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Review Article

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Optimizing Surgical Strategy for Cervical Spinal Deformity: Global Alignment and Surgical Targets
Neurospine. 2023;20(4):1246-1255.   Published online December 31, 2023
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Optimizing Surgical Strategy for Cervical Spinal Deformity: Global Alignment and Surgical Targets
Neurospine. 2023;20(4):1246-1255.   Published online December 31, 2023
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Cervical spinal deformity (CSD) is a complex condition characterized by abnormal curvature and cervical spine alignment. It can lead to a multitude of symptoms, including chronic pain, neurological deficits, and functional impairments, severely impacting an individual’s health-related quality of life (HRQoL). Surgical intervention is often necessary to address the deformity and alleviate symptoms, but optimal surgical strategies remain a topic of ongoing research and debate. This narrative review aims to provide an in-depth overview of the surgical management of CSD, focusing on optimizing patient outcomes and enhancing readers’ understanding of the complexities involved. We begin by discussing the importance of preoperative assessment, including comprehensive radiographic evaluation and careful consideration of the global spinal alignment. The relationship between the cervical spine and the reciprocal changes that occur are explored to guide surgeons in their decision-making process. Furthermore, we delve into the selection of fusion levels, emphasizing the significance of identifying the primary driver of deformity. We review the current literature on optimal alignment targets and strategies to optimize surgical planning. By providing a comprehensive analysis of the surgical management of CSD, this review aims to enhance the readers’ knowledge and assist surgeons in making informed decisions when planning and executing surgical interventions. Understanding the intricacies of CSD correction and the latest advancements in the field can ultimately improve patient outcomes and enhance HRQoL for individuals suffering from this challenging condition.

Citations

Citations to this article as recorded by  Crossref logo
  • A systematic review and meta-analysis of sagittal cervical spine parameters: Normative values, correlation with quality of life, and biomechanical modeling
    Vinicius Ricieri Ferraz, Carlos R. Goulart, Tobias Alecio Mattei
    North American Spine Society Journal (NASSJ).2026; 25: 100819.     CrossRef
  • Lordosis Distribution Index in an Asymptomatic Elderly Population : The Role of Lower and Upper Lumbar Lordosis According to Individual Pelvic Incidence and Roussouly Type
    Seung-Jae Hyun, Sanghyun Han, Youngbae B. Kim
    Journal of Korean Neurosurgical Society.2026; 69(1): 92.     CrossRef
  • Impact of T1 Slope as a Predictor of Loss of Cervical Lordosis and Health-Related Quality of Life after Laminoplasty in Patients with Ossification of the Posterior Longitudinal Ligament : A Retrospective Cohort Study
    Ji-Ho Jung, Jong-Hoon Jeong, Jong-Hwan Hong, Moon-Soo Han, Jung-Kil Lee
    Journal of Korean Neurosurgical Society.2026; 69(1): 124.     CrossRef
  • C2 Slope as an Independent Predictor of Cervical Lordosis Loss Following Laminoplasty
    Bin Zheng, Panfeng Yu, Zhenqi Zhu, Yan Liang, Haiying Liu
    Orthopaedic Surgery.2026; 18(3): 569.     CrossRef
  • Does Higher T1 Slope Predict Poor Outcomes Following Posterior Cervical Fusion for Degenerative Pathology?
    Harsh Jain, Sameer Sundrani, Iyan Younus, Nick De Oliveira, Omar Zakieh, Maryam Jawid, Naadir Jamal, Hani Chanbour, Tyler Zeoli, Ranbir Ahluwalia, Mitchell Bowers, Raymond J. Gardocki, Amir M. Abtahi, Byron F. Stephens, Scott L. Zuckerman
    World Neurosurgery.2026; 209: 124920.     CrossRef
  • Sagittal balance of the cervical spine in adults: a non-systematic literature review
    R. S. Chernyshyov, V. B. Lebedev, B. R. Kinzyagulov, A. A. Zuev
    Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika).2026; 23(1): 92.     CrossRef
  • Investigation of spinopelvic sagittal alignment and its correlations in asymptomatic pediatric populations
    Hao Qi, ZengHui Zhao, Feiyu Zu, Chenchen Wang, Chenxi Wang, Zuzhuo Zhang, Jianhua Ren, Rui Xue, Zhaoxuan Wang, Zhiyong Hou, Wei Chen, Di Zhang
    Scientific Reports.2025;[Epub]     CrossRef
  • Cervical Sagittal Alignment Revisited on the Path to Personalized Spine Surgery: A Big Picture Perspective Through Bibliometric Analysis and Visualization
    Luke L. Jouppi, Clifford Pierre, Anna Gorbacheva, Julius Gerstmeyer, Colin Gold, Cameron Hogsett, Nicholas Minissale, Mark Kraemer, Stephen Lockey, Amir Abdul-Jabbar, Rod J. Oskouian, Jens R. Chapman
    World Neurosurgery.2025; 202: 124387.     CrossRef
  • 5,743 View
  • 286 Download
  • 7 Web of Science
  • 8 Crossref

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Sacropelvic Fixation for Adult Deformity Surgery Comparing Iliac Screw and Sacral 2 Alar-Iliac Screw Fixation: Systematic Review and Updated Meta-Analysis
Neurospine. 2023;20(4):1469-1476.   Published online December 31, 2023
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Sacropelvic Fixation for Adult Deformity Surgery Comparing Iliac Screw and Sacral 2 Alar-Iliac Screw Fixation: Systematic Review and Updated Meta-Analysis
Neurospine. 2023;20(4):1469-1476.   Published online December 31, 2023
Close
Objective
Two commonly used techniques for spinopelvic fixation in adult deformity surgery are iliac screw (IS) and sacral 2 alar-iliac screw (S2AI) fixations. In this article, we systematically meta-analyzed the complications of sacropelvic fixation for adult deformity surgery comparing IS and S2AI.
Methods
The PubMed, Embase, Web of Science, and Cochrane clinical trial databases were systematically searched until March 29, 2023. The proportion of postoperative complications, including implant failure, revision, screw prominence, and wound complications after sacropelvic fixation, were pooled with a random-effects model. Subgroup analyses for the method of sacropelvic fixation were conducted.
Results
Ten studies with a total of 1,931 patients (IS, 925 patients; S2AI, 1,006 patients) were included. The pooled proportion of implant failure was not statistically different between the IS and S2AI groups (21.9% and 18.9%, respectively) (p = 0.59). However, revision was higher in the IS group (21.0%) than that in the S2AI group (8.5%) (p = 0.02). Additionally, screw prominence was higher in the IS group (9.6%) than that in the S2AI group (0.0%) (p < 0.01), and wound complication was also higher in the IS group (31.7%) than that in the S2AI group (3.9%) (p < 0.01).
Conclusion
IS and S2AI fixations showed that both techniques had similar outcomes in terms of implant failure. However, S2AI was revealed to have better outcomes than IS in terms of revision, screw prominence, and wound complications.

Citations

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  • A biomechanical study comparing combined S1AI and S3AI trajectories to other pelvic fixation techniques: A finite element analysis
    William Sheppard, Arpan A. Patel, Colin Rhoads, Landon Reading, Theodore Rudic, Joshua Wiener, Matthew Magro, Lauren M. Boden, Thomas Olson, Jason Savage, Michael Steinmetz, Edin Nevzati, Alexander Spiessberger
    Clinical Biomechanics.2026; 131: 106712.     CrossRef
  • Critical Assessment of Evidence Quality of Meta-Analyses Comparing Sacral 2 Alar–Iliac Fixation with Iliac Screws for Adult Spinal Deformity: An Umbrella Review with Emphasis on Methodological Limitations
    Ali Haider Bangash, Ananth S. Eleswarapu, Mitchell S. Fourman, Yaroslav Gelfand, Saikiran G. Murthy, Jaime A. Gomez, C. Rory Goodwin, Peter G. Passias, Reza Yassari, Rafael De la Garza Ramos
    Journal of Clinical Medicine.2026; 15(2): 753.     CrossRef
  • Modified iliac screw technique for pelvic fixation: a scoping review of technical characteristics and early clinical outcomes
    Hanyu Qiu, Dhruvish Patel, Moriah Thompson, Piper Tingleaf, Kishore Balasubramanian, Peter G. Passias, Luis M. Tumialan, Praveen V. Mummaneni, Nitin Agrawal, Ali K. Ozturk, Hakeem J. Shakir, John F. Burke, Chao Li, Zachary A. Smith, Andrew Jea, Angela E.
    Acta Neurochirurgica.2026;[Epub]     CrossRef
  • Performance of Porous Pelvic Fixation Implants in Multilevel Spine Fusion Surgery
    John Caridi, Richard Menger, Christopher Martin, Alexander Lemons, Isador Lieberman, Jeffrey Mullin, Jonathan Sembrano, Khalid Odeh, Evalina Burger, Taylor Lawson, Christopher J. Kleck
    Spine Open.2026;[Epub]     CrossRef
  • Asymmetric Safety Corridors for Free-Hand S2-Alar-Iliac Screw Placement: Quantifying Direction-Specific Tolerance Around Patient-Specific Optimal Trajectories
    Se Jun Park, Dong Kyu Kim, Sun Joon Yoo, Hyun Jun Jang, Bong Ju Moon, Jeong Yoon Park, Jun Jae Shin, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Kyung Hyun Kim
    Journal of Clinical Medicine.2026; 15(12): 4495.     CrossRef
  • S2AI and iliac screw prominence and removal for symptomatic prominence: a systematic review
    Rafael Garcia, Kari Odland, Paul Lender, David Polly
    European Spine Journal.2025; 34(4): 1398.     CrossRef
  • S2AI vs. iliac screws in spinopelvic fixation for adult spinal deformity: a propensity score-matched analysis
    Alejandro Gómez-Rice, Susana Núñez-Pereira, Sleiman Haddad, Riccardo Raganato, Yann Philippe Charles, Franciso Pérez-Grueso, Frank Kleinstück, Ibrahim Obeid, Ahmet Alanay, Ferran Pellise, Javier Pizones
    European Journal of Orthopaedic Surgery & Traumatology.2025;[Epub]     CrossRef
  • Clinical Outcomes Associated with Screw Loosening in S2 Alar-Iliac Fixation in Adult Spinal Deformity
    Yasuhiro Nagatani, Hiroaki Nakashima, Tokumi Kanemura, Mikito Tsushima, Hiroyuki Tomita, Kazuaki Morishita, Hiroki Oyama, Sadayuki Ito, Naoki Segi, Jun Ouchida, Ippei Yamauchi, Yukihito Ode, Yuya Okada, Shiro Imagama
    Journal of Clinical Medicine.2025; 14(6): 1881.     CrossRef
  • A biomechanical study on bilateral SAI annular fixation in the treatment of unilateral Denis Ⅱ sacral fractures
    Peishuai Zhao, Chengfei Peng, Honghu Lin, Wuqing Wei, Weiyi Pang, Chaoyong Bei
    Journal of Clinical Neuroscience.2025; 136: 111221.     CrossRef
  • AO Spine Clinical Practice Recommendations: Spinopelvic Fixation - What are the Key Items to Understand Performance?
    Robert Ravinsky, Stephen Lewis, Charles Fisher, David Polly
    Global Spine Journal.2025; 15(6): 2855.     CrossRef
  • Low rates of pain requiring sacroiliac joint fusion after countersunk iliac screw for spinopelvic fixation
    Rahul Kishore Chaliparambil, Mykhaylo Krushelnytskyy, Rishi Jain, Mehul Mittal, Amr Alwakeal, Muhammad T. Hassan, Nishanth S. Sadagopan, Pavlos Texakalidis, Najib El Tecle, Nader S. Dahdaleh, Tyler Koski
    Journal of Craniovertebral Junction and Spine.2025; 16(3): 284.     CrossRef
  • Comparative efficacy of S2-alar-iliac versus iliac screw techniques in treating adult spinal deformity: a meta-analysis of postoperative outcomes and complications
    Amit Saraf, Sanjeev Kumar Jain, Sonika Sharma
    Asian Spine Journal.2025; 19(5): 847.     CrossRef
  • What’s New in Spine Surgery
    Melvin D. Helgeson, Alfred J. Pisano, Donald R. Fredericks, Scott C. Wagner
    Journal of Bone and Joint Surgery.2024; 106(12): 1035.     CrossRef
  • Lumbar pedicle subtraction osteotomy: techniques and outcomes
    Anouar Bourghli, Louis Boissiere, Ibrahim Obeid
    North American Spine Society Journal (NASSJ).2024; 19: 100516.     CrossRef
  • 7,330 View
  • 232 Download
  • 16 Web of Science
  • 14 Crossref

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Development and Validation of an Online Calculator to Predict Proximal Junctional Kyphosis After Adult Spinal Deformity Surgery Using Machine Learning
Neurospine. 2023;20(4):1272-1280.   Published online December 31, 2023
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Development and Validation of an Online Calculator to Predict Proximal Junctional Kyphosis After Adult Spinal Deformity Surgery Using Machine Learning
Neurospine. 2023;20(4):1272-1280.   Published online December 31, 2023
Close
Objective
Although adult spinal deformity (ASD) surgery aims to restore and maintain alignment, proximal junctional kyphosis (PJK) may occur. While existing scoring systems predict PJK, they predominantly offer a generalized 3-tier risk classification, limiting their utility for nuanced treatment decisions. This study seeks to establish a personalized risk calculator for PJK, aiming to enhance treatment planning precision.
Methods
Patient data for ASD were sourced from the Korean spinal deformity database. PJK was defined a proximal junctional angle (PJA) of ≥ 20° at the final follow-up, or an increase in PJA of ≥ 10° compared to the preoperative values. Multivariable analysis was performed to identify independent variables. Subsequently, 5 machine learning models were created to predict individualized PJK risk post-ASD surgery. The most efficacious model was deployed as an online and interactive calculator.
Results
From a pool of 201 patients, 49 (24.4%) exhibited PJK during the follow-up period. Through multivariable analysis, postoperative PJA, body mass index, and deformity type emerged as independent predictors for PJK. When testing machine learning models using study results and previously reported variables as hyperparameters, the random forest model exhibited the highest accuracy, reaching 83%, with an area under the receiver operating characteristics curve of 0.76. This model has been launched as a freely accessible tool at: (https://snuspine.shinyapps.io/PJKafterASD/).
Conclusion
An online calculator, founded on the random forest model, has been developed to gauge the risk of PJK following ASD surgery. This may be a useful clinical tool for surgeons, allowing them to better predict PJK probabilities and refine subsequent therapeutic strategies.

Citations

Citations to this article as recorded by  Crossref logo
  • THE INTEGRATION OF ARTIFICIAL INTELLIGENCE IN SPINAL CARE ASSESSMENT AND SURGERY: A COMPREHENSIVE NARRATIVE REVIEW
    Anıl Murat Öztürk, Cemre Aydın, Onur Süer, Erhan Sesli, Ömer Akçalı, Emin Alıcı
    Journal of Turkish Spinal Surgery.2026; 37(1): 49.     CrossRef
  • Machine learning-based prediction of proximal junctional pathology after adult spinal deformity surgery: a systematic review and diagnostic test accuracy meta-analysis
    Shaan Patel, Shiva A. Nischal, Yi Hein Chai, Kush M. Kale, Kevin Hines, Joshua Heller, Jack Jallo, James S. Harrop, Srinivas K. Prasad
    Acta Neurochirurgica.2026;[Epub]     CrossRef
  • Explainable Machine Learning Approach to Prediction of Prolonged Intensive Care Unit Stay in Adult Spinal Deformity Patients: Machine Learning Outperforms Logistic Regression
    Bashar Zaidat, Mark Kurapatti, Jonathan S. Gal, Samuel K. Cho, Jun S. Kim
    Global Spine Journal.2025; 15(4): 1992.     CrossRef
  • Machine-learning models for the prediction of ideal surgical outcomes in patients with adult spinal deformity
    Dongfan Wang, Qijun Wang, Peng Cui, Shuaikang Wang, Di Han, Xiaolong Chen, Shibao Lu
    The Bone & Joint Journal.2025; 107-B(3): 337.     CrossRef
  • The Application of Artificial Intelligence in Spine Surgery: A Scoping Review
    Liangyu Shi, Hongfei Wang, Graham Ka-Hon Shea
    JAAOS: Global Research and Reviews.2025;[Epub]     CrossRef
  • Harnessing machine learning to predict and prevent proximal junctional kyphosis and failure in adult spinal deformity surgery: A systematic review
    Paolo Brigato, Gianluca Vadalà, Sergio De Salvatore, Leonardo Oggiano, Giuseppe Francesco Papalia, Fabrizio Russo, Rocco Papalia, Pier Francesco Costici, Vincenzo Denaro
    Brain and Spine.2025; 5: 104273.     CrossRef
  • Artificial intelligence in spine surgery
    Cheng Zhang, Shanshan Liu, Jialin Shi, Xingyu Zhou, Peter Passias, Nanfang Xu, Weishi Li
    Spine Research.2025; 1(1): 13.     CrossRef
  • Novel risk factors and personalized risk calculator for predicting proximal junctional kyphosis after adult spinal deformity surgery
    Qijun Wang, Zheng Wang, Dongfan Wang, Xuan Zhao, Xiaolong Chen, Shibao Lu
    The Bone & Joint Journal.2025; 107-B(8): 829.     CrossRef
  • Implications of artificial intelligence
    Michael W. Fields, Nathan J. Lee, Ronald A. Lehman
    Seminars in Spine Surgery.2024; 36(3): 101122.     CrossRef
  • Machine learning applications in adult spinal deformity corrective surgery: a narrative review
    Nader Toossi, Ozhan Jerry
    Artificial Intelligence Surgery.2024; 4(3): 258.     CrossRef
  • Prediction of postoperative mechanical complications in ASD patients based on total sequence and proportional score of spinal sagittal plane
    Wenbin Jiang, Huagang Shi, Tao Gu, Zonglin Cai, Qinglong Li
    SLAS Technology.2024; 29(6): 100222.     CrossRef
  • Predicting Proximal Junctional Kyphosis After Adult Spinal Deformity Surgery: A Step Towards True “Precision” Medicine?: Commentary on “Development and Validation of an Online Calculator to Predict Proximal Junctional Kyphosis After Adult Spinal Deformity
    Lara M. Höbner, Alexandra Grob, Victor E. Staartjes
    Neurospine.2023; 20(4): 1284.     CrossRef
  • Commentary on “Development and Validation of an Online Calculator to Predict Proximal Junctional Kyphosis After Adult Spinal Deformity Surgery Using Machine Learning”
    In Ho Han
    Neurospine.2023; 20(4): 1281.     CrossRef
  • From the Editor-in-Chief: Featured Articles in the December 2023 Issue
    Inbo Han
    Neurospine.2023; 20(4): 1093.     CrossRef
  • 5,860 View
  • 197 Download
  • 14 Web of Science
  • 14 Crossref

Erratum

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Erratum: Reciprocal Changes Following Cervical Realignment Surgery
Neurospine. 2023;20(3):1091-1092.   Published online September 30, 2023
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Erratum: Reciprocal Changes Following Cervical Realignment Surgery
Neurospine. 2023;20(3):1091-1092.   Published online September 30, 2023
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  • 3,636 View
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Surgical and Clinical Outcomes Associated With the Use of Barbed Sutures and Self-Adhering Mesh System and Polymeric Glue for Wound Closure in Multilevel or Revision Spinal Surgery: A Matched Cohort Comparative Study With Conventional Wound Closure Procedure
Neurospine. 2023;20(3):981-988.   Published online September 30, 2023
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Surgical and Clinical Outcomes Associated With the Use of Barbed Sutures and Self-Adhering Mesh System and Polymeric Glue for Wound Closure in Multilevel or Revision Spinal Surgery: A Matched Cohort Comparative Study With Conventional Wound Closure Procedure
Neurospine. 2023;20(3):981-988.   Published online September 30, 2023
Close
Objective
Multilevel or revisional posterior spinal surgery is prone to infection and delayed wound healing, related with the wound closure time and suture strength. Knotless barbed suture is an innovative self-locking, multianchor suture. This study aims to evaluate the safety and efficacy of the knotless barbed suture and self-adhering mesh with polymeric glue in multilevel or revisional posterior spinal surgery.
Methods
This is a single-center retrospective matched cohort study. Patients were divided into 2 groups based on the wound closure method: barbed suture group with novel wound closure, and conventional suture group with conventional wound closure, 1:1 matched by the level of surgery and sex, resulting in 120 subjects each. Total operation time and wound closure time were measured intraoperatively, and perioperative clinical outcome parameters including postoperative wound complication were investigated for the first 3 months postoperatively. The distribution of continuous variables was assessed for normality by Shapiro-Wilk test, then parametric or nonparametric tests were applied accordingly (paired t-test or Wilcoxon signed-rank test).
Results
Wound closure time was significantly shorter with the novel barbed suture than with conventional suture in all subgroups divided by the level of spinal surgery: 3–5, 6–9, ≥ 10 levels (p < 0.001). The 2 groups showed no significant differences in surgical complications (p = 1.000). Specially, total operation time and wound-closing time were significantly shorter in revisional subgroup.
Conclusion
Absorbable knotless barbed suture and self-adhering mesh with polymeric glue can shorten spinal wound closure time with noninferiority in complications for multilevel or revisional spinal surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • Barbed Versus Conventional Suture for Spinal Surgery: A Systematic Review and Meta-Analysis
    Hugo Nunes Pustilnik, Gabriel Araújo Cerqueira, Jefferson Heber Marques Fontes, Davi Amorim Meira, Gabriel Souza Medrado-Nunes, Beatriz Lopes Bernardo da Cunha, Silvio Porto Junior, Matheus Gomes da Silva da Paz, Tancredo Alcântara, Leonardo Miranda de Av
    World Neurosurgery.2025; 193: 241.     CrossRef
  • Expanded applications of knotless tissue control devices in neurosurgical cranial and spinal applications
    Samuel A. Tenhoeve, Clayton Rawson, Dora R. Tabachnick, Mohammed A. Azab, Omowumi Oladipo, Michael Karsy
    Journal of Clinical Neuroscience.2025; 134: 111108.     CrossRef
  • Clinical Outcomes Among Patients Undergoing Open Abdominal or Orthopedic Surgery with Wound Closure Incorporating Triclosan-Coated Barbed Sutures: A Multi-Institutional, Retrospective Database Study
    Stephen Fortin, Kerstin Spychaj, Jörg Tomaszewski, Holly Grebeck, Rithwik Yalla, Paul Coplan, Shumin Zhang
    Medical Devices: Evidence and Research.2025; Volume 18: 161.     CrossRef
  • Adhesive Strips vs. Sutures in Lumbar Spinal Fusion: A Non-inferiority Analysis of Surgical Site Infections
    Fernando A Núñez-Moreno, Christian Bepperling, Carlos Trenado, Steffen Eitelbuss, Karen Velázquez, Vasilis Karantzoulis, Maria C Ochoa Estrada, Edgar Santos, Farzam Vazifehdan
    Cureus.2025;[Epub]     CrossRef
  • Femtosecond laser micromachining of barbed sutures
    Walid Al Asad, Shubha Majumder, Karuna Nambi Gowri, Martin W. King, Xin Zhao
    Manufacturing Letters.2025; 44: 517.     CrossRef
  • Assessing the application of barbed sutures in comparison to conventional sutures for surgical applications: a global systematic review and meta-analysis of preclinical animal studies
    Nanyan Xiang, Yifei Lin, Xiaoyi Su, Zifan Hu, Jinyu Zhou, Yi Wu, Liang Du, Jin Huang
    International Journal of Surgery.2024; 110(5): 3060.     CrossRef
  • “Revolutionising spinal surgery: the impact of STRATAFIX™ symmetric barbed sutures on closure time and costs”
    Ume Aiman, Umer Bin Shahzad
    Neurosurgical Review.2024;[Epub]     CrossRef
  • Letter to the editor: Prospective analysis of STRATAFIX™ symmetric PDS plus suture for fascial closure in spinal surgery: a pilot study
    Ume Aiman
    Neurosurgical Review.2024;[Epub]     CrossRef
  • “Evaluating wound closure innovations in spinal surgery: impacts on efficiency and patient outcomes”
    Muhammad Ahmed, Manal Nadeem, Umer Bin Shahzad, Humzah Salim
    Neurosurgical Review.2024;[Epub]     CrossRef
  • Barbed sutures versus conventional sutures for wound closure in spine surgeries: a systematic review and meta-analysis
    Khalid Sarhan, Reem Reda Elmahdi, Rashad G. Mohamed, Ibrahim Serag, Mohamed Abouzid
    Neurosurgical Review.2024;[Epub]     CrossRef
  • 7,700 View
  • 263 Download
  • 10 Web of Science
  • 10 Crossref

Review Articles

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Proximal Junctional Kyphosis or Failure After Adult Spinal Deformity Surgery - Review of Risk Factors and Its Prevention
Neurospine. 2023;20(3):863-875.   Published online September 30, 2023
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Proximal Junctional Kyphosis or Failure After Adult Spinal Deformity Surgery - Review of Risk Factors and Its Prevention
Neurospine. 2023;20(3):863-875.   Published online September 30, 2023
Close
Proximal junction kyphosis (PJK) is a common imaging finding after long-level fusion, and proximal junctional failure (PJF) is an aggravated form of the progressive disease spectrum of PJK. This includes vertebral fracture of upper instrumented vertebra (UIV) or UIV+1, instability between UIV and UIV+1, neurological deterioration requiring surgery. Many studies have reported on PJK and PJF after long segment instrumentation for adult spinal deformity (ASD). In particular, for spine deformity surgeons, risk factors and prevention strategies of PJK and PJF are very important to minimize reoperation. Therefore, this review aims to help reduce the occurrence of PJK and PJF by updating the latest contents of PJK and PJF by 2023, focusing on the risk factors and prevention strategies of PJK and PJF. We conducted a search on multiple database for articles published until February 2023 using the search keywords “proximal junctional kyphosis,” “proximal junctional failure,” “proximal junctional disease,” and “adult spinal deformity.” Finally, 103 papers were included in this study. Numerous factors have been suggested as potential risks for the development of PJK and PJF, including a high body mass index, inadequate postoperative sagittal balance and overcorrection, advanced age, pelvic instrumentation, and osteoporosis. Recently, with the increasing elderly population, sarcopenia has been emphasized. The quality and quantity of muscle in the surgical site have been suggested as new risk factor. Therefore, spine surgeon should understand the pathophysiology of PJK and PJF, as well as individual risk factors, in order to develop appropriate prevention strategies for each patient.

Citations

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  • Identifying Distinct Risk Factors for Early-Onset and Late-Onset PJK in ASD: A Comparative Analysis Across Non-PJK, Early-Onset PJK, and Late-Onset PJK Groups
    Donghua Huang, Han Jo Kim, Zhan Wang, Mihir Dekhne, Robert Uzzo, Atahan Durbas, Gabrielle Dykhouse, Tejas Subramanian, Andrea Pezzi, Luis Felipe Colon, Stephane Owusu-Sarpong, Francis Lovecchio
    Global Spine Journal.2026; 16(1): 382.     CrossRef
  • Can proximal junctional failure be predicted after adult spinal deformity surgery by experienced deformity surgeons based on patient, surgical and radiographic parameters?
    Marc Khalifé, Ayman Mohamed, David Ben-Israel, Joshua T. Bunch, Alan H. Daniels, Bassel G. Diebo, Robert Eastlack, Richard G. Fessler, Munish C. Gupta, Kojo Hamilton, Richard Hostin, Han Jo Kim, Eric O. Klineberg, Lawrence G. Lenke, Jeffrey Mullin, Pravee
    European Spine Journal.2026; 35(5): 2295.     CrossRef
  • Lumbar Lateral Dislocation Fracture With Progressive Worsening of Trunk Tilt in Pisa Syndrome Associated With Parkinson′s Disease
    Kazuki Fujimoto, Narumi Maki, Daisuke Hashiba, Toshifumi Maeyama, Haruki Ito, Ryosuke Nakagawa, Tetsuhiro Ishikawa, Hajime Arai, Seiji Ohtori, Shashank Kaushik
    Case Reports in Orthopedics.2026;[Epub]     CrossRef
  • Outcomes of adult spinal deformity surgery in octogenarians - How old is too old? 
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    European Spine Journal.2026; 35(2): 388.     CrossRef
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Selection of Optimal Lower Instrumented Vertebra for Adolescent Idiopathic Scoliosis Surgery
Neurospine. 2023;20(3):799-807.   Published online September 30, 2023
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Selection of Optimal Lower Instrumented Vertebra for Adolescent Idiopathic Scoliosis Surgery
Neurospine. 2023;20(3):799-807.   Published online September 30, 2023
Close
Adolescent idiopathic scoliosis (AIS) affects approximately 2% of adolescents across all ethnicities. The objectives of surgery for AIS are to halt curve progression, correct the deformity in 3 dimensions, and preserve as many mobile spinal segments as possible, avoiding junctional complications. Despite ongoing development in algorithms and classification systems for the surgical treatment of AIS, there is still considerable debate about selecting the appropriate fusion level. In this study, we review the literature on fusion selection and present current concepts regarding the lower instrumented vertebra in the selection of the fusion level for AIS surgery.

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  • 7,868 View
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From the Spinopelvic Parameters to Global Alignment and Proportion Scores in Adult Spinal Deformity
Neurospine. 2023;20(2):467-477.   Published online June 30, 2023
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From the Spinopelvic Parameters to Global Alignment and Proportion Scores in Adult Spinal Deformity
Neurospine. 2023;20(2):467-477.   Published online June 30, 2023
Close
In the last 20 years, sagittal alignment and balance of the spine have become one of the most important issues in the field of spine surgery. Recent studies emphasize that sagittal balance and alignment are more important for health-related quality of life. The understanding of normal and abnormal sagittal alignment of the spine is necessary for the diagnosis and appropriate treatment of adult spinal deformity (ASD), and we will discuss the currently used classification of ASD, the parameters of sagittal alignment that are essential for the diagnosis of spinal deformity, compensatory actions to maintain sagittal balance, and the relationship between sagittal alignment and clinical symptoms. Furthermore, we will also discuss the recently introduced Global Alignment and Proportion scores. The Korean Spinal Deformity Society is publishing a series of review articles on spinal deformities to help spine surgeons better understand spinal deformities.

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    Mitsuhiro Nishizawa, Yuki Ishikawa, Soichiro Nakashima, Sun Zhongyuan, Marika G. Rosenfeld, Yuki Onishi, Junichi Ohya, Junichi Kunogi, Naohiro Kawamura
    European Spine Journal.2025; 34(7): 2890.     CrossRef
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    Davin C. Gong, Bradley P. Richey, Elinor A. Stern, Anthony N. Baumann, Nicole B. Covell, Joshua D. Piche, Rakesh D. Patel, Ilyas S. Aleem
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    N.N. Priorov Journal of Traumatology and Orthopedics.2025;[Epub]     CrossRef
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Reciprocal Changes Following Cervical Realignment Surgery
Neurospine. 2022;19(4):853-861.   Published online December 31, 2022
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Reciprocal Changes Following Cervical Realignment Surgery
Neurospine. 2022;19(4):853-861.   Published online December 31, 2022
Close
Over the last few decades, the importance of the sagittal plane and its contour has gained significant recognition. Through full-body stereoradiography, the understanding of compensatory mechanisms, and the concept of global balance and reciprocal change has expanded. There have been a few reports describing how cervical realignment surgery affects global spinal alignment (GSA) and global balance. Despite the research efforts, the concept of reciprocal change and global balance is still perplexing. Understanding the compensatory status and main drivers of deformity in a patient is vital because the compensatory mechanisms may resolve reciprocally following cervical realignment surgery. A meticulous preoperative evaluation of the whole-body alignment, including the pelvis and lower extremities, is paramount to appreciate optimal GSA in the correction of spinal malalignment. This study aims to summarize relevant literature on the reciprocal changes in the whole body caused by cervical realignment surgery and review recent perspectives regarding cervical compensatory mechanisms.

Citations

Citations to this article as recorded by  Crossref logo
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    R. S. Chernyshyov, V. B. Lebedev, B. R. Kinzyagulov, A. A. Zuev
    Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika).2026; 23(1): 92.     CrossRef
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    Tao Kang, Weiyou Chen, Longao Huang, Hongyuan Xu, Hua Jiang
    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
  • Long-term loss of intervertebral disc height after posterior cervical surgery for ossification of the posterior longitudinal ligament: a retrospective study with more than 3 years of follow-up
    Siyuan Qin, Ruomu Qu, Weili Zhao, Ruixin Yan, Yongye Chen, Feifei Zhou, Ning Lang
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
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    Sunho Kim, Seung-Jae Hyun, Jae-Koo Lee, Ki-Jeong Kim
    Journal of Korean Neurosurgical Society.2024; 67(2): 137.     CrossRef
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    Seungyoon Paik, Yunhee Choi, Chun Kee Chung, Young Il Won, Sung Bae Park, Seung Heon Yang, Chang-Hyun Lee, John Min Rhee, Kyoung-Tae Kim, Chi Heon Kim, Thamer Hamdan
    PLOS ONE.2023; 18(2): e0281926.     CrossRef
  • From the Spinopelvic Parameters to Global Alignment and Proportion Scores in Adult Spinal Deformity
    Yongjae Cho, Dae Jean Jo, Seung-Jae Hyun, Jin Hoon Park, Na Rae Yang
    Neurospine.2023; 20(2): 467.     CrossRef
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    Kwang-Ui Hong, Seung-Jae Hyun, Jae-Koo Lee, Ki-Jeong Kim
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  • Surgical and Clinical Outcomes Associated With the Use of Barbed Sutures and Self-Adhering Mesh System and Polymeric Glue for Wound Closure in Multilevel or Revision Spinal Surgery: A Matched Cohort Comparative Study With Conventional Wound Closure Proced
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    Neurospine.2023; 20(3): 981.     CrossRef
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    Seung-Ho Seo, Seung-Jae Hyun, Jae-Koo Lee, Yong Jae Cho, Dae Jean Jo, Jin Hoon Park, Ki-Jeong Kim
    Neurospine.2023; 20(3): 799.     CrossRef
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    Jae-Koo Lee, Seung-Jae Hyun, Ki-Jeong Kim
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  • 8,277 View
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  • 12 Web of Science
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Clinical Impact and Correlations of Odontoid Parameters Following Multilevel Posterior Cervical Fusion Surgery
Neurospine. 2022;19(4):912-920.   Published online December 31, 2022
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Clinical Impact and Correlations of Odontoid Parameters Following Multilevel Posterior Cervical Fusion Surgery
Neurospine. 2022;19(4):912-920.   Published online December 31, 2022
Close
Objective
C2 slope (C2S), a cervical parameter mathematically approximated as T1 slope minus cervical lordosis (T1S–CL), predicts functional improvement in cervical deformity patients. Nonetheless, C2S is a positional parameter based only on the horizontal axis. The current study aims to introduce novel odontoid parameters and establish their relationships with patient-reported health-related quality of life (HRQoL).
Methods
Lateral plain radiographs of 32 adults who underwent multilevel posterior cervical fusion were analyzed. The odontoid parameters included odontoid incidence (OI), C2S, odontoid tilt (OT), and gravity line-C2 distance (GL-C2), while the cervical parameters were the Cobb angle at C0–1, C1–2, C0–2, C2–7, C2–7 sagittal vertical axis (cSVA), T1 slope, and T1S–CL. The range of motion (ROM) of the occipito-atlantoaxial complex was measured in flexion and extension plain radiographs. Scores on the Neck Disability Index (NDI) and visual analogue scale (VAS) for axial neck (VASn) and arm pain were measured.
Results
Compared to asymptomatic subjects, patients had larger C2S, cSVA, and T1S–CL, and smaller OT. Preoperatively, OI was significantly correlated with the ROM of C1–2 (r = 0.37, p < 0.05) and C0–2 (r = 0.46, p < 0.01). OT and C2S had significant correlations with the C0–1, C1–2, and C0–2 angles, GL-C2, and T1S–CL. Postoperative NDI scores were significantly correlated with OI (r = -0.40, p < 0.05) and OT (ρ = -0.37, p < 0.05). VASn was significantly correlated with GL-C2 (r = -0.35, p < 0.05).
Conclusion
The odontoid parameters were significantly correlated with established cervical parameters and HRQoL measures. OI is a constant parameter representing the individual's compensatory reservoir at the upper cervical spine.

Citations

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  • Odontoid Parameters in Adolescent Idiopathic Scoliosis Patients
    Qiong-run Xiao, Long-ao Huang, Ke-lin Li, Yu-wang Du, Xiao Liang, Chong-yang Wang, Hua Jiang
    Clinical Spine Surgery.2026; 39(2): E74.     CrossRef
  • The effect of cervical spine flexion-extension motion on odontoid parameters
    Longao Huang, Dun Liu, Hongyuan Xu, Junfei Feng, Tao Kang, Shengwang Wei, Hua Jiang
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Correlation analysis between preoperative odontoid incidence and clinical outcomes 2 years after anterior cervical discectomy and fusion
    Yan Gong, Hao Liu, Yanchi Gan, Jiahui He, Zelin Zhou, Hang Zhuo, Yu Liu, De Liang, Hui Ren, Xiaobing Jiang, Zhaojun Cheng
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Lower C2 slope and milder uncovertebral joint degeneration are risk factors for pseudarthrosis after single-level anterior cervical corpectomy and fusion (ACCF): retrospective study of 102 patients with minimum 2-year follow-up
    Haoxiang Wang, Tian Xia, Ruomu Qu, Hanbo Geng, Yu Sun, Fengshan Zhang, Shengfa Pan, Xin Chen, Yanbin Zhao, Feifei Zhou
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Impact of anterior controllable antedisplacement and fusion (ACAF) on cervical lordosis and sagittal alignment in OPLL: A comparative radiographic analysis
    Shunmin Wang, Dong Liu, Jincui Li, Jingchuan Sun, Tiefeng Li, Jiangang Shi
    Journal of Orthopaedics.2025; 70: 158.     CrossRef
  • Odontoid parameters in subjects with and without degenerative cervical spondylosis
    Tao Kang, Weiyou Chen, Longao Huang, Hongyuan Xu, Hua Jiang
    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
  • Introducing the Modified Cobb Angle for Measuring Cervical Spine Curvature During Swallowing
    Catriona M. Steele, Makaya O' Grady, Sima Farpour, Melanie Peladeau‐Pigeon, Sophia Werden Abrams, Maureen Folsom, Emily K. Plowman, Ashwini M. Namasivayam‐MacDonald
    Laryngoscope Investigative Otolaryngology.2025;[Epub]     CrossRef
  • The Significance of Odontoid Incidence in Patients With Cervical Spondylotic Myelopathy
    Hongyu Qin, Weiyou Chen, Longao Huang, Xin Xiao, Qinghua Yang, Hua Jiang
    Global Spine Journal.2024; 14(8): 2374.     CrossRef
  • Variation of Odontoid Incidence According to Age in Asymptomatic Children
    Yuwang Du, Weiyou Chen, Hongyuan Xu, Xiao Liang, Chongyang Wang, Hongyu Qin, Hua Jiang
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  • Surgical and Clinical Outcomes Associated With the Use of Barbed Sutures and Self-Adhering Mesh System and Polymeric Glue for Wound Closure in Multilevel or Revision Spinal Surgery: A Matched Cohort Comparative Study With Conventional Wound Closure Proced
    Junho Mun, Seung-Jae Hyun, Jae-Koo Lee, Sungjae An, Ki-Jeong Kim
    Neurospine.2023; 20(3): 981.     CrossRef
  • Selection of Optimal Lower Instrumented Vertebra for Adolescent Idiopathic Scoliosis Surgery
    Seung-Ho Seo, Seung-Jae Hyun, Jae-Koo Lee, Yong Jae Cho, Dae Jean Jo, Jin Hoon Park, Ki-Jeong Kim
    Neurospine.2023; 20(3): 799.     CrossRef
  • Optimizing Surgical Strategy for Cervical Spinal Deformity: Global Alignment and Surgical Targets
    Jae-Koo Lee, Seung-Jae Hyun, Ki-Jeong Kim
    Neurospine.2023; 20(4): 1246.     CrossRef
  • Commentary on “Clinical Impact and Correlations of Odontoid Parameters Following Multilevel Posterior Cervical Fusion Surgery”
    Sang Hun Lee
    Neurospine.2022; 19(4): 921.     CrossRef
  • Significance of Atlantoaxial and Subaxial Spinal Instability in Cervical Spinal Spondylosis: Commentary on “Clinical Impact and Correlations of Odontoid Parameters Following Multilevel Posterior Cervical Fusion Surgery”
    Atul Goel
    Neurospine.2022; 19(4): 924.     CrossRef
  • 6,933 View
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  • 14 Crossref

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Safety and Efficacy of Recombinant Human Bone Morphogenetic Protein-2 in Multilevel Posterolateral Lumbar Fusion in a Prospective, Randomized, Controlled Trial
Neurospine. 2022;19(3):838-846.   Published online September 30, 2022
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Safety and Efficacy of Recombinant Human Bone Morphogenetic Protein-2 in Multilevel Posterolateral Lumbar Fusion in a Prospective, Randomized, Controlled Trial
Neurospine. 2022;19(3):838-846.   Published online September 30, 2022
Close
Objective
This study is an investigator-initiated, prospective, randomized, controlled study to evaluate the efficacy and safety of the combined use of recombinant human BMP-2 (rhBMP-2) and a hydroxyapatite (HA) carrier in multilevel fusion in patients with adult spinal deformity (ASD).
Methods
Thirty patients underwent posterolateral fusion for lumbar spinal deformities at 3 to 5 segments between L1 and S1. The patients received rhBMP-2+HA or HA on the left or right side of the transverse processes. They were followed up regularly at 1, 3, 6, and 12 months postoperatively. Fusion was defined according to the bone bridging on computed tomography scans. The fusion rate per segment was subanalyzed. Function and quality of life as well as pain in the lower back and lower extremities were evaluated.
Results
The union rate for the rhBMP-2+HA group was 100% at 6 and 12 months. The union rate for the HA group was 77.8% (21 of 27) at 6 months and 88.0% (22 of 25) at 12 months (p = 0.014 at 6 months; not significant at 12 months). All segments were fused at 6 and 12 months in the rhBMP-2+HA group (p < 0.001). In the HA group, 108 of 115 segments (93.5%) were fused at 6 months and 105 of 109 segments (96.3%) at 12 months. Other clinical parameters (visual analogue scale, 36-item Short Form Health Survey, and Scoliosis Research Society-22 scores) improved compared to baseline.
Conclusion
Combining rhBMP-2 and an HA carrier is a safe and effective method to achieve multilevel fusion in patients with ASD.

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  • Clinical and Radiologic Outcomes of NOVOSIS (rhBMP‐2 With Hydroxyapatite Carrier) Grafting for Scaphoid Waist Nonunion: A Preliminary Clinical Study
    Jisu Park, Ki Youn Kwon, Hyung Joon Ahn, Jin‐Rok Oh
    Orthopaedic Surgery.2026; 18(7): 1350.     CrossRef
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    Hye Yeong Lee, Seong Bae An, Sae Yeon Hwang, Gwang Yong Hwang, Hye-Lan Lee, Hyun Jung Park, Joongkyum Shin, Keung Nyun Kim, Sung Won Wee, Sol Lip Yoon, Yoon Ha
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    Haozhong Wang, Hao Zhang, Changming Xiao, Kaiquan Zhang, Lisheng Qi
    Neurosurgical Review.2025;[Epub]     CrossRef
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    Maria Chernysheva, Evgenii Ruchko, Artem Eremeev
    International Journal of Molecular Sciences.2025; 26(21): 10723.     CrossRef
  • The bone morphogenetic protein 2 analogue L51P enhances spinal fusion in combination with BMP2 in an in vivo rat tail model
    Benjamin Gantenbein, Katharina A.C. Oswald, Georg F. Erbach, Andreas S. Croft, Paola Bermudez-Lekerika, Franziska Strunz, Sebastian F. Bigdon, Christoph E. Albers
    Acta Biomaterialia.2024; 177: 148.     CrossRef
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    Zhuo-Wen Hao, Zhe-Yuan Zhang, Ze-Pu Wang, Ying Wang, Jia-Yao Chen, Tian-Hong Chen, Guang Shi, Han-Ke Li, Jun-Wu Wang, Min-Chao Dong, Li Hong, Jing-Feng Li
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    Hye-Yeong Lee, Ji-In Kang, Hye-Lan Lee, Gwang-Yong Hwang, Keung-Nyun Kim, Yoon Ha
    International Journal of Molecular Sciences.2023; 24(1): 892.     CrossRef
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    Anjalika Chalamgari, Daisy Valle, Xuban Palau Villarreal, Marco Foreman, Annika Liu, Aashay Patel, Akanksha Dave, Brandon Lucke-Wold
    Current Oncology.2023; 30(3): 3064.     CrossRef
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    Hye Yeong Lee, Da-Seul Kim, Gwang Yong Hwang, Jun-Kyu Lee, Hye-Lan Lee, Ji-Won Jung, Sae Yeon Hwang, Seung-Woon Baek, Sol lip Yoon, Yoon Ha, Keung Nyun Kim, Inbo Han, Dong Keun Han, Chang Kyu Lee
    Materials Today Bio.2023; 19: 100611.     CrossRef
  • Surgical and Clinical Outcomes Associated With the Use of Barbed Sutures and Self-Adhering Mesh System and Polymeric Glue for Wound Closure in Multilevel or Revision Spinal Surgery: A Matched Cohort Comparative Study With Conventional Wound Closure Proced
    Junho Mun, Seung-Jae Hyun, Jae-Koo Lee, Sungjae An, Ki-Jeong Kim
    Neurospine.2023; 20(3): 981.     CrossRef
  • Selection of Optimal Lower Instrumented Vertebra for Adolescent Idiopathic Scoliosis Surgery
    Seung-Ho Seo, Seung-Jae Hyun, Jae-Koo Lee, Yong Jae Cho, Dae Jean Jo, Jin Hoon Park, Ki-Jeong Kim
    Neurospine.2023; 20(3): 799.     CrossRef
  • Optimal Strategies for the Treatment of Osteoporotic Spinal Diseases
    Dae-Chul Cho
    Neurospine.2023; 20(4): 1095.     CrossRef
  • The Combined Effects of RhBMP-2 and Systemic RANKL Inhibitor in Patients With Bone Density Loss Undergoing Posterior Lumbar Interbody Fusion: A Retrospective Observational Analysis With Propensity Score Matching
    Seungjun Ryu, Seon-Jin Yoon, Chang Kyu Lee, Seong Yi, Keung-Nyun Kim, Yoon Ha, Dong Ah Shin
    Neurospine.2023; 20(4): 1186.     CrossRef
  • 9,120 View
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Odontoid Incidence: A Novel Cervical Parameter Influencing Cervical Alignment From Top to Bottom
Neurospine. 2022;19(2):463-471.   Published online June 30, 2022
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Odontoid Incidence: A Novel Cervical Parameter Influencing Cervical Alignment From Top to Bottom
Neurospine. 2022;19(2):463-471.   Published online June 30, 2022
Close
Objective
By using angulation of the axis itself, this study aims to define and analyze odontoid incidence (OI) and odontoid tilt (OT) as novel cervical alignment parameters and investigate their correlations with cervical alignment.
Methods
Novel and existing parameters were measured with whole-spine lateral plain radiographs and EOS images of 42 adults without cervical symptoms. The correlations of OI, OT, C2 slope (C2S), and T1 slope (T1S) were calculated.
Results
The OI, OT, and C2S showed significant correlations with C2–7 angle (r = 0.43, r = -0.42, r = 0.62, respectively) and C0–2 angle (r = -0.33, r = 0.48, r = -0.61, respectively). OI, OT, T1S were independent predictors of the C2–7 angle in univariate regression analysis (adjusted-R2 = 0.17, R2 = 0.15, R2 = 0.28, respectively). OI, OT, and T1S were independent predictors in the multivariable regression analysis with estimated standardized coefficients of 0.36, -0.67, -0.69, respectively (adjusted- R2 = 0.80, p < 0.001). Regarding the C0–2 angle, OI and OT were independent predictors in the univariate regression analysis (adjusted-R2 = 0.08, R2 = 0.21, respectively).
Conclusion
OI, OT, and C2S had significant correlations with cervical alignment. As the pelvic incidence, the OI is the only anatomical and constant parameter that could be used as a reference point related to the cervical spine from the rostral end. The study results may serve as baseline data for further studies on the alignment and balance of the cervical spine.

Citations

Citations to this article as recorded by  Crossref logo
  • Odontoid Parameters in Adolescent Idiopathic Scoliosis Patients
    Qiong-run Xiao, Long-ao Huang, Ke-lin Li, Yu-wang Du, Xiao Liang, Chong-yang Wang, Hua Jiang
    Clinical Spine Surgery.2026; 39(2): E74.     CrossRef
  • Investigation of the effects of odontoid bone anatomical location and structure on cervical lordosis angle in cervical ct examinations: A clinical study
    Alemiddin Özdemir, Ahmet Melih Erdoğan, Özge Sevimoğlu, Buket Oğuz, Buse Kaymakcı, Selma Çalışkan, Bülent Bakar
    Medical Journal of Western Black Sea.2026; 10(1): 39.     CrossRef
  • Artificial intelligence–driven data expansion for the validation of spinopelvic parameter correlations in asymptomatic subjects
    Domenico Compagnone, Davide Lamartina, Marco Giacalone, Riccardo Cecchinato, Pedro Berjano, Claudio Lamartina
    European Spine Journal.2026;[Epub]     CrossRef
  • Correlation analysis between preoperative odontoid incidence and clinical outcomes 2 years after anterior cervical discectomy and fusion
    Yan Gong, Hao Liu, Yanchi Gan, Jiahui He, Zelin Zhou, Hang Zhuo, Yu Liu, De Liang, Hui Ren, Xiaobing Jiang, Zhaojun Cheng
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • The effect of cervical spine flexion-extension motion on odontoid parameters
    Longao Huang, Dun Liu, Hongyuan Xu, Junfei Feng, Tao Kang, Shengwang Wei, Hua Jiang
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Odontoid parameters in subjects with and without degenerative cervical spondylosis
    Tao Kang, Weiyou Chen, Longao Huang, Hongyuan Xu, Hua Jiang
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The Last Touched Vertebra on Supine Radiographs Can Be the Optimal Lower Instrumented Vertebra in Adolescent Idiopathic Scoliosis Patients
Neurospine. 2022;19(1):236-243.   Published online March 31, 2022
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The Last Touched Vertebra on Supine Radiographs Can Be the Optimal Lower Instrumented Vertebra in Adolescent Idiopathic Scoliosis Patients
Neurospine. 2022;19(1):236-243.   Published online March 31, 2022
Close
Objective
To determine whether the last touched vertebra (LTV) on supine radiographs is suitable for the lower instrumented vertebra (LIV) in adolescent idiopathic scoliosis (AIS) correction surgery.
Methods
In total, 57 patients were included in the study following posterior instrumentation and fusion. The average follow-up period was 2.2 years. Patients were classified into 4 groups according to the relationship of the location of LIV, LTV, and the last substantially touched vertebra (LSTV) on upright radiographs and the LTV on supine radiographs. In group 1, the upright LTV and supine LTV were the same. Group 1 was subdivided into group 1A and group 1B according to whether the LTV and LSTV were different or the same, respectively. In group 2, the upright LTV was selected as the LIV, whereas in group 3, the supine LTV was selected as the LIV. The baseline characteristics and the preoperative and postoperative radiographic/clinical outcomes of the groups were analyzed.
Results
No differences were found in the preoperative clinical and radiographic baseline characteristics of the 4 groups except the LIV-central sacral vertical line distance. The immediate, 6-month, 1-year, and 2-year postoperative outcomes were not significantly different among the 4 groups. One patient (4.3%) in group 1A experienced radiographic addingon without clinical symptoms. No patients underwent revision surgery.
Conclusion
The group in whom the LIV was selected as the LTV on supine x-rays showed similar postoperative radiographic and clinical results to other groups. The LTV on preoperative supine radiographs is acceptable as the LIV in AIS surgery to maximize motion segments.

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Regional Anesthesia for Lumbar Spine Surgery: Can It Be a Standard in the Future?
Neurospine. 2021;18(4):733-740.   Published online December 31, 2021
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Regional Anesthesia for Lumbar Spine Surgery: Can It Be a Standard in the Future?
Neurospine. 2021;18(4):733-740.   Published online December 31, 2021
Close
This paper is an overview of various features of regional anesthesia (RA) and aims to introduce spine surgeons unfamiliar with RA. RA is commonly used for procedures that involve the lower extremities, perineum, pelvic girdle, or lower abdomen. However, general anesthesia (GA) is preferred and most commonly used for lumbar spine surgery. Spinal anesthesia (SA) and epidural anesthesia (EA) are the most commonly used RA methods, and a combined method of SA and EA (CSE). Compared to GA, RA offers numerous benefits including reduced intraoperative blood loss, arterial and venous thrombosis, pulmonary embolism, perioperative cardiac ischemic incidents, renal failure, hypoxic episodes in the postanesthetic care unit, postoperative morbidity and mortality, and decreased incidence of cognitive dysfunction. In spine surgery, RA is associated with lower pain scores, postoperative nausea and vomiting, positioning injuries, shorter anesthesia time, and higher patient satisfaction. Currently, RA is mostly used in short lumbar spine surgeries. However, recent findings illustrate the possibility of applying RA in spinal tumors and spinal fusion. Various researches reveal that SA is an effective alternative to GA with lower minor complications incidence. Comprehensive insight on RA will promote spine surgery under RA, thereby broadening the horizon of spine surgery under RA.

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Commentary on “Emerging Technologies in the Treatment of Adult Spinal Deformity”
Neurospine. 2021;18(3):428-429.   Published online September 30, 2021
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Commentary on “Emerging Technologies in the Treatment of Adult Spinal Deformity”
Neurospine. 2021;18(3):428-429.   Published online September 30, 2021
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  • 6,142 View
  • 97 Download