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Surgical Versus Conservative Management for Treating Unstable Atlas Fractures: A Multicenter Study
Neurospine. 2022;19(4):1013-1025.   Published online October 23, 2022
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Surgical Versus Conservative Management for Treating Unstable Atlas Fractures: A Multicenter Study
Neurospine. 2022;19(4):1013-1025.   Published online October 23, 2022
Close
Objective
This multicenter study compared radiological parameters and clinical outcomes between surgical and nonsurgical management and investigated treatment characteristics associated with the successful management of unstable atlas fractures.
Methods
We retrospectively evaluated 53 consecutive patients with unstable atlas fracture who underwent halo-vest immobilization (HVI) or surgical fixation. Clinical outcomes were assessed using neck visual analogue scale and disability index. The radiological assessment included total lateral mass displacement (LMD) and the anterior atlantodental interval (AADI).
Results
Thirty-two patients underwent surgical fixation and 21 received HVI (mean follow-up, 24.9 months). In the surgical fixation, but not in the HVI, LMD, and AADI showed statistically significant improvements at the last follow-up. The osseous healing rate and time-to-healing were 100% and 14.3 weeks with surgical fixation, compared with 71.43% and 20.0 weeks with HVI, respectively. Patients treated with HVI showed poorer neck pain and neck disability outcomes than those who received surgical treatment. LMD showed an association with osseous healing outcomes in nonoperative management. Clinical outcomes and osseous healing showed no significant differences according to Dickman’s classification of transverse atlantal ligament injuries.
Conclusion
Surgical internal fixation had a higher fusion rate, shorter fracture healing time, more favorable clinical outcomes, and a more significant reduction in LMD and AADI compared to nonoperative management. The pitfalls of external immobilization are inadequate maintenance and a lower probability of reducing fractured lateral masses. Stabilization by surgical reduction with interconnected fixation proved to be a more practical management strategy than nonoperative treatment for unstable atlas fractures.

Citations

Citations to this article as recorded by  Crossref logo
  • Motion preserving C1 ring lateral mass screw fixation with transverse rod for isolated unstable Jefferson fracture of atlas vertebra: a multicentric study
    Nathan Beucler, Anis Choucha, Kaissar Farah, Mikael Meyer, Arnaud Dagain, Stéphane Fuentes
    European Spine Journal.2026; 35(2): 936.     CrossRef
  • Anatomical basis for a new method of atlas osteosynthesis in unstable C1 vertebra fractures
    V.N. Rashidov, I.Yu. Lisitskii, A.V. Lychagin, R.L. Kambiev, K.M. Kulakov, A.Yu. Zarov, A.L. Korkunov, V.G. Cherepanov, I.A. Vyazankin, E.Yu. Tselischeva
    Burdenko's Journal of Neurosurgery.2026; 90(2): 37.     CrossRef
  • Clinical study of three internal fixation systems via transoral approach for motor function preservation in atlas fractures
    Yinghua He, Hu Chen, Hanmo Gu, Yansong Liu, Zhongbiao Liang, Xiangyang Ma, Jinahua Wang, Kai Zhang, Qiang Tu
    Journal of Orthopaedic Surgery and Research.2026;[Epub]     CrossRef
  • Original surgical technique of unstable atlas fracture osteosynthesis: case series analysis
    I. Yu. Lisitsky, V. N. Rashidov, A. V. Lychagin, A. Yu. Zarov, A. L. Korkunov, V. G. Cherepanov, I. A. Vyazankin, E. Yu. Tselishcheva
    Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika).2025; 22(1): 53.     CrossRef
  • Perioperative outcomes and technical and patient-reported success of rigid occipitocervical fusions in adults: a systematic review and meta-analysis
    Alexander O. Aguirre, Mohamed A.R. Soliman, Isabelle G. Stockman, Gaitree R. Boojraj, Esteban Quiceno, Asham Khan, Kyungduk Rho, John Pollina, Jeffrey P. Mullin
    European Spine Journal.2025; 34(8): 3408.     CrossRef
  • More postoperative complications and revision surgery after occipitocervical fusion than after atlantoaxial fusion: a retrospective multicenter cohort study
    Koji Uotani, Angel Oscar Paz Flores, Masato Tanaka, Shashank J Ekade, Shinya Arataki, Tadashi Komatsubara, Yoshiaki Oda, Kensuke Shinohara, Toshifumi Ozaki
    Asian Spine Journal.2025; 19(3): 444.     CrossRef
  • Craniocervical traumatic ligamentous injuries – AO spine type B injuries – Anatomy, biomechanics and clinical perspectives
    Andrei Fernandes Joaquim, Klaus John Schnake, Richard J. Bransford, Harvinder Singh Chabbra, Sebastian F. Bigdon, Mohammad El-Sharkawi, Gregory D. Schroeder
    Journal of Clinical Orthopaedics and Trauma.2025; 71: 103223.     CrossRef
  • Radiological and Clinical Outcomes of Monoaxial versus Polyaxial Screw Constructs in C1 Jefferson Fracture Osteosynthesis: A Retrospective Study
    Jae Taek Hong, Dong Hoon Kim, Jin Young Kim, Jung Woo Hur, Ho Jin Lee, Il Sup Kim
    World Neurosurgery.2025; 204: 124578.     CrossRef
  • Evaluation of the Classification Systems Used for Traumatic Atlas (C1) Injuries
    Thiago Magalhães De Souza, Lucas Dos Santos Pavesi, Andrei Fernandes Joaquim
    Clinical Spine Surgery.2025;[Epub]     CrossRef
  • Direct C1 posterior arch screws for reduction and osteosynthesis in the treatment of Jefferson fracture
    Chang Kyu Park, Man Kyu Choi
    Acta Neurochirurgica.2024;[Epub]     CrossRef
  • Design of a novel lateral mass screw–plate system for the treatment of unstable atlas fractures: a finite element analysis
    He-Gang Niu, Jing-Jing Zhang, Yi-Zhu Yan, Cheng-Kun Zhao, Kun Yang, Yin-Shun Zhang
    Journal of Orthopaedic Surgery and Research.2024;[Epub]     CrossRef
  • Comparison of Transoral Anterior Jefferson-Fracture Reduction Plate and Posterior Screw-Rod Fixation in C1-Ring Osteosynthesis for Unstable Atlas Fractures
    Mandi Cai, Yifeng Wu, Rencai Ma, Junlin Chen, Zexing Chen, Chenfu Deng, Xinzhao Huang, Xiangyang Ma, Xiaobao Zou
    Neurospine.2024; 21(2): 544.     CrossRef
  • C1-ring оsteosynthesis as a functionally preserving operation for unstable atlas fractures
    I. V. Basankin, Abram Akopovich Giulzatyan, I. M. Magomedov, K. K. Takhmazyan, M. I. Tomina, S. B. Malakhov, A. A. Afaunov, V. A. Porkhanov
    Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika).2024; 21(3): 6.     CrossRef
  • Commentary on “Surgical Versus Conservative Management for Treating Unstable Atlas Fractures: A Multicenter Study”
    Toshiyuki Takahashi
    Neurospine.2022; 19(4): 1026.     CrossRef
  • 14,034 View
  • 797 Download
  • 9 Web of Science
  • 14 Crossref

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Epidemiology of C5 Palsy after Cervical Spine Surgery: A 21-Center Study
Neurospine. 2019;16(3):558-562.   Published online September 30, 2019
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Epidemiology of C5 Palsy after Cervical Spine Surgery: A 21-Center Study
Neurospine. 2019;16(3):558-562.   Published online September 30, 2019
Close
Objective
C5 palsy is a severe complication after cervical spine surgery, the pathophysiology of which remains unclear. This multicenter study investigated the incidence of C5 palsy following cervical spine surgery in Korea.
Methods
We conducted a retrospective multicenter study involving 21 centers from the Korean Cervical Spine Study Group. The inclusion criteria were cervical spine surgery patients between 2012 and 2016, excluding cases of neck surgery. In patients with C5 palsy, the operative methods, disease category, onset time of C5 palsy, recovery time, C5 manual muscle testing (MMT) grade, and post-C5 palsy management were analyzed.
Results
We collected 15,097 cervical spine surgery cases from 21 centers. C5 palsy occurred in 88 cases (0.58%). C5 palsy was more common in male patients (p=0.019) and after posterior approach procedures (p<0.001). C5 palsy usually occurred within 3 days after surgery (77 of 88, 87.5%) and most C5 palsy patients recovered within 6 months (51 of 88, 57.95%). Thirty C5 palsy patients (34.09%) had motor weakness, with an MMT grade≤2. Only four C5 palsy patients (4.5%) did not recover during follow-up. Posterior cervical foraminotomy was performed in 7 cases (7.95%), and steroids were used in 56 cases (63.63%). Twenty-six cases (29.55%) underwent close observation only.
Conclusion
The overall incidence of C5 palsy was relatively low (0.58%). C5 palsy was more common after posterior cervical surgery and in male patients. C5 palsy usually developed within 3 days after surgery, and more than half of patients with C5 palsy recovered within 6 months.

Citations

Citations to this article as recorded by  Crossref logo
  • Risk Factors and Clinical Outcomes of Perioperative Complications Following Cervical Spine Surgery
    Narihito Nagoshi, Junichi Yamane, Toshiki Okubo, Yosuke Horiuchi, Yasuhiro Kamata, Norihiro Isogai, Hitoshi Kono, Yoshiomi Kobayashi, Reo Shibata, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
    Global Spine Journal.2026; 16(6): 2671.     CrossRef
  • What is the probability of recovery of C5 palsy after cervical spine surgery over time? A systematic review and meta-analysis
    Nienke A. Krijnen, Alexander J. Comerci, Christopher J. Fedor, Hamid Alahmari, James C. Bayley, Teun Teunis
    The Spine Journal.2026; 26(5): 853.     CrossRef
  • Risk factors for C5 nerve root palsy following surgery for cervical degenerative disease : a systematic review and meta-analysis
    Mingzhu Huang, Kang Chen, Yujin Zhang, Lanxin Zhang, Changyu Liu, Xuan Liu, Xiangzhuo Liu, Ningyuan Li, Ying Lu, Mingjiang Luo, Zhihong Xiao, Liquan Li
    Neurosurgical Review.2026;[Epub]     CrossRef
  • C5 Palsy After Cervical Decompression: A 10-Year Single-Institution Study Highlighting Early Onset, High Bilaterality, and Poor Recovery
    Sargunan B, Vishnu Prasath, Karthik Sudhakar, Thomas John
    Cureus.2026;[Epub]     CrossRef
  • De novo C5 palsy in the absence of prior surgery: a retrospective study of surgical management and outcomes in the United States
    Wesley Manz, Sameer Khawaja, Corey Spencer, Dale Segal, Zach Grabel, Doug Weinberg, Eli Garrard, John Rhee
    Asian Spine Journal.2026; 20(1): 34.     CrossRef
  • Incidence and prognostic factors of postoperative C5 palsy after cervical OPLL surgery: a nationwide prospective multicenter study
    Satoru Egawa, Takashi Hirai, Kenichiro Sakai, Kazuo Kusano, Shunji Tsutsui, Yu Matsukura, Kentaro Yamada, Hiroaki Onuma, Kanichiro Wada, Keiichi Katsumi, Masao Koda, Atsushi Kimura, Takeo Furuya, Satoshi Maki, Norihiro Nishida, Yukitaka Nagamoto, Yasushi
    Scientific Reports.2026;[Epub]     CrossRef
  • Preoperative Imaging Predictors of Postoperative C5 Palsy
    Jonathan Dalton, Rachel Huang, Michael Carter, Robert J. Oris, Joydeep Baidya, Joshua Mathew, Rajkishen Narayanan, Andrew Kim, Sebastian Fras, Jonah Blas, Anthony LaBarbiera, Matthew Ruiz, Evgeniy Uvarov, Keyur Patel, Mark F. Kurd, Ian David Kaye, Jose A.
    Spine.2026; 51(10): 692.     CrossRef
  • C4/5 Facetectomy Is Associated With Improved Recovery of C5 Palsy in Severe Foraminal Stenosis After Posterior Cervical Decompression and Fusion
    Yusuke Nakamura, Sohei Murata, Taisuke Yabe, Hiromu Ito
    Cureus.2026;[Epub]     CrossRef
  • Increased Change in Cervical Lordosis Is Associated With Decreased Rate of Recovery in Patients With C5 Palsy
    Joseph N. Frazzetta, Nathan Pecoraro, Ignacio Jusue-Torres, Paul M. Arnold, Ryan Hofler, G. Alexander Jones, Russ Nockels
    Clinical Spine Surgery.2025; 38(3): E152.     CrossRef
  • Phrenic Nerve Palsy After Posterior Cervical Fusion
    Thomas Falconiero, Anthony Viola, Mark LaGreca, Caleb M. Yeung, Jeffrey Rihn
    Clinical Spine Surgery.2025; 38(5): 217.     CrossRef
  • Biceps involvement and degree of motor deficit at diagnosis are independently predictive of timing of postoperative C5 palsy recovery
    Gregory Toci, Jonathan Dalton, Rachel Huang, Michael Carter, Robert J. Oris, Rajkishen Narayanan, Andrew Kim, Julienne Jeong, Brady Stallman, Kenneth McCall, Mark F. Kurd, Ian D. Kaye, Barrett I. Woods, Jeffrey A. Rihn, Jose A. Canseco, Alan S. Hilibrand,
    The Spine Journal.2025; 25(11): 2441.     CrossRef
  • Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
    Wenchao Zhou, Baifeng Sun, Zichuan Wu, Aochen Xu, Hanlin Song, Xuhong Zhang, Junbin Liu, Junzhe Sheng, Yang Liu
    Open Medicine.2025;[Epub]     CrossRef
  • C5 Nerve Palsy After Posterior Instrumentation and Decompression in Cervical Spine Surgery: A Review of the Literature
    Konstantinos Zygogiannis, Pavlos Gerasimidis, Spyridon Komaitis, Savvas Moschos, Georgios C Thivaios, Aikaterini Tsatsaragkou, Dimitrios Koulalis
    Cureus.2025;[Epub]     CrossRef
  • Transient C5 Palsy After Full‐Endoscopic Posterior Cervical Foraminotomy
    João Paulo Machado Bergamaschi, Ariel Falbel Lugão, Rangel Roberto de Assis, Kelsen de Oliveira Teixeira, Fernando Flores de Araújo, Thiago Queiroz Soares, Gustavo Vitelli Depieri, Álvaro Dowling, Robson Cruz de Oliveira, Fernanda Wirth, Fábio da Silva Fo
    Case Reports in Orthopedics.2025;[Epub]     CrossRef
  • Recovery patterns from C5 palsy after anterior cervical decompression and fusion, posterior cervical decompression and fusion, and laminoplasty for degenerative cervical myelopathy: systematic review and meta-analysis of 748 C5 palsy cases
    Vibhu Krishnan Viswanathan, Guna Pratheep Kalanchiam, Akilan Chinnappan, Sathish Muthu
    Asian Spine Journal.2025; 19(6): 1059.     CrossRef
  • Contralateral C7 nerve root transfer for post-stroke prolonged flaccid paralysis — Two cases report
    Shuai Zhu, Feng-Chi Sun, Xiang-Meng Su, Si-Wei Xu, Jun-Tao Feng, Hua-Wei Yin, Wen-Dong Xu, Yun-Dong Shen
    Hand Surgery and Rehabilitation.2025; 44(5): 102261.     CrossRef
  • Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Chang Kyu Lee, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Joongkyum Shin, Yoon Ha
    Neurospine.2025; 22(4): 937.     CrossRef
  • Comparison of Anterior Cervical Decompression and Fusion and Posterior Laminoplasty for Four-Segment Cervical Spondylotic Myelopathy: Clinical and Radiographic Outcomes
    Liang Shi, Tao Ding, Fang Wang, Chengcong Wu
    Journal of Neurological Surgery Part A: Central European Neurosurgery.2024; 85(04): 331.     CrossRef
  • A rare case of phrenic nerve palsy after cervical spine surgery
    Shubham Sanjay Lodha, Akash Vishnu Mane, Mandar Borde, K V Menon
    Indian Spine Journal.2024; 7(1): 100.     CrossRef
  • A systematic review of risk factors and adverse outcomes associated with anterior cervical discectomy and fusion surgery over the past decade
    Vikramaditya Rai, Vipin Sharma, Mukesh Kumar, Lokesh Thakur
    Journal of Craniovertebral Junction and Spine.2024; 15(2): 141.     CrossRef
  • Cervical kinematic change after posterior full-endoscopic cervical foraminotomy for disc herniation or foraminal stenosis
    Seungyoon Paik, Yunhee Choi, Chun Kee Chung, Young Il Won, Sung Bae Park, Seung Heon Yang, Chang-Hyun Lee, John Min Rhee, Kyoung-Tae Kim, Chi Heon Kim, Thamer Hamdan
    PLOS ONE.2023; 18(2): e0281926.     CrossRef
  • Posterior Preventive Foraminotomy before Laminectomy Combined with Pedicle Screw Fixation May Decrease the Incidence of C5 Palsy in Complex Cervical Spine Surgery in Patients with Severe Myeloradiculopathy
    Yong-Ho Lee, Mahmoud Abdou, Ji-Won Kwon, Kyung-Soo Suk, Seong-Hwan Moon, You-Gun Won, Tae-Jin Lee, Byung-Ho Lee
    Journal of Clinical Medicine.2023; 12(6): 2227.     CrossRef
  • Clinical Spectrum of Postsurgical Parsonage-Turner Syndrome: A Perspective From an Electrodiagnostic Laboratory
    Vasudeva G Iyer, Lisa B Shields, Yi Ping Zhang, Christopher B Shields
    Cureus.2023;[Epub]     CrossRef
  • Bilateral phrenic nerve palsy after posterior cervical decompression and fusion surgery: a rare event after surgery
    Glenn A. Gonzalez, Jingya Miao, Guilherme Porto, James Harrop
    Spinal Cord Series and Cases.2023;[Epub]     CrossRef
  • Progress of C5 Nerve Root Palsy after Open-Door Cervical Expansive Laminoplasty
    ·阿不力肯 阿不都沙拉木
    Advances in Clinical Medicine.2023; 13(10): 16813.     CrossRef
  • Management of Cerebrospinal Fluid Leakage by Pump-Regulated Volumetric Continuous Lumbar Drainage Following Anterior Cervical Decompression and Fusion for Ossification of the Posterior Longitudinal Ligament
    Sun Woo Jang, Sang Hyub Lee, Hong Kyung Shin, Sang Ryong Jeon, Sung Woo Roh, Jin Hoon Park
    Neurospine.2023; 20(4): 1421.     CrossRef
  • A Novel Method of Making Hinges Using a Newly Designed Sharp Rongeur to Enhance Radiological and Clinical Outcomes in French‐Door Cervical Expansive Laminoplasty
    Ningning Chen, Lanzhe Yu, Xizhe Liu, Guoliang Chen, Yanrun Li, Xuenong Zou, Dacheng He, Jiaming Yang, Shangbin Cui, Le Wang, Shaoyu Liu, Fuxin Wei
    Orthopaedic Surgery.2022; 14(12): 3349.     CrossRef
  • Defining postoperative C5 palsy and recovery: a systematic review
    Nachiket Deshpande, Amro M. Stino, Brandon W. Smith, Ann A. Little, Lynda J. S. Yang, Paul Park, Yamaan S. Saadeh
    Journal of Neurosurgery: Spine.2022; : 1.     CrossRef
  • Use of electromyography to predict likelihood of recovery following C5 palsy after posterior cervical spine surgery
    Daniel Lubelski, Zach Pennington, Ryan F. Planchard, Ahmet Hoke, Nicholas Theodore, Daniel M. Sciubba, Allan J. Belzberg
    The Spine Journal.2021; 21(3): 387.     CrossRef
  • A modified cutting line in the single-door cervical laminoplasty via a computed tomography-based morphological study of the subaxial cervical spine
    Guoliang Chen, Weicheng Huang, Mengxian Jia, Jiajin Lin, Yadong Sheng, Chaowei Lin, Kelun Huang, Honglin Teng
    Clinical Neurology and Neurosurgery.2021; 200: 106384.     CrossRef
  • A new nomenclature system for the surgical treatment of cervical spine deformity, developing, and validation of SOF system
    Jae Taek Hong, Heiko Koller, Kuniyoshi Abumi, Wen Yuan, Asdrubal Falavigna, Ho Jin Lee, Jong Beom Lee, Jean-Charles Le Huec, Jong-Hyeok Park, Il Sup Kim
    European Spine Journal.2021; 30(6): 1670.     CrossRef
  • C5 palsy after cervical laminectomy: natural history in a 10-year series
    Ryan C. Hofler, Joseph Frazzetta, Jehad Zakaria, Amany Aziz, William Adams, G. Alexander Jones
    The Spine Journal.2021; 21(9): 1473.     CrossRef
  • Preoperative Radiological Parameters to Predict Clinical and Radiological Outcomes after Laminoplasty
    Su Hun Lee, Dong Wuk Son, Jun Jae Shin, Yoon Ha, Geun Sung Song, Jun Seok Lee, Sang Weon Lee
    Journal of Korean Neurosurgical Society.2021; 64(5): 677.     CrossRef
  • Phrenic nerve palsy after cervical laminectomy and fusion
    Andrew S. Moon, Jeffrey M. Pearson, Jason L. Pittman
    North American Spine Society Journal (NASSJ).2020; 4: 100022.     CrossRef
  • 26,930 View
  • 477 Download
  • 32 Web of Science
  • 34 Crossref