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"Kyoung-Tae Kim"

Original Article

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Effectiveness of a Facet Joint Block Versus a Medial Branch Block in Spinal Pain Management: A Systematic Review and Meta-Analysis
Neurospine. 2025;22(2):441-450.   Published online June 30, 2025
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Effectiveness of a Facet Joint Block Versus a Medial Branch Block in Spinal Pain Management: A Systematic Review and Meta-Analysis
Neurospine. 2025;22(2):441-450.   Published online June 30, 2025
Close
Objective
Facet joint injections (FJIs) and medial branch blocks (MBBs) are commonly used interventions for chronic spinal pain, but their comparative effectiveness remains unclear. This meta-analysis aimed to compare the pain relief, functional improvement, complications, and patient satisfaction associated with FJI and MBB.
Methods
A systematic review and meta-analysis of randomized controlled trials and observational studies were conducted. Primary outcomes included pain relief (numerical rating scale) and functional improvement (Oswestry Disability Index [ODI]/Neck Disability Index). Secondary outcomes assessed adverse effects and patient satisfaction. The differences in characteristics between patients who were readmitted and those who were not were identified and analyzed using the Review Manager software.
Results
FJI resulted in lower pain and ODI scores compared to MBB, but the differences were not statistically significant. However, patient satisfaction was significantly higher in the FJI group (odds ratio, 1.81; 95% confidence interval, 1.02–3.24; p=0.04). Additionally, FJI had fewer adverse effects than MBB.
Conclusion
Both FJI and MBB are effective for chronic spinal pain, but FJI may be preferred for patients seeking immediate pain relief with fewer complications. Further high-quality studies are needed to refine treatment guidelines.
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Review Article

Special Issue on AI & Robotics

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Navigation-Guided/Robot-Assisted Spinal Surgery: A Review Article
Neurospine. 2024;21(1):8-17.   Published online March 31, 2024
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Navigation-Guided/Robot-Assisted Spinal Surgery: A Review Article
Neurospine. 2024;21(1):8-17.   Published online March 31, 2024
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The development of minimally invasive spinal surgery utilizing navigation and robotics has significantly improved the feasibility, accuracy, and efficiency of this surgery. In particular, these methods provide improved accuracy of pedicle screw placement, reduced radiation exposure, and shortened learning curves for surgeons. However, research on the clinical outcomes and cost-effectiveness of navigation and robot-assisted spinal surgery is still in its infancy. Therefore, there is limited available evidence and this makes it difficult to draw definitive conclusions regarding the long-term benefits of these technologies. In this review article, we provide a summary of the current navigation and robotic spinal surgery systems. We concluded that despite the progress that has been made in recent years, and the clear advantages these methods can provide in terms of clinical outcomes and shortened learning curves, cost-effectiveness remains an issue. Therefore, future studies are required to consider training costs, variable initial expenses, maintenance and service fees, and operating costs of these advanced platforms so that they are feasible for implementation in standard clinical practice.

Citations

Citations to this article as recorded by  Crossref logo
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    Yawen Jiang, Jikui Qian, Ling Zhang, Yan Yu, Liming Cheng, Jinwu Wang, Ying Yao, Shaobai Wang
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    Rubén Martín Láez, Fernando Álvarez-Sala Walther, Julen Monje, María Álvarez, Mehdi Zahra, Sofía De Pedro, Paula Castro Albarrán, Miguel Ángel Casado, José A. Fernández Alén
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  • O‐Arm Navigation Enhances Facet Preservation Without Compromising Clinical Outcomes in UBE Decompression for Radiographically Stable Adult Degenerative Scoliosis: A Single‐Center Comparative Study
    Yi Liu, Yiwei Xie, Zhibao Chen, Ruijun Xu, Haojie Chen, Xiaojian Ye, Jiangming Yu
    Orthopaedic Surgery.2026;[Epub]     CrossRef
  • Posterior and Transforaminal Lumbar Interbody Fusion
    Arpan A. Patel, Shaarada Srivatsa, Mark A. Davison, Michael P. Steinmetz
    Neurosurgery Clinics of North America.2025; 36(1): 11.     CrossRef
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    Felix C. Oettl, Bálint Zsidai, Jacob F. Oeding, Mazda Farshad, Michael T. Hirschmann, Kristian Samuelsson
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  • A systematic review and meta-analysis of radiation exposure in spinal surgeries: Comparing C-Arm, CT navigation, and O-Arm techniques
    Kamran Shirbache, Melika Heidarzadeh, Reihane Qahremani, Amin Karami, Shaghayegh Karami, Elham Madreseh, Julio J. Jauregui, Ebrahim Najafzadeh, Ali Kazemi, Mohammad Hossein Nabian
    Journal of Medical Imaging and Radiation Sciences.2025; 56(2): 101831.     CrossRef
  • S8 Navigation system combined with an ultrasonic osteotome for three-dimensional real-time dynamic visualization decompression to reduce postoperative neurological deterioration in thoracic ossification of the ligamentum flavum
    Shuai Li, Jinpeng Du, Xiaohui Wang, Yunfei Huang, Yansheng Huang, Zhen Chang, Liang Yan, Xuefang Zhang, Zhengwei Shi, Zhigang Zhao, Lin Gao, Songchuan Zhao, Baorong He
    European Spine Journal.2025; 34(3): 1004.     CrossRef
  • Robotic pedicle screw placement for minimal invasive thoracolumbar spine surgery: a technical note
    Luthfi Gatam, Phedy Phedy, Syafruddin Husin, Harmantya Mahadhipta, Asrafi Rizki Gatam, Mitchel Mitchel, Karina Sylvana Gani, Erica Kholinne
    Frontiers in Surgery.2025;[Epub]     CrossRef
  • How Do Robotics and Navigation Facilitate Minimally Invasive Spine Surgery? A Case Series and Narrative Review
    Esteban Quiceno, Mohamed A. R. Soliman, Asham Khan, Jeffrey P. Mullin, John Pollina
    Neurosurgery.2025; 96(3S): S84.     CrossRef
  • Robotic Systems in Spinal Surgery: A Review of Accuracy, Radiation Exposure, Hospital Readmission Rate, Cost, and Adverse Events
    Nadia V. Haik, Alison E. Burgess, Norris C. Talbot, Patrick Luther, James R. Bridges, Michael Folse, Elizabeth Jee, Jamie Toms
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  • Optimizing Single-Position Prone Lateral Lumbar Interbody Fusion with Exoscopic Technology: A Review of Key Innovations
    Christian Quinones, John Preston Wilson, Deepak Kumbhare, Bharat Guthikonda, Stanley Hoang
    Journal of Clinical Medicine.2025; 14(4): 1132.     CrossRef
  • Letter to the Editor Regarding “Robotic Systems in Spinal Surgery: A Review of Accuracy, Radiation Exposure, Hospital Readmission Rate, Cost, and Adverse Events”
    Yuxuan Dai, Yu Chen, Bing Wang, Jiao Zhang, Bo Chen
    World Neurosurgery.2025; 196: 123838.     CrossRef
  • Optimizing the clinical adoption of total joint replacement of the lumbar spine through imaging, robotics and artificial intelligence
    S. Craig Humphreys, Jon E. Block, Ahilan Sivaganesan, Louis J. Nel, Marc Peterman, Scott D. Hodges
    Expert Review of Medical Devices.2025; 22(5): 405.     CrossRef
  • Integrated Optical and Magnetic Navigation for Simplified Percutaneous Transforaminal Endoscopic Lumbar Discectomy: A Novel Approach
    Xing-Chen Yao, Jun-Peng Liu, Xin-Ru Du, Li Guan, Yong Hai, Jincai Yang, Aixing Pan
    Neurospine.2025; 22(1): 297.     CrossRef
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    Sadayuki Ito, Shiro Imagama, Hiroaki Nakashima, Masaaki Machino, Toshinori Sakai, Toshimi Aizawa, Hideyuki Arima, Hideaki Hamanaka, Yuyu Ishimoto, Satoshi Kato, Yoshiharu Kawaguchi, Hiroaki Konishi, Naohisa Miyakoshi, Hideki Murakami, Yukitaka Nagamoto, K
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    Trice A. Pickens, Cade F. Bennett, Daniel E. Herrera, Wellington K. Hsu, Srikanth N. Divi, Alpesh A. Patel
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  • Whole-Workflow Robotic-Assisted Percutaneous Endoscopic Lumbar Discectomy via a Two-Step Access Method: Technical Report and Preliminary Results
    Wenjie Zheng, Junlong Wu, Wen Xia, Rui Zuo, Xian Chang, Hong Yin, Changqing Li, Chao Zhang
    Journal of Pain Research.2025; Volume 18: 4361.     CrossRef
  • The Role of Robotic-Assisted Surgery in Orthopedic Practice: A Comprehensive Review of Opportunities, Challenges, and Future Directions
    Ahmed Elkohail, Ahmed M Khalifa, Ali Soffar, Ibrahim Omar, Mostafa Abdulaziz, Ahmed Elsaket, Ahmed Elnewishy, Momen Abdelglil, Siddhartha Murhekar, Ahmed Swealem
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  • The application of robotic and artificial intelligence technologies in spinal surgery: a review focused on prospects in remote areas of China
    Zhibin Liu, Junlong Huang, Hao Zhang, Shuzhuo Zhang, Honghao Dai, Yuexin Jiang, Hongtao Bi, Zhongshu Shan
    Journal of Robotic Surgery.2025;[Epub]     CrossRef
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    Rahul Kumar, Conor Dougherty, Kyle Sporn, Akshay Khanna, Puja Ravi, Pranay Prabhakar, Nasif Zaman
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    Muwaffak Abdulhak, Ross Jones, David Nay, Christopher Wybo
    Journal of Personalized Medicine.2025; 15(12): 564.     CrossRef
  • Preliminary evaluation of mixed reality navigation with single-vertebra registration in spinal surgery
    Zhongjie Shi, Zirui Su, Lingling Yang, Xin Gao, Deyong Xiao, Yilong Peng, Xiaojun Li, JianFeng Guo, Shujie Sun, Zhanxiang Wang
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    Wenjie Zheng, Wen Xia, Chao Liu, Zhengyang Wu, Minghan Liu, Rui Zuo, Linfeng Mo, Yue Zhou, Changqing Li, Chao Zhang
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    Favour Tope Adebusoye, Rohan S. Mane, Liyana Nithya Paaramee Priyankara, Mohammed Ahmed, Shubham Gaikwad, Jovan Ilic, Yash J. Pal, Brandon Lucke-Wold, Julie L. Chan, Daniel J. Hoh, Matthew Decker, Steven G. Roth, Daryl Pinion Fields, Paul R. Krafft
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  • Impact of Navigation Assistance on Perioperative Outcomes in Sacroiliac Joint Arthrodesis: A Comparative Study
    Attila Sarkadi, Adolf Mueller, Vitaly Sokotukhin , Stephan Lackermair, Eric O Sarpong, Hannes Egermann
    Cureus.2025;[Epub]     CrossRef
  • Hospitalizations and surgical management of lumbar disc degeneration in Italy: a 22-Year nationwide retrospective study
    Fabrizio Russo, Bruna Maria Rondinone, Giuseppe Francesco Papalia, Gianluca Vadalà, Rocco Papalia, Vincenzo Denaro, Sergio Iavicoli
    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
  • Accuracy of Robotic-Guided Pedicular Screw Insertion in Thoracolumbar Spinal Surgery
    Ignacio Dominguez, Rafael Luque, Angela Carrascosa, Juan Pablo Castaño, Alicia Collado, Pedro Alonso Lera, Fernando Marco
    Journal of Clinical Medicine.2025; 14(23): 8425.     CrossRef
  • Effectiveness and reliability of AI in diagnosis and robot-assisted spinal and cranial surgery: efficient outcomes and ethical worries
    Iqra Shahid, Ahmed Raza, Inshrah Qureshi, Umaima Cheema, Siraj Ul Muneer, Ayesha Sehar, Maryam Aqeel, Saleha Azeem, Ahmad Hussain, Calvin R. Wei, Samuel Mbabazi, Fabrice Kibukila, Dieudonné Kakusu, Aymar Akilimali
    Annals of Medicine & Surgery.2025; 87(11): 7280.     CrossRef
  • Bibliometric analysis of robotic-assisted hepatobiliary and pancreaticosplenic surgery
    Tao Liu, Kunming Zhao, Heqi Tai, Xiaofeng Tian
    Journal of Robotic Surgery.2025;[Epub]     CrossRef
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    Cheng Zhong, Zhe Han
    Journal of Robotic Surgery.2025;[Epub]     CrossRef
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    John R. Adler Jr
    Neurospine.2024; 21(1): 18.     CrossRef
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    Vinit Rathod, Milind R Gharpinde , Sandeep Shrivastav
    Cureus.2024;[Epub]     CrossRef
  • Commentary on “The Utility and Feasibility of Smart Glasses in Spine Surgery: Minimizing Radiation Exposure During Percutaneous Pedicle Screw Insertion”
    Wongthawat Liawrungrueang
    Neurospine.2024; 21(2): 440.     CrossRef
  • Efficacy and safety of navigation robot-assisted versus conventional oblique lateral lumbar interbody fusion with internal fixation in the treatment of lumbar degenerative diseases: A retrospective study
    Min Tong, Siping Zhang, Wenhao Zhang, Limin Mou, Zhenyu Dong, Rong Wang, Shida Li, Yifei Huang
    Medicine.2024; 103(32): e39261.     CrossRef
  • Overcoming the Learning Curve in Robot-Assisted Spinal Surgery—How Does It Compare to O-Arm Navigation?
    Pirateb Paramasivam Meenakshi Sundaram, Mun Chun Lai, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh
    Surgeries.2024; 5(4): 896.     CrossRef
  • Mid-term efficacy of non-contact orthopedic robot navigation in the treatment of lumbar spondylolisthesis
    XiaoPeng Gu, SongOu Zhang, YongTao Liu, JunLiang Qi, YueQuan Gu, WeiHu Ma
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • Letter to the editor regarding "Level-specific comparison of 3D navigated and robotic arm-guided screw placement: an accuracy assessment of 1210 pedicle screws in lumbar surgery" by Asada et al
    Sanaa Hameed, Fauziyya Muhammad, Lance M Villeneuve, Zachary A Smith
    The Spine Journal.2024; 24(12): 2428.     CrossRef
  • Evaluation of Pedicle Screw Position on Computerized Tomography Using Three-Dimensional Reconstruction Software
    Jiwon Park, Jin S. Yeom, Yeonho Kim, Yoonjoong Hwang, Namkug Kim, Sang-Min Park
    Medicina.2024; 60(12): 2040.     CrossRef
  • Does Robotic Spine Surgery Add Value to Surgical Practice over Navigation-Based Systems? A Study on Operating Room Efficiency
    Pirateb Paramasivam Meenakshi Sundaram, Daniel Yang Yao Peh, Jane Wenjin Poh, Guna Pratheep Kalanchiam, Wayne Ming Quan Yap, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh
    Medicina.2024; 60(12): 2112.     CrossRef
  • 23,435 View
  • 417 Download
  • 53 Web of Science
  • 57 Crossref

Original Article

Bone Biology and Osteoporosis Special Issue

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Fusion Assessment of Oblique Lumbar Interbody Fusion Using Demineralized Bone Matrix: A 2-Year Prospective Study
Neurospine. 2023;20(4):1205-1216.   Published online December 31, 2023
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Fusion Assessment of Oblique Lumbar Interbody Fusion Using Demineralized Bone Matrix: A 2-Year Prospective Study
Neurospine. 2023;20(4):1205-1216.   Published online December 31, 2023
Close
Objective
Although several studies have reported successful fusion rates after oblique lumbar interbody fusion (OLIF) using allografts or dimerized bone matrix (DBM) instead of autografts, whether OLIF can achieve satisfactory solid fusion without the use of autografts remains unclear. This study investigated the real fusion rates after OLIF using allografts and DBM, which were evaluated using both dynamic radiographs and computed tomography scans.
Methods
We enrolled 79 consecutive patients who underwent minimally invasive OLIF followed by percutaneous pedicle screw fixation. All patients were treated with OLIF between L2 and L5 and underwent radiographic and clinical follow-ups at 12, 18, and 24 months after surgery. Radiographic assessment of fusion was performed using the modified BrantigaSteffee-Fraser (mBSF) scale, which was categorized as follows: grades I (radiographic pseudoarthrosis), II (indeterminate fusion), and III (solid radiographic fusion). Other radiologic and clinical outcomes were evaluated using the following parameters: vertebral slippage distance, disc height, subsidence, Oswestry Disability Index (ODI), and visual analogue scale (VAS).
Results
Clinical outcomes demonstrated significant improvements in the VAS scores for back pain, leg pain, and ODI after surgery. Subsidence was present in 34 cases (35.4%) at 12 months postoperatively, which increased to 47.9% and reached 50.0% at 1.5 years and 2 years after surgery, respectively. The solid fusion rate after OLIF was 32.3% at 1 year, increased to 58.3% at 1.5 years, and reached 72.9% at 2 years. Radiographic pseudoarthrosis was 24.0% at 1 year, which decreased to 6.3% at 1.5 years and 3.1% at 2 years.
Conclusion
OLIF is a safe and effective surgical procedure for the treatment of degenerative lumbar diseases. The mBSF scale, which simultaneously evaluates both dynamic angles and bone bridge formation, offers great reliability for the radiological assessment of fusion. Moreover, OLIF using allografts and DBM, which is performed on one or 2 levels at L2–5, can achieve satisfactory fusion rates within 2 years after surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • Oblique lateral interbody fusion: role of the elastic modulus of the cage material in mechanically induced osteogenesis
    Teng Lu, Zhongwei Sun, Xijing He
    Computer Methods and Programs in Biomedicine.2026; 276: 109242.     CrossRef
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    Szu-Hsiang Peng, Jwo-Luen Pao
    Diagnostics.2026; 16(1): 140.     CrossRef
  • Understanding Spine Biologics: A Systematic Review of Demineralized Bone Matrix in Spinal Fusion From 2014-2024
    Molly Butler, Blake Martin, Christopher Carr, Muhsin Quraishi, Alexander F. Post, Fernando L. Vale
    Global Spine Journal.2026;[Epub]     CrossRef
  • Incidence and Risk Factors of Postoperative Ileus in Oblique Lumbar Interbody Fusion Surgery: A Retrospective Study
    Young-Seok Lee, Myeong Jin Ko, Seung Won Park
    Neurospine.2025; 22(1): 222.     CrossRef
  • Reduction-First Technique of Unilateral Biportal Endoscopy Lumbar Interbody Fusion for Spondylolisthesis
    JinWoo Jung, Man-Kyu Park, Yong Jin Park, Dae-Chul Cho, Young San Ko
    World Neurosurgery.2025; 198: 124005.     CrossRef
  • Comparative efficacy of autologous iliac bone versus allogeneic demineralized bone matrix in lateral lumbar interbody fusion using a novel minimally invasive iliac bone retrieval tool: a self-controlled study
    Jiaqi Li, Shaorong Li, Shuowen Zhang, Lin Liu, Weijian Wang, Han Wu, Qiang Yang, Wei Zhang
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • 7,190 View
  • 231 Download
  • 6 Web of Science
  • 6 Crossref

Editorial

Regular Issue

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The Importance of Vascular Repair as the First Step in Spinal Cord Injury Treatment: Commentary on “Therapeutic Approaches Targeting Vascular Repair After Experimental Spinal Cord Injury: A Systematic Review of the Literature”
Neurospine. 2022;19(4):976-977.   Published online December 31, 2022
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The Importance of Vascular Repair as the First Step in Spinal Cord Injury Treatment: Commentary on “Therapeutic Approaches Targeting Vascular Repair After Experimental Spinal Cord Injury: A Systematic Review of the Literature”
Neurospine. 2022;19(4):976-977.   Published online December 31, 2022
Close

Citations

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  • Revisiting the Emerging Role of Light-Based Therapies in the Management of Spinal Cord Injuries
    Santimoy Sen, Nidhi Parihar, Prathamesh Mahadev Patil, Suryanarayana Murty Upadhyayula, Deepak B. Pemmaraju
    Molecular Neurobiology.2025; 62(5): 5891.     CrossRef
  • 4,209 View
  • 134 Download
  • 1 Crossref

Original Articles

Spinal Cord Injury INTS-Neurospine Special Issue

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Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury
Neurospine. 2022;19(3):737-747.   Published online September 30, 2022
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Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury
Neurospine. 2022;19(3):737-747.   Published online September 30, 2022
Close
Objective
Neuropathic pain is a common secondary complication of spinal cord injury (SCI). N-methyl-D-aspartate (NMDA) receptor activation is critical for hypersensitivity in neuropathic pain. This activation requires the binding of both glutamate and the D-serine co-agonist to the NMDA glycine site. We evaluated the effects of D-serine on neuropathic pain after SCI and explored the underlying molecular mechanisms.
Methods
Anesthetized rats underwent T9 spinal cord contusion (130 kdyn). D-serine (500 and 1,000 mg/kg) and MK-801 hydrogen maleate (2.0 mg/kg) were injected daily for 2 weeks, starting the day after SCI. Functional outcomes were assessed according to the Basso, Beattie, and Bresnahan scale, while histological outcomes were evaluated based on lesion volume and spared tissue area. Mechanical allodynia and thermal hyperalgesia were evaluated by measuring the withdrawal threshold of a von Frey filament and hot/cold plate latency. Western blotting was performed to determine the expression levels of Trpv1, Nav1.9, calcitonin gene-related peptide (CGRP), and β-actin in damaged tissue.
Results
The withdrawal threshold values and latency of the D-serine group were significantly lower than those of the noninjection group. The MK-801 group showed higher threshold values and latencies than the other groups. Western blotting showed increased Nav1.9 and Trpv1 levels and lower CGRP levels in the D-serine group, whereas the MK-801 group showed the opposite results.
Conclusion
D-serine increases neuropathic pain after traumatic SCI by mediating the NMDA receptor. NMDA receptor antagonists alleviate neuropathic pain after traumatic SCI.

Citations

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Minimally Invasive Spinal Surgery SMISS-Neurospine Special Issue

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Indirect Decompression Using Oblique Lumbar Interbody Fusion Revision Surgery Following Previous Posterior Decompression: Comparison of Clinical and Radiologic Outcomes Between Direct and Indirect Decompression Revision Surgery
Neurospine. 2022;19(3):544-554.   Published online September 30, 2022
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Indirect Decompression Using Oblique Lumbar Interbody Fusion Revision Surgery Following Previous Posterior Decompression: Comparison of Clinical and Radiologic Outcomes Between Direct and Indirect Decompression Revision Surgery
Neurospine. 2022;19(3):544-554.   Published online September 30, 2022
Close
Objective
This study compared the radiological and clinical outcomes with transforaminal lumbar interbody fusion (TLIF) to evaluate the effect of indirect decompression through oblique lumbar interbody fusion (OLIF) as revision surgery.
Methods
We enrolled patients who underwent single-level fusion with revision surgery at the same level as the previous decompression level. We retrospectively reviewed 25 patients who underwent OLIF from 2017 to 2018 and 25 who received TLIF from 2014 to 2018. Radiologic and clinical outcomes were evaluated by cross-sectional area (CSA) of the spinal canal, thickness and area of ligamentum flavum (LF), subsidence, disc height, fusion rate, Oswestry Disability Index (ODI), and visual analogue scale (VAS).
Results
Compared with OLIF, the thickness and area of the LF after surgery were significantly less in TLIF, and the resulting CSA extension was also significantly higher. However, both groups showed improvement in ODI and VAS after surgery, and there was no difference between the groups. Complications related to the posterior approach in TLIF were 4 cases, and in OLIF, there were 2 cases that underwent additional posterior decompression surgery and 6 cases of transient paresthesia.
Conclusion
Since complications associated with the posterior approach can be avoided, OLIF is a safer and useful minimally invasive surgery. Therefore, appropriate indications are applied, OLIF is a good alternative to TLIF when revision surgery is considered.

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    Brain and Spine.2026; 6: 106043.     CrossRef
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    Andrew James Berg, Joseph Maalouly, Liam D. Rose, Prashanth J. Rao, Shay Menachem
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    Satoshi Hattori, Satoru Matsutani
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    Ruixin Zhen, Jiaqi Li, Shaorong Li, Han Wu, Wei Zhang
    Frontiers in Surgery.2025;[Epub]     CrossRef
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    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
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    Yanxiao Liu, Hua Wang, Lei Li
    Neurosurgical Review.2025;[Epub]     CrossRef
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    Seung-Yeon Jeong, Hyun-Jin Park, Jin-Ho Park, Gab-Lae Kim
    Journal of Advanced Spine Surgery.2025; 15(2): 84.     CrossRef
  • Improved intervertebral fusion in LLIF rabbit model with a novel titanium cage
    Jiaqi Li, Bingyi Zhao, Weijian Wang, Yafei Xu, Haoyu Wu, Wei Zhang
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    Hangeul Park, Juhee Lee, Yunhee Choi, Jun-Hoe Kim, Sum Kim, Young-Rak Kim, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Chi Heon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Is Direct Decompression Necessary for Lateral Lumbar Interbody Fusion (LLIF)? A Randomized Controlled Trial Comparing Direct and Indirect Decompression With LLIF in Selected Patients
    Worawat Limthongkul, Chayapong Thanapura, Khanathip Jitpakdee, Pakawas Praisarnti, Vit Kotheeranurak, Wicharn Yingsakmongkol, Teerachat Tanasansomboon, Weerasak Singhatanadgige
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  • Postoperative urinary retention after oblique lumbar interbody fusion under the systematic management protocol
    Joonsoo Lim, Jangyeob Lim, Asfandyar Khan, Chang-Hyun Lee, Jun-Hoe Kim, Sejin Choi, Tae-Shin Kim, Yunhee Choi, Chun Kee Chung, Sangwook T. Yoon, Kyoung-Tae Kim, Chi Heon Kim
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    Neurospine.2023; 20(2): 553.     CrossRef
  • Biomechanical Comparison of Different Surgical Approaches for the Treatment of Adjacent Segment Diseases after Primary Transforaminal Lumbar Interbody Fusion: A Finite Element Analysis
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    Orthopaedic Surgery.2023; 15(10): 2701.     CrossRef
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    Neurospine.2023; 20(4): 1450.     CrossRef
  • Fusion Assessment of Oblique Lumbar Interbody Fusion Using Demineralized Bone Matrix: A 2-Year Prospective Study
    Sangseok Lee, Jin Woo Jung, Sang-Woo Lee, Kyoung-Tae Kim, Heum-Dai Kwon, Subum Lee, Young San Ko, Pius Kim, Dae-Chul Cho
    Neurospine.2023; 20(4): 1205.     CrossRef
  • 7,810 View
  • 268 Download
  • 19 Web of Science
  • 22 Crossref

Review Article

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Curcumin as a Promising Neuroprotective Agent for the Treatment of Spinal Cord Injury: A Review of the Literature
Neurospine. 2022;19(2):249-261.   Published online June 30, 2022
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Curcumin as a Promising Neuroprotective Agent for the Treatment of Spinal Cord Injury: A Review of the Literature
Neurospine. 2022;19(2):249-261.   Published online June 30, 2022
Close
Curcumin is a polyphenolic chemical derived from the rhizomes of Curcuma longa. It has been used throughout the Indian subcontinent for medicinal purposes, religious events, and regional cuisine. It has various pharmacological benefits owing to its anti-inflammatory and antioxidant properties. Its neuroprotective effects on the brain and peripheral nerves have been demonstrated in several in vivo neuronal tissue studies. Because of these functional properties of curcumin, it is considered to have great potential for use in the treatment of spinal cord injuries (SCIs). Numerous immunopathological and biochemical studies have reported that curcumin can help prevent and alleviate subsequent secondary injuries, such as inflammation, edema, free radical damage, fibrosis, and glial scarring, after a primary SCI. Furthermore, following SCI, curcumin administration resulted in better outcomes of neurological function recovery as per the Basso, Beattie, and Bresnahan locomotor rating scale. However, to date, its utility in treating SCIs has only been reported in laboratories. More studies on its clinical applications are needed in the future for ensuring its bioavailability across the blood-brain barrier and for verifying the safe dose for treating SCIs in humans.

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Original Articles

Minimally Invasive Spinal Surgery SMISS-Neurospine Special Issue

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The Change of Spinal Canal According to Oblique Lumbar Interbody Fusion in Degenerative Spondylolisthesis: A Prospective Observational Study
Neurospine. 2022;19(3):492-500.   Published online May 13, 2022
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The Change of Spinal Canal According to Oblique Lumbar Interbody Fusion in Degenerative Spondylolisthesis: A Prospective Observational Study
Neurospine. 2022;19(3):492-500.   Published online May 13, 2022
Close
Objective
Oblique lumbar interbody fusion (OLIF) involves inserting large cages into the interbody disc space. This expands the spinal canal and neural foramen by stretching the ligament flavum and releasing the facet joint, resulting in indirect neural decompression. Our objective was to investigate the changes in the spinal canal and ligament flavum over time after OLIF.
Methods
This was a prospective observational study involving 30 patients who underwent OLIF L4–5 between 2015 and 2018. In total, 27 of the 30 patients underwent preoperative, early follow-up ( < 5 days), and late follow-up (10–14 months) magnetic resonance imaging to measure the area of the spinal canal and ligament flavum. Based on the results, the patients were divided into subsidence and nonsubsidence groups for further analysis.
Results
After OLIF, the spinal canal area gradually increased during the preoperative, early postoperative, and late postoperative periods (p < 0.001). The thickness and area of the ligament flavum decreased gradually over the same periods (p < 0.001). Low-grade subsidence (2–4.4 mm) did not influence the effects on the spinal canal and ligament.
Conclusion
After OLIF, the spinal canal and ligament flavum gradually change, which is effective for indirect neural decompression. In addition, the effects of low-grade subsidence on the remodeling of the spinal canal and ligament flavum are insignificant.

Citations

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  • Oblique Lateral Interbody Fusion With Lateral Vertebral Screw Fixation Versus Transforaminal Lumbar Interbody Fusion for Severe Lumbar Stenosis: Results of a Multicenter Randomized Controlled Trial
    Xuefeng Li, Cheng Lin, Tangyiheng Chen, Renjie Li, Dapeng Li, Sheng Song, Huilin Yang, Genlei Chu, Weimin Jiang, Yijie Liu
    Neurosurgery.2026;[Epub]     CrossRef
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    Kyle M M Behrens, Hossein Elgafy
    World Journal of Orthopedics.2025;[Epub]     CrossRef
  • Incidence and Risk Factors of Postoperative Ileus in Oblique Lumbar Interbody Fusion Surgery: A Retrospective Study
    Young-Seok Lee, Myeong Jin Ko, Seung Won Park
    Neurospine.2025; 22(1): 222.     CrossRef
  • Reduction-First Technique of Unilateral Biportal Endoscopy Lumbar Interbody Fusion for Spondylolisthesis
    JinWoo Jung, Man-Kyu Park, Yong Jin Park, Dae-Chul Cho, Young San Ko
    World Neurosurgery.2025; 198: 124005.     CrossRef
  • Is Congenital Lumbar Spinal Canal Stenosis a Contraindication for Indirect Decompression by Lateral Lumbar Interbody Fusion (LLIF)?
    Weerasak Singhatanadgige, Thada Nashinoros, Teerachat Tanasansomboon, Wicharn Yingsakmongkol, Vit Kotheeranurak, Worawat Limthongkul
    Global Spine Journal.2025;[Epub]     CrossRef
  • Efficacy observation of oblique lateral interbody fusion (OLIF) in treating severe spinal stenosis
    Yiliya Yilihamu, Jun Mo, Zhanjun Ma, Jianjiang Li, Yifei Huang
    BMC Surgery.2025;[Epub]     CrossRef
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    Jiaqi Li, Bingyi Zhao, Weijian Wang, Yafei Xu, Haoyu Wu, Wei Zhang
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  • A Comprehensive Analysis of Potential Complications after Oblique Lumbar Interbody Fusion : A Review of Postoperative Magnetic Resonance Scans in Over 400 Cases
    Kang-Hoon Lee, Su-Hun Lee, Jun-Seok Lee, Young-Ha Kim, Soon-Ki Sung, Dong-Wuk Son, Sang-Weon Lee, Geun-Sung Song
    Journal of Korean Neurosurgical Society.2024; 67(5): 550.     CrossRef
  • Intraoperative Facet Joint Block Reduces Pain After Oblique Lumbar Interbody Fusion
    Sung Hyeon Noh, Sang-Woo Lee, Jong-moon Hwang, JinWoo Jung, Eunyoung Lee, Dae-Chul Cho, Chi Heon Kim, Kyoung-Tae Kim
    Journal of Bone and Joint Surgery.2024;[Epub]     CrossRef
  • Postoperative urinary retention after oblique lumbar interbody fusion under the systematic management protocol
    Joonsoo Lim, Jangyeob Lim, Asfandyar Khan, Chang-Hyun Lee, Jun-Hoe Kim, Sejin Choi, Tae-Shin Kim, Yunhee Choi, Chun Kee Chung, Sangwook T. Yoon, Kyoung-Tae Kim, Chi Heon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Mini-Open Intercostal Retroperitoneal Approach for Upper Lumbar Spine Lateral Interbody Fusion
    Su Hun Lee, Dong Wuk Son, Sung Hyun Bae, Jun Seok Lee, Young Ha Kim, Soon Ki Sung, Sang Weon Lee, Geun Sung Song
    Neurospine.2023; 20(2): 553.     CrossRef
  • Perioperative Clinical Features and Long-term Prognosis After Oblique Lateral Interbody Fusion (OLIF), OLIF With Anterolateral Screw Fixation, or OLIF With Percutaneous Pedicle Fixation: A Comprehensive Treatment Strategy for Patients With Lumbar Degenera
    Xiangyu Zhang, Yutian Wang, Weikang Zhang, Shaocheng Liu, Zhenlei Liu, Kai Wang, Hao Wu
    Neurospine.2023; 20(2): 536.     CrossRef
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Spine and Spinal Cord Tumors DSPN-Neurospine Special Issue

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Mechanical Failure After Total En Bloc Spondylectomy and Salvage Surgery
Neurospine. 2022;19(1):146-154.   Published online March 31, 2022
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Mechanical Failure After Total En Bloc Spondylectomy and Salvage Surgery
Neurospine. 2022;19(1):146-154.   Published online March 31, 2022
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Objective
Total en bloc spondylectomy (TES) is a curative surgical method for spinal tumors. After resecting the 3 spinal columns, reconstruction is of paramount importance. We present cases of mechanical failure and suggest strategies for salvage surgery.
Methods
The medical records of 19 patients who underwent TES (9 for primary tumors and 10 for metastatic tumors) were retrospectively reviewed. Previously reported surgical techniques were used, and the surgical extent was 1 level in 16 patients and 2 levels in 3 patients. A titanium-based mesh-type interbody spacer filled with autologous and cadaveric bone was used for anterior support, and a pedicle screw/rod system was used for posterior support. Radiotherapy was performed in 11 patients (pre-TES, 5; post-TES, 6). They were followed up for 59 ± 38 months (range, 11–133 months).
Results
During follow-up, 8 of 9 primary tumor patients (89%) and 5 of 10 metastatic tumor patients (50%) survived (mean survival time, 124 ± 8 months vs. 51 ± 13 months; p = 0.11). Mechanical failure occurred in 3 patients (33%) with primary tumors and 2 patients (20%) with metastatic tumors (p = 0.63). The mechanical failure-free time was 94.4 ± 14 months (primary tumors, 95 ± 18 months; metastatic tumors, 68 ± 16 months; p = 0.90). Revision surgery was performed in 4 of 5 patients, and bilateral broken rods were replaced with dual cobalt-chromium alloy rods. Repeated rod fractures occurred in 1 of 4 patients 2 years later, and the third operation (with multiple cobalt-chromium alloy rods) was successful for over 6 years.
Conclusion
Considering the difficulty of reoperation and patients’ suffering, preemptive use of a multiple-rod system may be advisable.

Citations

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  • Single stage combined approach total en-bloc spondylectomy of L1 and L2 vertebrae for primary spinal and paraspinal synovial sarcoma
    Gurushankari Balakrishnan, Narayanaswamy Kathiresan, Chandra Kumar Krishnan, Vijay Sundar Ilangovan, Dileep Damodaran, Suresh Bapu Kandallu, Vijay Sankaran, Krishna Suresh, Anand Raja
    British Journal of Neurosurgery.2026; 40(2): 357.     CrossRef
  • The impact of pedicle screw transitional segment and thread distribution on postoperative rod-screw system failure
    Wen Peng, Weichao Wang, Jie Zhang, Yami Liu, Peiliang Yu, Haoling Huo, Jianzeng Ren, Zhongfa Mao, Xiaojian Wang, Yiguo Yan, Cheng Wang
    Bone & Joint Research.2026; 15(4): 383.     CrossRef
  • Reconstruction of posterior elements of the spine with femoral shaft allograft after spondylectomy for En bloc resection of tumor
    Alberto Benato, Pavlos Texakalidis, Jean-Paul Wolinsky
    European Spine Journal.2025;[Epub]     CrossRef
  • Biomechanical Impact of Titanium Cage Tilt in the Sagittal Plane in Lumbar Total Spondylectomy: a Finite Element Analysis
    Ye Han, Xuehong Ren, Siyuan Wang, Liqi Luo, Yijie Liang, Shaosong Sun, Xinghai Guan, Xinying Zhang, Xiaodong Wang
    Annals of Biomedical Engineering.2025;[Epub]     CrossRef
  • Case Report: Does the misplaced titanium mesh cage after total spondylectomy causing cervicothoracic cord compression need to be removed during revision surgery?
    Xin Wang, XiaoFei Cheng, Jie Zhao, ChangQing Zhao
    Frontiers in Surgery.2024;[Epub]     CrossRef
  • Biomechanical effects of transverse connectors on total en bloc spondylectomy of the lumbar spine: a finite element analysis
    Ye Han, Xuehong Ren, Yijie Liang, Xiaoyong Ma, Xiaodong Wang
    Journal of Orthopaedic Surgery and Research.2023;[Epub]     CrossRef
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  • 7,779 View
  • 270 Download
  • 8 Web of Science
  • 7 Crossref

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Development of Neuromonitoring Pedicle Screw - Results of Electrical Resistance and Neurophysiologic Test in Pig Model
Neurospine. 2021;18(1):117-125.   Published online November 18, 2020
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Development of Neuromonitoring Pedicle Screw - Results of Electrical Resistance and Neurophysiologic Test in Pig Model
Neurospine. 2021;18(1):117-125.   Published online November 18, 2020
Close
Objective
To analyze the electrical resistance of a newly developed neuromonitoring pedicle screw (Neuro-PS) and to verify the electrophysiologic properties of the Neuro-PS in a pig model.
Methods
We developed 2 types of the Neuro-PS in which a gold lead was located internally (type I) and externally (type II). We measured the electrical resistance of the Neuro-PS and the conventional screw and analyzed the electrical thresholds of triggered EMG (t-EMG) of each screw by intentionally penetrating the medial pedicle wall and contacting the exiting nerve root in a pig model.
Results
The electrical resistances of the Neuro-PS were remarkably lower than that of the conventional screw. In electrophysiologic testing, only the type II Neuro-PS under the leadnerve contact condition showed a significantly lower stimulation threshold as compared to the conventional screw.
Conclusion
The Neuro-PS demonstrated lower electrical resistances than the conventional screw. The type II Neuro-PS under the lead-nerve contact condition showed a significantly lower stimulation threshold compared to that of the other screws in the t-EMG test.

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  • Feasibility of Using Intraoperative Neurophysiological Monitoring for Detecting Bone Layer of Cervical Spine Surgery
    Weiyang Zuo, Lingjia Yu, Haining Tan, Xiang Li, Bin Zhu, Yuquan Liu, Xuan Peng, Yong Yang, Qi Fei
    Clinical Spine Surgery.2024; 37(10): E480.     CrossRef
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    Tong Yongjun, Zhao Yuntian, Chen Biao, Jiang Zenghui
    BMC Musculoskeletal Disorders.2023;[Epub]     CrossRef
  • 11,144 View
  • 260 Download
  • 2 Web of Science
  • 2 Crossref

Review Article

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Hemodynamic Management of Acute Spinal Cord Injury: A Literature Review
Neurospine. 2021;18(1):7-14.   Published online November 17, 2020
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Hemodynamic Management of Acute Spinal Cord Injury: A Literature Review
Neurospine. 2021;18(1):7-14.   Published online November 17, 2020
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The goal of acute spinal cord injury (SCI) management is to reduce secondary injuries and improve neurological recovery after its occurrence. This review aimed to explore the literature regarding hemodynamic management to reduce ischemic secondary injury and improve neurologic outcome following acute SCI. The PubMed database was searched for studies investigating blood flow, mean arterial pressure (MAP), and spinal cord perfusion pressure after SCI. The 2013 guidelines of the American Association of Neurological Surgeons/Congress of Neurological Surgeons recommended maintaining MAP at 85–90 mmHg for 7 days after SCI to potentially improve outcome. However, this recommendation was based on weak evidence for neurologic benefit. The maintenance of MAP will typically require vasopressors, which may have their own set of complications. More recently, studies have suggested the potential importance of considering spinal cord perfusion pressure in addition to the MAP. Further research on the hemodynamic management of acute SCI is required to determine how to optimize neurologic recovery. Evidence-based guidelines for hemodynamic management should acknowledge the gaps in knowledge and the limitations of the current literature.

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Original Article

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Does Preservation of Ligamentum Flavum in Percutaneous Endoscopic Lumbar Interlaminar Discectomy Improve Clinical Outcomes?
Neurospine. 2019;16(1):113-119.   Published online March 31, 2019
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Does Preservation of Ligamentum Flavum in Percutaneous Endoscopic Lumbar Interlaminar Discectomy Improve Clinical Outcomes?
Neurospine. 2019;16(1):113-119.   Published online March 31, 2019
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Objective
Ligamentum flavum (LF) is an important anatomical structure for prevention of postoperative adhesions, but the opening of LF is necessary for percutaneous endoscopic lumbar interlaminar discectomy (PEID). Although the defect in LF is small with conventional PEID, the defect could be minimized with LF splitting technique. The objective of this study was to compare clinical outcomes of PEID with opening of LF versus splitting of LF.
Methods
A retrospective study was performed for patients underwent PEID for L5–S1. PEID with the opening of LF (open-group) was performed for 55 patients and with splitting of LF (split-group) was performed for 34 patients. The defect of LF in Open-group was 3–5 mm, but the defect was negligible in split-group because the split LF was reapproximated by its elasticity. Clinical outcomes were evaluated with Korean version of the Oswestry Disability Index (K-ODI) and visual analogue pain scores for back (VASB) and leg (VASL). The changes of clinical outcomes during postoperative 24 months between groups were evaluated with linear mixed-effects model.
Results
The clinical outcomes were similar between groups for K-ODI (p=0.98), VASB (p=0.52), and VASL (p=0.59). Each outcome demonstrated significant improvement from preoperative baseline throughout the postoperative 24 months (p<0.05). Complications included recurrence in 4 patients and dural tear in 1 in open-group (9.1%), and residual disc herniation in 2 patients and transient weakness in 1 in split-group (8.8%).
Conclusion
Splitting versus opening LF in PEID may be left to the surgeon’s discretion. The potential risks and benefits of LF handling should be considered when performing this surgical technique in PEID.

Citations

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  • Endoscopic Spine Surgery Treatment of Lower Back Pain: Pathophysiology and Radiofrequency Treatment of Sinuvertebral and Basivertebral Neuropathic Spine Pain
    Pang Hung Wu, Rohit Akshay Kavishwar, Hyeun Sung Kim
    Journal of Minimally Invasive Spine Surgery and Technique.2025; 10(1): 100.     CrossRef
  • Full-Endoscopic Lumbar Discectomy Approach Selection
    Vit Kotheeranurak, Wongthawat Liawrungrueang, Javier Quillo-Olvera, Christoph J. Siepe, Zhen Zhou Li, Pramod V. Lokhande, Gun Choi, Yong Ahn, Chien-Min Chen, Kyung-Chul Choi, Facundo Van Isseldyk, Vincent Hagel, Sairyo Koichi, Christoph P. Hofstetter, Dav
    Spine.2023; 48(8): 534.     CrossRef
  • Narrative Review of Pathophysiology and Endoscopic Management of Basivertebral and Sinuvertebral Neuropathy for Chronic Back Pain
    Hyeun Sung Kim, Pang Hung Wu, Il-Tae Jang
    Journal of Korean Neurosurgical Society.2023; 66(4): 344.     CrossRef
  • Comparative study of the efficacy and safety of minimally invasive interlaminar full-endoscopic discectomy versus conventional microscopic discectomy in single-level lumbar herniated intervertebral disc (ENDO-F Trial): a multicenter, prospective, randomiz
    Jin-Sung Kim, Jun Ho Lee, Junseok Bae, Dong Chan Lee, Sang-Ha Shin, Han Joong Keum, Young Soo Choi, Sang Soo Eun, Seung Ho Shin, Hyun Jin Hong, Ji Yeon Kim, Tae Hyun Kim, Woojung Lim, Junghoon Kim, Sang-Min Park, Hyun-Jin Park, Hong-Jae Lee
    Journal of Orthopaedic Surgery and Research.2022;[Epub]     CrossRef
  • Percutaneous endoscopic lumbar discectomy via the medial foraminal and interlaminar approaches: A comparative study with 2-year follow-up
    Sen Huang, Zhenfei Wang, Long Xu, Jinhui Bu, Bo He, Mengjiao Xia, Tao Chen, Juan Gao, Guangpu Liu, Ru Niu, Chao Ma, Guangwang Liu
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Technical Considerations of Interlaminar Approach for Lumbar Disc Herniation
    Kuo-Tai Chen, Chun Tseng, Li-Wei Sun, Kai-Sheng Chang, Chien-Min Chen
    World Neurosurgery.2021; 145: 612.     CrossRef
  • Nonsurgical treatment outcomes for surgical candidates with lumbar disc herniation: a comprehensive cohort study
    Chi Heon Kim, Yunhee Choi, Chun Kee Chung, Ki-Jeong Kim, Dong Ah Shin, Youn-Kwan Park, Woo-Keun Kwon, Seung Heon Yang, Chang Hyun Lee, Sung Bae Park, Eun Sang Kim, Hyunsook Hong, Yongeun Cho
    Scientific Reports.2021;[Epub]     CrossRef
  • Overview of Tips in Overcoming Learning Curve in Uniportal and Biportal Endoscopic Spine Surgery
    Pang Hung Wu, Hyeun Sung Kim, Dae Jung Choi, Yu-Heng Tan Gamaliel
    Journal of Minimally Invasive Spine Surgery and Technique.2021; 6(Suppl 1): S84.     CrossRef
  • Dural leakage due to ipsilateral needle placement for spinal level localization in unilateral decompression surgery: A case report
    Lukas Andereggen, Markus M. Luedi
    Surgical Neurology International.2021; 12: 205.     CrossRef
  • A Narrative Review of Development of Full-Endoscopic Lumbar Spine Surgery
    Pang Hung Wu, Hyeun Sung Kim, Il-Tae Jang
    Neurospine.2020; 17(Suppl 1): S20.     CrossRef
  • Treatment of high-iliac-crest L5-S1 lumbar disc herniation via a transverse process endoscopic transforaminal approach
    Zuowei Wang, Zan Chen, Hao Wu, Xingwen Wang, Kai Wang, Wanru Duan, Jian Guan, Zhenlei Liu, Fengzeng Jian
    Clinical Neurology and Neurosurgery.2020; 197: 106087.     CrossRef
  • Current and Future of Endoscopic Spine Surgery: What are the Common Procedures we Have Now and What Lies Ahead?
    Hyeun Sung Kim, Pang Hung Wu, Il-Tae Jang
    World Neurosurgery.2020; 140: 642.     CrossRef
  • 10,342 View
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  • 12 Web of Science
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Clinical Article

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The Therapeutic Effects of Combination Therapy with Curcumin and Alendronate on Spine Fusion Surgery in the Ovariectomized Rats
Korean J Spine. 2017;14(2):35-40.   Published online June 30, 2017
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The Therapeutic Effects of Combination Therapy with Curcumin and Alendronate on Spine Fusion Surgery in the Ovariectomized Rats
Korean J Spine. 2017;14(2):35-40.   Published online June 30, 2017
Close
Objective
The purpose of this study was to evaluate the therapeutic effects of combination therapy with curcumin and alendronate on spine fusion surgery in ovariectomized rats. Methods: Thirty-two female Sprague-Dawley rats (12 weeks old) underwent bilateral ovariectomy (OVX). Eight weeks after surgery, animals underwent intertransverse spine fusion at L4-5. The rats were randomly distributed amongst 4 groups; untreated OVX group, curcumin administered group, alendronate administered group, and the combination therapy group. At 8 weeks after fusion surgery, the animals were sacrificed and the fusion mass was assessed by manual palpation, radiographic scan, and micro-computed tomographic scan. In addition, mechanical strength was determined by a 3-point bending test. Results: Based on the results of manual palpation testing and 3-dimensional micro-computed tomography scanning, solid bone fusion rate was 50% (4 of 8) in the OVX group, 75% (6 of 8) in the alendronate-only and curcumin-only group, and 87.5% (7 of 8) in the combination therapy group, respectively. The combination therapy group had a higher fusion rate compared with the other treatment groups, though not statistically significantly (p>0.05). And the combination therapy group had a significant increase in fusion volume at 8 weeks after spine fusion surgery compared with curcumin-only group (p=0.039). The 3-point bending test showed that combination therapy group had a significantly greater maximal load value compared to that of curcumin-only group (p=0.024). Conclusion: The present study demonstrated that additional treatment of curcumin and alendronate after spine fusion surgery in rat can promote higher fusion volume, and improve bone mechanical strength.

Citations

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  • The Effect of Duloxetine on Fusion in Rats Undergoing Posterolateral Spinal Fusion
    Ozan Güner, Murat Erem, Mert Çiftdemir, Ufuk Usta, Nermin Tunçbilek
    Journal of Clinical Medicine.2026; 15(5): 2087.     CrossRef
  • The Early Effect of Alendronate, Hop Extract and Their Combination on Bone Structural Properties in a Rat Model of Osteoporosis
    Edi Rođak, Robert Grgac, Rok Kostanjšek, Milorad Zjalić, Nada Oršolić, Nikola Bijelić
    Medical Sciences.2026; 14(2): 239.     CrossRef
  • Protective effects of curcumin against osteoporosis and its molecular mechanisms: a recent review in preclinical trials
    Shenglei Yang, Yuying Sun, Leonid Kapilevich, Xin’an Zhang, Yue Huang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Highly porous multiple-cell-laden collagen/hydroxyapatite scaffolds for bone tissue engineering
    YoungWon Koo, Hyeongjin Lee, Chang Su Lim, Su Yeon Kwon, Inbo Han, Geun Hyung Kim
    International Journal of Biological Macromolecules.2022; 222: 1264.     CrossRef
  • Evaluation of La(XT), a novel lanthanide compound, in an OVX rat model of osteoporosis
    Yunyun Di, Ellen K. Wasan, Jacqueline Cawthray, Jaweria Syeda, Munawar Ali, David M.L. Cooper, Ahmad Al-Dissi, Nima Ashjaee, Wubin Cheng, James Johnston, David M. Weekes, Thomas I. Kostelnik, Chris Orvig, Kishor M. Wasan
    Bone Reports.2021; 14: 100753.     CrossRef
  • Non-flavonoid polyphenols in osteoporosis: preclinical evidence
    Daniele Bellavia, Fabio Caradonna, Eufrosina Dimarco, Viviana Costa, Valeria Carina, Angela De Luca, Lavinia Raimondi, Milena Fini, Carla Gentile, Gianluca Giavaresi
    Trends in Endocrinology & Metabolism.2021; 32(7): 515.     CrossRef
  • Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis
    Tae-Keun Ahn, Kyoung-Tae Kim, Hari Prasad Joshi, Kwang Hwan Park, Jae Won Kyung, Un-Yong Choi, Seil Sohn, Seung-Hun Sheen, Dong-Eun Shin, Soo-Hong Lee, In-Bo Han
    International Journal of Molecular Sciences.2020; 21(12): 4274.     CrossRef
  • 10,650 View
  • 138 Download
  • 7 Crossref

Technical Note

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Repair of Inaccessible Ventral Dural Defect in Thoracic Spine: Double Layered Duraplasty
Korean J Spine. 2016;13(2):87-90.   Published online June 30, 2016
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Repair of Inaccessible Ventral Dural Defect in Thoracic Spine: Double Layered Duraplasty
Korean J Spine. 2016;13(2):87-90.   Published online June 30, 2016
Close

We propose a double layered (intradural and epidural patch) duraplasty that utilizes Lyoplant and Duraseal. We examined a 47-year-old woman after decompression for thoracic ossification of posterior longitudinal ligament was performed in another hospital. On postoperative day 7, she complained of weakness in both legs. Postoperative magnetic resonance imaging (MRI) showed cerebrospinal fluid (CSF) collection with cord compression. In the operative field, we found 2 large dural defects on the ventral dura mater. We performed a conventional fat graft with fibrin glue. However, the patient exhibited neurologic deterioration, and a postoperative MRI again showed CSF collection. We performed dorsal midline durotomy and inserted a intradural and epidural Lyoplant patch. She immediately experienced diminishing back pain postoperatively. Her visual analog scale and motor power improved markedly. Postoperative MRIs performed at 2 and 16 months showed no spinal cord compression or CSF leakage to the epidural space. We describe a new technique for double layered duraplasty. Although we do not recommend this technique for all dural repairs, double-layered duraplasty may be useful for repairing large inaccessible dural tears in cases of persistent CSF leakage refractory to conventional management.

Citations

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  • Dural Closure Techniques and Cerebrospinal Fluid Leak Incidence After Resection of Primary Intradural Spinal Tumors
    Arjun Syal, Francesca M. Cozzi, Sima Vazquez, Eris Spirollari, Alexandria F. Naftchi, Ankita Das, Christina Ng, OluwaToba Akinleye, Thomas Gagliardi, Jose F. Dominguez, Arthur Wang, Merritt D. Kinon
    Clinical Spine Surgery.2024; 37(7): 291.     CrossRef
  • Massive lumbar disc herniation treated with a transdural approach and posterior fusion. A case report
    Takashi Sono, Kenji Nakatani, Kazuaki Morizane, Kazushi Otsuka, Kazutaka Takatsuka
    Interdisciplinary Neurosurgery.2024; 36: 101924.     CrossRef
  • Importance of Multimodal Spinal Cord Monitoring and Hemodynamic Augmentation during High Thoracic Ventral Dural Tear Repair Using the Posterior Approach
    Ramamani Mariappan, Sajo Thomas, Krishnaprabhu Raju
    Journal of Neuroanaesthesiology and Critical Care.2023; 10(03): 202.     CrossRef
  • A novel two-layer, intradural and extradural patch graft approach to treating dural defects and tears: illustrative case
    Daniella Lazarus, Charlotte Hawks, Namrita Kumar, Tara McCaffrey, Arthur L. Jenkins
    Journal of Neurosurgery: Case Lessons.2022;[Epub]     CrossRef
  • Pedicled Multifidus Muscle Flap To Treat Inaccessible Dural Tear In Spine Surgery: Technical Note And Preliminary Experience
    Domenico Policicchio, Riccardo Boccaletti, Giosuè Dipellegrini, Artan Doda, Andrea Stangoni, Santonio Filippo Veneziani
    World Neurosurgery.2021; 145: 267.     CrossRef
  • Letter to the editor: Dural Leak: Is It Deterrent to Outcomes in Spine Surgery?: 10 Years Retrospective Analysis of Incidence, Management Protocol, and Surgical Outcomes
    Vishal Kumar, Sanjay Singh Rawat
    Spine.2021; 46(17): E954.     CrossRef
  • Anterior Dural Tear in Thoracic and Lumbar Spinal Fractures: Single-Center Experience with Coating Technique and Literature Review of the Available Strategies
    Giorgio Lofrese, Jacopo Visani, Francesco Cultrera, Pasquale De Bonis, Luigino Tosatto, Alba Scerrati
    Life.2021; 11(9): 875.     CrossRef
  • Medical Communication Services after Traumatic Spinal Cord Injury
    Jamal Alshorman, Yulong Wang, Fengzhao Zhu, Lian Zeng, Kaifang Chen, Sheng Yao, Xirui Jing, Yanzhen Qu, Tingfang Sun, Xiaodong Guo, Malik Alazzam
    Journal of Healthcare Engineering.2021; 2021: 1.     CrossRef
  • 17,978 View
  • 212 Download
  • 8 Crossref

Clinical Article

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Risk Factors and Incidence for Peripheral Arterial Disease in Patients with Typical Lumbar Spinal Stenosis
Korean J Spine. 2014;11(3):183-187.   Published online September 30, 2014
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Risk Factors and Incidence for Peripheral Arterial Disease in Patients with Typical Lumbar Spinal Stenosis
Korean J Spine. 2014;11(3):183-187.   Published online September 30, 2014
Close
Objective

Intermittent claudication (IC) is a typical symptom of peripheral arterial disease (PAD) and lumbar spinal stenosis (LSS). In order to prevent misdiagnosis of vascular disease, it is important to know the incidence of and risk factors for PAD in patients with LSS. Therefore, the aim of our study was to evaluate the incidence of and risk factors for PAD in patients with typical and severe LSS who underwent spinal surgical treatment.

Methods

The occurrence of PAD was examined retrospectively in 171 consecutive patients with LSS and severe IC who underwent surgical treatment at our hospital from June 2012 to June 2013. Data were collected on background characteristics (sex, age) and known risk factors for PAD, such as hypertension, diabetes mellitus, smoking, hyperlipidemia, stroke, and ischemic heart disease.

Results

Of the 171 patients enrolled, 7 had an abnormal ankle-brachial index (ABI). Computed tomography angiography (CTA) was performed in these patients, and a final diagnosis of PAD was established for all 7 patients. The incidence of PAD in all patients with LSS was 4.1%(7 of 171). Stroke and ischemic heart disease were significantly more common in the LSSPAD group compared with the LSS group. Multiple logistic regression analyses with a forced-entry method revealed that age and stroke (p<0.05) were independent risk factors for PAD.

Conclusion

To prevent misdiagnosis of fatal PAD, we recommend ABI be assessed in patients with LSS and history of stroke.

Citations

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  • Development of multidisciplinary, evidenced-based protocol recommendations and implementation strategies for anterior lumbar interbody fusion surgery following a literature review
    Richard Meyrat, Elaina Vivian, Archana Sridhar, R. Heath Gulden, Sue Bruce, Amber Martinez, Lisa Montgomery, Donald N. Reed, Peter J. Rappa, Hetendra Makanbhai, Kenneth Raney, Jennifer Belisle, Stacey Castellanos, Judy Cwikla, Kristin Elzey, Kristen Wilck
    Medicine.2023; 102(47): e36142.     CrossRef
  • Lumbale Spinalkanalstenose
    Christof Birkenmaier, Manuel Fuetsch
    Die Orthopädie.2022; 51(11): 943.     CrossRef
  • Lower Extremity Arterial Disease and Lumbar Spinal Stenosis: A Study of Exercise-Induced Arterial Ischemia in 5197 Patients Complaining of Claudication
    Simon Lecoq, Jeanne Hersant, Mathieu Feuilloy, Henri-François Parent, Samir Henni, Pierre Abraham
    Journal of Clinical Medicine.2022; 11(19): 5550.     CrossRef
  • Reliability of the Edinburgh Claudication Questionnaire for Identifying Symptomatic PAD in General Practice
    Luke Boylan, Craig Nesbitt, Lesley Wilson, John Allen, Andrew Sims, Ina Guri, Philip Mawson, Crispian Oates, Gerard Stansby, On Behalf of the NOTEPAD Investigators
    Angiology.2021; 72(5): 474.     CrossRef
  • The association between pain, balance, fall, and disability in patients with lumbar spinal stenosis with vascular claudication
    Musa Güneş, Tarık Özmen, Tuğba Moralı Güler
    The Korean Journal of Pain.2021; 34(4): 471.     CrossRef
  • Diagnostic tests in the clinical diagnosis of lumbar spinal stenosis: Consensus and Results of an International Delphi Study
    Christy Tomkins-Lane, Markus Melloh, Arnold Wong
    European Spine Journal.2020; 29(9): 2188.     CrossRef
  • A Case of Peripheral Arterial Disease Presenting with Groin Pain after Surgery for Lumbar Canal Stenosis
    Hidekazu Tanaka, Yutaka Ito, Kunio Yokoyama, Makoto Yamada, Masashi Yamashita, Akira Sugie, Masahiro Kawanishi
    Spinal Surgery.2020; 34(2): 169.     CrossRef
  • Accuracy of Peripheral Arterial Disease Registers in UK General Practice: Case-Control Study
    Daniel Kyle, Luke Boylan, Lesley Wilson, Shona Haining, Crispian Oates, Andrew Sims, Ina Guri, John Allen, Scott Wilkes, Gerry Stansby
    Journal of Primary Care & Community Health.2020;[Epub]     CrossRef
  • Alleviation of thalamic pain by cilostazol administration: a case report
    Ayaka Haruta‐Tsukamoto, Hideki Funahashi, Yu Miyahara, Tomoko Matsuo, Toshikazu Nishimori, Yasushi Ishida
    Clinical Case Reports.2018; 6(2): 380.     CrossRef
  • Cauda Equina Conduction Time Determined by F-Waves in Normal Subjects and Patients With Neurogenic Intermittent Claudication Caused by Lumbar Spinal Stenosis
    Yasuaki Imajo, Tsukasa Kanchiku, Hidenori Suzuki, Masahiro Funaba, Norihiro Nishida, Kazuhiro Fujimoto, Toshihiko Taguchi
    Journal of Clinical Neurophysiology.2017; 34(2): 132.     CrossRef
  • The Effect of Lumbar Spinal Stenosis on Results of Treatment in Peripheral Arterial Disease
    Chung-Shik Shin, Byeong-Yeol Choi, Seung-Bum Park, Kyung-Tae Kim, Tae-Ho Kim, Chul-Seung Kim, Kyu-Dam Han
    Journal of the Korean Orthopaedic Association.2016; 51(5): 357.     CrossRef
  • 11,538 View
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  • 11 Crossref