neurobiology of Disease.2026; 218: 107245.     CrossRef
  • D-serine: A Multitalented Neuromodulator in Brain Function, Systemic Homeostasis, and Disease
    Jing Wang, Yujin Guo, Wenxiu Han, Hailiang Zhang, Pei Jiang
    Cellular and Molecular Neurobiology.2026;[Epub]     CrossRef
  • Prospects and challenges in NMDAR signaling in spinal cord injury recovery and neural circuit remodeling
    Han Gong, Xin Xu, Zuliyaer Talifu, Chun-Jia Zhang, Yu-Zhe Sun, Zhao-Ming Yue, Jia-Sheng Rao, Liang-Jie Du, Xiao-Xia Du
    Regenerative Therapy.2025; 29: 381.     CrossRef
  • MiR-23b regulation of metabolites in neuropathic pain: A novel approach
    Shu-Jing Hao, Yu-Ying Zhao, Zi-Jun Wu, Meng-Yao An, Cheng-Cheng Song, Jing Li
    Behavioural Brain Research.2025; 495: 115768.     CrossRef
  • IUPHAR review: Navigating the role of preclinical models in pain research
    Seyed Asaad Karimi, Fatama Tuz Zahra, Loren J. Martin
    Pharmacological Research.2024; 200: 107073.     CrossRef
  • Therapeutic potential of luteolin-loaded poly(lactic-co-glycolic acid)/modified magnesium hydroxide microsphere in functional thermosensitive hydrogel for treating neuropathic pain
    So-Yeon Park, Joon Hyuk Jung, Da-Seul Kim, Jun-Kyu Lee, Byeong Gwan Song, Hae Eun Shin, Ji-Won Jung, Seung-Woon Baek, Seungkwon You, Inbo Han, Dong Keun Han
    Journal of Tissue Engineering.2024;[Epub]     CrossRef
  • Neuropathic Pain Induced by Spinal Cord Injury from the Glia Perspective and Its Treatment
    Ying Ye, Xinjin Su, Jun Tang, Chao Zhu
    Cellular and Molecular Neurobiology.2024;[Epub]     CrossRef
  • Co-Administration of Resolvin D1 and Peripheral Nerve-Derived Stem Cell Spheroids as a Therapeutic Strategy in a Rat Model of Spinal Cord Injury
    Seung-Young Jeong, Hye-Lan Lee, SungWon Wee, HyeYeong Lee, GwangYong Hwang, SaeYeon Hwang, SolLip Yoon, Young-Il Yang, Inbo Han, Keung-Nyun Kim
    International Journal of Molecular Sciences.2023; 24(13): 10971.     CrossRef
  • The dual role of microglia in neuropathic pain after spinal cord injury: Detrimental and protective effects
    Chang Sun, Junhao Deng, Yifei Ma, Fanqi Meng, Xiang Cui, Ming Li, Jiantao Li, Jia Li, Pengbin Yin, Lingjie Kong, Licheng Zhang, Peifu Tang
    Experimental Neurology.2023; 370: 114570.     CrossRef
  • Role of spinal astrocytes through the perisynaptic astrocytic process in pathological pain
    Hyoung-Gon Ko, Heejung Chun, Seunghyo Han, Bong-Kiun Kaang
    Molecular Brain.2023;[Epub]     CrossRef
  • 7,398 View
  • 221 Download
  • 10 Web of Science
  • 10 Crossref

Minimally Invasive Spinal Surgery SMISS-Neurospine Special Issue

Indirect Decompression Using Oblique Lumbar Interbody Fusion Revision Surgery Following Previous Posterior Decompression: Comparison of Clinical and Radiologic Outcomes Between Direct and Indirect Decompression Revision Surgery
Sang-Jin Park, Jong-Moon Hwang, Dae-Chul Cho, Subum Lee, Chi Heon Kim, Inbo Han, Dae-Won Park, Heum-Dai Kwon, Kyoung-Tae Kim
Neurospine 2022;19(3):544-554.   Published online September 30, 2022
DOI: https://doi.org/10.14245/ns.2244242.121

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Indirect Decompression Using Oblique Lumbar Interbody Fusion Revision Surgery Following Previous Posterior Decompression: Comparison of Clinical and Radiologic Outcomes Between Direct and Indirect Decompression Revision Surgery
Neurospine. 2022;19(3):544-554.   Published online September 30, 2022
DOI: https://doi.org/10.14245/ns.2244242.121
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Indirect Decompression Using Oblique Lumbar Interbody Fusion Revision Surgery Following Previous Posterior Decompression: Comparison of Clinical and Radiologic Outcomes Between Direct and Indirect Decompression Revision Surgery
Neurospine. 2022;19(3):544-554.   Published online September 30, 2022
DOI: https://doi.org/10.14245/ns.2244242.121
Close
Objective
This study compared the radiological and clinical outcomes with transforaminal lumbar interbody fusion (TLIF) to evaluate the effect of indirect decompression through oblique lumbar interbody fusion (OLIF) as revision surgery.
Methods
We enrolled patients who underwent single-level fusion with revision surgery at the same level as the previous decompression level. We retrospectively reviewed 25 patients who underwent OLIF from 2017 to 2018 and 25 who received TLIF from 2014 to 2018. Radiologic and clinical outcomes were evaluated by cross-sectional area (CSA) of the spinal canal, thickness and area of ligamentum flavum (LF), subsidence, disc height, fusion rate, Oswestry Disability Index (ODI), and visual analogue scale (VAS).
Results
Compared with OLIF, the thickness and area of the LF after surgery were significantly less in TLIF, and the resulting CSA extension was also significantly higher. However, both groups showed improvement in ODI and VAS after surgery, and there was no difference between the groups. Complications related to the posterior approach in TLIF were 4 cases, and in OLIF, there were 2 cases that underwent additional posterior decompression surgery and 6 cases of transient paresthesia.
Conclusion
Since complications associated with the posterior approach can be avoided, OLIF is a safer and useful minimally invasive surgery. Therefore, appropriate indications are applied, OLIF is a good alternative to TLIF when revision surgery is considered.

Citations

Citations to this article as recorded by  Crossref logo
  • Global research landscape and citation dynamics of oblique lumbar interbody fusion (OLIF): A bibliometric analysis of the 100 most influential articles
    Badr Hafiz, Thamer Alsharif, Faisal Sukkar, Moaath Alghamdi, Ali Zaki Alhabib, Shuruq Obaid Alshammari, Saleh Baeesa
    Brain and Spine.2026; 6: 106043.     CrossRef
  • Oblique lumbar interbody fusion for adjacent spinal stenosis after posterior lumbar fusion
    Feifei Chen, Xin Nie, Yanjun Ren, Yubin Qi
    Asian Journal of Surgery.2025; 48(6): 4008.     CrossRef
  • Anterior to psoas fusion: Radiological parameters and associated clinical outcomes
    Andrew James Berg, Joseph Maalouly, Liam D. Rose, Prashanth J. Rao, Shay Menachem
    Seminars in Spine Surgery.2025; 37(1): 101167.     CrossRef
  • Three Cases of Indirect Decompression Failure Following Oblique Lumbar Interbody Fusion Requiring Early Direct Posterior Decompression: Analysis of Etiologies and Literature Review
    Satoshi Hattori, Satoru Matsutani
    Cureus.2025;[Epub]     CrossRef
  • Oral Eupolyphaga sinensis extract promotes lumbar interbody fusion by enhancing vascularization of cartilage endplate
    Ruixin Zhen, Jiaqi Li, Shaorong Li, Han Wu, Wei Zhang
    Frontiers in Surgery.2025;[Epub]     CrossRef
  • Can Wallis topping-off surgery reduce radiographic adjacent segment degeneration? a single-center study with at least 8 years of long-term follow-up
    Sixue Chen, Yang Xiong, Ziye Qiu, Ningning Feng, Guozheng Jiang, Junji Yang, Xing Yu
    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
  • Research trends and clustering analysis of postoperative infections following lumbar interbody fusion: a bibliometric study
    Yanxiao Liu, Hua Wang, Lei Li
    Neurosurgical Review.2025;[Epub]     CrossRef
  • Clinical and Radiological Outcomes of Biportal Endoscopic Revision Extraforaminal Lumbar Interbody Fusion Following Previous Central Decompression: A Case Series
    Seung-Yeon Jeong, Hyun-Jin Park, Jin-Ho Park, Gab-Lae Kim
    Journal of Advanced Spine Surgery.2025; 15(2): 84.     CrossRef
  • Improved intervertebral fusion in LLIF rabbit model with a novel titanium cage
    Jiaqi Li, Bingyi Zhao, Weijian Wang, Yafei Xu, Haoyu Wu, Wei Zhang
    The Spine Journal.2024; 24(6): 1109.     CrossRef
  • Screening patients requiring secondary lumbar surgery for degenerative lumbar spine diseases: a nationwide sample cohort study
    Hangeul Park, Juhee Lee, Yunhee Choi, Jun-Hoe Kim, Sum Kim, Young-Rak Kim, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Chi Heon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Is Direct Decompression Necessary for Lateral Lumbar Interbody Fusion (LLIF)? A Randomized Controlled Trial Comparing Direct and Indirect Decompression With LLIF in Selected Patients
    Worawat Limthongkul, Chayapong Thanapura, Khanathip Jitpakdee, Pakawas Praisarnti, Vit Kotheeranurak, Wicharn Yingsakmongkol, Teerachat Tanasansomboon, Weerasak Singhatanadgige
    Neurospine.2024; 21(1): 342.     CrossRef
  • Trends in degenerative lumbar spinal surgery during the early COVID-19 pandemic in Republic of Korea: A national study utilizing the national health insurance database
    Woon Tak Yuh, Jinhee Kim, Mi-Sook Kim, Jun-Hoe Kim, Young Rak Kim, Sum Kim, Chun Kee Chung, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Young San Ko, Chi Heon Kim, Kentaro Yamada
    PLOS ONE.2024; 19(6): e0305128.     CrossRef
  • Efficacy and safety of navigation robot-assisted versus conventional oblique lateral lumbar interbody fusion with internal fixation in the treatment of lumbar degenerative diseases: A retrospective study
    Min Tong, Siping Zhang, Wenhao Zhang, Limin Mou, Zhenyu Dong, Rong Wang, Shida Li, Yifei Huang
    Medicine.2024; 103(32): e39261.     CrossRef
  • Postoperative urinary retention after oblique lumbar interbody fusion under the systematic management protocol
    Joonsoo Lim, Jangyeob Lim, Asfandyar Khan, Chang-Hyun Lee, Jun-Hoe Kim, Sejin Choi, Tae-Shin Kim, Yunhee Choi, Chun Kee Chung, Sangwook T. Yoon, Kyoung-Tae Kim, Chi Heon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Commentary on “Mini-Open Intercostal Retroperitoneal Approach for Upper Lumbar Spine Lateral Interbody Fusion”
    Alexander E. Ropper
    Neurospine.2023; 20(2): 564.     CrossRef
  • Mini-Open Intercostal Retroperitoneal Approach for Upper Lumbar Spine Lateral Interbody Fusion
    Su Hun Lee, Dong Wuk Son, Sung Hyun Bae, Jun Seok Lee, Young Ha Kim, Soon Ki Sung, Sang Weon Lee, Geun Sung Song
    Neurospine.2023; 20(2): 553.     CrossRef
  • Biomechanical Comparison of Different Surgical Approaches for the Treatment of Adjacent Segment Diseases after Primary Transforaminal Lumbar Interbody Fusion: A Finite Element Analysis
    Wencan Ke, Teng Zhang, Bingjin Wang, Wenbin Hua, Kun Wang, Jason Pui Yin Cheung, Cao Yang
    Orthopaedic Surgery.2023; 15(10): 2701.     CrossRef
  • Letter to the Editor : Classifying the Anatomical Location of the Ureter after Retroperitoneal Dissection
    Su-Hun Lee, Dong-Wuk Son, Jun-Seok Lee, Geun-Sung Song
    Journal of Korean Neurosurgical Society.2023; 66(5): 605.     CrossRef
  • Surgical treatment of spondylolisthesis by oblique lumbar interbody fusion and transpedicular screw fixation: Comparison between conventional double position versus navigation-assisted single lateral position
    Junghoon Han, Chang-Min Ha, Woon Tak Yuh, Young San Ko, Jun-Hoe Kim, Tae-Shin Kim, Chang-Hyun Lee, Sungjoon Lee, Sun-Ho Lee, Asfandyar Khan, Chun Kee Chung, Chi Heon Kim, Mohamed El-Sayed Abdel-Wanis
    PLOS ONE.2023; 18(9): e0291114.     CrossRef
  • The Influence of Spondylolisthesis Reduction on the Adjacent Lumbar Segment
    Tae-Hwan Park, Yunhee Choi, Tae-Shin Kim, Jun-Hoe Kim, Chang-Hyun Lee, Sum Kim, Young Rak Kim, Yong San Ko, Woon Tak Yuh, John M. Rhee, Kyoung-Tae Kim, Chun Kee Chung, Chi Heon Kim
    The Nerve.2023; 9(2): 91.     CrossRef
  • An Expanded Surgical Corridor of Oblique Lateral Interbody Fusion at L4–5: A Magnetic Resonance Imaging Study
    Worawat Limthongkul, Pakawas Praisarnti, Teerachat Tanasansomboon, Natavut Prasertkul, Vit Kotheeranurak, Wicharn Yingsakmongkol, Weerasak Singhatanadgige
    Neurospine.2023; 20(4): 1450.     CrossRef
  • Fusion Assessment of Oblique Lumbar Interbody Fusion Using Demineralized Bone Matrix: A 2-Year Prospective Study
    Sangseok Lee, Jin Woo Jung, Sang-Woo Lee, Kyoung-Tae Kim, Heum-Dai Kwon, Subum Lee, Young San Ko, Pius Kim, Dae-Chul Cho
    Neurospine.2023; 20(4): 1205.     CrossRef
  • 7,810 View
  • 268 Download
  • 19 Web of Science
  • 22 Crossref

Review Article

Curcumin as a Promising Neuroprotective Agent for the Treatment of Spinal Cord Injury: A Review of the Literature
Subum Lee, Dae-Chul Cho, Inbo Han, Kyoung-Tae Kim
Neurospine 2022;19(2):249-261.   Published online June 30, 2022
DOI: https://doi.org/10.14245/ns.2244148.074

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Curcumin as a Promising Neuroprotective Agent for the Treatment of Spinal Cord Injury: A Review of the Literature
Neurospine. 2022;19(2):249-261.   Published online June 30, 2022
DOI: https://doi.org/10.14245/ns.2244148.074
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Curcumin as a Promising Neuroprotective Agent for the Treatment of Spinal Cord Injury: A Review of the Literature
Neurospine. 2022;19(2):249-261.   Published online June 30, 2022
DOI: https://doi.org/10.14245/ns.2244148.074
Close
Curcumin is a polyphenolic chemical derived from the rhizomes of Curcuma longa. It has been used throughout the Indian subcontinent for medicinal purposes, religious events, and regional cuisine. It has various pharmacological benefits owing to its anti-inflammatory and antioxidant properties. Its neuroprotective effects on the brain and peripheral nerves have been demonstrated in several in vivo neuronal tissue studies. Because of these functional properties of curcumin, it is considered to have great potential for use in the treatment of spinal cord injuries (SCIs). Numerous immunopathological and biochemical studies have reported that curcumin can help prevent and alleviate subsequent secondary injuries, such as inflammation, edema, free radical damage, fibrosis, and glial scarring, after a primary SCI. Furthermore, following SCI, curcumin administration resulted in better outcomes of neurological function recovery as per the Basso, Beattie, and Bresnahan locomotor rating scale. However, to date, its utility in treating SCIs has only been reported in laboratories. More studies on its clinical applications are needed in the future for ensuring its bioavailability across the blood-brain barrier and for verifying the safe dose for treating SCIs in humans.

Citations

Citations to this article as recorded by  Crossref logo
  • Curcumin suppresses EMT to alleviate oral submucous fibrosis progression through XIST/miR-25-3p-mediated inactivation of the TGF-β1/Smads signalling pathway
    Qian Min, Yao Liu, Jian Liu, Yue Zhao, Jian Qin
    International Dental Journal.2026; 76(1): 103975.     CrossRef
  • From translational medicine to functional foods: Mechanistic insights and therapeutic applications of hormetic phytochemicals
    Kajal Rana, Sristi Kumari, Garima Chouhan, Dev Sehgal, Praveen Yadav, Abhay Tiwari
    Food Chemistry Advances.2026; 10: 101204.     CrossRef
  • Mechanism of curcumin mediated carbon cycle network and energy metabolism to improve the storage quality and flavor of pepper
    Wenjuan Xu, Yansheng Wang, Chengli Jia, Zhiqing Gong, Jian Zhang, Fengjuan Jia, Wenjia Cui, Shasha Song, Xiaochun Qin, Wenliang Wang, Junyan Shi
    Postharvest Biology and Technology.2026; 234: 114164.     CrossRef
  • Curcumin-loaded multifunctional hydrogel drives spinal cord neural regeneration through immune microenvironment remodeling
    Yiyang Hou, Yuxing Jiang, Xiaoyuan Niu, Yihan Li, Tao Zhu, Hongtao Rong, Yu Yi, Lianyong Wang
    Nano Research.2026; 19(4): 94908574.     CrossRef
  • Poly(curcumin-co-poly(ethylene glycol)) films provide neuroprotection following reactive oxygen species insult in vitro
    Adelle E Hamilton, Nikita Waskiewicz, Geraldine B Quinones, Jeffrey R Capadona, Marvin Bentley, Edmund F Palermo, Ryan J Gilbert
    Journal of Neural Engineering.2025; 22(1): 016015.     CrossRef
  • A Review of the Potential Use of Antioxidants in Spinal Cord Injuries
    Agnieszka Nowacka, Maciej Śniegocki, Ewa Ziółkowska
    Antioxidants.2025; 14(9): 1081.     CrossRef
  • Preparation, rheological properties, and in vitro digestibility of starch-based hydrogel beads for curcumin delivery
    Ping Shi, Siyu Liu, Hafiz Umer Javed, Jinming Lu, Yuansen Liu
    Carbohydrate Polymer Technologies and Applications.2025; 11: 100994.     CrossRef
  • Curcumin treatment reduces motor impairments and protects against rotenone-induced neurodegeneration in a rat model of Parkinson disease
    L. V. Darbinyan, L. E. Hambardzumyan, L. P. Manukyan, M. H. Danielyan, K. V. Karapetyan, V. H. Sarkisian, K. V. Simonyan
    Metabolic Brain Disease.2025;[Epub]     CrossRef
  • Letter to the Editor: Commentary on Investigating the Impact of Turmeric on Neuroinflammation and Degenerative Changes in Repetitive Traumatic Brain Injuries: Insights from Murine Model (Korean J Neurotrauma 2025;21:18-31)
    Subum Lee
    Korean Journal of Neurotrauma.2025; 21(3): 224.     CrossRef
  • Neuroprotective Potential of Curcumin in Neurodegenerative Diseases: Clinical Insights Into Cellular and Molecular Signaling Pathways
    Md. Rezaul Islam, Abdur Rauf, Sumiya Akter, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Md. Tazul Islam, Hassan A. Hemeg, Waleed Al Abdulmonem, Abdullah S. M. Aljohani, Marcello Iriti
    Journal of Biochemical and Molecular Toxicology.2025;[Epub]     CrossRef
  • Neuroprotective Potential of Ocimum sanctum Polyphenols: Mechanisms and Therapeutic Implications
    Nikhat Parween, Saurabh Pandey, Birendra Prasad
    Iranian Biomedical Journal.2025; 29(5): 267.     CrossRef
  • Intramedullary Neural Stem Cell Transplantation in Spinal Cord Injury: Timing, Targets, and Techniques
    Sunghyun Kwon, Suk Hyung Kang, Myeong Jin Ko, Byung-Jou Lee, Woo-Keun Kwon, Sang Ryong Jeon, Kyung Taek Oh, Subum Lee
    Korean Journal of Neurotrauma.2025; 21(4): 265.     CrossRef
  • Curcumin and Resveratrol Synergy: A Multi-Target Strategy Against Neurodegenerative Disease Pathology
    Apurwa Singh, Sanyogita Shahi
    Journal for Research in Applied Sciences and Biotechnology.2025; 4(5): 95.     CrossRef
  • Electrical stimulation promotes functional recovery after spinal cord injury by activating endogenous spinal cord-derived neural stem/progenitor cell: an in vitro and in vivo study
    Woo-Seok Bang, Inbo Han, Seul-Ah Mun, Jong-Moon Hwang, Sung Hyun Noh, Wonsoo Son, Dae-Chul Cho, Byoung-Joon Kim, Chi Heon Kim, Hyuk Choi, Kyoung-Tae Kim
    The Spine Journal.2024; 24(3): 534.     CrossRef
  • A Curcumin-Decorated Nanozyme with ROS Scavenging and Anti-Inflammatory Properties for Neuroprotection
    Feng Gao, Wenyu Liang, Qixin Chen, Bairu Chen, Yuchen Liu, Zhibo Liu, Xu Xu, Rongrong Zhu, Liming Cheng
    Nanomaterials.2024; 14(5): 389.     CrossRef
  • Modulation of the LIMK Pathway by Myricetin: A Protective Strategy Against Neurological Impairments in Spinal Cord Injury
    Abhishek Roy, Santimoy Sen, Rudradip Das, Amit Shard, Hemant Kumar
    Neurospine.2024; 21(3): 878.     CrossRef
  • Innovative Strategies in 3D Bioprinting for Spinal Cord Injury Repair
    Daniel Youngsuk Kim, Yanting Liu, Gyubin Kim, Seong Bae An, Inbo Han
    International Journal of Molecular Sciences.2024; 25(17): 9592.     CrossRef
  • Mechanisms and Potential Benefits of Neuroprotective Agents in Neurological Health
    Burcu Pekdemir, António Raposo, Ariana Saraiva, Maria João Lima, Zayed D. Alsharari, Mona N. BinMowyna, Sercan Karav
    Nutrients.2024; 16(24): 4368.     CrossRef
  • Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease
    Adelle E. Hamilton, Ryan J. Gilbert
    Bioengineering.2023; 10(2): 262.     CrossRef
  • Curcumin Attenuates Periodontal Injury via Inhibiting Ferroptosis of Ligature-Induced Periodontitis in Mice
    Yawei Wang, Hongbing Lin, Wenxin Huang, Zixian Liu, Zhen Chen, Xuetao Zhao, Tong Ding, Wenguang Qin, Yuqin Shen
    International Journal of Molecular Sciences.2023; 24(12): 9835.     CrossRef
  • Commentary on “Different Ways to Die: Cell Death Pathways and Their Association With Spinal Cord Injury”
    Jeffrey Luo, Joshua B. Stein, Ki-Bum Lee
    Neurospine.2023; 20(2): 449.     CrossRef
  • A multifunctional surgical suture with electroactivity assisted by oligochitosan/gelatin-tannic acid for promoting skin wound healing and controlling scar proliferation
    Hui Han, Liqin Tang, Yan Li, Yong Li, Ming Bi, Jun Wang, Fujun Wang, Lu Wang, Jifu Mao
    Carbohydrate Polymers.2023; 320: 121236.     CrossRef
  • 12,701 View
  • 306 Download
  • 20 Web of Science
  • 22 Crossref

Original Articles

Minimally Invasive Spinal Surgery SMISS-Neurospine Special Issue

The Change of Spinal Canal According to Oblique Lumbar Interbody Fusion in Degenerative Spondylolisthesis: A Prospective Observational Study
Young-Seok Lee, Dong-Hyun Lee, Dae-Chul Cho, Inbo Han, Chi Heon Kim, Heum-Dai Kwon, Kyoung-Tae Kim
Neurospine 2022;19(3):492-500.   Published online May 13, 2022
DOI: https://doi.org/10.14245/ns.2143274.637

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

The Change of Spinal Canal According to Oblique Lumbar Interbody Fusion in Degenerative Spondylolisthesis: A Prospective Observational Study
Neurospine. 2022;19(3):492-500.   Published online May 13, 2022
DOI: https://doi.org/10.14245/ns.2143274.637
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
The Change of Spinal Canal According to Oblique Lumbar Interbody Fusion in Degenerative Spondylolisthesis: A Prospective Observational Study
Neurospine. 2022;19(3):492-500.   Published online May 13, 2022
DOI: https://doi.org/10.14245/ns.2143274.637
Close
Objective
Oblique lumbar interbody fusion (OLIF) involves inserting large cages into the interbody disc space. This expands the spinal canal and neural foramen by stretching the ligament flavum and releasing the facet joint, resulting in indirect neural decompression. Our objective was to investigate the changes in the spinal canal and ligament flavum over time after OLIF.
Methods
This was a prospective observational study involving 30 patients who underwent OLIF L4–5 between 2015 and 2018. In total, 27 of the 30 patients underwent preoperative, early follow-up ( < 5 days), and late follow-up (10–14 months) magnetic resonance imaging to measure the area of the spinal canal and ligament flavum. Based on the results, the patients were divided into subsidence and nonsubsidence groups for further analysis.
Results
After OLIF, the spinal canal area gradually increased during the preoperative, early postoperative, and late postoperative periods (p < 0.001). The thickness and area of the ligament flavum decreased gradually over the same periods (p < 0.001). Low-grade subsidence (2–4.4 mm) did not influence the effects on the spinal canal and ligament.
Conclusion
After OLIF, the spinal canal and ligament flavum gradually change, which is effective for indirect neural decompression. In addition, the effects of low-grade subsidence on the remodeling of the spinal canal and ligament flavum are insignificant.

Citations

Citations to this article as recorded by  Crossref logo
  • Oblique Lateral Interbody Fusion With Lateral Vertebral Screw Fixation Versus Transforaminal Lumbar Interbody Fusion for Severe Lumbar Stenosis: Results of a Multicenter Randomized Controlled Trial
    Xuefeng Li, Cheng Lin, Tangyiheng Chen, Renjie Li, Dapeng Li, Sheng Song, Huilin Yang, Genlei Chu, Weimin Jiang, Yijie Liu
    Neurosurgery.2026;[Epub]     CrossRef
  • Factors affecting outcomes of indirect decompression after oblique and lateral lumbar interbody fusions
    Kyle M M Behrens, Hossein Elgafy
    World Journal of Orthopedics.2025;[Epub]     CrossRef
  • Incidence and Risk Factors of Postoperative Ileus in Oblique Lumbar Interbody Fusion Surgery: A Retrospective Study
    Young-Seok Lee, Myeong Jin Ko, Seung Won Park
    Neurospine.2025; 22(1): 222.     CrossRef
  • Reduction-First Technique of Unilateral Biportal Endoscopy Lumbar Interbody Fusion for Spondylolisthesis
    JinWoo Jung, Man-Kyu Park, Yong Jin Park, Dae-Chul Cho, Young San Ko
    World Neurosurgery.2025; 198: 124005.     CrossRef
  • Is Congenital Lumbar Spinal Canal Stenosis a Contraindication for Indirect Decompression by Lateral Lumbar Interbody Fusion (LLIF)?
    Weerasak Singhatanadgige, Thada Nashinoros, Teerachat Tanasansomboon, Wicharn Yingsakmongkol, Vit Kotheeranurak, Worawat Limthongkul
    Global Spine Journal.2025;[Epub]     CrossRef
  • Efficacy observation of oblique lateral interbody fusion (OLIF) in treating severe spinal stenosis
    Yiliya Yilihamu, Jun Mo, Zhanjun Ma, Jianjiang Li, Yifei Huang
    BMC Surgery.2025;[Epub]     CrossRef
  • Improved intervertebral fusion in LLIF rabbit model with a novel titanium cage
    Jiaqi Li, Bingyi Zhao, Weijian Wang, Yafei Xu, Haoyu Wu, Wei Zhang
    The Spine Journal.2024; 24(6): 1109.     CrossRef
  • A Comprehensive Analysis of Potential Complications after Oblique Lumbar Interbody Fusion : A Review of Postoperative Magnetic Resonance Scans in Over 400 Cases
    Kang-Hoon Lee, Su-Hun Lee, Jun-Seok Lee, Young-Ha Kim, Soon-Ki Sung, Dong-Wuk Son, Sang-Weon Lee, Geun-Sung Song
    Journal of Korean Neurosurgical Society.2024; 67(5): 550.     CrossRef
  • Intraoperative Facet Joint Block Reduces Pain After Oblique Lumbar Interbody Fusion
    Sung Hyeon Noh, Sang-Woo Lee, Jong-moon Hwang, JinWoo Jung, Eunyoung Lee, Dae-Chul Cho, Chi Heon Kim, Kyoung-Tae Kim
    Journal of Bone and Joint Surgery.2024;[Epub]     CrossRef
  • Postoperative urinary retention after oblique lumbar interbody fusion under the systematic management protocol
    Joonsoo Lim, Jangyeob Lim, Asfandyar Khan, Chang-Hyun Lee, Jun-Hoe Kim, Sejin Choi, Tae-Shin Kim, Yunhee Choi, Chun Kee Chung, Sangwook T. Yoon, Kyoung-Tae Kim, Chi Heon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Mini-Open Intercostal Retroperitoneal Approach for Upper Lumbar Spine Lateral Interbody Fusion
    Su Hun Lee, Dong Wuk Son, Sung Hyun Bae, Jun Seok Lee, Young Ha Kim, Soon Ki Sung, Sang Weon Lee, Geun Sung Song
    Neurospine.2023; 20(2): 553.     CrossRef
  • Perioperative Clinical Features and Long-term Prognosis After Oblique Lateral Interbody Fusion (OLIF), OLIF With Anterolateral Screw Fixation, or OLIF With Percutaneous Pedicle Fixation: A Comprehensive Treatment Strategy for Patients With Lumbar Degenera
    Xiangyu Zhang, Yutian Wang, Weikang Zhang, Shaocheng Liu, Zhenlei Liu, Kai Wang, Hao Wu
    Neurospine.2023; 20(2): 536.     CrossRef
  • Commentary on “Mini-Open Intercostal Retroperitoneal Approach for Upper Lumbar Spine Lateral Interbody Fusion”
    Alexander E. Ropper
    Neurospine.2023; 20(2): 564.     CrossRef
  • Letter to the Editor : Classifying the Anatomical Location of the Ureter after Retroperitoneal Dissection
    Su-Hun Lee, Dong-Wuk Son, Jun-Seok Lee, Geun-Sung Song
    Journal of Korean Neurosurgical Society.2023; 66(5): 605.     CrossRef
  • Surgical treatment of spondylolisthesis by oblique lumbar interbody fusion and transpedicular screw fixation: Comparison between conventional double position versus navigation-assisted single lateral position
    Junghoon Han, Chang-Min Ha, Woon Tak Yuh, Young San Ko, Jun-Hoe Kim, Tae-Shin Kim, Chang-Hyun Lee, Sungjoon Lee, Sun-Ho Lee, Asfandyar Khan, Chun Kee Chung, Chi Heon Kim, Mohamed El-Sayed Abdel-Wanis
    PLOS ONE.2023; 18(9): e0291114.     CrossRef
  • The Influence of Spondylolisthesis Reduction on the Adjacent Lumbar Segment
    Tae-Hwan Park, Yunhee Choi, Tae-Shin Kim, Jun-Hoe Kim, Chang-Hyun Lee, Sum Kim, Young Rak Kim, Yong San Ko, Woon Tak Yuh, John M. Rhee, Kyoung-Tae Kim, Chun Kee Chung, Chi Heon Kim
    The Nerve.2023; 9(2): 91.     CrossRef
  • Fusion Assessment of Oblique Lumbar Interbody Fusion Using Demineralized Bone Matrix: A 2-Year Prospective Study
    Sangseok Lee, Jin Woo Jung, Sang-Woo Lee, Kyoung-Tae Kim, Heum-Dai Kwon, Subum Lee, Young San Ko, Pius Kim, Dae-Chul Cho
    Neurospine.2023; 20(4): 1205.     CrossRef
  • An Expanded Surgical Corridor of Oblique Lateral Interbody Fusion at L4–5: A Magnetic Resonance Imaging Study
    Worawat Limthongkul, Pakawas Praisarnti, Teerachat Tanasansomboon, Natavut Prasertkul, Vit Kotheeranurak, Wicharn Yingsakmongkol, Weerasak Singhatanadgige
    Neurospine.2023; 20(4): 1450.     CrossRef
  • 7,857 View
  • 325 Download
  • 17 Web of Science
  • 18 Crossref
Intraoperative Monitoring for Cauda Equina Tumors: Surgical Outcomes and Neurophysiological Data Accrued Over 10 Years
Subum Lee, Dae-Chul Cho, Seung Chul Rhim, Byung Jou Lee, Seok Ho Hong, Yong Seo Koo, Jin Hoon Park
Neurospine 2021;18(2):281-289.   Published online June 30, 2021
DOI: https://doi.org/10.14245/ns.2040660.330

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Intraoperative Monitoring for Cauda Equina Tumors: Surgical Outcomes and Neurophysiological Data Accrued Over 10 Years
Neurospine. 2021;18(2):281-289.   Published online June 30, 2021
DOI: https://doi.org/10.14245/ns.2040660.330
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Intraoperative Monitoring for Cauda Equina Tumors: Surgical Outcomes and Neurophysiological Data Accrued Over 10 Years
Neurospine. 2021;18(2):281-289.   Published online June 30, 2021
DOI: https://doi.org/10.14245/ns.2040660.330
Close
Objective
Cauda equina tumors affect the peripheral nervous system, and the validities of triggered electromyogram (tEMG) and intraoperative neurophysiologic monitoring (IOM) are unclear. We sought to evaluate the accuracy and relevance of tEMG combined with IOM during cauda equina tumor resection.
Methods
Between 2008 and 2018, an experienced surgeon performed cauda equina tumor resections using tEMG at a single institution. A cauda equina tumor was defined as an intradural-extramedullary or intradural-extradural tumor at the level of L2 or lower. The clinical presentation, extent of resection, pathology, recurrence, postoperative neurological outcomes, and intraoperative tEMG mapping and IOM data were retrospectively analyzed.
Results
One hundred three patients who underwent intraoperative tEMG were included; 38 underwent only tEMG (tEMG-only group), and 65 underwent a combination of tEMG and multimodal IOM (MIOM group). There were no significant differences between the neurologic outcomes, extents of resection, or recurrence rates of the 2 groups. No significant therapeutic benefit was observed; however, the accuracy of intraoperative predetection improved with the combination of IOM and tEMG (accuracy: tEMG-only group, 86.8%; MIOM group, 92.3%). When the involved rootlet was resected despite the positive tEMG result, motor function worsened in 3 of 8 cases. The sensitivity and specificity of tEMG were 37.5% and 94.7%, respectively.
Conclusion
tEMG is an essential adjunctive surgical tool for deciding on and planning for rootlet resection. If the tEMG finding is negative, complete resection, involving the rootlet, may be safe. The accuracy may be further improved by using a combination of tEMG and IOM.

Citations

Citations to this article as recorded by  Crossref logo
  • A Case of Normal-pressure Hydrocephalus Caused by Cauda Equina Capillary Malformation
    Tetsuo OTA, Daisu ABE, Hiroshi SHINTAKU, Motoki INAJI, Yoji TANAKA, Taketoshi MAEHARA
    NMC Case Report Journal.2025; 12: 103.     CrossRef
  • The Improvement of Intraoperative Motor Evoked Potential after Decompression in Cervical Compressive Myelopathy: Its Significance and Related Factors
    Jong Yun Kwon, Dong Hwan Kim, Kyoung Hyup Nam, Byung Kwan Choi, In Ho Han
    The Nerve.2024; 10(2): 80.     CrossRef
  • Free running and triggered electromyography for surgical planning during spinal cord tumor removal: a case report
    Jinyoung Park, Yura Goh, Dawoon Kim, Hyosik Eom, Yejin Lee, Joo Eun Park, Yoon Ghil Park
    Journal of Intraoperative Neurophysiology.2024; 6(2): 9.     CrossRef
  • Sacrifice of Involved Nerve Root during Surgical Resection of Foraminal and/or Dumbbell Spinal Neurinomas
    Alberto Vandenbulcke, Ginevra Federica D’Onofrio, Gabriele Capo, Wassim Baassiri, Cédric Y. Barrey
    Brain Sciences.2023; 13(1): 109.     CrossRef
  • The efficacy of intraoperative neuromonitoring, including triggered electromyography, in intradural extramedullary spine tumors: a successful case study
    Joo Eun Park, Yoon Ghil Park, Dawoon Kim, Hyosik Eom, Jinyoung Park, Myungeun Yoo
    Journal of Intraoperative Neurophysiology.2023; 5(2): 43.     CrossRef
  • Mechanical Failure After Total En Bloc Spondylectomy and Salvage Surgery
    Shin Won Kwon, Chun Kee Chung, Young Il Won, Woon Tak Yuh, Sung Bae Park, Seung Heon Yang, Chang Hyun Lee, John M. Rhee, Kyoung-Tae Kim, Chi Heon Kim
    Neurospine.2022; 19(1): 146.     CrossRef
  • Another Milestone for Spinal Intramedullary Tumor Treatment
    Chi Heon Kim
    Neurospine.2022; 19(1): 30.     CrossRef
  • Prediction of Post-operative Long-Term Outcome of the Motor Function by Multimodal Intraoperative Neuromonitoring With Transcranial Motor-Evoked Potential and Spinal Cord-Evoked Potential After Microsurgical Resection for Spinal Cord Tumors
    Shinsuke Yamada, Satoshi Kawajiri, Hidetaka Arishma, Makoto Isozaki, Takahiro Yamauchi, Ayumi Akazawa, Masamune Kidoguchi, Toshiaki Kodera, Yoshinori Shibaike, Hideto Umeda, Yu Tsukinowa, Ryota Hagihara, Kenichiro Kikuta
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Long-term recurrence after surgery for schwannoma of the cauda equina
    Hirotomo Tanaka, Yoshiyuki Takaishi, Shinichi Miura, Takashi Mizowaki, Takeshi Kondoh, Takashi Sasayama
    Surgical Neurology International.2022; 13: 272.     CrossRef
  • Feasibility and efficacy of spinal microtubular technique for resection of lumbar dumbbell-shaped tumors
    Rui Wang, Zeyan Liang, Yan Chen, Xiongjie Xu, Chunmei Chen
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Description of the Diversity in Surgical Indication and Surgical Strategies for Primary Spinal Cord Tumors: A Nationwide Survey by the Neurospinal Society of Japan
    Yasukazu Hijikata, Shigeo Ueda, Takao Yasuhara, Daisuke Umebayashi, Toshiki Endo, Toshihiro Takami, Masaki Mizuno, Kazutoshi Hida, Minoru Hoshimaru
    Neurospine.2022; 19(4): 1122.     CrossRef
  • Impact of general anaesthesia on parameters of bulbocavernosus reflex
    D. E. Malyshok, A. Yu. Orlov, M. V. Aleksandrov
    Medical alphabet.2021; (36): 37.     CrossRef
  • 9,546 View
  • 176 Download
  • 7 Web of Science
  • 12 Crossref
Development of Neuromonitoring Pedicle Screw - Results of Electrical Resistance and Neurophysiologic Test in Pig Model
Woo-Seok Bang, Jonghoo Park, Kyoung-Tae Kim, Dae-Chul Cho, K. Daniel Riew, Du-Hwan Kim, In-Bo Han, Seung-Jae Hyun, Do-Heum Yoon, Young-Baeg Kim
Neurospine 2021;18(1):117-125.   Published online November 18, 2020
DOI: https://doi.org/10.14245/ns.2040424.212

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Development of Neuromonitoring Pedicle Screw - Results of Electrical Resistance and Neurophysiologic Test in Pig Model
Neurospine. 2021;18(1):117-125.   Published online November 18, 2020
DOI: https://doi.org/10.14245/ns.2040424.212
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Development of Neuromonitoring Pedicle Screw - Results of Electrical Resistance and Neurophysiologic Test in Pig Model
Neurospine. 2021;18(1):117-125.   Published online November 18, 2020
DOI: https://doi.org/10.14245/ns.2040424.212
Close
Objective
To analyze the electrical resistance of a newly developed neuromonitoring pedicle screw (Neuro-PS) and to verify the electrophysiologic properties of the Neuro-PS in a pig model.
Methods
We developed 2 types of the Neuro-PS in which a gold lead was located internally (type I) and externally (type II). We measured the electrical resistance of the Neuro-PS and the conventional screw and analyzed the electrical thresholds of triggered EMG (t-EMG) of each screw by intentionally penetrating the medial pedicle wall and contacting the exiting nerve root in a pig model.
Results
The electrical resistances of the Neuro-PS were remarkably lower than that of the conventional screw. In electrophysiologic testing, only the type II Neuro-PS under the leadnerve contact condition showed a significantly lower stimulation threshold as compared to the conventional screw.
Conclusion
The Neuro-PS demonstrated lower electrical resistances than the conventional screw. The type II Neuro-PS under the lead-nerve contact condition showed a significantly lower stimulation threshold compared to that of the other screws in the t-EMG test.

Citations

Citations to this article as recorded by  Crossref logo
  • Feasibility of Using Intraoperative Neurophysiological Monitoring for Detecting Bone Layer of Cervical Spine Surgery
    Weiyang Zuo, Lingjia Yu, Haining Tan, Xiang Li, Bin Zhu, Yuquan Liu, Xuan Peng, Yong Yang, Qi Fei
    Clinical Spine Surgery.2024; 37(10): E480.     CrossRef
  • Intraoperative triggered electromyographic monitoring of pedicle screw efficiently reduces the lumbar pedicle breach and re-operative rate-a retrospective analysis based on postoperative computed tomography scan
    Tong Yongjun, Zhao Yuntian, Chen Biao, Jiang Zenghui
    BMC Musculoskeletal Disorders.2023;[Epub]     CrossRef
  • 11,143 View
  • 260 Download
  • 2 Web of Science
  • 2 Crossref

Editorial

In the Era of COVID-19: The Role of Spine Surgeons at the Epicenter of the Outbreak
Dae-Chul Cho
Neurospine 2020;17(2):337-338.   Published online May 18, 2020
DOI: https://doi.org/10.14245/ns.2040244.122

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

In the Era of COVID-19: The Role of Spine Surgeons at the Epicenter of the Outbreak
Neurospine. 2020;17(2):337-338.   Published online May 18, 2020
DOI: https://doi.org/10.14245/ns.2040244.122
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
In the Era of COVID-19: The Role of Spine Surgeons at the Epicenter of the Outbreak
Neurospine. 2020;17(2):337-338.   Published online May 18, 2020
DOI: https://doi.org/10.14245/ns.2040244.122
Close

Citations

Citations to this article as recorded by  Crossref logo
  • Trends in degenerative lumbar spinal surgery during the early COVID-19 pandemic in Republic of Korea: A national study utilizing the national health insurance database
    Woon Tak Yuh, Jinhee Kim, Mi-Sook Kim, Jun-Hoe Kim, Young Rak Kim, Sum Kim, Chun Kee Chung, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Young San Ko, Chi Heon Kim, Kentaro Yamada
    PLOS ONE.2024; 19(6): e0305128.     CrossRef
  • Loss of Moral Values During Business-Like Transformations in Healthcare Services
    Naci Balak, Tiit I. Mathiesen
    World Neurosurgery.2024; 191: 149.     CrossRef
  • 7,092 View
  • 101 Download
  • 2 Web of Science
  • 2 Crossref

Original Article

Epidemiology of C5 Palsy after Cervical Spine Surgery: A 21-Center Study
Jae Keun Oh, Jae Taek Hong, Dong Ho Kang, Sang-Woo Kim, Seok Won Kim, Young Jin Kim, Chun Kee Chung, Jun Jae Shin, Seong Yi, Jung Kil Lee, Jun Ho Lee, Chang-Hyun Lee, Ho Jin Lee, Hyoung-Joon Chun, Dae-Chul Cho, Yong Eun Cho, Yong Jun Jin, Kyung-Chul Choi, In Ho Han, Seung-Jae Hyun, Jung-Woo Hur, Ki-Jeong Kim
Neurospine 2019;16(3):558-562.   Published online September 30, 2019
DOI: https://doi.org/10.14245/ns.1938142.071

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Epidemiology of C5 Palsy after Cervical Spine Surgery: A 21-Center Study
Neurospine. 2019;16(3):558-562.   Published online September 30, 2019
DOI: https://doi.org/10.14245/ns.1938142.071
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Epidemiology of C5 Palsy after Cervical Spine Surgery: A 21-Center Study
Neurospine. 2019;16(3):558-562.   Published online September 30, 2019
DOI: https://doi.org/10.14245/ns.1938142.071
Close
Objective
C5 palsy is a severe complication after cervical spine surgery, the pathophysiology of which remains unclear. This multicenter study investigated the incidence of C5 palsy following cervical spine surgery in Korea.
Methods
We conducted a retrospective multicenter study involving 21 centers from the Korean Cervical Spine Study Group. The inclusion criteria were cervical spine surgery patients between 2012 and 2016, excluding cases of neck surgery. In patients with C5 palsy, the operative methods, disease category, onset time of C5 palsy, recovery time, C5 manual muscle testing (MMT) grade, and post-C5 palsy management were analyzed.
Results
We collected 15,097 cervical spine surgery cases from 21 centers. C5 palsy occurred in 88 cases (0.58%). C5 palsy was more common in male patients (p=0.019) and after posterior approach procedures (p<0.001). C5 palsy usually occurred within 3 days after surgery (77 of 88, 87.5%) and most C5 palsy patients recovered within 6 months (51 of 88, 57.95%). Thirty C5 palsy patients (34.09%) had motor weakness, with an MMT grade≤2. Only four C5 palsy patients (4.5%) did not recover during follow-up. Posterior cervical foraminotomy was performed in 7 cases (7.95%), and steroids were used in 56 cases (63.63%). Twenty-six cases (29.55%) underwent close observation only.
Conclusion
The overall incidence of C5 palsy was relatively low (0.58%). C5 palsy was more common after posterior cervical surgery and in male patients. C5 palsy usually developed within 3 days after surgery, and more than half of patients with C5 palsy recovered within 6 months.

Citations

Citations to this article as recorded by  Crossref logo
  • What is the probability of recovery of C5 palsy after cervical spine surgery over time? A systematic review and meta-analysis
    Nienke A. Krijnen, Alexander J. Comerci, Christopher J. Fedor, Hamid Alahmari, James C. Bayley, Teun Teunis
    The Spine Journal.2026; 26(5): 853.     CrossRef
  • Risk factors for C5 nerve root palsy following surgery for cervical degenerative disease : a systematic review and meta-analysis
    Mingzhu Huang, Kang Chen, Yujin Zhang, Lanxin Zhang, Changyu Liu, Xuan Liu, Xiangzhuo Liu, Ningyuan Li, Ying Lu, Mingjiang Luo, Zhihong Xiao, Liquan Li
    Neurosurgical Review.2026;[Epub]     CrossRef
  • C5 Palsy After Cervical Decompression: A 10-Year Single-Institution Study Highlighting Early Onset, High Bilaterality, and Poor Recovery
    Sargunan B, Vishnu Prasath, Karthik Sudhakar, Thomas John
    Cureus.2026;[Epub]     CrossRef
  • De novo C5 palsy in the absence of prior surgery: a retrospective study of surgical management and outcomes in the United States
    Wesley Manz, Sameer Khawaja, Corey Spencer, Dale Segal, Zach Grabel, Doug Weinberg, Eli Garrard, John Rhee
    Asian Spine Journal.2026; 20(1): 34.     CrossRef
  • Incidence and prognostic factors of postoperative C5 palsy after cervical OPLL surgery: a nationwide prospective multicenter study
    Satoru Egawa, Takashi Hirai, Kenichiro Sakai, Kazuo Kusano, Shunji Tsutsui, Yu Matsukura, Kentaro Yamada, Hiroaki Onuma, Kanichiro Wada, Keiichi Katsumi, Masao Koda, Atsushi Kimura, Takeo Furuya, Satoshi Maki, Norihiro Nishida, Yukitaka Nagamoto, Yasushi
    Scientific Reports.2026;[Epub]     CrossRef
  • Preoperative Imaging Predictors of Postoperative C5 Palsy
    Jonathan Dalton, Rachel Huang, Michael Carter, Robert J. Oris, Joydeep Baidya, Joshua Mathew, Rajkishen Narayanan, Andrew Kim, Sebastian Fras, Jonah Blas, Anthony LaBarbiera, Matthew Ruiz, Evgeniy Uvarov, Keyur Patel, Mark F. Kurd, Ian David Kaye, Jose A.
    Spine.2026; 51(10): 692.     CrossRef
  • Increased Change in Cervical Lordosis Is Associated With Decreased Rate of Recovery in Patients With C5 Palsy
    Joseph N. Frazzetta, Nathan Pecoraro, Ignacio Jusue-Torres, Paul M. Arnold, Ryan Hofler, G. Alexander Jones, Russ Nockels
    Clinical Spine Surgery.2025; 38(3): E152.     CrossRef
  • Phrenic Nerve Palsy After Posterior Cervical Fusion
    Thomas Falconiero, Anthony Viola, Mark LaGreca, Caleb M. Yeung, Jeffrey Rihn
    Clinical Spine Surgery.2025; 38(5): 217.     CrossRef
  • Biceps involvement and degree of motor deficit at diagnosis are independently predictive of timing of postoperative C5 palsy recovery
    Gregory Toci, Jonathan Dalton, Rachel Huang, Michael Carter, Robert J. Oris, Rajkishen Narayanan, Andrew Kim, Julienne Jeong, Brady Stallman, Kenneth McCall, Mark F. Kurd, Ian D. Kaye, Barrett I. Woods, Jeffrey A. Rihn, Jose A. Canseco, Alan S. Hilibrand,
    The Spine Journal.2025; 25(11): 2441.     CrossRef
  • Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
    Wenchao Zhou, Baifeng Sun, Zichuan Wu, Aochen Xu, Hanlin Song, Xuhong Zhang, Junbin Liu, Junzhe Sheng, Yang Liu
    Open Medicine.2025;[Epub]     CrossRef
  • C5 Nerve Palsy After Posterior Instrumentation and Decompression in Cervical Spine Surgery: A Review of the Literature
    Konstantinos Zygogiannis, Pavlos Gerasimidis, Spyridon Komaitis, Savvas Moschos, Georgios C Thivaios, Aikaterini Tsatsaragkou, Dimitrios Koulalis
    Cureus.2025;[Epub]     CrossRef
  • Transient C5 Palsy After Full‐Endoscopic Posterior Cervical Foraminotomy
    João Paulo Machado Bergamaschi, Ariel Falbel Lugão, Rangel Roberto de Assis, Kelsen de Oliveira Teixeira, Fernando Flores de Araújo, Thiago Queiroz Soares, Gustavo Vitelli Depieri, Álvaro Dowling, Robson Cruz de Oliveira, Fernanda Wirth, Fábio da Silva Fo
    Case Reports in Orthopedics.2025;[Epub]     CrossRef
  • Recovery patterns from C5 palsy after anterior cervical decompression and fusion, posterior cervical decompression and fusion, and laminoplasty for degenerative cervical myelopathy: systematic review and meta-analysis of 748 C5 palsy cases
    Vibhu Krishnan Viswanathan, Guna Pratheep Kalanchiam, Akilan Chinnappan, Sathish Muthu
    Asian Spine Journal.2025; 19(6): 1059.     CrossRef
  • Contralateral C7 nerve root transfer for post-stroke prolonged flaccid paralysis — Two cases report
    Shuai Zhu, Feng-Chi Sun, Xiang-Meng Su, Si-Wei Xu, Jun-Tao Feng, Hua-Wei Yin, Wen-Dong Xu, Yun-Dong Shen
    Hand Surgery and Rehabilitation.2025; 44(5): 102261.     CrossRef
  • Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Chang Kyu Lee, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Joongkyum Shin, Yoon Ha
    Neurospine.2025; 22(4): 937.     CrossRef
  • Risk Factors and Clinical Outcomes of Perioperative Complications Following Cervical Spine Surgery
    Narihito Nagoshi, Junichi Yamane, Toshiki Okubo, Yosuke Horiuchi, Yasuhiro Kamata, Norihiro Isogai, Hitoshi Kono, Yoshiomi Kobayashi, Reo Shibata, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
    Global Spine Journal.2025;[Epub]     CrossRef
  • Comparison of Anterior Cervical Decompression and Fusion and Posterior Laminoplasty for Four-Segment Cervical Spondylotic Myelopathy: Clinical and Radiographic Outcomes
    Liang Shi, Tao Ding, Fang Wang, Chengcong Wu
    Journal of Neurological Surgery Part A: Central European Neurosurgery.2024; 85(04): 331.     CrossRef
  • A rare case of phrenic nerve palsy after cervical spine surgery
    Shubham Sanjay Lodha, Akash Vishnu Mane, Mandar Borde, K V Menon
    Indian Spine Journal.2024; 7(1): 100.     CrossRef
  • A systematic review of risk factors and adverse outcomes associated with anterior cervical discectomy and fusion surgery over the past decade
    Vikramaditya Rai, Vipin Sharma, Mukesh Kumar, Lokesh Thakur
    Journal of Craniovertebral Junction and Spine.2024; 15(2): 141.     CrossRef
  • Cervical kinematic change after posterior full-endoscopic cervical foraminotomy for disc herniation or foraminal stenosis
    Seungyoon Paik, Yunhee Choi, Chun Kee Chung, Young Il Won, Sung Bae Park, Seung Heon Yang, Chang-Hyun Lee, John Min Rhee, Kyoung-Tae Kim, Chi Heon Kim, Thamer Hamdan
    PLOS ONE.2023; 18(2): e0281926.     CrossRef
  • Posterior Preventive Foraminotomy before Laminectomy Combined with Pedicle Screw Fixation May Decrease the Incidence of C5 Palsy in Complex Cervical Spine Surgery in Patients with Severe Myeloradiculopathy
    Yong-Ho Lee, Mahmoud Abdou, Ji-Won Kwon, Kyung-Soo Suk, Seong-Hwan Moon, You-Gun Won, Tae-Jin Lee, Byung-Ho Lee
    Journal of Clinical Medicine.2023; 12(6): 2227.     CrossRef
  • Clinical Spectrum of Postsurgical Parsonage-Turner Syndrome: A Perspective From an Electrodiagnostic Laboratory
    Vasudeva G Iyer, Lisa B Shields, Yi Ping Zhang, Christopher B Shields
    Cureus.2023;[Epub]     CrossRef
  • Bilateral phrenic nerve palsy after posterior cervical decompression and fusion surgery: a rare event after surgery
    Glenn A. Gonzalez, Jingya Miao, Guilherme Porto, James Harrop
    Spinal Cord Series and Cases.2023;[Epub]     CrossRef
  • Progress of C5 Nerve Root Palsy after Open-Door Cervical Expansive Laminoplasty
    ·阿不力肯 阿不都沙拉木
    Advances in Clinical Medicine.2023; 13(10): 16813.     CrossRef
  • Management of Cerebrospinal Fluid Leakage by Pump-Regulated Volumetric Continuous Lumbar Drainage Following Anterior Cervical Decompression and Fusion for Ossification of the Posterior Longitudinal Ligament
    Sun Woo Jang, Sang Hyub Lee, Hong Kyung Shin, Sang Ryong Jeon, Sung Woo Roh, Jin Hoon Park
    Neurospine.2023; 20(4): 1421.     CrossRef
  • A Novel Method of Making Hinges Using a Newly Designed Sharp Rongeur to Enhance Radiological and Clinical Outcomes in French‐Door Cervical Expansive Laminoplasty
    Ningning Chen, Lanzhe Yu, Xizhe Liu, Guoliang Chen, Yanrun Li, Xuenong Zou, Dacheng He, Jiaming Yang, Shangbin Cui, Le Wang, Shaoyu Liu, Fuxin Wei
    Orthopaedic Surgery.2022; 14(12): 3349.     CrossRef
  • Defining postoperative C5 palsy and recovery: a systematic review
    Nachiket Deshpande, Amro M. Stino, Brandon W. Smith, Ann A. Little, Lynda J. S. Yang, Paul Park, Yamaan S. Saadeh
    Journal of Neurosurgery: Spine.2022; : 1.     CrossRef
  • Use of electromyography to predict likelihood of recovery following C5 palsy after posterior cervical spine surgery
    Daniel Lubelski, Zach Pennington, Ryan F. Planchard, Ahmet Hoke, Nicholas Theodore, Daniel M. Sciubba, Allan J. Belzberg
    The Spine Journal.2021; 21(3): 387.     CrossRef
  • A modified cutting line in the single-door cervical laminoplasty via a computed tomography-based morphological study of the subaxial cervical spine
    Guoliang Chen, Weicheng Huang, Mengxian Jia, Jiajin Lin, Yadong Sheng, Chaowei Lin, Kelun Huang, Honglin Teng
    Clinical Neurology and Neurosurgery.2021; 200: 106384.     CrossRef
  • A new nomenclature system for the surgical treatment of cervical spine deformity, developing, and validation of SOF system
    Jae Taek Hong, Heiko Koller, Kuniyoshi Abumi, Wen Yuan, Asdrubal Falavigna, Ho Jin Lee, Jong Beom Lee, Jean-Charles Le Huec, Jong-Hyeok Park, Il Sup Kim
    European Spine Journal.2021; 30(6): 1670.     CrossRef
  • C5 palsy after cervical laminectomy: natural history in a 10-year series
    Ryan C. Hofler, Joseph Frazzetta, Jehad Zakaria, Amany Aziz, William Adams, G. Alexander Jones
    The Spine Journal.2021; 21(9): 1473.     CrossRef
  • Preoperative Radiological Parameters to Predict Clinical and Radiological Outcomes after Laminoplasty
    Su Hun Lee, Dong Wuk Son, Jun Jae Shin, Yoon Ha, Geun Sung Song, Jun Seok Lee, Sang Weon Lee
    Journal of Korean Neurosurgical Society.2021; 64(5): 677.     CrossRef
  • Phrenic nerve palsy after cervical laminectomy and fusion
    Andrew S. Moon, Jeffrey M. Pearson, Jason L. Pittman
    North American Spine Society Journal (NASSJ).2020; 4: 100022.     CrossRef
  • 24,567 View
  • 467 Download
  • 31 Web of Science
  • 33 Crossref

Clinical Article

The Therapeutic Effects of Combination Therapy with Curcumin and Alendronate on Spine Fusion Surgery in the Ovariectomized Rats
Dae-Chul Cho, Kyoungsu Ryu, Kyoung-Tae Kim, Joo-Kyung Sung
Korean J Spine 2017;14(2):35-40.   Published online June 30, 2017
DOI: https://doi.org/10.14245/kjs.2017.14.2.35

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

The Therapeutic Effects of Combination Therapy with Curcumin and Alendronate on Spine Fusion Surgery in the Ovariectomized Rats
Korean J Spine. 2017;14(2):35-40.   Published online June 30, 2017
DOI: https://doi.org/10.14245/kjs.2017.14.2.35
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
The Therapeutic Effects of Combination Therapy with Curcumin and Alendronate on Spine Fusion Surgery in the Ovariectomized Rats
Korean J Spine. 2017;14(2):35-40.   Published online June 30, 2017
DOI: https://doi.org/10.14245/kjs.2017.14.2.35
Close
Objective
The purpose of this study was to evaluate the therapeutic effects of combination therapy with curcumin and alendronate on spine fusion surgery in ovariectomized rats. Methods: Thirty-two female Sprague-Dawley rats (12 weeks old) underwent bilateral ovariectomy (OVX). Eight weeks after surgery, animals underwent intertransverse spine fusion at L4-5. The rats were randomly distributed amongst 4 groups; untreated OVX group, curcumin administered group, alendronate administered group, and the combination therapy group. At 8 weeks after fusion surgery, the animals were sacrificed and the fusion mass was assessed by manual palpation, radiographic scan, and micro-computed tomographic scan. In addition, mechanical strength was determined by a 3-point bending test. Results: Based on the results of manual palpation testing and 3-dimensional micro-computed tomography scanning, solid bone fusion rate was 50% (4 of 8) in the OVX group, 75% (6 of 8) in the alendronate-only and curcumin-only group, and 87.5% (7 of 8) in the combination therapy group, respectively. The combination therapy group had a higher fusion rate compared with the other treatment groups, though not statistically significantly (p>0.05). And the combination therapy group had a significant increase in fusion volume at 8 weeks after spine fusion surgery compared with curcumin-only group (p=0.039). The 3-point bending test showed that combination therapy group had a significantly greater maximal load value compared to that of curcumin-only group (p=0.024). Conclusion: The present study demonstrated that additional treatment of curcumin and alendronate after spine fusion surgery in rat can promote higher fusion volume, and improve bone mechanical strength.

Citations

Citations to this article as recorded by  Crossref logo
  • The Effect of Duloxetine on Fusion in Rats Undergoing Posterolateral Spinal Fusion
    Ozan Güner, Murat Erem, Mert Çiftdemir, Ufuk Usta, Nermin Tunçbilek
    Journal of Clinical Medicine.2026; 15(5): 2087.     CrossRef
  • The Early Effect of Alendronate, Hop Extract and Their Combination on Bone Structural Properties in a Rat Model of Osteoporosis
    Edi Rođak, Robert Grgac, Rok Kostanjšek, Milorad Zjalić, Nada Oršolić, Nikola Bijelić
    Medical Sciences.2026; 14(2): 239.     CrossRef
  • Protective effects of curcumin against osteoporosis and its molecular mechanisms: a recent review in preclinical trials
    Shenglei Yang, Yuying Sun, Leonid Kapilevich, Xin’an Zhang, Yue Huang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Highly porous multiple-cell-laden collagen/hydroxyapatite scaffolds for bone tissue engineering
    YoungWon Koo, Hyeongjin Lee, Chang Su Lim, Su Yeon Kwon, Inbo Han, Geun Hyung Kim
    International Journal of Biological Macromolecules.2022; 222: 1264.     CrossRef
  • Evaluation of La(XT), a novel lanthanide compound, in an OVX rat model of osteoporosis
    Yunyun Di, Ellen K. Wasan, Jacqueline Cawthray, Jaweria Syeda, Munawar Ali, David M.L. Cooper, Ahmad Al-Dissi, Nima Ashjaee, Wubin Cheng, James Johnston, David M. Weekes, Thomas I. Kostelnik, Chris Orvig, Kishor M. Wasan
    Bone Reports.2021; 14: 100753.     CrossRef
  • Non-flavonoid polyphenols in osteoporosis: preclinical evidence
    Daniele Bellavia, Fabio Caradonna, Eufrosina Dimarco, Viviana Costa, Valeria Carina, Angela De Luca, Lavinia Raimondi, Milena Fini, Carla Gentile, Gianluca Giavaresi
    Trends in Endocrinology & Metabolism.2021; 32(7): 515.     CrossRef
  • Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis
    Tae-Keun Ahn, Kyoung-Tae Kim, Hari Prasad Joshi, Kwang Hwan Park, Jae Won Kyung, Un-Yong Choi, Seil Sohn, Seung-Hun Sheen, Dong-Eun Shin, Soo-Hong Lee, In-Bo Han
    International Journal of Molecular Sciences.2020; 21(12): 4274.     CrossRef
  • 10,650 View
  • 138 Download
  • 7 Crossref

Technical Note

Repair of Inaccessible Ventral Dural Defect in Thoracic Spine: Double Layered Duraplasty
Dong-Hyun Lee, Kyoung-Tae Kim, Jeong-Ill Park, Ki-Su Park, Dae-Chul Cho, Joo-Kyung Sung
Korean J Spine 2016;13(2):87-90.   Published online June 30, 2016
DOI: https://doi.org/10.14245/kjs.2016.13.2.87

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

Include:

Repair of Inaccessible Ventral Dural Defect in Thoracic Spine: Double Layered Duraplasty
Korean J Spine. 2016;13(2):87-90.   Published online June 30, 2016
DOI: https://doi.org/10.14245/kjs.2016.13.2.87
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Repair of Inaccessible Ventral Dural Defect in Thoracic Spine: Double Layered Duraplasty
Korean J Spine. 2016;13(2):87-90.   Published online June 30, 2016
DOI: https://doi.org/10.14245/kjs.2016.13.2.87
Close

We propose a double layered (intradural and epidural patch) duraplasty that utilizes Lyoplant and Duraseal. We examined a 47-year-old woman after decompression for thoracic ossification of posterior longitudinal ligament was performed in another hospital. On postoperative day 7, she complained of weakness in both legs. Postoperative magnetic resonance imaging (MRI) showed cerebrospinal fluid (CSF) collection with cord compression. In the operative field, we found 2 large dural defects on the ventral dura mater. We performed a conventional fat graft with fibrin glue. However, the patient exhibited neurologic deterioration, and a postoperative MRI again showed CSF collection. We performed dorsal midline durotomy and inserted a intradural and epidural Lyoplant patch. She immediately experienced diminishing back pain postoperatively. Her visual analog scale and motor power improved markedly. Postoperative MRIs performed at 2 and 16 months showed no spinal cord compression or CSF leakage to the epidural space. We describe a new technique for double layered duraplasty. Although we do not recommend this technique for all dural repairs, double-layered duraplasty may be useful for repairing large inaccessible dural tears in cases of persistent CSF leakage refractory to conventional management.

Citations

Citations to this article as recorded by  Crossref logo
  • Dural Closure Techniques and Cerebrospinal Fluid Leak Incidence After Resection of Primary Intradural Spinal Tumors
    Arjun Syal, Francesca M. Cozzi, Sima Vazquez, Eris Spirollari, Alexandria F. Naftchi, Ankita Das, Christina Ng, OluwaToba Akinleye, Thomas Gagliardi, Jose F. Dominguez, Arthur Wang, Merritt D. Kinon
    Clinical Spine Surgery.2024; 37(7): 291.     CrossRef
  • Massive lumbar disc herniation treated with a transdural approach and posterior fusion. A case report
    Takashi Sono, Kenji Nakatani, Kazuaki Morizane, Kazushi Otsuka, Kazutaka Takatsuka
    Interdisciplinary Neurosurgery.2024; 36: 101924.     CrossRef
  • Importance of Multimodal Spinal Cord Monitoring and Hemodynamic Augmentation during High Thoracic Ventral Dural Tear Repair Using the Posterior Approach
    Ramamani Mariappan, Sajo Thomas, Krishnaprabhu Raju
    Journal of Neuroanaesthesiology and Critical Care.2023; 10(03): 202.     CrossRef
  • A novel two-layer, intradural and extradural patch graft approach to treating dural defects and tears: illustrative case
    Daniella Lazarus, Charlotte Hawks, Namrita Kumar, Tara McCaffrey, Arthur L. Jenkins
    Journal of Neurosurgery: Case Lessons.2022;[Epub]     CrossRef
  • Pedicled Multifidus Muscle Flap To Treat Inaccessible Dural Tear In Spine Surgery: Technical Note And Preliminary Experience
    Domenico Policicchio, Riccardo Boccaletti, Giosuè Dipellegrini, Artan Doda, Andrea Stangoni, Santonio Filippo Veneziani
    World Neurosurgery.2021; 145: 267.     CrossRef
  • Letter to the editor: Dural Leak: Is It Deterrent to Outcomes in Spine Surgery?: 10 Years Retrospective Analysis of Incidence, Management Protocol, and Surgical Outcomes
    Vishal Kumar, Sanjay Singh Rawat
    Spine.2021; 46(17): E954.     CrossRef
  • Anterior Dural Tear in Thoracic and Lumbar Spinal Fractures: Single-Center Experience with Coating Technique and Literature Review of the Available Strategies
    Giorgio Lofrese, Jacopo Visani, Francesco Cultrera, Pasquale De Bonis, Luigino Tosatto, Alba Scerrati
    Life.2021; 11(9): 875.     CrossRef
  • Medical Communication Services after Traumatic Spinal Cord Injury
    Jamal Alshorman, Yulong Wang, Fengzhao Zhu, Lian Zeng, Kaifang Chen, Sheng Yao, Xirui Jing, Yanzhen Qu, Tingfang Sun, Xiaodong Guo, Malik Alazzam
    Journal of Healthcare Engineering.2021; 2021: 1.     CrossRef
  • 17,978 View
  • 212 Download
  • 8 Crossref
First First Prev Prev
Page of 2
Next Next Last Last
NS : Neurospine
Facebook Twitter