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"Seong Yi"

Original Articles

Clinical Study – Cervical Spine

Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Chang Kyu Lee, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Joongkyum Shin, Yoon Ha
Neurospine 2025;22(4):937-948.   Published online December 31, 2025
DOI: https://doi.org/10.14245/ns.2551108.554

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Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
Neurospine. 2025;22(4):937-948.   Published online December 31, 2025
DOI: https://doi.org/10.14245/ns.2551108.554
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Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
Neurospine. 2025;22(4):937-948.   Published online December 31, 2025
DOI: https://doi.org/10.14245/ns.2551108.554
Close
Objective
To evaluate the clinical significance of a negative K-line in the neck flexion position (FK-line [-]), which indicates that cervical ossification of the posterior longitudinal ligament (OPLL) crosses the K-line during flexion, and to compare surgical outcomes between laminoplasty (LP) and laminectomy with fusion (LF) for multilevel FK-line (-) cervical OPLL.
Methods
A total of 349 patients with multiple cervical OPLL who underwent posterior decompression surgery (LP or LF) with a minimum of 2 years of follow-up were stratified by FK-line status. Clinical and radiological parameters were compared between the FK-line (+) and FK-line (-) groups. Subgroup analysis of FK-line (-) patients evaluated the efficacy of LP versus LF. Multivariate regression identified predictors of neurological recovery.
Results
Patients with FK-line (-) OPLL exhibited a smaller FK-line distance, more kyphotic alignment, greater cervical flexion, and lower recovery ratios compared to those with FK-line (+). In the FK-line (-) subgroup, LF achieved a significantly greater increase in FK-line distance, better correction of the flexion angle, and more neurological recovery than LP. Multivariate analyses identified postoperative FK-line distance, C2–7 flexion angle, and preoperative dynamic extension reserve as independent predictors of neurological outcomes.
Conclusion
FK-line status reflects the sagittal cord position and predicts surgical outcomes in cervical OPLL. In FK-line (-) patients, LF provides better neurological recovery and more effective posterior cord shift and kyphotic alignment correction than LP. Incorporating FK-line assessment to guide surgical planning could improve individualized treatment outcomes for multilevel OPLL.

Citations

Citations to this article as recorded by  Crossref logo
  • A Commentary on “Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion”
    John H. Chi
    Neurospine.2025; 22(4): 951.     CrossRef
  • A Commentary on “Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion”
    Yutaro Kanda
    Neurospine.2025; 22(4): 949.     CrossRef
  • From the Editor-in-Chief: Featured Articles in the December 2025 Issue
    Inbo Han
    Neurospine.2025; 22(4): 877.     CrossRef
  • 2,006 View
  • 88 Download
  • 3 Web of Science
  • 3 Crossref

Cervical Spine

The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study
Jun Jae Shin, Sun Joon Yoo, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Won Joo Jeong, Tae Woo Kim, Chang Kyu Lee, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Joongkyum Shin, Yoon Ha
Neurospine 2025;22(2):337-348.   Published online June 30, 2025
DOI: https://doi.org/10.14245/ns.2550184.092

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The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study
Neurospine. 2025;22(2):337-348.   Published online June 30, 2025
DOI: https://doi.org/10.14245/ns.2550184.092
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The Role of K-Line and Canal-Occupying Ratio in Surgical Outcomes for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Retrospective Multicenter Study
Neurospine. 2025;22(2):337-348.   Published online June 30, 2025
DOI: https://doi.org/10.14245/ns.2550184.092
Close
Objective
To evaluate the impact of the K-line and canal-occupying ratio (COR) on surgical outcomes in patients with multilevel cervical ossification of the posterior longitudinal ligament (OPLL).
Methods
Patients with cervical myelopathy due to multilevel OPLL who underwent decompression surgery (anterior or posterior) from 2013 to 2022, with 2-year minimum follow-up, were enrolled. Radiological evaluations included K-line, COR, OPLL type/level, and cervical parameters (C2 slope [C2S], T1 slope [T1S], K-line tilt). Clinical outcomes included Japanese Orthopaedic Association (JOA) score and neck-pain visual analogue scale. Patients were categorized by K-line status (+/-) and COR (<50% or ≥50%).
Results
Among 575 patients, JOA recovery was significantly better in the K-line (+) and in low COR (<50%). In high COR (≥50%), K-line (-) was associated with poorer recovery. In low COR, outcomes were similar regardless of K-line. Anterior decompression with fusion (ADF) yielded the best outcomes. Laminoplasty (LP) was optimal for COR ≥50% and/or K-line (+), while laminectomy with fusion (LF) was better for COR ≥50% and K-line (-). In high COR, K-line was influenced by cervical alignment, C2S, and T1S, while in low COR, it was mainly affected by COR percentage.
Conclusion
Combining K-line and COR is essential for surgical planning in multilevel OPLL. When COR is high, K-line plays a significant role in predicting neurological recovery. ADF led to superior recovery, whereas for patients with K-line (-) and high COR, LF offered better results than LP. Cervical parameters at high COR influence the K-line more.

Citations

Citations to this article as recorded by  Crossref logo
  • Evaluating the demographics and complications of North American surgical patients with ossification of the posterior longitudinal ligament
    Aaron Phung, Justin Hyde, Justin Azmoodeh, Theodore Quan, Lancelot Benn, Christopher P. Bellaire, Oliver Tannous, Joseph Ferguson, Seyed B Kalantar, David Weiner, Andrew Mo, Fred Mo, Sean Bae, Ala Alshomali, Crisanto L. Macaraeg, Kevin Yoon, Jonathan P. J
    Journal of Clinical Neuroscience.2026; 144: 111790.     CrossRef
  • Radiological assessment in cervical spine myelopathy
    Shanmuganathan Rajasekaran, Gnanaprakash Gurusamy, Pushpa Bhari Thippeswamy, Karthik Ramachandran, Stefano Conti
    Journal of Clinical Orthopaedics and Trauma.2026; 72: 103301.     CrossRef
  • C2-Involving Cervical Ossification of the Posterior Longitudinal Ligament (OPLL): Dome-like Laminoplasty Versus Laminectomy With Fusion
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Joongkyum Shin, Yoon Ha
    Global Spine Journal.2026;[Epub]     CrossRef
  • Dynamic K-Line Status and Surgical Outcomes in Multilevel Cervical OPLL: A Multicenter Comparative Study
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Chang Kyu Lee, Keung Nyun Kim, Tae Woo Kim, Yoon Ha
    Journal of Clinical Medicine.2026; 15(2): 520.     CrossRef
  • A comparative study on surgical management of long-course symptomatic cervical OPLL between anterior en bloc resection and posterior laminectomy with instrumented fusion
    Kefu Chen, Yiwei Lu, Shu Liu, Lianshun Jia, Xingcheng Dong, Tianwen Ye
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • Reduction of Spinal Cord Cross-Sectional Area Is Associated With Myelopathy in Severe Cervical Ossification of the Posterior Longitudinal Ligaments
    Hyun-Jun Jang, Dong-Kyu Kim, Bong-Ju Moon, Kyung-Hyun Kim, Jeong-Yoon Park, Sung-Uk Kuh, Keun-Su Kim, Yong-Eun Cho, Dong-Kyu Chin
    Neurosurgery.2026;[Epub]     CrossRef
  • Spinal cord extracellular matrix hydrogel enhances organoid maturation and functional regeneration after spinal cord injury
    Junghoon Kim, Songzi Zhang, Joon-Hyuk Jung, Mi-Jeong Lee, Inbo Han, Seung-Woo Cho
    Materials Today Bio.2026; 38: 103168.     CrossRef
  • Surgical Technique and Technical Pearls of O-arm Navigation-assisted Anterior Cervical Corpectomy and Fusion for Cervical Ossification of the Posterior Longitudinal Ligament (OPLL)
    Yusuke Nishimura
    Spinal Surgery.2026; 40(1): 8.     CrossRef
  • Risk Factors for Persistent Neurological Deterioration After Biportal Endoscopic Posterior Decompression for Multilevel Cervical Myelopathy: The “Structural Mismatch” Concept
    Ji Yeon Kim, Woon Tak Yuh, Su Yong Choi, Min Gyu Kang, Seok Won Lee
    Journal of Minimally Invasive Spine Surgery and Technique.2026; 11(Suppl 2): S302.     CrossRef
  • Anterior Cervical Discectomy and Fusion Achieves Outcomes Comparable to Laminoplasty in Patients With Spinal Cord-Canal Mismatch
    Dong-Ho Lee, Sehan Park, Myeong G. Song, Chang J. Hwang, Jae H. Cho
    Clinical Spine Surgery.2026;[Epub]     CrossRef
  • Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Chang Kyu Lee, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Joongkyum Shin, Yoon Ha
    Neurospine.2025; 22(4): 937.     CrossRef
  • 10,476 View
  • 280 Download
  • 10 Web of Science
  • 11 Crossref

Commentaries on the Special Issue: “Robotics and AI in Spine”

Special Issue on AI & Robotics

Artificial Intelligence (AI)-Robotics Started When Human Capability Reached Limit, Human Creativity Begin Again When the Capability of AI-Robotics Reaches a Plateau
Seong Yi
Neurospine 2024;21(1):3-5.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2448234.117

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Artificial Intelligence (AI)-Robotics Started When Human Capability Reached Limit, Human Creativity Begin Again When the Capability of AI-Robotics Reaches a Plateau
Neurospine. 2024;21(1):3-5.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2448234.117
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Artificial Intelligence (AI)-Robotics Started When Human Capability Reached Limit, Human Creativity Begin Again When the Capability of AI-Robotics Reaches a Plateau
Neurospine. 2024;21(1):3-5.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2448234.117
Close

Citations

Citations to this article as recorded by  Crossref logo
  • Artificial intelligence and robotic technologies redefining precision and personalization in orthopedic surgery: a narrative review
    Fawwaz Al-Smadi, Sajeda Al-Smadi, Xudong Xie, Xiayidan Abudourusuli, Lizhi Ouyang, Ruiyin Zeng, Longyu Du, Yuheng Liao, Bobin Mi, Guohui Liu
    Frontiers in Bioengineering and Biotechnology.2026;[Epub]     CrossRef
  • Applications of human-machine collaborative decision-making: A review of research with recent developments
    Yun Luo, Yanpuze Hao, Haochen Gong, Bo Li
    iScience.2026; 29(6): 116056.     CrossRef
  • Artificial Intelligence in Orthopedic Surgery: Current Applications, Challenges, and Future Directions
    Fei Han, Xiao Huang, Xin Wang, Yong‐feng Chen, Chuang Lu, Shasha Li, Lu Lu, Da‐Wei Zhang
    MedComm.2025;[Epub]     CrossRef
  • Artificial Intelligence (AI) Agents Versus Agentic AI: What’s the Effect in Spine Surgery?
    Wongthawat Liawrungrueang
    Neurospine.2025; 22(2): 473.     CrossRef
  • 5,205 View
  • 211 Download
  • 4 Web of Science
  • 4 Crossref

Original Articles

Special Issue on AI & Robotics

A Propensity Score-Matched Cohort Study Comparing 3 Different Spine Pedicle Screw Fixation Methods: Freehand, Fluoroscopy-Guided, and Robot-Assisted Techniques
Yoon Ha Hwang, Byeong-Jin Ha, Hyung Cheol Kim, Byung Ho Lee, Jeong-Yoon Park, Dong-Kyu Chin, Seong Yi
Neurospine 2024;21(1):83-94.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2448036.018

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A Propensity Score-Matched Cohort Study Comparing 3 Different Spine Pedicle Screw Fixation Methods: Freehand, Fluoroscopy-Guided, and Robot-Assisted Techniques
Neurospine. 2024;21(1):83-94.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2448036.018
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A Propensity Score-Matched Cohort Study Comparing 3 Different Spine Pedicle Screw Fixation Methods: Freehand, Fluoroscopy-Guided, and Robot-Assisted Techniques
Neurospine. 2024;21(1):83-94.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2448036.018
Close
Objective
This study aimed to compare the accuracy of robotic spine surgery and conventional pedicle screw fixation in lumbar degenerative disease. We evaluated clinical and radiological outcomes to demonstrate the noninferiority of robotic surgery.
Methods
This study employed propensity score matching and included 3 groups: robot-assisted mini-open posterior lumbar interbody fusion (PLIF) (robotic surgery, RS), c-arm guided minimally invasive surgery transforaminal lumbar interbody fusion (C-arm guidance, CG), and freehand open PLIF (free of guidance, FG) (54 patients each). The mean follow-up period was 2.2 years. The preoperative spine condition was considered. Accuracy was evaluated using the Gertzbein-Robbins scale (GRS score) and Babu classification (Babu score). Radiological outcomes included adjacent segmental disease (ASD) and mechanical failure. Clinical outcomes were assessed based on the visual analogue scale, Oswestry Disability Index, 36-item Short Form health survey, and clinical ASD rate.
Results
Accuracy was higher in the RS group (p < 0.01) than in other groups. The GRS score was lower in the CG group, whereas the Babu score was lower in the FG group compared with the RS group. No significant differences were observed in radiological and clinical outcomes among the 3 groups. Regression analysis identified preoperative facet degeneration, GRS and Babu scores as significant variables for radiological and clinical ASD. Mechanical failure was influenced by the GRS score and patients’ age.
Conclusion
This study showed the superior accuracy of robotic spine surgery compared with conventional techniques. When combined with minimally invasive surgery, robotic surgery is advantageous with reduced ligament and muscle damage associated with traditional open procedures.

Citations

Citations to this article as recorded by  Crossref logo
  • Robot-Assisted Pedicle Screw Insertion in Pediatric Spine Surgery: An Institutional Experience and Meta-Analysis
    Taha Khalilullah, Abdul Karim Ghaith, Xinlan Yang, Linda Tang, Shaan Bhandarkar, Meghana Bhimreddy, Arjun D. Menta, Daniel Davidar, Andrew Hersh, Carly Weber-Levine, Kelly Jiang, Patrick Kramer, Ritvik Jillala, Maria Jennings, Jawad M. Khalifeh, Tej D. Az
    Operative Neurosurgery.2026; 31(2): 202.     CrossRef
  • Biomechanical stability and pedicle screw loosening
    Chenxi Cui, Haisheng Yang
    Journal of Biomechanics.2026; 197: 113174.     CrossRef
  • L-Point Entry, Juxtapedicular, and Endplate-Parallel Trajectory (L-JET) Screw Fixation: A Novel Technique in Thoracic Spinal Tumor Surgery
    Seunghoon Lee, Young Rak Kim, Chang-Hyun Lee, Jungbo Sim, Woojin Kim, Ho Sung Myeong, Hangeul Park, Jun-Hoe Kim, Chi Heon Kim
    Journal of Minimally Invasive Spine Surgery and Technique.2026; 11(1): 6.     CrossRef
  • Robot-assisted pedicle screw placement in spinal surgery: an updated systematic umbrella review and meta-meta-analysis of comparisons against freehand and navigation-guided techniques
    Yan-Xin Du, Wen-Xi Sun, Luo-Qi Mai, Xin-Yuan Chen, Lu-Lu Li, Hong-Shen Wang, Yong-Peng Lin, Bo-Lai Chen
    EFORT Open Reviews.2026; 11(1): 57.     CrossRef
  • Lumbar Adjacent Segment Disease: A Modern Perspective and Review of the Literature
    Jonathan Dalton, Rahul Ramanathan, Alan S. Hilibrand, Alexander R. Vaccaro
    Journal of the American Academy of Orthopaedic Surgeons.2026;[Epub]     CrossRef
  • Biomechanical Impact of Cement Augmentation on Pedicle Screw Fixation and Adjacent Segment Disease in Multilevel Lumbar Fusion: A Finite Element Analysis
    Min-Young Jo, Sung-Jae Lee, Je-Hoon An, Young-Hoon Kim, Jun-Seok Lee, Hyung-Youl Park
    Neurospine.2025; 22(3): 763.     CrossRef
  • From the Editor-in-Chief: Featured Articles in the March 2024 Issue
    Inbo Han
    Neurospine.2024; 21(1): 1.     CrossRef
  • Commentary on “A Propensity Score-Matched Cohort Study Comparing 3 Different Spine Pedicle Screw Fixation Methods: Freehand, Fluoroscopy-Guided, and Robot-Assisted Techniques”
    Jacob Yoong-Leong Oh
    Neurospine.2024; 21(1): 95.     CrossRef
  • 10,143 View
  • 180 Download
  • 9 Web of Science
  • 8 Crossref

Special Issue on AI & Robotics

Robotic-Assisted Spine Surgery: Role in Training the Next Generation of Spine Surgeons
Jun Seok Lee, Dong Wuk Son, Su Hun Lee, Jong Hyeok Lee, Young Ha Kim, Sang Weon Lee, Bu Kwang Oh, Soon Ki Sung, Geun Sung Song, Seong Yi
Neurospine 2024;21(1):116-127.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2448006.003

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Robotic-Assisted Spine Surgery: Role in Training the Next Generation of Spine Surgeons
Neurospine. 2024;21(1):116-127.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2448006.003
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Robotic-Assisted Spine Surgery: Role in Training the Next Generation of Spine Surgeons
Neurospine. 2024;21(1):116-127.   Published online March 31, 2024
DOI: https://doi.org/10.14245/ns.2448006.003
Close
Objective
This study aimed to assess the degree of interest in robot-assisted spine surgery (RASS) among residents and to investigate the learning curve for beginners performing robotic surgery.
Methods
We conducted a survey to assess awareness and interest in RASS among young neurosurgery residents. Subsequently, we offered a hands-on training program using a dummy to educate one resident. After completing the program, the trained resident performed spinal fusion surgery with robotic assistance under the supervision of a mentor. The clinical outcomes and learning curve associated with robotic surgery were then analyzed.
Results
Neurosurgical residents had limited opportunities to participate in spinal surgery during their training. Despite this, there was a significant interest in the emerging field of robotic surgery. A trained resident performed RASS under the supervision of a senior surgeon. A total of 166 screw insertions were attempted in 28 patients, with 2 screws failing due to skiving. According to the Gertzbein-Robbins classification, 85.54% of the screws were rated as grade A, 11.58% as grade B, 0.6% as grade C, and 1.2% as grade D. The clinical acceptance rate was approximately 96.99%, which is comparable to the results reported by senior experts and time per screw statistically significantly decreased as experience was gained.
Conclusion
RASS can be performed with high accuracy within a relatively short timeframe, if residents receive adequate training.

Citations

Citations to this article as recorded by  Crossref logo
  • Robot-Assisted Pedicle Screw Insertion in Pediatric Spine Surgery: An Institutional Experience and Meta-Analysis
    Taha Khalilullah, Abdul Karim Ghaith, Xinlan Yang, Linda Tang, Shaan Bhandarkar, Meghana Bhimreddy, Arjun D. Menta, Daniel Davidar, Andrew Hersh, Carly Weber-Levine, Kelly Jiang, Patrick Kramer, Ritvik Jillala, Maria Jennings, Jawad M. Khalifeh, Tej D. Az
    Operative Neurosurgery.2026; 31(2): 202.     CrossRef
  • Spinale Robotik vs. Cone-Beam-Navigation
    Patrick Strube, Alexander Hölzl, Anna-Maria Vogel, Georg Matziolis, Chris Lindemann
    Die Orthopädie.2026;[Epub]     CrossRef
  • A Comprehensive Review of the Role of the Latest Minimally Invasive Neurosurgery Techniques and Outcomes for Brain and Spinal Surgeries
    Simone Laguardia, Alessio Piccioni, Jorge Eduardo Alonso Vera, Ali Muqaddas, Milko Garcés, Sidra Ambreen, Sarmishtha Sharma, Tara Sabzvari
    Cureus.2025;[Epub]     CrossRef
  • Visuohaptic Feedback in Robotic-Assisted Spine Surgery for Pedicle Screw Placement
    Giuseppe Loggia, Fedan Avrumova, Darren R. Lebl
    Journal of Clinical Medicine.2025; 14(11): 3804.     CrossRef
  • Robot-assisted versus navigated spinal fusion surgery: a comparative multicenter study on transpedicular screw placement accuracy and patient outcomes
    Giada Garufi, Gianluca Scalia, Francesca Graziano, Roberta Costanzo, Massimiliano Porzio, Giancarlo Ponzo, Massimiliano Giuffrida, Giuseppe Ricciardo, Giuseppe Emmanuele Umana, Giovanni Federico Nicoletti, Salvatore Massimiliano Cardali
    Neurosurgical Review.2025;[Epub]     CrossRef
  • Evolving Paradigms in Spine Surgery Training: Integrating Technology, Ethics, and Minimally Invasive Techniques
    G. Balamurali, Soma Sundar Subramanian, Keerthivasan Panneerselvam
    Journal of Minimally Invasive Spine Surgery and Technique.2025; 10(Suppl 2): S107.     CrossRef
  • Commentary on “The Utility and Feasibility of Smart Glasses in Spine Surgery: Minimizing Radiation Exposure During Percutaneous Pedicle Screw Insertion”
    Wongthawat Liawrungrueang
    Neurospine.2024; 21(2): 440.     CrossRef
  • 10,164 View
  • 186 Download
  • 6 Web of Science
  • 7 Crossref

Bone Biology and Osteoporosis Special Issue

The Combined Effects of RhBMP-2 and Systemic RANKL Inhibitor in Patients With Bone Density Loss Undergoing Posterior Lumbar Interbody Fusion: A Retrospective Observational Analysis With Propensity Score Matching
Seungjun Ryu, Seon-Jin Yoon, Chang Kyu Lee, Seong Yi, Keung-Nyun Kim, Yoon Ha, Dong Ah Shin
Neurospine 2023;20(4):1186-1192.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2346702.351

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The Combined Effects of RhBMP-2 and Systemic RANKL Inhibitor in Patients With Bone Density Loss Undergoing Posterior Lumbar Interbody Fusion: A Retrospective Observational Analysis With Propensity Score Matching
Neurospine. 2023;20(4):1186-1192.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2346702.351
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The Combined Effects of RhBMP-2 and Systemic RANKL Inhibitor in Patients With Bone Density Loss Undergoing Posterior Lumbar Interbody Fusion: A Retrospective Observational Analysis With Propensity Score Matching
Neurospine. 2023;20(4):1186-1192.   Published online December 31, 2023
DOI: https://doi.org/10.14245/ns.2346702.351
Close
Objective
The risks of nonunion and subsidence are high in patients with bone density loss undergoing spinal fusion surgery. The internal application of recombinant human bone morphogenic protein 2 (rhBMP-2) in an interbody cage improves spinal fusion; however, related complications have been reported. Denosumab, a human monoclonal antibody targeting the receptor activator of nuclear factor kappa B ligand (RANKL), hinders osteoblast differentiation and function. Therefore, this study aimed to observe the combined effect of the local application of rhBMP-2 in a lumbar cage and systemic RANKL inhibition on postoperative spinal fusion in patients with bone density loss undergoing posterior lumbar interbody fusion (PLIF).
Methods
This retrospective observational study included 251 consecutive patients with spinal stenosis who underwent PLIF at a single center between 2017 and 2021. Clinical outcomes were assessed, and radiographic evaluations included lumbar flexion, extension, range of motion, and subsidence. Statistical analyses were conducted to identify the combined effect of the treatment and the subsidence and spinal fusion status.
Results
One hundred patients were included in the final analysis. Denosumab treatment significantly reduced the rate of osteolysis (p = 0.013). When denosumab was administered in combination with rhBMP-2, the fusion status remained similar; however, the incidences of postoperative osteolysis and postoperative oozing day decreased.
Conclusion
The combined use of rhBMP-2 and RANKL inhibition in patients with bone density loss can enhance bone formation after PLIF with fewer complications than rhBMP-2 alone.

Citations

Citations to this article as recorded by  Crossref logo
  • Postoperative bone loss after posterior lumbar interbody fusion is a risk factor of cage subsidence independently of preoperative CT-derived attenuation: a retrospective study based on hounsfield unit
    Yunsheng Wang, Ruiling Wang, Tong Tong, Dechao Miao, Feng Wang, Linfeng Wang
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • Histomorphologic Assessment of Osteoregeneration in a Rabbit Femur Model With Xenograft, Bone Morphogenetic Protein-2, Platelet-Rich Plasma, and Denosumab
    Berik Tuleubayev, Yevgeniy Kamyshanskiy, Yerkin-Dauir Kurmangaliyev, Amina Koshanova, Ivan Avromidi, Yekaterina Kossilova, Daryn Darybayev
    Plastic and Reconstructive Surgery - Global Open.2026; 14(4): e7593.     CrossRef
  • Comparable Fusion Response, but Increased Inflammatory Response, with Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2 in Posterior Lumbar Interbody Fusion Surgery
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    Journal of Clinical Medicine.2026; 15(11): 4026.     CrossRef
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    Global Spine Journal.2025; 15(4): 2226.     CrossRef
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Three-Dimensional Quantitative Assessment of Pedicle Screw Accuracy in Clinical Utilization of a New Robotic System in Spine Surgery: A Multicenter Study
Byeong-Jin Ha, Jong-Min Lee, Seon-Jin Yoon, Byung-Kwan Kim, Junseok Lee, Suhun Lee, Seungjae Ryu, Yongyeob Cha, Sungteac Hwang, Donggi Woo, Chang Kyu Lee, Dong Ah Shin, Yoon Ha, Sung Uk Kuh, Keung Nyun Kim, Dongwuk Son, Seong Yi
Neurospine 2023;20(3):1028-1039.   Published online September 30, 2023
DOI: https://doi.org/10.14245/ns.2346552.276

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Three-Dimensional Quantitative Assessment of Pedicle Screw Accuracy in Clinical Utilization of a New Robotic System in Spine Surgery: A Multicenter Study
Neurospine. 2023;20(3):1028-1039.   Published online September 30, 2023
DOI: https://doi.org/10.14245/ns.2346552.276
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Three-Dimensional Quantitative Assessment of Pedicle Screw Accuracy in Clinical Utilization of a New Robotic System in Spine Surgery: A Multicenter Study
Neurospine. 2023;20(3):1028-1039.   Published online September 30, 2023
DOI: https://doi.org/10.14245/ns.2346552.276
Close
Objective
The objective of this study was to evaluate the accuracy of pedicle screw placement in patients undergoing percutaneous pedicle screw fixation with robotic guidance, using a newly developed 3-dimensional quantitative measurement system. The study also aimed to assess the clinical feasibility of the robotic system in the field of spinal surgery.
Methods
A total of 113 patients underwent pedicle screw insertion using the CUVIS-spine pedicle screw guide system (CUREXO Inc.). Intraoperative O-arm images were obtained, and screw insertion pathways were planned accordingly. Image registration was performed using paired-point registration and iterative closest point methods. The accuracy of the robotic-guided pedicle screw insertion was assessed using 3-dimensional offset calculation and the Gertzbein-Robbins system (GRS).
Results
A total of 448 screws were inserted in the 113 patients. The image registration success rate was 95.16%. The average error of entry offset was 2.86 mm, target offset was 2.48 mm, depth offset was 1.99 mm, and angular offset was 3.07°. According to the GRS grading system, 88.39% of the screws were classified as grade A, 9.60% as grade B, 1.56% as grade C, 0.22% as grade D, and 0.22% as grade E. Clinically acceptable screws (GRS grade A or B) accounted for 97.54% of the total, with no reported neurologic complications.
Conclusion
Our study demonstrated that pedicle screw insertion using the novel robot-assisted navigation method is both accurate and safe. Further prospective studies are necessary to explore the potential benefits of this robot-assisted technique in comparison to conventional approaches.

Citations

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  • Evaluation of pedicle screw accuracy and deviation from preoperative planning in intraoperative Cone-Beam Computed Tomography-Navigated lumbar spinal fusion: a prospective study
    Gianluca Vadalà, Giuseppe Francesco Papalia, Niccolò Nardi, Fabrizio Russo, Luca Ambrosio, Girolamo Maltese, Rocco Papalia, Vincenzo Denaro
    Brain and Spine.2026; 6: 105988.     CrossRef
  • Combining Engineering Precision with Clinical Relevance: A Novel Dual Framework for Assessing Pedicle Screw Accuracy in Spine Surgery
    Arnaud Delafontaine, Olivier Cartiaux, Bernard G. Francq, Virginie Cordemans
    Journal of Clinical Medicine.2026; 15(6): 2328.     CrossRef
  • A comprehensive framework for planning pedicle screw trajectory using ANTs template-based registration approach
    Hang Phuong Nguyen, Suk-Joong Lee, Sungmin Kim
    European Spine Journal.2026;[Epub]     CrossRef
  • Robotic Spine Surgery: Systematic Review of Common Error Types and Best Practices
    Diwas Gautam, Sheela Vivekanandan, Marcus D. Mazur
    Operative Neurosurgery.2025; 28(3): 295.     CrossRef
  • Advancements in robotic-assisted spine surgery: A literature review and technology comparison
    Jonathan Hammond, Stefano Priola
    Interdisciplinary Neurosurgery.2025; 40: 102056.     CrossRef
  • Robotic-Guided Spine Surgery: Implementation of a System in Routine Clinical Practice—An Update
    Mirza Pojskić, Miriam Bopp, Omar Alwakaa, Christopher Nimsky, Benjamin Saß
    Journal of Clinical Medicine.2025; 14(13): 4463.     CrossRef
  • Evaluating accuracy in robotic-assisted thoracolumbar pedicle screw placement: Insights from a single-center study of 410 patients
    Abhishek Soni, Vidyadhara Srinivasa, Akhil Xavier Joseph, Balamurugan Thirugnanam, Alia Vidyadhara
    Journal of Craniovertebral Junction and Spine.2025; 16(4): 408.     CrossRef
  • Robotic-Assisted Spine Surgery: Role in Training the Next Generation of Spine Surgeons
    Jun Seok Lee, Dong Wuk Son, Su Hun Lee, Jong Hyeok Lee, Young Ha Kim, Sang Weon Lee, Bu Kwang Oh, Soon Ki Sung, Geun Sung Song, Seong Yi
    Neurospine.2024; 21(1): 116.     CrossRef
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    Seong Yi
    Neurospine.2024; 21(1): 3.     CrossRef
  • Navigation-Guided/Robot-Assisted Spinal Surgery: A Review Article
    Young-Seok Lee, Dae-Chul Cho, Kyoung-Tae Kim
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  • Fully automated determination of robotic pedicle screw accuracy and precision utilizing computer vision algorithms
    Benjamin N. Groisser, Ankush Thakur, Howard J. Hillstrom, Akshitha Adhiyaman, Colson Zucker, Jerry Du, Matthew Cunningham, M. Timothy Hresko, Ram Haddas, John Blanco, Hollis G. Potter, Douglas N. Mintz, Ryan E. Breighner, Jessica H. Heyer, Roger F. Widman
    Journal of Robotic Surgery.2024;[Epub]     CrossRef
  • 11,195 View
  • 237 Download
  • 14 Web of Science
  • 11 Crossref

Commentary

To Be Trustworthy, the Robot Assisted Cervical Spine Surgery Needs More Than Accuracy Beyond Technological Limitations: Commentary on “Robotics in Cervical Spine Surgery: Feasibility and Safety of Posterior Screw Placement”
Seong Yi
Neurospine 2023;20(2):725-727.   Published online June 30, 2023
DOI: https://doi.org/10.14245/ns.2346460.230

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To Be Trustworthy, the Robot Assisted Cervical Spine Surgery Needs More Than Accuracy Beyond Technological Limitations: Commentary on “Robotics in Cervical Spine Surgery: Feasibility and Safety of Posterior Screw Placement”
Neurospine. 2023;20(2):725-727.   Published online June 30, 2023
DOI: https://doi.org/10.14245/ns.2346460.230
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To Be Trustworthy, the Robot Assisted Cervical Spine Surgery Needs More Than Accuracy Beyond Technological Limitations: Commentary on “Robotics in Cervical Spine Surgery: Feasibility and Safety of Posterior Screw Placement”
Neurospine. 2023;20(2):725-727.   Published online June 30, 2023
DOI: https://doi.org/10.14245/ns.2346460.230
Close

Citations

Citations to this article as recorded by  Crossref logo
  • Safety and Accuracy of Robot-Assisted Cervical Screw Placement: A Systematic Review and Meta-Analysis
    Jing Peng, Qiang Li, Xuejun Zhang, Jiaheng Li, Song Wan, Shuangqi Yu, Wei Chen, Dong Chen, Fan Ding
    World Neurosurgery.2024; 181: e163.     CrossRef
  • 5,304 View
  • 160 Download
  • 1 Web of Science
  • 1 Crossref

Review Article

Surgical Strategies for Cervical Deformities Associated With Neuromuscular Disorders
Jong Joo Lee, Sung Han Oh, Yeong Ha Jeong, Sang Man Park, Hyeong Seok Jeon, Hyung-Cheol Kim, Seong Bae An, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Do Heum Yoon, Jun Jae Shin, Yoon Ha
Neurospine 2020;17(3):513-524.   Published online September 30, 2020
DOI: https://doi.org/10.14245/ns.2040464.232

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Surgical Strategies for Cervical Deformities Associated With Neuromuscular Disorders
Neurospine. 2020;17(3):513-524.   Published online September 30, 2020
DOI: https://doi.org/10.14245/ns.2040464.232
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Surgical Strategies for Cervical Deformities Associated With Neuromuscular Disorders
Neurospine. 2020;17(3):513-524.   Published online September 30, 2020
DOI: https://doi.org/10.14245/ns.2040464.232
Close
Neuromuscular disorders (NMDs) are diseases involving the upper and lower motor neurons and muscles. In patients with NMDs, cervical spinal deformities are a very common issue; however, unlike thoracolumbar spinal deformities, few studies have investigated these disorders. The patients with NMDs have irregular spinal curvature caused by poor balance and poor coordination of their head, neck, and trunk. Particularly, cervical deformity occurs at younger age, and is known to show more rigid and severe curvature at high cervical levels. Muscular physiologic dynamic characteristics such as spasticity or dystonia combined with static structural factors such as curvature flexibility can result in deformity and often lead to traumatic spinal cord injury. In addition, postoperative complication rate is higher due to abnormal involuntary movement and muscle tone. Therefore, it is important to control abnormal involuntary movement perioperatively along with strong instrumentation for correction of deformity. Various methods such as botulinum toxin injection, physical therapy, muscle division technique, or intrathecal baclofen pump implant may help control abnormal involuntary movements and improve spinal stability. Surgical management for cervical deformities associated with NMDs requires a multidisciplinary effort and a customized strategy.

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  • Perioperative opioid-minimization approach as a useful protocol in the management of patients with Ehlers–Danlos syndrome-hypermobility type, craniocervical instability and severe chronic pain who are to undergo occipito-cervical fixation
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    Michael Folse, Ryan Diaz, Racheal Peterson, Jamie Toms
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    Hak Sun Kim, Ji Won Kwon, Kun-Bo Park
    Neurospine.2022; 19(1): 177.     CrossRef
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    Hyung Cheol Kim, Sung Han Oh, Jae Keun Oh, Yoon Ha
    Neurospine.2022; 19(4): 868.     CrossRef
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    Akinori Tani, Sumito Kinjo, Keisuke Ito, Yohei Ishimine, Yoshiro Musha
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    Michael Vitale, Benjamin Roye, Zachary Bloom, Jennifer A. Kunes, Hiroko Matsumoto, David Roye, David Farrington, Jack Flynn, Matthew Halanski, Carol Hasler, Lotfi Miladi, Susana Quijano-Roy, Christopher Reilly, Paul Sponseller, Muharrem Yazici, Brian Snyd
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    Fahri Eryilmaz , Faheem Ahmed, Asim K Rehmani, Sundas Karimi, Aamna Qazi, Sufyan Mustafa, Arif Zulfiqar, Zubia Nadeem, Ayyaz A Sultan, Umar Farooque
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    Hyung Cheol Kim, Hyeongseok Jeon, Yeong Ha Jeong, Sangman Park, Seong Bae An, Jeong Hyun Heo, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Yoon Ha, Sung-Rae Cho
    Journal of Korean Neurosurgical Society.2021; 64(5): 808.     CrossRef
  • 12,719 View
  • 219 Download
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Original Articles

Epidemiology of C5 Palsy after Cervical Spine Surgery: A 21-Center Study
Jae Keun Oh, Jae Taek Hong, Dong Ho Kang, Sang-Woo Kim, Seok Won Kim, Young Jin Kim, Chun Kee Chung, Jun Jae Shin, Seong Yi, Jung Kil Lee, Jun Ho Lee, Chang-Hyun Lee, Ho Jin Lee, Hyoung-Joon Chun, Dae-Chul Cho, Yong Eun Cho, Yong Jun Jin, Kyung-Chul Choi, In Ho Han, Seung-Jae Hyun, Jung-Woo Hur, Ki-Jeong Kim
Neurospine 2019;16(3):558-562.   Published online September 30, 2019
DOI: https://doi.org/10.14245/ns.1938142.071

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Epidemiology of C5 Palsy after Cervical Spine Surgery: A 21-Center Study
Neurospine. 2019;16(3):558-562.   Published online September 30, 2019
DOI: https://doi.org/10.14245/ns.1938142.071
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Epidemiology of C5 Palsy after Cervical Spine Surgery: A 21-Center Study
Neurospine. 2019;16(3):558-562.   Published online September 30, 2019
DOI: https://doi.org/10.14245/ns.1938142.071
Close
Objective
C5 palsy is a severe complication after cervical spine surgery, the pathophysiology of which remains unclear. This multicenter study investigated the incidence of C5 palsy following cervical spine surgery in Korea.
Methods
We conducted a retrospective multicenter study involving 21 centers from the Korean Cervical Spine Study Group. The inclusion criteria were cervical spine surgery patients between 2012 and 2016, excluding cases of neck surgery. In patients with C5 palsy, the operative methods, disease category, onset time of C5 palsy, recovery time, C5 manual muscle testing (MMT) grade, and post-C5 palsy management were analyzed.
Results
We collected 15,097 cervical spine surgery cases from 21 centers. C5 palsy occurred in 88 cases (0.58%). C5 palsy was more common in male patients (p=0.019) and after posterior approach procedures (p<0.001). C5 palsy usually occurred within 3 days after surgery (77 of 88, 87.5%) and most C5 palsy patients recovered within 6 months (51 of 88, 57.95%). Thirty C5 palsy patients (34.09%) had motor weakness, with an MMT grade≤2. Only four C5 palsy patients (4.5%) did not recover during follow-up. Posterior cervical foraminotomy was performed in 7 cases (7.95%), and steroids were used in 56 cases (63.63%). Twenty-six cases (29.55%) underwent close observation only.
Conclusion
The overall incidence of C5 palsy was relatively low (0.58%). C5 palsy was more common after posterior cervical surgery and in male patients. C5 palsy usually developed within 3 days after surgery, and more than half of patients with C5 palsy recovered within 6 months.

Citations

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  • Risk Factors and Clinical Outcomes of Perioperative Complications Following Cervical Spine Surgery
    Narihito Nagoshi, Junichi Yamane, Toshiki Okubo, Yosuke Horiuchi, Yasuhiro Kamata, Norihiro Isogai, Hitoshi Kono, Yoshiomi Kobayashi, Reo Shibata, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
    Global Spine Journal.2026; 16(6): 2671.     CrossRef
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    Nienke A. Krijnen, Alexander J. Comerci, Christopher J. Fedor, Hamid Alahmari, James C. Bayley, Teun Teunis
    The Spine Journal.2026; 26(5): 853.     CrossRef
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    Mingzhu Huang, Kang Chen, Yujin Zhang, Lanxin Zhang, Changyu Liu, Xuan Liu, Xiangzhuo Liu, Ningyuan Li, Ying Lu, Mingjiang Luo, Zhihong Xiao, Liquan Li
    Neurosurgical Review.2026;[Epub]     CrossRef
  • C5 Palsy After Cervical Decompression: A 10-Year Single-Institution Study Highlighting Early Onset, High Bilaterality, and Poor Recovery
    Sargunan B, Vishnu Prasath, Karthik Sudhakar, Thomas John
    Cureus.2026;[Epub]     CrossRef
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    Wesley Manz, Sameer Khawaja, Corey Spencer, Dale Segal, Zach Grabel, Doug Weinberg, Eli Garrard, John Rhee
    Asian Spine Journal.2026; 20(1): 34.     CrossRef
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    Satoru Egawa, Takashi Hirai, Kenichiro Sakai, Kazuo Kusano, Shunji Tsutsui, Yu Matsukura, Kentaro Yamada, Hiroaki Onuma, Kanichiro Wada, Keiichi Katsumi, Masao Koda, Atsushi Kimura, Takeo Furuya, Satoshi Maki, Norihiro Nishida, Yukitaka Nagamoto, Yasushi
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    Jonathan Dalton, Rachel Huang, Michael Carter, Robert J. Oris, Joydeep Baidya, Joshua Mathew, Rajkishen Narayanan, Andrew Kim, Sebastian Fras, Jonah Blas, Anthony LaBarbiera, Matthew Ruiz, Evgeniy Uvarov, Keyur Patel, Mark F. Kurd, Ian David Kaye, Jose A.
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    Yusuke Nakamura, Sohei Murata, Taisuke Yabe, Hiromu Ito
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    Laura Ganau, So Kato, Zheqing Zhang, Gianfranco K.I. Ligarotti, Michael G. Fehlings, Mario Ganau
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    Haoteng Chen, Fei Liu, Shiyu Zhuo, Yuanxiang Lin, Changzhen Jiang, Tong Zhao
    BMC Surgery.2026;[Epub]     CrossRef
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    Joseph N. Frazzetta, Nathan Pecoraro, Ignacio Jusue-Torres, Paul M. Arnold, Ryan Hofler, G. Alexander Jones, Russ Nockels
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    Thomas Falconiero, Anthony Viola, Mark LaGreca, Caleb M. Yeung, Jeffrey Rihn
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    Gregory Toci, Jonathan Dalton, Rachel Huang, Michael Carter, Robert J. Oris, Rajkishen Narayanan, Andrew Kim, Julienne Jeong, Brady Stallman, Kenneth McCall, Mark F. Kurd, Ian D. Kaye, Barrett I. Woods, Jeffrey A. Rihn, Jose A. Canseco, Alan S. Hilibrand,
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    Konstantinos Zygogiannis, Pavlos Gerasimidis, Spyridon Komaitis, Savvas Moschos, Georgios C Thivaios, Aikaterini Tsatsaragkou, Dimitrios Koulalis
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    Seungyoon Paik, Yunhee Choi, Chun Kee Chung, Young Il Won, Sung Bae Park, Seung Heon Yang, Chang-Hyun Lee, John Min Rhee, Kyoung-Tae Kim, Chi Heon Kim, Thamer Hamdan
    PLOS ONE.2023; 18(2): e0281926.     CrossRef
  • Posterior Preventive Foraminotomy before Laminectomy Combined with Pedicle Screw Fixation May Decrease the Incidence of C5 Palsy in Complex Cervical Spine Surgery in Patients with Severe Myeloradiculopathy
    Yong-Ho Lee, Mahmoud Abdou, Ji-Won Kwon, Kyung-Soo Suk, Seong-Hwan Moon, You-Gun Won, Tae-Jin Lee, Byung-Ho Lee
    Journal of Clinical Medicine.2023; 12(6): 2227.     CrossRef
  • Clinical Spectrum of Postsurgical Parsonage-Turner Syndrome: A Perspective From an Electrodiagnostic Laboratory
    Vasudeva G Iyer, Lisa B Shields, Yi Ping Zhang, Christopher B Shields
    Cureus.2023;[Epub]     CrossRef
  • Bilateral phrenic nerve palsy after posterior cervical decompression and fusion surgery: a rare event after surgery
    Glenn A. Gonzalez, Jingya Miao, Guilherme Porto, James Harrop
    Spinal Cord Series and Cases.2023;[Epub]     CrossRef
  • Progress of C5 Nerve Root Palsy after Open-Door Cervical Expansive Laminoplasty
    ·阿不力肯 阿不都沙拉木
    Advances in Clinical Medicine.2023; 13(10): 16813.     CrossRef
  • Management of Cerebrospinal Fluid Leakage by Pump-Regulated Volumetric Continuous Lumbar Drainage Following Anterior Cervical Decompression and Fusion for Ossification of the Posterior Longitudinal Ligament
    Sun Woo Jang, Sang Hyub Lee, Hong Kyung Shin, Sang Ryong Jeon, Sung Woo Roh, Jin Hoon Park
    Neurospine.2023; 20(4): 1421.     CrossRef
  • A Novel Method of Making Hinges Using a Newly Designed Sharp Rongeur to Enhance Radiological and Clinical Outcomes in French‐Door Cervical Expansive Laminoplasty
    Ningning Chen, Lanzhe Yu, Xizhe Liu, Guoliang Chen, Yanrun Li, Xuenong Zou, Dacheng He, Jiaming Yang, Shangbin Cui, Le Wang, Shaoyu Liu, Fuxin Wei
    Orthopaedic Surgery.2022; 14(12): 3349.     CrossRef
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    Nachiket Deshpande, Amro M. Stino, Brandon W. Smith, Ann A. Little, Lynda J. S. Yang, Paul Park, Yamaan S. Saadeh
    Journal of Neurosurgery: Spine.2022; : 1.     CrossRef
  • Use of electromyography to predict likelihood of recovery following C5 palsy after posterior cervical spine surgery
    Daniel Lubelski, Zach Pennington, Ryan F. Planchard, Ahmet Hoke, Nicholas Theodore, Daniel M. Sciubba, Allan J. Belzberg
    The Spine Journal.2021; 21(3): 387.     CrossRef
  • A modified cutting line in the single-door cervical laminoplasty via a computed tomography-based morphological study of the subaxial cervical spine
    Guoliang Chen, Weicheng Huang, Mengxian Jia, Jiajin Lin, Yadong Sheng, Chaowei Lin, Kelun Huang, Honglin Teng
    Clinical Neurology and Neurosurgery.2021; 200: 106384.     CrossRef
  • A new nomenclature system for the surgical treatment of cervical spine deformity, developing, and validation of SOF system
    Jae Taek Hong, Heiko Koller, Kuniyoshi Abumi, Wen Yuan, Asdrubal Falavigna, Ho Jin Lee, Jong Beom Lee, Jean-Charles Le Huec, Jong-Hyeok Park, Il Sup Kim
    European Spine Journal.2021; 30(6): 1670.     CrossRef
  • C5 palsy after cervical laminectomy: natural history in a 10-year series
    Ryan C. Hofler, Joseph Frazzetta, Jehad Zakaria, Amany Aziz, William Adams, G. Alexander Jones
    The Spine Journal.2021; 21(9): 1473.     CrossRef
  • Preoperative Radiological Parameters to Predict Clinical and Radiological Outcomes after Laminoplasty
    Su Hun Lee, Dong Wuk Son, Jun Jae Shin, Yoon Ha, Geun Sung Song, Jun Seok Lee, Sang Weon Lee
    Journal of Korean Neurosurgical Society.2021; 64(5): 677.     CrossRef
  • Phrenic nerve palsy after cervical laminectomy and fusion
    Andrew S. Moon, Jeffrey M. Pearson, Jason L. Pittman
    North American Spine Society Journal (NASSJ).2020; 4: 100022.     CrossRef
  • 27,548 View
  • 478 Download
  • 33 Web of Science
  • 36 Crossref

APCSS special Topic-Craniovertebral Junction Surgery

Independent Correlation of the C1–2 Cobb Angle With Patient-Reported Outcomes After Correcting Chronic Atlantoaxial Instability
Zhimin Pan, Yanhai Xi, Wei Huang, Keung Nyun Kim, Seong Yi, Dong Ah Shin, Kai Huang, Yu Chen, Zhongren Huang, Da He, Yoon Ha
Neurospine 2019;16(2):267-276.   Published online June 30, 2019
DOI: https://doi.org/10.14245/ns.1836268.134

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Independent Correlation of the C1–2 Cobb Angle With Patient-Reported Outcomes After Correcting Chronic Atlantoaxial Instability
Neurospine. 2019;16(2):267-276.   Published online June 30, 2019
DOI: https://doi.org/10.14245/ns.1836268.134
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Independent Correlation of the C1–2 Cobb Angle With Patient-Reported Outcomes After Correcting Chronic Atlantoaxial Instability
Neurospine. 2019;16(2):267-276.   Published online June 30, 2019
DOI: https://doi.org/10.14245/ns.1836268.134
Close
Objective
To investigate three-planar radiographic results and patient-reported outcomes (PROs) after correcting chronic atlantoaxial instability (AAI) by translaminar screw (TLS) and pedicle screw (PS) fixation, and to explore the potential association of atlantoaxial realignment with PRO improvements.
Methods
Twenty-three patients who underwent C1 lateral mass screw (LMS)-C2 TLS and 29 who underwent C1 LMS-C2 PS with ≥ 2 years of follow-up were retrospectively analyzed. Three-planar (sagittal, coronal, and axial) radiographic parameters were measured. PROs including the Neck Disability Index (NDI), Japanese Orthopaedic Association (JOA) score and the Short Form 36 Physical Component Summary (SF-36 PCS) were documented. Factors potentially associated with PROs were identified.
Results
The radiographic parameters significantly changed postoperatively except the C1–2 midlines’ intersection angle in the TLS group (p = 0.073) and posterior atlanto-dens interval in both groups (p = 0.283, p = 0.271, respectively). The difference in bilateral odontoid lateral mass interspaces at last follow-up was better corrected in the TLS group than in the PS group (p = 0.010). Postoperative PROs had significantly improved in both groups (all p < 0.05). Thereinto, NDI at last follow-up was significantly lower in the TLS group compared with PS group (p = 0.013). In addition, blood loss and operative time were obviously lesser in TLS group compared with PS group (p = 0.010, p = 0.004, respectively). Multivariable regression analysis revealed that a change in C1–2 Cobb angle was independently correlated to PROs improvement (NDI: β = -0.435, p = 0.003; JOA score: β = 0.111, p = 0.033; SF-36 PCS: β = 1.013, p = 0.024, respectively), also age ≤ 40 years was independently associated with NDI (β = 5.40, p = 0.002).
Conclusion
Three-planar AAI should be reconstructed by C1 LMS-C2 PS fixation, while sagittal or coronal AAI could be corrected by C1 LMS-C2 TLS fixation. PROs may improve after atlantoaxial reconstruction in patients with chronic AAI. The C1–2 Cobb angle is an independent predictor of PROs after correcting chronic AAI, as is age ≤ 40 years for postoperative NDI.

Citations

Citations to this article as recorded by  Crossref logo
  • Mobility Assessment Using Multi-Positional MRI in Children with Cranio-Vertebral Junction Anomalies
    Flavie Grenier-Chartrand, Maxime Taverne, Syril James, Lelio Guida, Giovanna Paternoster, Klervie Loiselet, Kevin Beccaria, Volodia Dangouloff-Ros, Raphaël Levy, Timothée de Saint Denis, Thomas Blauwblomme, Roman Hossein Khonsari, Nathalie Boddaert, Sandr
    Journal of Clinical Medicine.2023; 12(21): 6714.     CrossRef
  • Reciprocal Changes in the Whole-Body Following Realignment Surgery in Adult Spinal Deformity
    Jae-Koo Lee, Seung-Jae Hyun, Ki-Jeong Kim
    Asian Spine Journal.2022; 16(6): 958.     CrossRef
  • Reciprocal Changes Following Cervical Realignment Surgery
    Jae-Koo Lee, Seung-Jae Hyun, Seung Heon Yang, Ki-Jeong Kim
    Neurospine.2022; 19(4): 853.     CrossRef
  • Modification of Wright’s Technique for C2 Translaminar Screws Based on Medical Imaging Analysis
    Dong-Dong Xia, Shu-Meng Huang, Jian-Le Wang, Xiang-Xiang Pan, Mei-Jun Yan, Chi Zhang, Bai-Wen Hu, Cui Wang, Xiang-Yang Wang
    Journal of Medical Imaging and Health Informatics.2021; 11(8): 2097.     CrossRef
  • Regional Anesthesia for Lumbar Spine Surgery: Can It Be a Standard in the Future?
    Jae-Koo Lee, Jong Hwa Park, Seung-Jae Hyun, Daniel Hodel, Oliver N. Hausmann
    Neurospine.2021; 18(4): 733.     CrossRef
  • Surgical Impact on Global Sagittal Alignment and Health-Related Quality of Life Following Cervical Kyphosis Correction Surgery: Systematic Review
    Chang-Wook Kim, Seung-Jae Hyun, Ki-Jeong Kim
    Neurospine.2020; 17(3): 497.     CrossRef
  • 11,416 View
  • 175 Download
  • 6 Web of Science
  • 6 Crossref

Clinical Article

Efficacy and Safety of Sodium Hyaluronate with 1,4-Butanediol Diglycidyl Ether Compared to Sodium Carboxymethylcellulose in Preventing Adhesion Formation after Lumbar Discectomy
Gyu Yeul Ji, Chang Hyun Oh, Byung Gwan Moon, Seong Yi, In Bo Han, Dong Hwa Heo, Ki-Tack Kim, Dong Ah Shin, Keung Nyun Kim
Korean J Spine 2015;12(2):41-47.   Published online June 30, 2015
DOI: https://doi.org/10.14245/kjs.2015.12.2.41

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Efficacy and Safety of Sodium Hyaluronate with 1,4-Butanediol Diglycidyl Ether Compared to Sodium Carboxymethylcellulose in Preventing Adhesion Formation after Lumbar Discectomy
Korean J Spine. 2015;12(2):41-47.   Published online June 30, 2015
DOI: https://doi.org/10.14245/kjs.2015.12.2.41
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Efficacy and Safety of Sodium Hyaluronate with 1,4-Butanediol Diglycidyl Ether Compared to Sodium Carboxymethylcellulose in Preventing Adhesion Formation after Lumbar Discectomy
Korean J Spine. 2015;12(2):41-47.   Published online June 30, 2015
DOI: https://doi.org/10.14245/kjs.2015.12.2.41
Close
Objective

Epidural injection of hyaluronic acid may prevent adhesion formation after spine surgery, but the compounds used to stabilize hyaluronidase could interfere with its anti-adhesion effects. The present study was conducted as a clinical trial to evaluate the efficacy and safety of an experimental medical gel in preventing adhesion formation.

Methods

This study was designed as a multicenter, randomized, double-blind, and comparative controlled clinical trial with an observation period of 6 weeks. Subjects were randomly assigned into two groups: group A with sodium hyaluronate + 1,4-butanediol diglycidyl ether (BDDE) and group B with sodium hyaluronate + sodium carboxymethylcellulose (CMC). Visual analogue scale (VAS) of back and leg pain and the Oswestry disability index (ODI) and scar score ratings were assessed after surgery.

Results

Mean scar grade was 2.37±1.13 in group A and 2.75±0.97 in group B, a statistically significant difference (p=0.012). VAS of back and leg pain and ODI scores decreased significantly from baseline to 3 and 6 weeks postoperatively in both groups (p<0.001). However, VAS and ODI scores were not statistically different between groups A and B at baseline or at 3 and 6 weeks after operation (p>0.3). The number of adverse reactions related to the anti-adhesion gels was not statistically different (p=0.569), but subsequent analysis of nervous adverse reactions showed group B was superior with a statistically difference (p=0.027).

Conclusion

Sodium hyaluronate with BDDE demonstrated similar anti-adhesion properties to sodium hyaluronate with CMC. But, care should be used to nervous adverse reactions by using sodium hyaluronate with BDDE.

Citations

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  • Are We Overlooking Harms of BDDE-Cross-Linked Dermal Fillers? A Scoping Review
    Marta Wojtkiewicz, Albert Stachura, Bartłomiej Roszkowski, Natalia Winiarska, Karolina Kazimierska, Kamilla Stachura
    Aesthetic Plastic Surgery.2024; 48(23): 5147.     CrossRef
  • Evaluation of the optimal dose for maximizing the anti-adhesion performance of a self-degradable dextran-based material
    Woogi Hyon, Suong-Hyu Hyon, Kazuaki Matsumura
    Carbohydrate Polymer Technologies and Applications.2022; 4: 100255.     CrossRef
  • MORPHOLOGICAL PATTERNS OF DEVELOPMENT AND PREVENTION OF EXPERIMENTAL EPIDURAL FIBROSIS
    I.A. SHURYGINA, A.P. ZHIVOTENKO, O.A. GOLDBERG, V.A. SOROKOVIKOV
    AVICENNA BULLETIN.2022; 24(2): 176.     CrossRef
  • Therapeutic niche of hyaluronic acid derivatives in osteoarthritis
    I. G. Krasivina, L. N. Dolgova, N. V. Dolgov
    Meditsinskiy sovet = Medical Council.2021; (10): 123.     CrossRef
  • Using cross-linked hyaluronic acid gel to prevent postoperative lumbar epidural space adhesion: in vitro and in vivo studies
    Kun Wang, Xiao long Li, Jinbo Liu, Xiaoliang Sun, Huilin Yang, Xin Gao
    European Spine Journal.2020; 29(1): 129.     CrossRef
  • Antiadhesion effect of the C17 glycerin ester of isoprenoid-type lipid forming a nonlamellar liquid crystal
    Takahide Murakami, Ichiro Hijikuro, Kota Yamashita, Shigeru Tsunoda, Kenjiro Hirai, Takahisa Suzuki, Yoshiharu Sakai, Yasuhiko Tabata
    Acta Biomaterialia.2019; 84: 257.     CrossRef
  • Advances in biomaterials for preventing tissue adhesion
    Wei Wu, Ruoyu Cheng, José das Neves, Jincheng Tang, Junyuan Xiao, Qing Ni, Xinnong Liu, Guoqing Pan, Dechun Li, Wenguo Cui, Bruno Sarmento
    Journal of Controlled Release.2017; 261: 318.     CrossRef
  • Efficacy of hyaluronic acid and hydroxyethyl starch in preventing adhesion following endoscopic sinus surgery
    Su-Jong Kim, Jae-Min Shin, Eun Jung Lee, Il-Ho Park, Heung-Man Lee, Kyung-Su Kim
    European Archives of Oto-Rhino-Laryngology.2017; 274(10): 3643.     CrossRef
  • A glance at … dietary emulsifiers, the human intestinal mucus and microbiome, and dietary fiber
    Michael J. Glade, Michael M. Meguid
    Nutrition.2016; 32(5): 609.     CrossRef
  • Dual crosslinked hyaluronic acid nanofibrous membranes for prolonged prevention of post-surgical peritoneal adhesion
    Chialin Sheu, K. T. Shalumon, Chih-Hao Chen, Chang-Yi Kuo, Yi Teng Fong, Jyh-Ping Chen
    Journal of Materials Chemistry B.2016; 4(41): 6680.     CrossRef
  • 12,533 View
  • 158 Download
  • 10 Crossref

Original Articles

Surgical Outcomes of Spine Disorders in Patients with Parkinson's Disease.
Sang Hyuk Park, Jae Keun Oh, Tae Yup Kim, Eui Hyun Kim, Hyo Sang Lee, Nam Gyu Yu, Gwi Hyun Choi, Seong Yi, Yoon Ha, Do Heum Yoon, Keung Nyun Kim
Korean J Spine 2011;8(3):208-214.
DOI: https://doi.org/10.14245/kjs.2011.8.3.208

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Surgical Outcomes of Spine Disorders in Patients with Parkinson's Disease.
Korean J Spine. 2011;8(3):208-214.
DOI: https://doi.org/10.14245/kjs.2011.8.3.208
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Surgical Outcomes of Spine Disorders in Patients with Parkinson's Disease.
Korean J Spine. 2011;8(3):208-214.
DOI: https://doi.org/10.14245/kjs.2011.8.3.208
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PURPOSE
Patients with Parkinson's disease also commonly have movement disorders, osteoporosis, and other comorbidities. These patients are more likely to have complications after spinal surgery. The aim of the present study is to show the relation ship between complications of spinal surgery and Parkinson's disease.
METHODS
A computerized search using diagnostic and procedural codes identified 13 patients with Parkinson's disease who underwent spinal surgery between January 1998 and December 2010. Their medical records and imaging studies were reviewed and recent updatesfor all patients were done by telephone interview.
RESULTS
Retrospectively, 13 consecutive patients were reviewed. The mean age was 63.8 (range 44~87) years old and the mean durationof Parkinson's disease was 7.6 (range 1~22) years at the time of the index procedure. The mean T score of the lumbar spine on Dual-energy X-ray absorptiometry (DEXA) scan bone mineral density (BMD) was -2.5 (range -1.0~-5.1). These patients had nine lumbar lesions, two thoracic lesions, one cervical lesion, and one thoracolumbar lesion. Nine patients required no more surgical treatment for lesions which had been previously operated on (index level). However, four patients (30.8%) needed at least one more operation related to their index procedure; segmental degeneration on the adjacent levels in two, retropulsion of an intervertebral cage with screw loosening in one, and pedicle fracture in one.
CONCLUSION
It has been reported that patients with Parkinson's disease have high complication rates in spinal surgery. Spine surgeons should be aware of the risk of complications and need to conduct careful follow-up after the surgery.

Citations

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  • Morphogenetic Designs, and Disease Models in Central Nervous System Organoids
    Minsung Bock, Sung Jun Hong, Songzi Zhang, Yerin Yu, Somin Lee, Haeeun Shin, Byung Hyune Choi, Inbo Han
    International Journal of Molecular Sciences.2024; 25(14): 7750.     CrossRef
  • 7,079 View
  • 41 Download
  • 1 Crossref
Comparison of the Outcomes after Intralesional, Intracisternal, and Intravenous Transplantation of Human Bone Marrow Derived Mesenchymal Stem Cells for Spinal Cord Injured Rat.
Gwi Hyun Choi, Dong Ah Shin, Do Heum Yoon, Yoon Ha, Seong Yi, Keung Nyun Kim
Korean J Spine 2011;8(2):88-96.
DOI: https://doi.org/10.14245/kjs.2011.8.2.88

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Comparison of the Outcomes after Intralesional, Intracisternal, and Intravenous Transplantation of Human Bone Marrow Derived Mesenchymal Stem Cells for Spinal Cord Injured Rat.
Korean J Spine. 2011;8(2):88-96.
DOI: https://doi.org/10.14245/kjs.2011.8.2.88
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Comparison of the Outcomes after Intralesional, Intracisternal, and Intravenous Transplantation of Human Bone Marrow Derived Mesenchymal Stem Cells for Spinal Cord Injured Rat.
Korean J Spine. 2011;8(2):88-96.
DOI: https://doi.org/10.14245/kjs.2011.8.2.88
Close
OBJECTIVE
Mesenchymal stem cells (MSCs) have shown promise in potentially repairing injured spinal cord. These and similar cell types are being tested clinically, but the understanding about delivering method and subsequent results is lacking. This study was designed to compare the MSCs engraftment results after intralesional, intracisternal, or intravenous injection in a rat with spinal cord injury (SCI).
METHODS
A total of 48 male Sprague-Dawley rats (300-350 g in size) were used with 12 in each group. Allogenic MSCs were cultured from human bone marrow aspirates. The SCI was induced using an NYU (New York University) impactor and MSCs were transplanted 1 week after the SCI. Behavioral testing was performed weekly for 6 weeks. The recipients were analyzed histologically to evaluate the extent of cell delivery and survival at the injury site.
RESULTS
All three experimental groups showed better behavioral recovery compared with the control group since 6 weeks after stem cell injection (p<0.05). The intracisternal injection group showed the best functional improvement (p<0.05). The intralesional injection group showed the best engraftment until 4 weeks after stem cell injection (p<0.05). A number of the injected MSCs were trapped in the spleen in the intravenous injection group.
CONCLUSION
Transplantation of stem cells by a variety of routes can deliver cells with the potential to repair injured spinal cord. Intracisternal injection can easily be translated to patients after some modifications, thus accelerating clinical application of cell therapies.
  • 5,647 View
  • 30 Download

Case Report

Rapid Recurrence of Spinal Idiopathic Hypertrophic Pachymeningitis: A Case Report.
Hong June Choi, Do Heum Yoon, Dong Yeop Lee, Poong Gee Ahn, Moon Sool Yang, Seong Yi, Yoon Ha, Keung Nyun Kim, Se Hoon Kim, Dong Ah Shin
Korean J Spine 2008;5(3):211-214.

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Rapid Recurrence of Spinal Idiopathic Hypertrophic Pachymeningitis: A Case Report.
Korean J Spine. 2008;5(3):211-214.
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Rapid Recurrence of Spinal Idiopathic Hypertrophic Pachymeningitis: A Case Report.
Korean J Spine. 2008;5(3):211-214.
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Idiopathic hypertrophic pachymeningitis is a rare inflammatory disorder of the dura mater. Spinal involvement is extremely rare and there are few case reports. We present a 36 year-old female of idiopathic hypertrophic spinal pachymeningitis compressing thoracic spinal cord which showed rapid recurrence.
  • 4,014 View
  • 31 Download
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