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"Dong Kyu Chin"

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"Dong Kyu Chin"

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Clinical Study – Cervical Spine

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Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
Neurospine. 2025;22(4):937-948.   Published online December 31, 2025
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Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
Neurospine. 2025;22(4):937-948.   Published online December 31, 2025
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Objective
To evaluate the clinical significance of a negative K-line in the neck flexion position (FK-line [-]), which indicates that cervical ossification of the posterior longitudinal ligament (OPLL) crosses the K-line during flexion, and to compare surgical outcomes between laminoplasty (LP) and laminectomy with fusion (LF) for multilevel FK-line (-) cervical OPLL.
Methods
A total of 349 patients with multiple cervical OPLL who underwent posterior decompression surgery (LP or LF) with a minimum of 2 years of follow-up were stratified by FK-line status. Clinical and radiological parameters were compared between the FK-line (+) and FK-line (-) groups. Subgroup analysis of FK-line (-) patients evaluated the efficacy of LP versus LF. Multivariate regression identified predictors of neurological recovery.
Results
Patients with FK-line (-) OPLL exhibited a smaller FK-line distance, more kyphotic alignment, greater cervical flexion, and lower recovery ratios compared to those with FK-line (+). In the FK-line (-) subgroup, LF achieved a significantly greater increase in FK-line distance, better correction of the flexion angle, and more neurological recovery than LP. Multivariate analyses identified postoperative FK-line distance, C2–7 flexion angle, and preoperative dynamic extension reserve as independent predictors of neurological outcomes.
Conclusion
FK-line status reflects the sagittal cord position and predicts surgical outcomes in cervical OPLL. In FK-line (-) patients, LF provides better neurological recovery and more effective posterior cord shift and kyphotic alignment correction than LP. Incorporating FK-line assessment to guide surgical planning could improve individualized treatment outcomes for multilevel OPLL.

Citations

Citations to this article as recorded by  Crossref logo
  • A Commentary on “Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion”
    John H. Chi
    Neurospine.2025; 22(4): 951.     CrossRef
  • A Commentary on “Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion”
    Yutaro Kanda
    Neurospine.2025; 22(4): 949.     CrossRef
  • From the Editor-in-Chief: Featured Articles in the December 2025 Issue
    Inbo Han
    Neurospine.2025; 22(4): 877.     CrossRef
  • 1,759 View
  • 84 Download
  • 3 Web of Science
  • 3 Crossref

Cervical Spine

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The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study
Neurospine. 2025;22(2):337-348.   Published online June 30, 2025
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The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study
Neurospine. 2025;22(2):337-348.   Published online June 30, 2025
Close
Objective
To evaluate the impact of the K-line and canal-occupying ratio (COR) on surgical outcomes in patients with multilevel cervical ossification of the posterior longitudinal ligament (OPLL).
Methods
Patients with cervical myelopathy due to multilevel OPLL who underwent decompression surgery (anterior or posterior) from 2013 to 2022, with 2-year minimum follow-up, were enrolled. Radiological evaluations included K-line, COR, OPLL type/level, and cervical parameters (C2 slope [C2S], T1 slope [T1S], K-line tilt). Clinical outcomes included Japanese Orthopaedic Association (JOA) score and neck-pain visual analogue scale. Patients were categorized by K-line status (+/-) and COR (<50% or ≥50%).
Results
Among 575 patients, JOA recovery was significantly better in the K-line (+) and in low COR (<50%). In high COR (≥50%), K-line (-) was associated with poorer recovery. In low COR, outcomes were similar regardless of K-line. Anterior decompression with fusion (ADF) yielded the best outcomes. Laminoplasty (LP) was optimal for COR ≥50% and/or K-line (+), while laminectomy with fusion (LF) was better for COR ≥50% and K-line (-). In high COR, K-line was influenced by cervical alignment, C2S, and T1S, while in low COR, it was mainly affected by COR percentage.
Conclusion
Combining K-line and COR is essential for surgical planning in multilevel OPLL. When COR is high, K-line plays a significant role in predicting neurological recovery. ADF led to superior recovery, whereas for patients with K-line (-) and high COR, LF offered better results than LP. Cervical parameters at high COR influence the K-line more.

Citations

Citations to this article as recorded by  Crossref logo
  • Evaluating the demographics and complications of North American surgical patients with ossification of the posterior longitudinal ligament
    Aaron Phung, Justin Hyde, Justin Azmoodeh, Theodore Quan, Lancelot Benn, Christopher P. Bellaire, Oliver Tannous, Joseph Ferguson, Seyed B Kalantar, David Weiner, Andrew Mo, Fred Mo, Sean Bae, Ala Alshomali, Crisanto L. Macaraeg, Kevin Yoon, Jonathan P. J
    Journal of Clinical Neuroscience.2026; 144: 111790.     CrossRef
  • Radiological assessment in cervical spine myelopathy
    Shanmuganathan Rajasekaran, Gnanaprakash Gurusamy, Pushpa Bhari Thippeswamy, Karthik Ramachandran, Stefano Conti
    Journal of Clinical Orthopaedics and Trauma.2026; 72: 103301.     CrossRef
  • C2-Involving Cervical Ossification of the Posterior Longitudinal Ligament (OPLL): Dome-like Laminoplasty Versus Laminectomy With Fusion
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Joongkyum Shin, Yoon Ha
    Global Spine Journal.2026;[Epub]     CrossRef
  • Dynamic K-Line Status and Surgical Outcomes in Multilevel Cervical OPLL: A Multicenter Comparative Study
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Chang Kyu Lee, Keung Nyun Kim, Tae Woo Kim, Yoon Ha
    Journal of Clinical Medicine.2026; 15(2): 520.     CrossRef
  • A comparative study on surgical management of long-course symptomatic cervical OPLL between anterior en bloc resection and posterior laminectomy with instrumented fusion
    Kefu Chen, Yiwei Lu, Shu Liu, Lianshun Jia, Xingcheng Dong, Tianwen Ye
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • Reduction of Spinal Cord Cross-Sectional Area Is Associated With Myelopathy in Severe Cervical Ossification of the Posterior Longitudinal Ligaments
    Hyun-Jun Jang, Dong-Kyu Kim, Bong-Ju Moon, Kyung-Hyun Kim, Jeong-Yoon Park, Sung-Uk Kuh, Keun-Su Kim, Yong-Eun Cho, Dong-Kyu Chin
    Neurosurgery.2026;[Epub]     CrossRef
  • Spinal cord extracellular matrix hydrogel enhances organoid maturation and functional regeneration after spinal cord injury
    Junghoon Kim, Songzi Zhang, Joon-Hyuk Jung, Mi-Jeong Lee, Inbo Han, Seung-Woo Cho
    Materials Today Bio.2026; 38: 103168.     CrossRef
  • Surgical Technique and Technical Pearls of O-arm Navigation-assisted Anterior Cervical Corpectomy and Fusion for Cervical Ossification of the Posterior Longitudinal Ligament (OPLL)
    Yusuke Nishimura
    Spinal Surgery.2026; 40(1): 8.     CrossRef
  • Risk Factors for Persistent Neurological Deterioration After Biportal Endoscopic Posterior Decompression for Multilevel Cervical Myelopathy: The “Structural Mismatch” Concept
    Ji Yeon Kim, Woon Tak Yuh, Su Yong Choi, Min Gyu Kang, Seok Won Lee
    Journal of Minimally Invasive Spine Surgery and Technique.2026; 11(Suppl 2): S302.     CrossRef
  • Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Chang Kyu Lee, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Joongkyum Shin, Yoon Ha
    Neurospine.2025; 22(4): 937.     CrossRef
  • 9,996 View
  • 274 Download
  • 9 Web of Science
  • 10 Crossref

Minimally Invasive Spine Surgery

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Comparative Outcomes of Biportal Endoscopic Decompression, Conventional Subtotal Laminectomy, and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Central Stenosis
Neurospine. 2024;21(4):1178-1189.   Published online December 31, 2024
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Comparative Outcomes of Biportal Endoscopic Decompression, Conventional Subtotal Laminectomy, and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Central Stenosis
Neurospine. 2024;21(4):1178-1189.   Published online December 31, 2024
Close
Objective
Spinal stenosis is a prevalent condition; however, the optimal surgical treatment for central lumbar stenosis remains controversial. This study compared the clinical outcomes and radiological parameters of 3 surgical methods: unilateral laminectomy bilateral decompression with unilateral biportal endoscopy (ULBD-UBE), conventional subtotal laminectomy (STL), and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).
Methods
This retrospective study included 86 patients, divided into ULBD-UBE (n=34), STL (n=24), and MIS-TLIF (n=28) groups. We evaluated demographics and perioperative factors and assessed clinical outcomes using the visual analogue scale (VAS), Oswestry Disability Index (ODI), and neurogenic intermittent claudication (NIC). Radiological parameters assessed included lumbar lordosis, L4S1 Cobb angle (L4S1), T12S1 Cobb angle (T12S1), increased cross-sectional dural area (CSA), dynamic angulation (DA), dynamic slip (DS), and development of postoperative instability.
Results
The ULBD-UBE group showed a significantly shorter hospital stay duration and operation time and reduced blood loss than the other groups (p<0.001). ULBD-UBE group showed a trend towards greater VAS and ODI improvement at 1 month and postoperative NIC symptom relief. Radiologically, MIS-TLIF group exhibited lower postoperative DA and DS (p<0.001), indicating higher postoperative stability. Postoperative instability was lower in the ULBD-UBE group (2.9%) than in the STL group (16.7%) and similar to the MIS-TLIF group (0.0%) (p=0.028). The CSA was highest in the MIS-TLIF group (295.5%) compared to that in the other groups (ULBD-UBE, 216.3%; STL, 245.2%) (p<0.001).
Conclusion
Compared to other procedures, ULBD-UBE is a safe, effective, and viable surgical procedure for treating lumbar central stenosis.

Citations

Citations to this article as recorded by  Crossref logo
  • Bilateral versus Unilateral Decompression in Single-Level Transforaminal Lumbar Interbody Fusion for Degenerative Spondylolisthesis: A Retrospective Comparative Study
    Lu-ming Nong, Jian-jian Yin, Gong-ming Gao, Nan-wei Xu, Gong-yin Zhao, Yu-qing Jiang, Long Han
    World Neurosurgery.2026; 206: 124784.     CrossRef
  • Comparison of paraspinal muscle changes after biportal endoscopic and microscopic lumbar discectomy or decompression
    Ki-Han You, Sang-Min Park, Daniel Park, Min-Seok Kang, Seung-Yeon Jeong, Sun-Ho Cha, Samuel Cho, Hyun-Jin Park
    European Spine Journal.2026;[Epub]     CrossRef
  • O‐Arm Navigation Enhances Facet Preservation Without Compromising Clinical Outcomes in UBE Decompression for Radiographically Stable Adult Degenerative Scoliosis: A Single‐Center Comparative Study
    Yi Liu, Yiwei Xie, Zhibao Chen, Ruijun Xu, Haojie Chen, Xiaojian Ye, Jiangming Yu
    Orthopaedic Surgery.2026; 18(6): 1203.     CrossRef
  • A minimally invasive robotic spinal surgical system for anterior lumbar nerve decompression
    Qingxiang Zhao, Xiandi Wang, Xin Zhong, Runfeng Zhu, Peizhi Zhou, Dan Pu, Baitao Lin, Tao Li, Shiyuan Sui, Haonan Zhou, Yuxi Cheng, Hao Zheng, Henry K. Chu, Jiancheng Zeng, Kang Li
    Science Robotics.2026;[Epub]     CrossRef
  • The impact of body mass index on early readmission and reoperation following endoscopic vs. open/microsurgical lumbar surgery: A nationwide analysis
    Abdul Karim Ghaith, Yazan Alasadi, Xinlan Yang, Mohamad Ghaith, Melanie Alfonzo Horowitz, Husni Alasadi, Meghana Bhimreddy, Arjun K. Menta, Joshua Weinberg, Antony Fuleihan, Daniel Lubelski, Nicholas Theodore
    Clinical Neurology and Neurosurgery.2026; 269: 109553.     CrossRef
  • Totally endoscopic trans‑superior articular process lumbar interbody fusion: A case series on the development and preliminary evaluation of an innovative minimally invasive lumbar spine surgical technique
    Hualv Liu, Junjie Li, Yuhao Gao, Shilei Qin, Pengfei Han, Yunfeng Xu
    Experimental and Therapeutic Medicine.2025; 30(1): 1.     CrossRef
  • Bilateral–Contralateral Endoscopic Decompression as a Fusion-Deferral Strategy in Upper Lumbar Stenosis: A Structural Rationale and Conditional Framework—A Technical Note with Cases Review
    Dong Hyun Lee, Sang Yeop Han, Seung Young Jeong, Il-Tae Jang
    Journal of Clinical Medicine.2025; 14(16): 5726.     CrossRef
  • Reply Letter: A Commentary on “Comparative Outcomes of Biportal Endoscopic Decompression, Conventional Subtotal Laminectomy, and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Central Stenosis”
    Jeong-Yoon Park
    Neurospine.2025; 22(3): 875.     CrossRef
  • Efficacy of unilateral biportal endoscopy vs. unilateral portal endoscopy for the treatment of lumbar spinal stenosis: a systematic review and meta-analysis
    Yongjia Yu, Yuguang An, Chang Liu, Kemin Wang, Wuqiao Liang, Huazhong Gan, Zhaoju Hong, Qingmei Zhang, Maolin He, Daqin Feng
    Frontiers in Surgery.2025;[Epub]     CrossRef
  • A Commentary on “Comparative Outcomes of Biportal Endoscopic Decompression, Conventional Subtotal Laminectomy, and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Central Stenosis”
    Xiangge Liu
    Neurospine.2025; 22(3): 873.     CrossRef
  • Comparison of unilateral biportal endoscopic lumbar fusion and modified minimally invasive tubular lumbar fusion for lumbar disc herniation: a two-year retrospective study
    Jialong Qi, Mingxiang Liu, Tao Shan, Zhou Dong, Guosong Han, Zhihao Ni, Ke Zheng, Li Ma, Zhidong Zhang
    Frontiers in Neurology.2025;[Epub]     CrossRef
  • 8,907 View
  • 184 Download
  • 12 Web of Science
  • 11 Crossref

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Predicting Mechanical Complications After Adult Spinal Deformity Operation Using a Machine Learning Based on Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density
Neurospine. 2023;20(1):265-274.   Published online March 31, 2023
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Predicting Mechanical Complications After Adult Spinal Deformity Operation Using a Machine Learning Based on Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density
Neurospine. 2023;20(1):265-274.   Published online March 31, 2023
Close
Objective
This study aimed to create an ideal machine learning model to predict mechanical complications in adult spinal deformity (ASD) surgery based on GAPB (modified global alignment and proportion scoring with body mass index and bone mineral density) factors.
Methods
Between January 2009 and December 2018, 238 consecutive patients with ASD, who received at least 4-level fusions and were followed-up for ≥ 2 years, were included in the study. The data were stratified into training (n = 167, 70%) and test (n = 71, 30%) sets and input to machine learning algorithms, including logistic regression, random forest gradient boosting system, and deep neural network.
Results
Body mass index, bone mineral density, the relative pelvic version score, the relative lumbar lordosis score, and the relative sagittal alignment score of the global alignment and proportion score were significantly different in the training and test sets (p < 0.05) between the complication and no complication groups. In the training set, the area under receiver operating characteristics (AUROCs) for logistic regression, gradient boosting, random forest, and deep neural network were 0.871 (0.817–0.925), 0.942 (0.911–0.974), 1.000 (1.000–1.000), and 0.947 (0.915–0.980), respectively, and the accuracies were 0.784 (0.722–0.847), 0.868 (0.817–0.920), 1.000 (1.000–1.000), and 0.856 (0.803–0.909), respectively. In the test set, the AUROCs were 0.785 (0.678–0.893), 0.808 (0.702–0.914), 0.810 (0.710–0.910), and 0.730 (0.610–0.850), respectively, and the accuracies were 0.732 (0.629–0.835), 0.718 (0.614–0.823), 0.732 (0.629–0.835), and 0.620 (0.507–0.733), respectively. The random forest achieved the best predictive performance on the training and test dataset.
Conclusion
This study created a comprehensive model to predict mechanical complications after ASD surgery. The best prediction accuracy was 73.2% for predicting mechanical complications after ASD surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • Determining the risk factors for postoperative mechanical complication in degenerative scoliosis: a machine learning approach based on musculoskeletal metrics
    Jie Li, Zhen Tian, Yinyu Fang, Zhong He, Yanjie Xu, Hui Xu, Zezhang Zhu, Yong Qiu, Zhen Liu
    European Spine Journal.2026; 35(1): 156.     CrossRef
  • Development and validation of a deep learning–powered system for multi-version global alignment and proportion score to predict mechanical complications after adult degenerative scoliosis surgery
    Qifeng Lan, Shanshan Liu, Cheng Zhang, Chenyi Guo, Yiming Shi, Jian He, Xingyu Zhou, Jiaheng Shang, Qiang Qi, Zhaoqing Guo, Zhuoran Sun, Siyu Zhou, Ji Wu, Nanfang Xu, Weishi Li
    European Spine Journal.2026; 35(2): 375.     CrossRef
  • Proximal Junctional Kyphosis Prevention in Adult Spinal Deformity Surgery: A Technical Review of Tethering and Adjunctive Strategies
    Paritash Tahmasebpour, Pawel P. Jankowski, Jason Liang, Joshua Lin, Kyriakos D. Chatzis, Peter S. Tretiakov, Spencer Matthews, Louis Boissiere, John F. Burke, Christopher I. Shaffrey, Aaron Hockley, Peter Passias
    Operative Neurosurgery.2026;[Epub]     CrossRef
  • Not just alignment: body shape influences adult spinal deformity biomechanics
    Elisa R. Rosanò, Abdul Hulleck, Tao Liu, Marwan El-Rich, Markus Loibl, Fabio Galbusera, Frank Kleinstück, Tamas Fekete, Daniel Haschtmann, Sarah Richner-Wunderlin, Ferran Pellisé, Ibrahim Obeid, Javier Pizones, Ahmet Alanay, Caglar Yilgor, Luigi La Barber
    European Spine Journal.2026;[Epub]     CrossRef
  • Machine learning–based prediction of perioperative complications in spine surgery: a large-scale model development and validation study
    Andrea Campagner, Francesco Langella, Pablo Bellosta-López, Francesca Barile, Riccardo Cecchinato, Domenico Compagnone, Marco Damilano, Claudio Lamartina, Andrea Redaelli, Daniele Vanni, Federico Cabitza, Claudia Meroni, Pedro Berjano
    European Spine Journal.2026;[Epub]     CrossRef
  • Predicting postoperative mechanical complications with the ethnicity-adjusted global alignment and proportion score in degenerative scoliosis: does paraspinal muscle degeneration matter?
    Peiyu Li, Jie Li, Abdukahar Kiram, Zhen Tian, Xing Sun, Xiaodong Qin, Benlong Shi, Yong Qiu, Zhen Liu, Zezhang Zhu
    The Spine Journal.2025; 25(2): 347.     CrossRef
  • Uso de inteligencia artificial para predecir complicaciones en cirugías de columna toracolumbar degenerativa: revisión sistemática
    G. Ricciardi, J.I. Cirillo Totera, R. Pons Belmonte, L. Romero Valverde, F. López Muñoz, A. Manríquez Díaz
    Revista Española de Cirugía Ortopédica y Traumatología.2025; 69(5): 446.     CrossRef
  • Risk Factors of 90-Day Unplanned Readmission After Lumbar Spine Surgery for Degenerative Lumbar Disk Disease: A Systematic Review and Meta-Analysis
    Jeong In Seol, Jeong Hoon Yoo, Hyeon Gyu Sung, Hyun Ho Park, Sung Hyeon Noh
    Neurosurgery.2025; 97(4): 908.     CrossRef
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    Mohsin Khan, Kaustubh Ahuja, Athanasios I Tsirikos
    Bone & Joint Open.2025; 6(5): 569.     CrossRef
  • Novel risk factors and personalized risk calculator for predicting proximal junctional kyphosis after adult spinal deformity surgery
    Qijun Wang, Zheng Wang, Dongfan Wang, Xuan Zhao, Xiaolong Chen, Shibao Lu
    The Bone & Joint Journal.2025; 107-B(8): 829.     CrossRef
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    G. Ricciardi, J.I. Cirillo Totera, R. Pons Belmonte, L. Romero Valverde, F. López Muñoz, A. Manríquez Díaz
    Revista Española de Cirugía Ortopédica y Traumatología.2025; 69(5): T446.     CrossRef
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    鑫 王
    Advances in Clinical Medicine.2025; 15(09): 91.     CrossRef
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    Vinicius Ricieri Ferraz, Guilherme Santos Piedade, Carlos R. Goulart, Maria Fernanda Ricieri Ferraz Franco de Souza, Marcelo Ochoa Coelho de Souza Furlan, Philippe A. Mercier, Tobias A. Mattei
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    Akihiko Hiyama, Daisuke Sakai, Hiroyuki Katoh, Masato Sato, Masahiko Watanabe
    Scientific Reports.2025;[Epub]     CrossRef
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    Ethan Schonfeld, Aaradhya Pant, Aaryan Shah, Sina Sadeghzadeh, Dhiraj Pangal, Adrian Rodrigues, Kelly Yoo, Neelan Marianayagam, Ghani Haider, Anand Veeravagu
    Journal of Clinical Medicine.2024; 13(3): 656.     CrossRef
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    Tyler K. Williamson, Ezekial J. Koslosky, Jordan Lebovic, Stephane Owusu-Sarpong, Peter Tretiakov, Jamshaid Mir, Pooja Dave, Andrew J. Schoenfeld, Bassel G. Diebo, Heiko Koller, Renaud Lafage, Virginie Lafage, Peter G. Passias
    Clinical Spine Surgery.2024; 37(10): E503.     CrossRef
  • Commentary on “Performance of a Large Language Model in the Generation of Clinical Guidelines for Antibiotic Prophylaxis in Spine Surgery”
    Sun-Ho Lee
    Neurospine.2024; 21(1): 147.     CrossRef
  • Deep Learning Method for Precise Landmark Identification and Structural Assessment of Whole-Spine Radiographs
    Sung Hyun Noh, Gaeun Lee, Hyun-Jin Bae, Ju Yeon Han, Su Jeong Son, Deok Kim, Jeong Yeon Park, Seung Kyeong Choi, Pyung Goo Cho, Sang Hyun Kim, Woon Tak Yuh, Su Hun Lee, Bumsoo Park, Kwang-Ryeol Kim, Kyoung-Tae Kim, Yoon Ha
    Bioengineering.2024; 11(5): 481.     CrossRef
  • Research of Global Tilt and Functional Independence: Insights into Spinal Health of Older Women
    Yu-Chieh Chiu, Ping-Chiao Tsai, Ssu-Hsien Lee, Wen-Tien Wu, Tzai-Chiu Yu, Ru-Ping Lee, Ing-Ho Chen, Jen-Hung Wang, Kuang-Ting Yeh
    Bioengineering.2024; 11(5): 493.     CrossRef
  • Trends in degenerative lumbar spinal surgery during the early COVID-19 pandemic in Republic of Korea: A national study utilizing the national health insurance database
    Woon Tak Yuh, Jinhee Kim, Mi-Sook Kim, Jun-Hoe Kim, Young Rak Kim, Sum Kim, Chun Kee Chung, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Young San Ko, Chi Heon Kim, Kentaro Yamada
    PLOS ONE.2024; 19(6): e0305128.     CrossRef
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    Nader Toossi, Ozhan Jerry
    Artificial Intelligence Surgery.2024; 4(3): 258.     CrossRef
  • Prediction of postoperative mechanical complications in ASD patients based on total sequence and proportional score of spinal sagittal plane
    Wenbin Jiang, Huagang Shi, Tao Gu, Zonglin Cai, Qinglong Li
    SLAS Technology.2024; 29(6): 100222.     CrossRef
  • Classification of lumbar spine disorders using large language models and MRI segmentation
    Rongpeng Dong, Xueliang Cheng, Mingyang Kang, Yang Qu
    BMC Medical Informatics and Decision Making.2024;[Epub]     CrossRef
  • Proximal Junctional Failure Development Despite Achieving Ideal Sagittal Correction According to Age-Adjusted Alignment Target in Patients With Adult Spinal Deformity: Risk Factor Analysis of 196 Cases Undergoing Low Thoracic to Pelvic Fusion
    Se-Jun Park, Jin-Sung Park, Dong-Ho Kang, Minwook Kang, Kyunghun Jung, Chong-Suh Lee
    Neurospine.2024; 21(4): 1080.     CrossRef
  • Complication Rates and Utilization Trends of 3-Level Posterior Column Osteotomy Compared to Single-Level Pedicle Subtraction Osteotomy
    Emily S. Mills, Kevin Mertz, Ethan Faye, Jennifer A. Bell, Andy T. Ton, Jeffrey C. Wang, Ram K. Alluri, Raymond J. Hah
    Neurospine.2023; 20(2): 662.     CrossRef
  • Proximal Junctional Failure in Adult Spinal Deformity Surgery: An In-depth Review
    Mitsuru Yagi, Kento Yamanouchi, Naruhito Fujita, Haruki Funao, Shigeto Ebata
    Neurospine.2023; 20(3): 876.     CrossRef
  • Proximal Junctional Kyphosis or Failure After Adult Spinal Deformity Surgery - Review of Risk Factors and Its Prevention
    Byung-Jou Lee, Sung Soo Bae, Ho Young Choi, Jin Hoon Park, Seung-Jae Hyun, Dae Jean Jo, Yongjae Cho
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Clinical, Radiographic, and Genetic Analyses in a Population-Based Cohort of Adult Spinal Deformity in the Older Population
Neurospine. 2021;18(3):608-617.   Published online September 30, 2021
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Clinical, Radiographic, and Genetic Analyses in a Population-Based Cohort of Adult Spinal Deformity in the Older Population
Neurospine. 2021;18(3):608-617.   Published online September 30, 2021
Close
Objective
This study aimed to identify the sagittal parameters associated with health-related quality of life and genetic variations that increase the risk of adult spinal deformity (ASD) onset in the older population.
Methods
We recruited 120 participants who had a sagittal vertical axis > 50 mm in a sagittal imbalance study. Sagittal radiographic parameters, cross-sectional area, and intramuscular fatty infiltration using the Goutallier classification in the paraspinal lumbar muscles were evaluated. Functional scales included the self-reported Oswestry Disability Index (ODI), 36-item Short Form Health Survey (SF-36), and visual analogue scales (VAS) for back and leg pain. We performed whole-exome sequencing and an exome-wide association study using the 100 control subjects and 63 individuals with severe phenotypes of sagittal imbalance.
Results
Pelvic incidence minus lumbar lordosis (PI–LL) mismatch was negatively associated with the SF-36 and positively correlated with ODI and VAS for back and leg pain. PI–LL was related to the quality and size of the paraspinal muscles, especially the multifidus muscle. We identified common individual variants that reached exome-wide significance using single-variant analysis. The most significant single-nucleotide polymorphism was rs78773460, situated in an exon of the SVIL gene (odds ratio, 9.61; p = 1.15 × 10-9).
Conclusion
Older age, higher body mass index, and a more significant PI–LL mismatch were associated with unfavorable results on functional scales. We found a genetic variation in the SVIL gene, which has been associated with the integrity of the cytoskeleton and the development of skeletal muscles, in severe ASD phenotypes. Our results help to elucidate the pathogenesis of ASD.

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Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density Analysis in Global Alignment and Proportion Score of Each 3 Categories for Predicting Mechanical Complications After Adult Spinal Deformity Surgery
Neurospine. 2021;18(3):484-491.   Published online September 30, 2021
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Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density Analysis in Global Alignment and Proportion Score of Each 3 Categories for Predicting Mechanical Complications After Adult Spinal Deformity Surgery
Neurospine. 2021;18(3):484-491.   Published online September 30, 2021
Close
Objective
This study aimed to analyze the prediction rate of the modified Global Alignment and Proportion (GAP) scoring system with body mass index and bone mineral density (GAPB) in each GAP of the 3 categories.
Methods
Between January 2009 and December 2016, 203 consecutive patients with adult spinal deformity (ASD) underwent corrective fusion of more than 4 levels and were followedup for more than 2 years. As a validation of the GAPB, the GAPB was divided into tertiles (Q1, Q2, Q3) for each section of the GAP score. Each patient’s GAP score and GAPB system complication rate were examined.
Results
Of the 203 patients, 89 patients (44%) developed mechanical complications after ASD surgery. A GAP score analysis of the patients found that 42 patients were proportioned, 85 patients were moderately disproportioned, and 76 patients were severely disproportioned. Mechanical complications occurred with increasing GAPB in the proportioned group, but were not statistically significant (p = 0.0534). However, mechanical complications occurred in a statistically significant manner in the moderately disproportioned and severely disproportioned groups as GAPB increased (p < 0.001).
Conclusion
The GAPB system showed improved predictability for mechanical complications after surgery for ASD in each category of the GAP score.

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Characteristics and Risk Factors of Rod Fracture Following Adult Spinal Deformity Surgery: A Systematic Review and Meta-Analysis
Neurospine. 2021;18(3):447-454.   Published online September 30, 2021
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Characteristics and Risk Factors of Rod Fracture Following Adult Spinal Deformity Surgery: A Systematic Review and Meta-Analysis
Neurospine. 2021;18(3):447-454.   Published online September 30, 2021
Close
Objective
The aim of study is to investigate the features and risk factors of rod fracture (RF) following adult spinal deformity (ASD) surgery.
Methods
We searched the PubMed, Embase, Web of Science, and Cochrane Library databases to identify relevant studies. Patient’s data including age, sex, body mass index (BMI), previous spine surgery, pedicle subtraction osteotomy (PSO), interbody fusion, fusion to the pelvis, smoking history, preoperative sagittal vertical axis (SVA), preoperative pelvic tilt (PT), preoperative pelvic incidence minus lumbar lordosis, preoperative thoracic kyphosis (TK), and change in the SVA were documented. Comparable factors were evaluated using odds ratio (OR) and weighted mean difference (WMD) with 95% confidence interval (CI).
Results
Seven studies were included. The overall incidence of RF following ASD surgery was 12%. Advanced age (WMD, 2.8; 95% CI, 1.01–4.59; p < 0.002), higher BMI (WMD, 1.98; 95% CI, 0.65–3.31; p = 0.004), previous spine surgery (OR, 1.47; 95% CI, 1.05–2.04; p = 0.02), PSO (OR, 2.28; 95% CI, 1.62–3.19; p < 0.0001), a larger preoperative PT (WMD, 6.17; 95% CI, 3.55–8.97; p < 0.00001), and a larger preoperative TK (WMD, 5.19; 95% CI, 1.41–8.98; p = 0.007) were identified as risk factors for incidence of RF.
Conclusion
The incidence of RF in patients following ASD surgery was 12%. Advanced age, higher BMI, previous spine surgery, and PSO were significantly associated with an increased occurrence of RF. A larger preoperative PT and TK were also identified as risk factors for occurrence of RF following ASD surgery.

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  • Surgical outcome of minimal invasive oblique lateral interbody fusion with percutaneous pedicle screw fixation in the treatment of adult degenerative scoliosis
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    Medicine.2022; 101(48): e31879.     CrossRef
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Clinical Articles

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Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats
Korean J Spine. 2015;12(2):55-59.   Published online June 30, 2015
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Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats
Korean J Spine. 2015;12(2):55-59.   Published online June 30, 2015
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Objective

To investigate a suitable animal model for studies of male osteoporosis. Osteoporosis has a particularly high incidence in postmenopausal women, resulting in a substantial amount of research with respect to this disease in women. However, research on osteoporosis in men is still lacking.

Methods

Twenty 10-week-old male Sprague Dawley rats were used in this study, including 4 rats used to establish a baseline bone mineral density (BMD). The other 16 rats were divided into two groups: a sham surgery group (n=8), which underwent a sham operation, and an orchiectomized rat group (OCX) (n=8), which underwent bilateral OCX at 10 weeks of age. Bone mineral density was measured in 4 rats from both the sham surgery group and the OCX group 8 weeks after the surgery, while BMD in the remainder of the rats was measured 10 weeks post-surgery.

Results

Femoral BMD at 8 weeks post-surgery was found to be significantly lower in the OCX group compared to the sham group; a finding that was also similar 10 weeks post-surgery.

Conclusion

8 weeks after undergoing orchiectomy performed via a scrotal, white rats are a suitable model for studies of male osteoporosis.

Citations

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  • The antiosteoporotic effect of oxymatrine compared to testosterone in orchiectomized rats
    Anwaar M. Shaban, Eman A. Ali, Sara G. Tayel, Sara Kamal Rizk, Dalia F. El Agamy
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Promotion of Bone Formation in a Rat Osteoporotic Vertebral Body Defect Model via Suppression of Osteoclastogenesis by Ectopic Embryonic Calvaria Derived Mesenchymal Stem Cells
    Yerin Yu, Somin Lee, Minsung Bock, Seong Bae An, Hae Eun Shin, Jong Seop Rim, Jun-oh Kwon, Kwang-Sook Park, Inbo Han
    International Journal of Molecular Sciences.2024; 25(15): 8174.     CrossRef
  • Effects on Bone and Muscle upon Treadmill Interval Training in Hypogonadal Male Rats
    Ioannis Stratos, Ingmar Rinas, Konrad Schröpfer, Katharina Hink, Philipp Herlyn, Mario Bäumler, Tina Histing, Sven Bruhn, Brigitte Müller-Hilke, Michael D. Menger, Brigitte Vollmar, Thomas Mittlmeier
    Biomedicines.2023; 11(5): 1370.     CrossRef
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    David S. Hydock
    Transgender Health.2022; 7(1): 43.     CrossRef
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    Ji-won Park, Myung-In Jeong, Wu-Jin Jeong, Hae-Won Hong, Ji-eun Koo, Sung-won Choi, Da-hyun Kyung
    Journal of Acupuncture Research.2022; 39(3): 234.     CrossRef
  • Physiological testosterone replacement effects on male aged rats with orchiectomy-induced osteoporosis in advanced stage: a tomographic and biomechanical pilot study
    Vinícius de Paiva Gonçalves, Adriana Alicia Cabrera-Ortega, Jhonatan de Souza Carvalho, Dania Ramadan, Luís Carlos Spolidorio
    The Aging Male.2021; 24(1): 139.     CrossRef
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    Hong Yoon, Jung-Ho Kim, Dal-Sung Ryu, Seung-Hwan Yoon
    The Nerve.2021; 7(2): 64.     CrossRef
  • Effects of 12 Weeks Resistance Exercise on Blood Testosterone, DHT and Bone-Related Metabolism in Orchiectomized Rats
    Kyung A Back, Se Hwan Park, Jin Hwan Yoon
    Exercise Science.2020; 29(2): 138.     CrossRef
  • Effect of Selective Androgen Receptor Modulator Enobosarm on Bone Healing in a Rat Model for Aged Male Osteoporosis
    Marina Komrakova, Janek Nagel, Daniel Bernd Hoffmann, Wolfgang Lehmann, Arndt Friedrich Schilling, Stephan Sehmisch
    Calcified Tissue International.2020; 107(6): 593.     CrossRef
  • Impact of Dehydroepiandrosterone (DHEA) on Bone Mineral Density and Bone Mineral Content in a Rat Model of Male Hypogonadism
    Hussein F. Sakr, Abdelaziz M. Hussein, Elsayed A. Eid, Ammar Boudaka, Lashin S. Lashin
    Veterinary Sciences.2020; 7(4): 185.     CrossRef
  • La prêle des champs : une plante médicinale d'avenir
    M. Ben Laiba, W. Douki, R. Chemli
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  • Changes in Bone Metabolism in Young Castrated Male Rats
    Seong-Jun Ryu, Dal-Sung Ryu, Jong-Yeol Kim, Jeong-Yoon Park, Kyung-Hyun Kim, Dong-Kyu Chin, Keun-Su Kim, Yong-Eun Cho, Sung-Uk Kuh
    Yonsei Medical Journal.2016; 57(6): 1386.     CrossRef
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A PET/CT-based Morphometric Study of Spinal Canal in Korean Young Adults: Anteroposterior Diameter from Cervical Vertebra to Sacrum
Korean J Spine. 2012;9(3):165-169.   Published online September 30, 2012
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A PET/CT-based Morphometric Study of Spinal Canal in Korean Young Adults: Anteroposterior Diameter from Cervical Vertebra to Sacrum
Korean J Spine. 2012;9(3):165-169.   Published online September 30, 2012
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Objective

To establish normative data for spinal canal AP diameter from cervical vertebra to sacrum in the Korean young and to assess the exposed spinal canal after laminectomy which was related with restenosis by post-laminectomy membrane formation.

Methods

From PET/CT, axial bone-window CT of 83 young adults (20-29 years) were obtained, and we measured AP diameters of C3, C5, C7, T1, T4, T8, T12, L1, L3, L5 and S1. We also measured exposed AP diameter of C3, C5, C7, T1 and T2 above imaginary line for laminectomy.

Results

The shortest mean AP diameter was at C5 (14.5±1.5 mm), and the longest was at S1 (17.4±2.3 mm). AP diameter increased from C3 (14.6±1.1 mm) to T1 (16.1±1.2 mm) at cervical spine. In the thoracic spine, the diameter gradually decreased from T1 (16.1±1.2 mm) to T8 (14.6±1.3 mm) and increased to T12 (16.7±1.2 mm). The diameter decreased from L1 (16.7±1.3 mm) to L3 (15.7±1.9 mm), and it increased to S1 (17.4±2.3 mm) at lumbar spine. Exposed AP diameter above imaginary line for laminectomy was the longest at C3 (4.8±1.2 mm) and gradually decreased to T1 (3.3±0.9 mm) and T2 (0 mm).

Conclusions

Spinal AP diameter was the shortest in the mid-cervical area (C5) and increased to the upper thoracic area. From the upper thoracic vertebra, the diameter gradually decreased to the mid-thoracic vertebra (T8) and then increased to the lower thoracic vertebra. Lumbar vertebra also was similar with thoracic vertebra. Below T2, there was no exposed dural sac after laminectomy. This means that restenosis by post-laminectomy membrane formation can occur above T1.

Citations

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    Hyeon Jae Jo, Sook-In Jung, Eu Suk Kim, Kyoung-Ho Song, Kyung-Hwa Park, Nam Joong Kim
    BMC Infectious Diseases.2026;[Epub]     CrossRef
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    Alexander Shao-Rong Pang, Fang Nian Joanne Lim, Pirateb Paramasivam Meenakshi Sundaram, Jacob Yoong-Leong Oh
    Spine.2026; 51(7): E169.     CrossRef
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    Soo-Im Jang, Soyoun Choi, Seung Ae Kim, Hoe Jong Jeong, Ja-Young Choi, Mi Ji Lee
    Journal of Clinical Neurology.2026; 22(3): 364.     CrossRef
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    Brian T. Ragel, Matthew McGehee, Nicolas Karvelas, Ahmed M. Raslan
    Pain Practice.2025;[Epub]     CrossRef
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    Shinsuke Yoshida, Takaaki Suzuki, Masayuki Tanabe, Kazuo Saita
    Acta Neurochirurgica.2025;[Epub]     CrossRef
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    Brian T. Ragel, Tressa Riedman, Matthew McGehee, Ahmed M. Raslan
    Pain Practice.2024; 24(1): 91.     CrossRef
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    Hunter Xavier Leech, David Anthony Provenzano, Leonard DeRiggi, David Oliver-Smith
    Regional Anesthesia & Pain Medicine.2024; 49(8): 615.     CrossRef
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    Mikael Aseged Shimekit, Aemro Mazengia Andualem, Kaleab Tesfaye Reda, Mahelt Getachew Lemma
    Interdisciplinary Neurosurgery.2023; 34: 101862.     CrossRef
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    Brain.2019; 142(8): 2265.     CrossRef
  • Biometrics of the Cervical Spinal Canal and Cord by Computer Tomography in Togo
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    Open Journal of Radiology.2017; 07(01): 45.     CrossRef
  • 15,887 View
  • 118 Download
  • 10 Crossref

Original Articles

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The Clinical and Radiological Characteristics of Male Patients who Underwent Vertebroplasty Due to Osteoporotic Compression Fracture.
Korean J Spine. 2011;8(3):178-182.
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The Clinical and Radiological Characteristics of Male Patients who Underwent Vertebroplasty Due to Osteoporotic Compression Fracture.
Korean J Spine. 2011;8(3):178-182.
Close
OBJECTIVE
To investigate the clinical characteristics of male population who underwent vertebroplasty for osteoporotic compression fracture and evaluate the clinical, radiological outcomes compared to female group.
METHODS
The medical records and radiological data were reviewed in total 155 patients who underwent vertebroplasty for osteoporotic vertebral compression fracture from February 2006 to November 2009. We compared 32 male patients with 123 female patients in terms of preoperative factors, intraoperative factors, and clinical and radiologic outcomes.
RESULTS
The mean age of male group was 67.8~8.6 years and their mean T-score on bone mineral density (BMD) was -3.2+/-0.8. The mean age of female group was 71.8+/-8.9 years and their mean T-score was -3.7+/-0.7 (p=0.025 for age, p=0.002 for BMD). Male patients (21 out of 32, 65.6%) had more frequent traumatic event than female patients (51 out of 123, 41.5%) (p=0.012). The secondary osteoporosis was more frequently seen in male group than female group (53.1% vs 26.8%, p=0.005). The lump cement distribution pattern was found more frequently in male group than female group (46.9% vs 28.5%, p=0.040). There was no statistically significant difference between the two groups in clinical outcomes.
CONCLUSION
Male patients had significantly more risk factors for secondary osteoporosis and obvious traumatic event than female group. Clinicians should always be aware of secondary causes of osteoporosis and history of traumatic events in male patients with osteoporotic compression fracture and also pay attention to correct the cause of secondary osteoporosis and recommend anti-osteoporosis management.
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Technical Strategies and Surgical Results of C1 Lateral Mass-C2 Pedicular Screw Fixation in Atlantoaxial Disorders.
Korean J Spine. 2008;5(3):196-202.
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Technical Strategies and Surgical Results of C1 Lateral Mass-C2 Pedicular Screw Fixation in Atlantoaxial Disorders.
Korean J Spine. 2008;5(3):196-202.
Close
OBJECTIVE
There are various posterior fusion techniques in managing C1-2 instability. The aim of this study is to evaluate surgical techniques and clinical results including complications of the C1 lateral mass and C2 pedicle screw fixation (C1-2 LMPSF) in atlantoaxial disorders.
METHODS
From February 1997 to July 2008, 24 patients were performed C1-2 LMPSF due to C1-2 instability. Pathway of vertebral artery was classified into three groups by 3D-angiogram. Diameter of C1 lateral mass and C2 isthmus on the plain X-ray and CT was measured before operation. Surgical method was divided into four groups according to fixation site (bilateral or unilateral) and bone graft (with or without graft). Stability of C1-2 fixation was postoperatively evaluated by flexion and extension cervical lateral films. We reviewed clinical data, imaging studies and old chart retrospectively as sources for analysis.
RESULTS
Among 24 patients, os odontoideum was the most common cause (16 out of 24). Four patients had anomalous vertebral artery. Mean diameters of C1 lateral mass was 9.9(range 4.2~16.4) mm at right side, 10.3 (range 3.4~14.2) mm at left side. Mean diameter of C2 isthmus was 5.8 (range 1.0~10.1) mm at right side and 5.8(range 2.1~8.2) mm at left side. Two patients showed very narrow C2 isthmus. As a result, unilateral C1-2 LMPSF was performed on 6 patients (4 for anomalous vertebral arteries and 2 for narrow C2 isthmus). 12 of 18 patients were with C1-2 interlaminar bone graft and 6 patients without bone graft. All patients showed stable C1-2 fixation by flexion and extension cervical lateral X-ray films taken at least 6 months after surgery. Five out of 8 patients who had preoperative radiculopathy only showed improved symptoms. However, Seven out of 8 patients who had myelopathy showed little neurological improvement .
CONCLUSION
For C1-2 LMPSF, preoperative 3D CT-angiogram study is mandatory to identify abnormal vertebral artery and narrow C2 isthmus. Bilateral C1-2 LMPSF without bone graft is enough to obtain stable C1-2 fixation. If there is an abnormal vertebral artery or narrow C2 isthmus, unilateral C1-2 LMPSF with bone graft and wiring is alternative successful method.
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Clinical and Radiological Outcome of an Interspinous Dynamic Stabilization System in Degenerative Lumbar Disease:24 Cases with Over 24 Months of Follow-up.
Korean J Spine. 2009;6(3):175-180.
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Clinical and Radiological Outcome of an Interspinous Dynamic Stabilization System in Degenerative Lumbar Disease:24 Cases with Over 24 Months of Follow-up.
Korean J Spine. 2009;6(3):175-180.
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OBJECTIVE
The purpose of this study was to analyze the clinical and radiological outcomes of dynamic stabilization with DIAM implants.
METHODS
We evaluated 24 cases in which lumbar decompressive surgery was performed with dynamic stabilization using DIAM and having more than 24 months of follow up. Indications consisted of spinal stenosis with or without a herniated disc and transition level stenosis of the instrumented fusion segment. Operative data, clinical outcome, and plain and flexion/extension radiographs were obtained and compared to preoperative and postoperative data.
RESULTS
The mean age at operation was 56.2 years(range 47-68); the mean follow-up duration was 28.4 months(range 24-37 months).The mean pain and function scores improved significantly from baseline to follow-up, as follows: back pain VAS score from 6.2 to 2.5, leg pain VAS score from 7.2 to 2.4, and Prolo's economic and functional rating score from 5.8 to 8.2. Radiological data demonstrated that the heights of the intervertebral foramen and the posterior disc increased significantly after the procedure. There were no implant-associated complications except for two spinous process fractures which occurred during DIAM insertion, and one case of wound infection. Flexion instability and spondylolisthesis occurred in two cases during the follow-up period.
CONCLUSION
These mid-term results suggest that DIAM is a safe and effective alternative surgical option in the treatment of degenerative lumbar stenosis without flexion instability. Careful follow-up is needed to watch for the development of flexion instability and spondylolisthesis.
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