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"Sung-Hye Park"

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"Sung-Hye Park"

Review Article

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Pathological Classification of the Intramedullary Spinal Cord Tumors According to 2021 World Health Organization Classification of Central Nervous System Tumors, a Single-Institute Experience
Neurospine. 2022;19(3):780-791.   Published online September 30, 2022
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Pathological Classification of the Intramedullary Spinal Cord Tumors According to 2021 World Health Organization Classification of Central Nervous System Tumors, a Single-Institute Experience
Neurospine. 2022;19(3):780-791.   Published online September 30, 2022
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According to the new 2021 World Health Organization (WHO) classification of tumors of the central nervous system (CNS) the classification of the primary intramedullary spinal cord tumors (IM-SCT) follows that of CNS tumors. However, since the genetics and methylation profile of ependymal tumors depend on the location of the tumor, the ‘spinal (SP)’ should be added for the ependymoma (EPN) and subependymoma (SubEPN). For an evidence-based review, the authors reviewed SCTs in the archives of the Seoul National University Hospital over the past decade. The frequent pathologies of primary IM-SCT were SP-EPN (45.1%), hemangioblastoma (20.0%), astrocytic tumors (17.4%, including pilocytic astrocytoma [4.6%] and diffuse midline glioma, H3 K27-altered [4.0%]), myxopapillary EPN (11.0%), and SP-subEPN (3.0%) in decreasing order. IDH-mutant astrocytomas, oligodendrogliomas, glioneuronal tumors, embryonal tumors, and germ cell tumors can occur but are extremely rare in the spinal cord. Genetic studies should support for the primary IM-SCT classification. In the 2021 WHO classifications, extramedullary SCT did not change significantly but contained several new genetically defined types of mesenchymal tumors. This article focused on primary IM-SCT for tumor frequency, age, sex difference, pathological features, and genetic abnormalities, based on a single-institute experience.

Citations

Citations to this article as recorded by  Crossref logo
  • Outcomes of initially chosen non-operative management for spinal ependymoma
    Guang-Hao Zheng, Yao-Wu Zhang, Kai Ji, Hui Qiao, Xiao Wu, Yi-Xiang Liu, Wei-Hao Liu, Bo Wang, Chong Wang, Xing-Yu Liu, Yong-Zhi Wang, Wen-Qing Jia
    Journal of Clinical Neuroscience.2026; 144: 111780.     CrossRef
  • Minimally invasive approaches to intramedullary spinal cord tumors: a systematic review of techniques and outcomes
    Nadir Al-Saidi, Dina Mohammed, Zainab Fatima, Ali Haider Bangash, Saikiran G. Murthy, Yaroslav Gelfand, Reza Yassari, Rafael De la Garza Ramos
    European Spine Journal.2026;[Epub]     CrossRef
  • Sodium Fluorescein-Guided Microsurgery for Intramedullary Spinal Ependymomas: Technical Nuances, Surgical Workflow, and Operative Video
    Silvia Michelini, Amer A. Alomari, Flavia Fraschetti, Ettore Carpineta, Luciano Mastronardi
    World Neurosurgery.2026; 212: 125092.     CrossRef
  • Neurological complications of CAR T cell therapy for cancers
    Philipp Karschnia, Jörg Dietrich
    Nature Reviews Neurology.2025; 21(8): 422.     CrossRef
  • RETRACTED ARTICLE: DQSCTC: design of an efficient deep dyna-Q network for spinal cord tumour classification to identify cervical diseases
    Nilesh P. Sable, Priti Shende, Vishal Ashok Wankhede, Kishor S. Wagh, J. V. N. Ramesh, Sunita Chaudhary
    Soft Computing.2024; 28(S2): 733.     CrossRef
  • Incidence and Survival of Patients With Malignant Primary Spinal Cord Tumors: A Population-Based Analysis
    Huanbing Liu, Linnan Duan, Zhibin Li, Yuanhao Liu, Yubo Wang
    Neurospine.2024; 21(2): 588.     CrossRef
  • The Role of Radiotherapy, Chemotherapy, and Targeted Therapies in Adult Intramedullary Spinal Cord Tumors
    Ines Esparragosa Vazquez, François Ducray
    Cancers.2024; 16(16): 2781.     CrossRef
  • Astrocytomas of the spinal cord
    Joerg-Christian Tonn, Nico Teske, Philipp Karschnia
    Neuro-Oncology Advances.2024; 6(Supplement): iii48.     CrossRef
  • To Seek Appropriate Management for Intramedullary Spinal Cord Tumor: Commentary on Special Issue “Spinal Intramedullary Tumor”
    Toshiyuki Takahashi, Tomoo Inoue
    Neurospine.2023; 20(3): 733.     CrossRef
  • 14,537 View
  • 959 Download
  • 12 Web of Science
  • 9 Crossref

Case Reports

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Cervical Spine Chondroma Compressing Spinal Cord: A Case Report and Literature Review
Korean J Spine. 2015;12(4):275-278.   Published online December 31, 2015
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Cervical Spine Chondroma Compressing Spinal Cord: A Case Report and Literature Review
Korean J Spine. 2015;12(4):275-278.   Published online December 31, 2015
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Chondromas are benign tumor of cartilaginous tissue that is rarely found in spine. The authors document a rare case of a 72 year old male patient with a cervical spinal chondroma compressing the spinal cord. The patient had symptoms of motor and sensory deficits, dysphagia and dysarthria. C1 and C2 laminotomy was done and the spinal tumor was removed. The patient gradually recovered from his previous symptom after the surgery.

Citations

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  • En Bloc Resection of Malignant Cervical Spine Tumors With Consideration of Vertebral Artery Involvement
    Rosa M. Egea-Gámez, Jaime García-Fernández, María Galán-Olleros, Alfonso González- Menocal, Ana M. Morales-Codina, Antonio Martín-Belloch, Rafael González-Díaz
    Clinical Spine Surgery.2025;[Epub]     CrossRef
  • Chondroma of the cervicothoracic intervertebral foramen: A case report and literature review
    Lin Xiao, Wansheng Lin, Wei Zhang, Fei Wang
    Asian Journal of Surgery.2023; 46(8): 3096.     CrossRef
  • Chondromas of the Lumbar Spine: A Systematic Review
    Luis A. Robles, Greg M. Mundis
    Global Spine Journal.2021; 11(2): 232.     CrossRef
  • Extradural Chondroma on the Lumbar Spine: A Case Report
    Yong Guk Kim, Tae Wan Kim, Eun Ju Kim, Kwan Ho Park
    The Nerve.2020; 6(2): 86.     CrossRef
  • A Rare Case of Acute-Onset Spastic Quadriparesis Caused by a Chondroma of the Cervical Spine
    Kaori Momota, Toshihiko Nishisho, Ryo Miyagi, Shunichi Toki, Kazuta Yamashita, Fumitake Tezuka, Yoichiro Takata, Toshinori Sakai, Akihiro Nagamachi, Toru Maeda, Koichi Sairyo
    Case Reports in Orthopedics.2019; 2019: 1.     CrossRef
  • Oropharyngeal Dysphagia Evaluation Tools in Adults with Solid Malignancies Outside the Head and Neck and Upper GI Tract: A Systematic Review
    Ciarán Kenny, Órla Gilheaney, Declan Walsh, Julie Regan
    Dysphagia.2018; 33(3): 303.     CrossRef
  • Retro-odontoid mass without atlantoaxial instability causing cervical myelopathy: a case report of transdural surgical resection
    Hiroyuki Tominaga, Takao Setoguchi, Satoshi Nagano, Ichiro Kawamura, Masahiko Abematsu, Takuya Yamamoto, Yasuhiro Ishidou, Kanehiro Matsuyama, Kosei Ijiri, Fumito Tanabe, Setsuro Komiya
    Spinal Cord Series and Cases.2016;[Epub]     CrossRef
  • 10,735 View
  • 113 Download
  • 7 Crossref

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Primary Spinal Cord Oligodendroglioma with Postoperative Adjuvant Radiotherapy: A Case Report
Korean J Spine. 2015;12(3):160-164.   Published online September 30, 2015
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Primary Spinal Cord Oligodendroglioma with Postoperative Adjuvant Radiotherapy: A Case Report
Korean J Spine. 2015;12(3):160-164.   Published online September 30, 2015
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Primary spinal cord oligodendrogliomas are rare tumors comprising two percent of all spinal cord tumors. Although a treatment guideline has yet to be established, maximal surgical resection is primary in the treatment of spinal cord oligodendrogliomas. Adjuvant radiotherapy has remained controversial, and it is unclear whether chemotherapy adds any benefit. In this case report, the authors present a 24-year-old male who had a seven-year history of left leg weakness and a radiating pain in both legs. Magnetic resonance image (MRI) showed an intramedullary mass at the T4-T8 level. He underwent subtotal removal of the tumor and pathologic diagnosis revealed a WHO grade II oligodendroglioma. The patient was treated with radiotherapy postoperatively and followed up with MRI annually. Clinical and radiological status of the patient had been stationary for four years after the surgery. The five-year follow-up MRI showed an increase in the size and extent of the residual tumor. Despite radiological progression, considering that symptoms and the performance status of the patient had remained unchanged, further treatment has not been performed. Given the clinical outcome of this patient, close observation after subtotal removal with adjuvant radiotherapy is one of the acceptable treatment options for WHO grade II spinal cord oligodendrogliomas.

Citations

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  • A rare case of primary spinal cord oligodendroglioma
    K Eppy Buchori Aristiady, Ellya
    Radiology Case Reports.2023; 18(6): 2303.     CrossRef
  • 8,649 View
  • 79 Download
  • 1 Crossref