Our extensive basic research on photodynamic therapy (PDT) application in models of intracranial malignant astrocytoma led to its clinical application for intracranial malignant astrocytoma in Japan. Having considered the safety and effectiveness of this pathology, we initiate a first-in-human clinical study of PDT for spinal cord malignant astrocytoma. This study has an open-label, single-arm design. The initial follow-up period is 12 months, at the end of which we will quantify survival after PDT for spinal cord malignant astrocytoma as primary objective. The secondary objective is to quantify the overall progression-free survival of treated patients and the percentage of patients surviving 6 months after PDT without recurrence. Twenty patients suffering from spinal cord malignant astrocytoma will be recruited. In particular, 10 of those should be newly diagnosed World Health Organization grade 4. After obtaining consent, each patient will receive a single intravenous injection of talaporfin sodium (40 mg/m2) 1 day before tumor resection. One day after completing tumor removal, the residual lesion and/or resection cavity will be irradiated using a 664-nm semiconductor laser with a radiation power density of 150 mW/cm2 and a radiation energy density of 27 J/cm2. The procedure will be performed 22–26 hours after talaporfin sodium administration. This study protocol has been reviewed and approved by the Certified Committee in the Japanese Ministry of Health, Labor, and Welfare University Hospital Medical Information Network Clinical Trials Registry (Japan Registry of Clinical Trials number, jRCT2021220040).
Jun Muto, Hidetoshi Murata, Seiji Shigekawa, Takafumi Mitsuhara, Daisuke Umebayashi, Ryo Kanematsu, Masahiro Joko, Tatsushi Inoue, Tomoo Inoue, Toshiki Endo, Yuichi Hirose, for the Investigators of Intramedullary Spinal Cord Tumors in the Neurospinal Society of Japan
Neurospine 2023;20(3):774-782. Published online September 30, 2023
Objective The characteristics, imaging features, long-term surgical outcomes, and recurrence rates of primary spinal pilocytic astrocytomas (PAs) have not been clarified owing to their rarity and limited reports. Thus, this study aimed to analyze the clinical presentation, radiological features, pathological findings, and long-term outcomes of spinal PAs.
Methods Eighteen patients with spinal PAs who were surgically treated between 2009 and 2020 at 58 institutions were included in this retrospective multicenter study. Patient data, including demographics, radiographic features, treatment modalities, and long-term outcomes, were evaluated.
Results Among the 18 consecutive patients identified, 11 were women and 7 were men; the mean age at presentation was 31 years (3–73 years). Most PAs were located eccentrically, were solid or heterogeneous in appearance (cystic and solid), and had unclear margins. Gross total resection (GTR), subtotal resection (STR), partial resection (PR), and biopsy were performed in 28%, 33%, 33%, and 5% of cases, respectively. During a follow-up period of 65 ± 49 months, 4 patients developed a recurrence; however, the recurrence-free survival did not differ significantly between the GTR and non-GTR (STR, PR, and biopsy) groups.
Conclusion Primary spinal PAs are rare and present as eccentric and intermixed cystic and solid intramedullary cervical tumors. The imaging features of spinal PAs are nonspecific, and a definitive diagnosis requires pathological support. Surgical resection with prevention of neurological deterioration can serve as the first-line treatment; however, the resection rate does not affect recurrence-free survival. Investigation of relevant molecular biomarkers is required to elucidate the regrowth risk and prognostic factors.
Citations
Citations to this article as recorded by
Thoracic intramedullary spinal cord astrocytoma associated with syringomyelia: a case report of gross total resection Igin Ginting, Larona Hydravianto, Lukas Widhiyanto International Journal of Surgery Case Reports.2026; 138(3): 987. CrossRef
The 4S of spinal astrocytoma: specific location, syrinx, spasticity and score on Modified Mccormick Scale (MMS) predict long term outcomes in patients undergoing surgical resection of intramedullary spinal astrocytomas Bhavya Pahwa, Gaurav Singh, Shashank Sharad Kale Journal of Neuro-Oncology.2025; 171(1): 131. CrossRef
Current Treatment Outcomes for Intramedullary Spinal Cord Tumors in Japan Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Akira Ito, Tatsuya Sasaki Japanese Journal of Neurosurgery.2025; 34(6): 327. CrossRef
The Role of Radiotherapy, Chemotherapy, and Targeted Therapies in Adult Intramedullary Spinal Cord Tumors Ines Esparragosa Vazquez, François Ducray Cancers.2024; 16(16): 2781. CrossRef
Cervical Pilocytic Astrocytoma Mimicking Spondylotic Myelopathy: A Case Report and Literature Review Morgane M Soler-Rico, Lina Daoud, Edward Fomekong Cureus.2024;[Epub] CrossRef
The Inside Story of the Multi–center Studies in the Neurospinal Society of Japan Keisuke Takai Spinal Surgery.2024; 38(2): 105. CrossRef
Current Trends and Future Perspective of Intramedullary Spinal Cord Tumor Treatments Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki Japanese Journal of Neurosurgery.2024; 33(6): 408. CrossRef
Ryo Kanematsu, Masaki Mizuno, Tomoo Inoue, Toshiyuki Takahashi, Toshiki Endo, Seiji Shigekawa, Jun Muto, Daisuke Umebayashi, Takafumi Mitsuhara, Kazutoshi Hida, Junya Hanakita, for the Investigators of Intramedullary Spinal Cord Tumors in the Neurospinal Society of Japan
Neurospine 2023;20(3):766-773. Published online September 30, 2023
Objective The impact of adjuvant radiotherapy on overall survival (OS) and progression-free survival (PFS) of patients with grade II spinal cord astrocytomas remains controversial. Additionally, the relationship between progression and clinical deterioration after radiotherapy has not been well investigated.
Methods This study included 53 patients with grade II intramedullary spinal cord astrocytomas treated by either subtotal, partial resection or open biopsy. Their clinical performance status was assessed immediately before operation and 1, 6, 12, 24, and 60 months after surgery by Karnofsky Performance Scale (KPS). Patients with and without adjuvant radiotherapy were compared.
Results The groups with and without radiation comprised 23 and 30 patients with a mean age of 50.3 ± 22.6 years (range, 2–88 years). The mean overall disease progression rate was 47.1% during a mean follow-up period of 48.4 ± 39.8 months (range, 2.5–144.5 months). In the radiation group, 11 patients (47.8%) presented with progressive disease, whereas 14 patients (46.7%) presented with progressive disease in the group without radiation. There were no significant differences in OS or PFS among patients with or without adjuvant radiotherapy. KPS in both groups, especially radiation group, gradually decreased after operation and deteriorated before the confirmation of disease progression.
Conclusion Adjuvant radiotherapy did not show effectiveness regarding PFS or OS in patients with grade II spinal cord astrocytoma according to classical classification based on pathohistological findings.
Citations
Citations to this article as recorded by
Intramedullary Spinal Cord Tumors in the Elderly Patient Max Ward, Ethan D.L. Brown, Apratim Maity, Sheng-Fu Larry Lo, Daniel M. Sciubba Neurosurgery Clinics of North America.2026; 37(3): 363. CrossRef
The 4S of spinal astrocytoma: specific location, syrinx, spasticity and score on Modified Mccormick Scale (MMS) predict long term outcomes in patients undergoing surgical resection of intramedullary spinal astrocytomas Bhavya Pahwa, Gaurav Singh, Shashank Sharad Kale Journal of Neuro-Oncology.2025; 171(1): 131. CrossRef
The impact of adjuvant radiotherapy on overall survival in spinal low-grade gliomas: a propensity score-matched analysis Victor Gabriel El-Hajj, Sruthi Ranganathan, Harry Hoang, Abdul Karim Ghaith, Mohamad Bydon, Adrian Elmi-Terander Journal of Neuro-Oncology.2025; 171(3): 629. CrossRef
Current Treatment Outcomes for Intramedullary Spinal Cord Tumors in Japan Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Akira Ito, Tatsuya Sasaki Japanese Journal of Neurosurgery.2025; 34(6): 327. CrossRef
Molecular insights and the role of 18F-FDG-PET/CT in the diagnosis of spinal gliomas Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Junya Yamaguchi, Shoichi Haimoto, Fumiharu Ohka, Kazuya Motomura, Takashi Abe, Mamoru Matsuo, Eisuke Tsukamoto, Masahito Hara, Ryuta Saito Acta Neurochirurgica.2024;[Epub] CrossRef
The Role of Radiotherapy, Chemotherapy, and Targeted Therapies in Adult Intramedullary Spinal Cord Tumors Ines Esparragosa Vazquez, François Ducray Cancers.2024; 16(16): 2781. CrossRef
The Inside Story of the Multi–center Studies in the Neurospinal Society of Japan Keisuke Takai Spinal Surgery.2024; 38(2): 105. CrossRef
Spinal intramedullary tumors Belal Neyazi, Aiden Haghikia, Christian Mawrin, Elke Hattingen, Dirk Vordermark, I. Erol Sandalcioglu Deutsches Ärzteblatt international.2024;[Epub] CrossRef
Current Trends and Future Perspective of Intramedullary Spinal Cord Tumor Treatments Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki Japanese Journal of Neurosurgery.2024; 33(6): 408. CrossRef
Hiroto Kageyama, Kotaro Tatebayashi, Shinichi Yoshimura, Toshiki Endo, Kazutoshi Hida, Masaki Mizuno, for the Investigators of Intramedullary Spinal Cord Tumors in the Neurospinal Society of Japan
Neurospine 2023;20(2):678-691. Published online June 30, 2023
Objective Intramedullary spinal cord tumors (IMSCTs) are uncommon and difficult to treat. Studies examining the efficacy of rare IMSCT surgery in the elderly are limited. We conducted a subanalysis using multicenter retrospective-historical data provided by the Japan Neurospinal Society to compare surgical outcomes between older and younger adults with IMSCTs.
Methods We classified patients with IMSCTs into younger (aged 18–64 years) or older ( ≥ 65 years) groups. The primary outcomes of “improved” or “worsened” from the preoperative period to 6 months after surgery were evaluated using the modified McCormick scale (mMCs). A favorable outcome was defined as an mMCs grade of I/II at 6 months.
Results Among 841 patients registered, there were 658 younger (78.2%) and 183 older patients (21.8%) evaluated using mMCs at 6 months. Median preoperative mMCs grades were significantly worse in older patients than in younger patients. Neither the “improved” nor “worsened” rate differed significantly between the groups (28.1% vs. 25.1%; crude odds ratio [cOR], 0.86; 95% confidence interval [CI], 0.59–1.25; adjusted OR [aOR], 0.84; 95% CI, 0.55–1.28; 16.9% vs. 23.0%; cOR, 1.47; 95% CI, 0.98–2.20; aOR, 1.28; 95% CI, 0.83–1.97). Favorable outcomes were significantly less common among older adults in the univariate analysis but were not significant in the multivariate analysis (66.4% vs. 53.0%; cOR, 0.57; 95% CI, 0.41–0.80; aOR, 0.77; 95% CI, 0.50–1.19). In both younger and older patients, preoperative mMCs accurately predicted favorable outcomes.
Conclusion Age alone is not a sufficient reason to prohibit surgery for IMSCTs.
Citations
Citations to this article as recorded by
Clinical predictors of overall survival in pediatric patients with intramedullary spinal tumors: an analysis of the SEER database Arjit Singh, Saarang Patel, Jacob Gould, Noah Yaffe, Guan Li, Lou Blanpain, Julian Gendreau Child's Nervous System.2026;[Epub] CrossRef
Intramedullary Spinal Cord Tumors in the Elderly Patient Max Ward, Ethan D.L. Brown, Apratim Maity, Sheng-Fu Larry Lo, Daniel M. Sciubba Neurosurgery Clinics of North America.2026; 37(3): 363. CrossRef
Surgical outcomes of cervical spinal cord tumor in elderly patients assessed by the Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire Shuhei Ito, Narihito Nagoshi, Toshiki Okubo, Masahiro Ozaki, Satoshi Suzuki, Kazuki Takeda, Takahito Iga, Morio Matsumoto, Masaya Nakamura, Kota Watanabe Spinal Cord.2025; 63(5): 239. CrossRef
Current Treatment Outcomes for Intramedullary Spinal Cord Tumors in Japan Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Akira Ito, Tatsuya Sasaki Japanese Journal of Neurosurgery.2025; 34(6): 327. CrossRef
Prognostic Factors of Spinal Intramedullary Hemangioblastoma : Analysis of Surgical Outcomes and Tumor Characteristics Hyun-Jun Jang, Bong-Ju Moon, Kyung-Hyun Kim, Jeong-Yoon Park, Dong-Kyu Chin, Yong-Eun Cho, Keun-Su Kim Journal of Korean Neurosurgical Society.2024; 67(6): 637. CrossRef
The Inside Story of the Multi–center Studies in the Neurospinal Society of Japan Keisuke Takai Spinal Surgery.2024; 38(2): 105. CrossRef
An overview of intramedullary spinal cord metastases accompanied by a 2D intraoperative video Nehemiah Stewart, Brandon Lee, George Bourdages, Michael Galgano Surgical Neurology International.2024; 15: 461. CrossRef
Current Trends and Future Perspective of Intramedullary Spinal Cord Tumor Treatments Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki Japanese Journal of Neurosurgery.2024; 33(6): 408. CrossRef
Objective Spinal cord cavernous malformation (CM) is an intramedullary vascular lesion that may present with progressive symptoms. Surgery is recommended for symptomatic patients, but optimal timing of surgery is debatable. Some advocate waiting until plateau of neurological recovery and others support emergency surgery. There is no statistic on how commonly these strategies are utilized. We aimed to find contemporary practice pattern among neurosurgical spine centers in Japan.
Methods A database of intramedullary spinal cord tumors assembled by Neurospinal Society of Japan was surveyed and 160 patients with spinal cord CM were identified. Neurological function, disease duration, and number of days between presentation to hospitals and surgery were analyzed.
Results Duration of disease before presentation to hospitals ranged from 0 to 336 months (median, 4 months). Number of days between patients’ presentation and surgery ranged from 0 to 6,011 days (median, 32 days). Time from symptom onset to surgery ranged from 0 to 336.9 months (median, 6.6 months). Patients with severe preoperative neurological dysfunction had shorter duration of disease, fewer days between presentation and surgery, and shorter time between symptom onset and surgery. Patients with paraplegia or quadriplegia were more likely to improve when operated on within 3 months from onset.
Conclusion Timing of surgery for spinal cord CM in Japanese neurosurgical spine centers generally was early, with 50% of patients undergoing surgery within 32 days after presentation. Further study is needed to clarify optimal timing of surgery.
Citations
Citations to this article as recorded by
Spontaneous Regression of De Novo Cavernous Malformation in the Spinal Canal after Hemorrhage: A Case Report Minami Saura, Kiyoyuki Yanaka, Kuniyuki Onuma, Kazuhiro Nakamura, Nobuyuki Takahashi, Aiki Marushima, Eiichi Ishikawa Asian Journal of Neurosurgery.2026; 21(01): 153. CrossRef
Spinal Cavernous Malformations: A Narrative Review Aleeza Safdar, Ali Osman, Rouzbeh Motiei-Langroudi NeuroSci.2026; 7(1): 17. CrossRef
Reporting practices of baseline and surgical variables in spinal cavernous malformation surgery: a systematic review Tomas Ferreira, Louis Naraine, Joecelyn Kirani Tan, Hussein T. Malik, Mario K. Teo Neurosurgical Review.2026;[Epub] CrossRef
Treatment of patients with spinal cavernous malformations: a systematic review Abel Clemens Adriaan Sandmann, Marinus Abraham Kempeneers, K. Mariam Slot, René van den Berg, William Peter Vandertop, Dagmar Verbaan, Jonathan M. Coutinho Brain and Spine.2026; 6: 106021. CrossRef
The Role of Indocyanine Green Videoangiography in Intramedullary Spinal Cord Tumor Surgery: Focus on Lesion Localization Accuracy Jungbo SIM, Chang-Hyun LEE, Ayoung YOO, Yunhee CHOI, Woojin KIM, Hosung MYEONG, Hangeul PARK, Jun-Hoe KIM, Chi Heon KIM, Chun Kee CHUNG Neurologia medico-chirurgica.2026; 66(7): 426. CrossRef
Utility of narrow band imaging in a patient with a spinal cord cavernous malformation Kazuya Otsuki, Hideki Hayashi, Kazuhiro Kasashima, Hiroki Toda European Spine Journal.2025; 34(2): 719. CrossRef
Cavernoma of the cauda equina mimicking schwannoma: A case report Reza Naseri, Maryam Haghighi-Morad, Zahra Mohammadi Manesh, Farahnaz Bidari Zerehpoosh, Hadi Vahedi, Hamidreza Ashayeri Radiology Case Reports.2025; 20(4): 2140. CrossRef
Current Treatment Outcomes for Intramedullary Spinal Cord Tumors in Japan Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Akira Ito, Tatsuya Sasaki Japanese Journal of Neurosurgery.2025; 34(6): 327. CrossRef
The Inside Story of the Multi–center Studies in the Neurospinal Society of Japan Keisuke Takai Spinal Surgery.2024; 38(2): 105. CrossRef
Current Trends and Future Perspective of Intramedullary Spinal Cord Tumor Treatments Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki Japanese Journal of Neurosurgery.2024; 33(6): 408. CrossRef
The Reality of Benefit in Surgical Removal for Spinal Cord Cavernous Malformation: Commentary on “Acceptance of Early Surgery for Treatment of Spinal Cord Cavernous Malformation in Contemporary Japan” Toshiyuki Takahashi, Ryo Kanematsu Neurospine.2023; 20(2): 595. CrossRef
Commentary on “Surgical Outcomes of Symptomatic Intramedullary Spinal Cord Cavernous Malformations: Analysis of Consecutive Cases in a Single Center” Romulo Augusto Andrade de Almeida, Claudio Esteves Tatsui Neurospine.2023; 20(3): 822. CrossRef
Objective This study aimed to analyze the clinical characteristics, treatment strategies, and surgical outcomes of subependymoma patients from the 2022 Neurospinal Society of Japan multicenter intramedullary spinal cord tumor study.
Methods Twenty-six patients with spinal cord subependymoma who were included in the index study of 1,033 patients were retrospectively analyzed.
Results Mean patient age was 49.4 years. Seventeen patients were men and 9 were women. Sensory disturbance was reported in 22 patients and motor weakness in 18. Median duration of symptoms was 24 months. The tumor was eccentrically located in 19 patients (73.1%) and unilateral in 17 (65.4%). Gross total resection was achieved in 6 patients (23.1%). The same rate for ependymoma patients in the index study was significantly higher (74.8%). Median follow-up was 40.5 months (interquartile range, 18–68 months). In 2 patients who underwent only partial resection, reoperation was required owing to progression 68 and 90 months after surgery, respectively. No recurrence occurred in patients who underwent gross total resection. Five patients experienced neurological worsening after surgery.
Conclusion Although spinal cord subependymoma can be difficult to distinguish from other intramedullary spinal cord lesions before surgery, it is characterized by an indolent clinical course and eccentric location. Surgical treatment should prioritize functional preservation because the prognosis is good even after subtotal resection.
Citations
Citations to this article as recorded by
Microsurgical removal of a C1-C5 laterally located intramedullary subependymoma through a postero-lateral sulcus approach: case report, surgical video and critical review of diagnostic and surgical challenges Ciro Mastantuoni, Antonio Bocchetti, Maria Rosaria Scala, Valentina Cioffi, Giuseppe Corazzelli, Salvatore Di Colandrea, Stefania Garofalo, Francesco Fiorentino, Rosa Della Monica, Lorenzo Chiarotti, Raffaele de Falco European Spine Journal.2026; 35(6): 3572. CrossRef
Rare Spinal Cord Tumors Daniel Lubelski, Lansaol Yang, Abdul Karim Ghaith Neurosurgery Clinics of North America.2026; 37(3): 389. CrossRef
A rare case of multi-segmental lumbar intradural ependymoma: clinical presentation and surgical management: a case report Tao Chen, Jianfeng Chen, Bin Wu, Weijin Li, Fan Zhang, Jie Lin Frontiers in Oncology.2026;[Epub] CrossRef
Clinical characteristics and prognostic factors of primary spinal subependymoma: a single-center cohort study and systematic review Guang-Hao Zheng, Yao-Wu Zhang, Yi-Xiang Liu, Wei-Hao Liu, Bo Wang, Chong Wang, Kai Ji, Yong-Zhi Wang, Wen-Qing Jia Journal of Neuro-Oncology.2025; 172(3): 675. CrossRef
Genetic Markers and Mutations in Primary Spinal Cord Tumors and Their Impact on Clinical Management Rouzbeh Motiei-Langroudi Brain Sciences.2025; 15(10): 1028. CrossRef
Current Treatment Outcomes for Intramedullary Spinal Cord Tumors in Japan Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Akira Ito, Tatsuya Sasaki Japanese Journal of Neurosurgery.2025; 34(6): 327. CrossRef
Takeshi Hara, Masaki Mizuno, Kazutoshi Hida, Toru Sasamori, Yasuyuki Miyoshi, Hisaaki Uchikado, Hiroki Ohashi, Taku Sugawara, Yasuhiro Takeshima, Yukoh Ohara, Akihide Kondo, Toshiki Endo, for the Investigators of Intramedullary Spinal Cord Tumors in the Neurospinal Society of Japan
Neurospine 2023;20(3):747-755. Published online June 20, 2023
Objective This study was aimed to report the clinical characteristics of intramedullary schwannomas and discuss imaging findings and treatment strategies.
Methods The inclusion criterion was consecutive patients with intramedullary schwannomas who were surgically treated at 8 centers between 2009 and 2020. Clinical characteristics included age, sex, clinical presentation, disease duration, and follow-up period. The modified McCormick scale was used to compare the preoperative and postoperative conditions. Pre- and postoperative magnetic resonance images (MRI) of each case were analyzed.
Results The mean age of the total 11 patients at the operation was 50.2 years. The mean duration of the symptoms was 23 months, with limb paresthesia being the most common clinical presentation. The cervical spine was the most common localization level of the tumor in 6 cases. The mean follow-up duration was 49.4 months. Gross total resection (GTR) and subtotal resection (STR) was achieved in 9 and 2 cases, respectively. According to the modified McCormick scale at 6 months postoperatively, 7 cases (63.6%) had improved and 4 cases (36.3%) had unchanged grades. Typical MRI findings of the intramedullary schwannoma included ring-like enhancement, syringomyelia, cystic formation, intramedullary edema, and hemosiderin deposition. Gadolinium enhancement was homogenous in 8 cases (72.7%). The tumor margins were well demarcated in all cases.
Conclusion Intramedullary schwannoma should be considered when sharp margins and well-enhanced tumors are present at the cervical spine level and the initial symptoms are relatively mild, such as dysesthesia. When GTR cannot be achieved, STR for tumor decompression is recommended.
Citations
Citations to this article as recorded by
Diagnostic accuracy of preoperative imaging and intraoperative pathology in intradural spinal tumors and their impact on reoperation rate Shogo Hashimoto, Narihito Nagoshi, Toshiki Okubo, Masahiro Ozaki, Takahito Iga, Kazuki Takeda, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe Journal of Orthopaedic Science.2026; 31(2): 313. CrossRef
Spinal schwannoma with broad pial adhesion: A case report Masaki Yoshimura, Masato Hatanaka, Shin Kawamura Surgical Neurology International.2026; 17: 512. CrossRef
Intramedullary Schwannomas: A Rare Case Report Ali İmran Özmarasalı, Pınar Eser Ocak, Mine Özşen, Şeref Doğan Uludağ Üniversitesi Tıp Fakültesi Dergisi.2025; 50(3): 557. CrossRef
Intramedullary Schwannoma of the Conus Medullaris Presenting With Progressive Paraparesis: A Rare Case From a Resource‐Limited Setting William Nkenguye, Mujaheed Suleman, Alex Mremi, Felister Uisso, Hiten Solanki, Happiness Rabiel, Jay Lodhia Clinical Case Reports.2025;[Epub] CrossRef
Comparative analysis of MRI features and surgical outcomes between intramedullary and extramedullary schwannomas in the spinal cord Takahiro Kitagawa, Narihito Nagoshi, Manabu Hase, Toshiki Okubo, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Osahiko Tsuji, Morio Matsumoto, Masaya Nakamura, Kota Watanabe Spinal Cord.2025; 63(11): 607. CrossRef
Current Treatment Outcomes for Intramedullary Spinal Cord Tumors in Japan Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Akira Ito, Tatsuya Sasaki Japanese Journal of Neurosurgery.2025; 34(6): 327. CrossRef
The utility of intraoperative ultrasonography for spinal cord surgery Hangeul Park, Jun-Hoe Kim, Chang-Hyun Lee, Sum Kim, Young-Rak Kim, Kyung-Tae Kim, Ji-hoon Kim, John M. Rhee, Woo-Young Jo, Hyongmin Oh, Hee-Pyoung Park, Chi Heon Kim, Barry Kweh PLOS ONE.2024; 19(7): e0305694. CrossRef
The Inside Story of the Multi–center Studies in the Neurospinal Society of Japan Keisuke Takai Spinal Surgery.2024; 38(2): 105. CrossRef
Intramedullary schwannoma of conus medullaris with syringomyelia: a case report and literature review Hua Guo, Yao Wang, Liankun Wang, Dianhui Han, Xiangyi Meng, Qingchun Mu, Xiaofeng Chen Frontiers in Oncology.2024;[Epub] CrossRef
Current Trends and Future Perspective of Intramedullary Spinal Cord Tumor Treatments Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki Japanese Journal of Neurosurgery.2024; 33(6): 408. CrossRef
Yasuhiro Takeshima, Hirokazu Takami, Toshiki Endo, Masaki Mizuno, Kazutoshi Hida, for the Investigators of Intramedullary Spinal Cord Tumors in the Neurospinal Society of Japan
Neurospine 2023;20(3):756-765. Published online June 20, 2023
Objective This study aimed to clarify the relationship between recurrence and the extent of resection in surgery for intramedullary spinal hemangioblastoma (sHB) and its impact on von Hippel-Lindau (vHL) disease.
Methods Data on sHB cases followed up for at least 6 months after surgery were extracted from a nationwide registry of 1,033 consecutive spinal intramedullary tumors surgically treated between 2009 and 2020, and were retrospectively categorized into a sporadic or vHL group. The diagnosis of vHL disease was made at each institution based on clinical findings.
Results A total of 168 patients (sporadic group, 101; vHL group, 67) were included in the study. Compared with the sporadic group, the vHL group had a younger onset (45.4 ± 16.8 years vs. 39.6 ± 14.1 years, p = 0.02), more preoperative motor (47.5% vs. 68.7%, p < 0.01) and gait (37.6% vs. 61.2%, p < 0.01) impairments, and more patients with worsening neurological symptoms at discharge (p = 0.02). The gross total resection (GTR) rates and the recurrence rates were not statistically different between the sporadic and the vHL groups. GTR significantly improved recurrence-free survival compared to non-GTR in all patient analysis (p < 0.01) but this trend was not observed in the sporadic group. Physical functional improvement from discharge to 6 months after surgery was observed in the sporadic group (p < 0.01) but not in the vHL group.
Conclusion A high GTR rate may sufficiently decrease susceptibility to recurrence, especially in patients with sHB with vHL. In sporadic sHB, postoperative functional improvement can be expected, and the long-term functional prognosis is favorable.
Citations
Citations to this article as recorded by
Clinical features and long-term surgical outcomes of conus medullaris hemangioblastomas Liang Zhang, Bo Han, Wenqing Jia Egyptian Journal of Neurosurgery.2026;[Epub] CrossRef
Long-term surgical outcomes and prognosis of cervical spinal hemangioblastomas Liang Zhang, Bo Han, Wenqing Jia Clinical Neurology and Neurosurgery.2025; 249: 108753. CrossRef
Local tumor control and neurological outcomes after surgery for spinal hemangioblastomas in sporadic and von Hippel–Lindau disease: A multicenter study Johannes Wach, Alim Emre Basaran, Martin Vychopen, Tarik Tihan, Maria Wostrack, Vicki M Butenschoen, Bernhard Meyer, Sebastian Siller, Nils Ole Schmidt, Julia Onken, Peter Vajkoczy, Alejandro N Santos, Laurèl Rauschenbach, Philipp Dammann, Ulrich Sure, Ja Neuro-Oncology.2025; 27(6): 1567. CrossRef
Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years Abdel-Hameed Al-Mistarehi, Khaled J. Zaitoun, Sania Javed, Yuanxuan Xia, Andrew Hersh, Abdul Karim Ghaith, Carly Weber-Levine, Kelly Jiang, Majid Khan, Benjamin Mendelson, Noa Ksabi, Daniel M. Sciubba, Ziya L. Gokaslan, George I. Jallo, Jean-Paul Wolinsky Cancers.2025; 17(13): 2112. CrossRef
Autonomic Dysfunction Following Surgical Resection of Cervicomedullary Hemangioblastoma: A Case Report and Literature Review Naif Alshahrani, Maysoon Alqurashi, Turki Alzidani, Badr E Hafiz, Abdulaziz A Basurrah, Mohammed Aref Cureus.2025;[Epub] CrossRef
Prognostic relevance of MIB-1 labeling index in VHL-associated and sporadic spinal hemangioblastomas: a subgroup analysis from a multicentric study Johannes Wach, Alim Emre Basaran, Obada T. Alhalabi, Jürgen Beck, Vicki M. Butenschoen, Steven D. Chang, Marcus Czabanka, Tomasz Czernicki, Philipp Dammann, Roberto Doria-Medina, Sven Oliver Eicker, Alonso Barrantes-Freer, Christine Gizaw, Erdem Güresir, Acta Neuropathologica Communications.2025;[Epub] CrossRef
The two faces of hemangioblastoma: Examining the differences between sporadic and familial hemangioblastomas Molly Monsour, Samantha Schimmel, Bryan Clampitt, Elliot Pressman, Harry van Loveren, Siviero Agazzi, Kunal Vakharia International Journal of Neurooncology.2025; 7(1): 23. CrossRef
Current Treatment Outcomes for Intramedullary Spinal Cord Tumors in Japan Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Akira Ito, Tatsuya Sasaki Japanese Journal of Neurosurgery.2025; 34(6): 327. CrossRef
Prognostic Factors of Spinal Intramedullary Hemangioblastoma : Analysis of Surgical Outcomes and Tumor Characteristics Hyun-Jun Jang, Bong-Ju Moon, Kyung-Hyun Kim, Jeong-Yoon Park, Dong-Kyu Chin, Yong-Eun Cho, Keun-Su Kim Journal of Korean Neurosurgical Society.2024; 67(6): 637. CrossRef
The Inside Story of the Multi–center Studies in the Neurospinal Society of Japan Keisuke Takai Spinal Surgery.2024; 38(2): 105. CrossRef
Objective To assess the current management of primary spinal cord tumors (PSCTs) and determine whether and to what extent there are differences in surgical strategies for PSCTs.
Methods The Neurospinal Society of Japan conducted a survey between April 1 and 30, 2021. Certified spine surgeons were requested for information on the frequency of surgeries in 2020 and the surgical strategies adopted for each PSCTs. The following tumor histologies were focused: schwannoma, meningioma, and cauda equina tumor as extramedullary tumors; and ependymoma, hemangioblastoma, astrocytoma, and cavernoma as intramedullary tumors. The participants were divided according to their response as follows: experts, who had experienced ≥ 100 surgeries for PSCTs, and nonexperts.
Results Among 308 participants (63%), 35 (11%) were experts. The total number of PSCTs in 2020 was 802 of which 564 tumors were extramedullary and 223 were intramedullary. Schwannoma accounted for 53% of the extramedullary tumors, and ependymoma accounted for 39% of the intramedullary tumors. Surgical strategies significantly differed among both the experts and nonexperts groups. Some discrepancies in the adopted surgical strategies were observed between groups. Some of the nonexperts, and none of the experts, ruled out surgery for schwannomas (Eden type 4), astrocytomas, or cavernomas. Five nonexperts (2.2%), and none of the experts, resected the entire dura for meningiomas.
Conclusion A nationwide survey revealed that a sufficient consensus did not exist regarding surgical strategies for PSCTs. A disease-specific registry for PSCTs is necessary in academic societies.
Citations
Citations to this article as recorded by
Spinal Cavernous Malformations: A Narrative Review Aleeza Safdar, Ali Osman, Rouzbeh Motiei-Langroudi NeuroSci.2026; 7(1): 17. CrossRef
Treatments for Spinal Cord Malignant Astrocytic Tumors : Up to Date Toshiki Endo, Tomoo Inoue, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki Spinal Surgery.2024; 38(1): 17. CrossRef
Single-Center Experience of Resection of 120 Cases of Intradural Spinal Tumors Mirza Pojskić, Miriam Bopp, Benjamin Saß, Christopher Nimsky World Neurosurgery.2024; 187: e233. CrossRef
The Inside Story of the Multi–center Studies in the Neurospinal Society of Japan Keisuke Takai Spinal Surgery.2024; 38(2): 105. CrossRef
Current Trends and Future Perspective of Intramedullary Spinal Cord Tumor Treatments Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki Japanese Journal of Neurosurgery.2024; 33(6): 408. CrossRef
Acceptance of Early Surgery for Treatment of Spinal Cord Cavernous Malformation in Contemporary Japan Ryu Kurokawa, Toshiki Endo, Toshihiro Takami Neurospine.2023; 20(2): 587. CrossRef
Comparison of the Recurrence and Surgical Outcome of Spinal Hemangioblastoma in Sporadic and Von Hippel-Lindau Diseases: A Subanalysis of a Nationwide Study by the Neurospinal Society of Japan Yasuhiro Takeshima, Hirokazu Takami, Toshiki Endo, Masaki Mizuno, Kazutoshi Hida Neurospine.2023; 20(3): 756. CrossRef
To Seek Appropriate Management for Intramedullary Spinal Cord Tumor: Commentary on Special Issue “Spinal Intramedullary Tumor” Toshiyuki Takahashi, Tomoo Inoue Neurospine.2023; 20(3): 733. CrossRef
Toshiki Endo, Tomoo Inoue, Masaki Mizuno, Ryu Kurokawa, Kiyoshi Ito, Shigeo Ueda, Toshihiro Takami, Kazutoshi Hida, Minoru Hoshimaru, Investigators of intramedullary spinal cord tumors in the Neurospinal Society of Japan
Neurospine 2022;19(2):441-452. Published online June 30, 2022
Objective We performed a retrospective observational study to demonstrate the surgical risks and long-term prognoses of intramedullary tumors in Japan using a multicenter registry authorized by the Neurospinal Society of Japan.
Methods Data from 1,033 consecutive patients with intramedullary tumors, treated between 2009 and 2020, were collected from 58 centers. Patients with spinal lipomas or myxopapillary ependymomas were excluded. Patient characteristics, clinical presentations, imaging characteristics, treatments, and outcomes were analyzed. The modified McCormick scale was used to classify functional status. Survival was described using Kaplan-Meier curves, and multivariable logistic regression analyses were performed.
Results The mean age of the patients was 48.4 years. Data of 361 ependymomas, 196 hemangioblastomas, 168 astrocytic tumors, 160 cavernous malformations, and the remaining 126 cases including subependymomas, metastases, schwannomas, capillary hemangiomas, and intravascular B-cell lymphomas were analyzed. Twenty-two patients were undiagnosed. The mean follow-up duration was 46.1 ± 38.5 months. Gross total tumor removal was achieved in 672 tumors (65.1%). On the modified McCormick scale, 234 patients (22.7%) had worse postoperative grades at the time of discharge. However, neurological status gradually improved. At 6 months postoperatively, 251 (27.5%), 500 (54.9%), and 160 patients (17.6%) had improved, unchanged, and worsened grades, respectively. Preoperative functional status, gross total tumor removal, and histopathological type were significantly associated with mortality and functional outcomes.
Conclusion Our findings demonstrate better postoperative functional outcomes in patients with fewer preoperative neurological deficits. Degree of resection, postoperative treatments, and prognoses are closely related to the histology of intramedullary tumors.
Citations
Citations to this article as recorded by
Impact of Cigarette Smoking on Clinical Outcomes after Surgical Resection in Patients with Intramedullary Spinal Cord Tumors: A Retrospective Comparative Study Toshiki Okubo, Narihito Nagoshi, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe Spine Surgery and Related Research.2026; 10(1): 80. CrossRef
Clinical predictors of overall survival in pediatric patients with intramedullary spinal tumors: an analysis of the SEER database Arjit Singh, Saarang Patel, Jacob Gould, Noah Yaffe, Guan Li, Lou Blanpain, Julian Gendreau Child's Nervous System.2026;[Epub] CrossRef
Use of gross total resection and adjunctive therapy in treatment of spinal column tumors in low- and middle-income countries: A meta-analysis Alexa R. Lauinger, Helen Kemprocos, Samuel Blake, Alan Fullenkamp, Amogh Angadi, Gregory Matthew Polites, Paul M. Arnold Surgical Neurology International.2026; 17: 61. CrossRef
Clinical Characteristics, Management, and Outcomes of Intramedullary Spinal Cord Ependymomas: A Systematic Review and Meta-Analysis Yuris Wira Artha, Lukas Widhiyanto, Primadenny Ariesa Airlangga, Aries Rakhmat Hidayat, Komang Agung Irianto Spine Surgery and Related Research.2026; 10(2): 151. CrossRef
Preoperative risk stratification for long-term neurological status in spinal ependymoma: an MRI-centered nomogram Bo Wang, Weihao Liu, Chong Wang, Kai Ji, Yaowu Zhang, Guanghao Zheng, Xingyu Liu, Tianyi Zhang, Yixiang Liu, Ting Sun, Yongzhi Wang, Wenqing Jia European Spine Journal.2026;[Epub] CrossRef
Surgical Outcomes and Medical Costs Associated with Spinal Cord Tumors―Comparison of Extramedullary and Intramedullary Tumors― Takumi Hoshimaru, Masao Fukumura, Ryokichi Yagi, Motomasa Furuse, Shinji Kawabata, Toshihiro Takami, Masahiko Wanibuchi Spinal Surgery.2026; 40(1): 69. CrossRef
Machine Learning–Based Prediction of Independent Ambulation Following Intramedullary Spinal Cord Tumor Resection Blake Perdikis, Adhith Palla, Nicolas K. Goff, Hammad A. Khan, Sumedha Rai, Zoran Budimlija, Darryl Lau, Anthony Frempong-Boadu, Ilya Laufer Neurosurgery.2026;[Epub] CrossRef
C2 Laminoplasty with Reconstruction of the Deep Extensor Muscles for Preventing Cervical Kyphosis after High Cervical Spinal Tumor Removal: Technical Notes Keisuke TAKAI, Takeaki ENDO, Shinsuke YOSHIDA, Ayako ISOO Neurologia medico-chirurgica.2026; 66(8): 573. CrossRef
Comment on "Thoracic Intradural Extramedullary Cavernous Malformation Mimicking Meningioma" Yoshinori SHIBAIKE NMC Case Report Journal.2026; 13: 415. CrossRef
Assessment of the Postoperative Progression in Patients With Intramedullary Spinal Cord Tumors Based on the Severity of Preoperative Gait Disturbance Toshiki Okubo, Narihito Nagoshi, Takahito Iga, Kazuki Takeda, Masahiro Ozaki, Satoshi Suzuki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe Global Spine Journal.2025; 15(4): 2183. CrossRef
PRO-QOL after gross total resection of spinal ependymoma: a retrospective study based on 3-year follow-up observations in a single center Dingbang Chen, Tianxiang Shao, Haocheng Zhu, Xin Gao, Quan Huang, Xinghai Yang, Qi Jia, Jianru Xiao European Spine Journal.2025; 34(2): 665. CrossRef
Machine learning-driven national analysis for predicting adverse outcomes in intramedullary spinal cord tumor surgery Marc Ghanem, Abdul Karim Ghaith, Sung Huang Laurent Tsai, Yu-Cheng Yeh, Oluwaseun O. Akinduro, Loizos Michaelides, Victor Gabriel El-Hajj, Hassan Saad, Ali Tfaily, Antonio Bon Nieves, Alfredo Quiñones-Hinojosa, Kingsley Abode-Iyamah, Mohamad Bydon European Spine Journal.2025; 34(9): 3863. CrossRef
Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years Abdel-Hameed Al-Mistarehi, Khaled J. Zaitoun, Sania Javed, Yuanxuan Xia, Andrew Hersh, Abdul Karim Ghaith, Carly Weber-Levine, Kelly Jiang, Majid Khan, Benjamin Mendelson, Noa Ksabi, Daniel M. Sciubba, Ziya L. Gokaslan, George I. Jallo, Jean-Paul Wolinsky Cancers.2025; 17(13): 2112. CrossRef
Modern treatment strategy intramedullary tumors of the spinal cord N. A. Konovalov, R. A. Onoprienko, S. V. Kaprova, E. S. Brinyuk, Yu. M. Poluektov, M. O. Kudymets, L. R. Gabrielyan, N. D. Shmelev Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery).2025; (7): 962. CrossRef
The Role of D-Wave Monitoring in Motor-Evoked Potential Loss During Intramedullary Spinal Cord Tumors Resection Hangeul Park, Woojin Kim, Jungbo Sim, Ho Sung Myeong, Young Doo Choi, Gilho Kwak, Bo Eun Kim, Jeongeum Park, Sung-Min Kim, Keewon Kim, Hee-Pyoung Park, Jun-Hoe Kim, Chang-Hyun Lee, Chun Kee Chung, Chi Heon Kim Neurospine.2025; 22(3): 650. CrossRef
Current Treatment Outcomes for Intramedullary Spinal Cord Tumors in Japan Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Akira Ito, Tatsuya Sasaki Japanese Journal of Neurosurgery.2025; 34(6): 327. CrossRef
Tradition and Inheritance of Neurospine Surgery Toshihiro Takami Japanese Journal of Neurosurgery.2025; 34(7): 377. CrossRef
Surgical Outcomes and Medical Costs Associated with Spinal Cord Tumors: Comparison of Extramedullary and Intramedullary Tumors Takumi Hoshimaru, Kosuke Sakai, Yusuke Fukuo, Takuya Kosaka, Masao Fukumura, Ryokichi Yagi, Ryo Hiramatsu, Masahiro Kameda, Naosuke Nonoguchi, Motomasa Furuse, Shinji Kawabata, Toshihiro Takami, Masahiko Wanibuchi World Neurosurgery.2024; 181: e234. CrossRef
Epidemiology and Comparative Analysis of Outcomes of Intramedullary Spinal Cord Tumor Between Pediatric and Adult Patients Daisuke Umebayashi, Kentaro Naito, Ryu Kurokawa, Toshiki Endo, Masaki Mizuno, Minoru Hoshimaru, Phyo Kim, Kazutoshi Hida, Toshihiro Takami Spine.2024; 49(2): 107. CrossRef
Thoracic Intra and Extramedullary Capillary Hemangioma with Subacute Clinical Course: A Case Report and Literature Review Yumeki YAMAMOTO, Hiroya SHIMAUCHI-OHTAKI, Fumiaki HONDA, Takahiro SHIRAKURA, Keigo ARAMAKI, Ryosuke SHINTOKU, Takaaki MIYAGISHIMA, Masanori AIHARA, Hideaki YOKOO, Yuhei YOSHIMOTO NMC Case Report Journal.2024; 11: 85. CrossRef
Treatments for Spinal Cord Malignant Astrocytic Tumors : Up to Date Toshiki Endo, Tomoo Inoue, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki Spinal Surgery.2024; 38(1): 17. CrossRef
Nondysraphic intramedullary spinal cord lipoma: a case report Susmin Karki, Prakash Regmi, Asmita Parajuli, Khusbu Kumari, Bikas Thapa, Sushil K. Shilpakar Annals of Medicine & Surgery.2024; 86(6): 3683. CrossRef
The Inside Story of the Multi–center Studies in the Neurospinal Society of Japan Keisuke Takai Spinal Surgery.2024; 38(2): 105. CrossRef
First-in-Human Trial of Photodynamic Therapy for Spinal Cord Malignant Astrocytoma: Study Protocol Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki, Aya Sato, Shinjiro Fukami, Satoshi Miyata, Jiro Akimoto Neurospine.2024; 21(4): 1276. CrossRef
Conservative, Nonsurgical Management of Low Back Pain in the Primary Care Setting Ahmed Mohammed Ahmed Mohieldin Asian Journal of Pharmaceutical Research and Health Care.2024; 16(4): 352. CrossRef
Current Trends and Future Perspective of Intramedullary Spinal Cord Tumor Treatments Toshiki Endo, Yoshiharu Takahashi, Taketo Nishizawa, Tatsuya Sasaki Japanese Journal of Neurosurgery.2024; 33(6): 408. CrossRef
First Clinical Report of the Intraoperative Macro- and Micro-Photodiagnosis and Photodynamic Therapy Using Talaporfin Sodium for a Patient with Disseminated Lumbar Medulloblastoma Jiro Akimoto, Shinjiro Fukami, Kenta Nagai, Michihiro Kohno Journal of Clinical Medicine.2023; 12(2): 432. CrossRef
Clinical Characteristics and Treatment Outcomes of Long-Level Intramedullary Spinal Cord Tumors: A Consecutive Series of 43 Cases Dongao Zhang, Tao Fan, Wayne Fan, Xingang Zhao, Cong Liang, Yinqian Wang, Kun Wu Neurospine.2023; 20(1): 231. CrossRef
Predictors of Progression-Free Survival in Patients With Spinal Intramedullary Ependymoma: A Multicenter Retrospective Study by the Neurospinal Society of Japan Kentaro Naito, Daisuke Umebayashi, Ryu Kurokawa, Toshiki Endo, Masaki Mizuno, Minoru Hoshimaru, Phyo Kim, Kazutoshi Hida, Toshihiro Takami Neurosurgery.2023; 93(5): 1046. CrossRef
The Reality of Benefit in Surgical Removal for Spinal Cord Cavernous Malformation: Commentary on “Acceptance of Early Surgery for Treatment of Spinal Cord Cavernous Malformation in Contemporary Japan” Toshiyuki Takahashi, Ryo Kanematsu Neurospine.2023; 20(2): 595. CrossRef
Outcomes of Intramedullary Spinal Cord Tumor Surgery in Older Versus Younger Adults: A Multicenter Subanalysis Study by the Neurospinal Society of Japan Hiroto Kageyama, Kotaro Tatebayashi, Shinichi Yoshimura, Toshiki Endo, Kazutoshi Hida, Masaki Mizuno Neurospine.2023; 20(2): 678. CrossRef
Acceptance of Early Surgery for Treatment of Spinal Cord Cavernous Malformation in Contemporary Japan Ryu Kurokawa, Toshiki Endo, Toshihiro Takami Neurospine.2023; 20(2): 587. CrossRef
The evolution of spinal cord surgery: history, people, instruments, and results Nir Shimony, Katie Fehnel, I. Rick Abbott, George I. Jallo Child's Nervous System.2023; 39(10): 2687. CrossRef
Clinical Characteristics and Long-term Outcomes of Spinal Pilocytic Astrocytomas: A Multicenter Retrospective Study by the Neurospinal Society of Japan Jun Muto, Hidetoshi Murata, Seiji Shigekawa, Takafumi Mitsuhara, Daisuke Umebayashi, Ryo Kanematsu, Masahiro Joko, Tatsushi Inoue, Tomoo Inoue, Toshiki Endo, Yuichi Hirose Neurospine.2023; 20(3): 774. CrossRef
To Seek Appropriate Management for Intramedullary Spinal Cord Tumor: Commentary on Special Issue “Spinal Intramedullary Tumor” Toshiyuki Takahashi, Tomoo Inoue Neurospine.2023; 20(3): 733. CrossRef
Impact of surgical treatment for intramedullary spinal cord metastasis on neurological function and survival: A multicenter retrospective study by the Neurospinal Society of Japan Motoyuki Iwasaki, Kentaro Naito, Toshiki Endo, Yasukazu Hijikata, Masaki Mizuno, Minoru Hoshimaru, Kazutoshi Hida, Toshihiro Takami Journal of Clinical Neuroscience.2023; 117: 27. CrossRef
The Impact of Adjuvant Radiotherapy on Clinical Performance Status in Patients With Grade II Spinal Cord Astrocytoma – A Nationwide Analysis by the Neurospinal Society of Japan Ryo Kanematsu, Masaki Mizuno, Tomoo Inoue, Toshiyuki Takahashi, Toshiki Endo, Seiji Shigekawa, Jun Muto, Daisuke Umebayashi, Takafumi Mitsuhara, Kazutoshi Hida, Junya Hanakita Neurospine.2023; 20(3): 766. CrossRef
Comparison of the Recurrence and Surgical Outcome of Spinal Hemangioblastoma in Sporadic and Von Hippel-Lindau Diseases: A Subanalysis of a Nationwide Study by the Neurospinal Society of Japan Yasuhiro Takeshima, Hirokazu Takami, Toshiki Endo, Masaki Mizuno, Kazutoshi Hida Neurospine.2023; 20(3): 756. CrossRef
Intramedullary Schwannoma of the Spinal Cord: A Nationwide Analysis by the Neurospinal Society of Japan Takeshi Hara, Masaki Mizuno, Kazutoshi Hida, Toru Sasamori, Yasuyuki Miyoshi, Hisaaki Uchikado, Hiroki Ohashi, Taku Sugawara, Yasuhiro Takeshima, Yukoh Ohara, Akihide Kondo, Toshiki Endo Neurospine.2023; 20(3): 747. CrossRef
Spinal Cord Subependymoma: A Subanalysis of the Neurospinal Society of Japan’s Multicenter Study of Intramedullary Spinal Cord Tumors Takashi Yagi, Masaki Mizuno, Hiroto Kageyama, Kotaro Tatebayashi, Toshiki Endo, Yasuhiro Takeshima, Motoyuki Iwasaki, Ryu Kurokawa, Keisuke Takai, Misao Nishikawa, Kazutoshi Hida Neurospine.2023; 20(3): 735. CrossRef
Description of the Diversity in Surgical Indication and Surgical Strategies for Primary Spinal Cord Tumors: A Nationwide Survey by the Neurospinal Society of Japan Yasukazu Hijikata, Shigeo Ueda, Takao Yasuhara, Daisuke Umebayashi, Toshiki Endo, Toshihiro Takami, Masaki Mizuno, Kazutoshi Hida, Minoru Hoshimaru Neurospine.2022; 19(4): 1122. CrossRef
The present study reports the case of an 81-year-old woman who underwent lumboperitoneal shunt (LPS) placement for idiopathic normal-pressure hydrocephalus. After LPS placement, the patient presented with radicular pain. A computed tomography scan revealed that the intradural lumbar catheter was tangled at the T11 vertebra; therefore, we decided to remove the catheter under local anesthesia. When 1 cm of the lumbar catheter was withdrawn, the patient suddenly complained of complete loss of bilateral leg sensation and muscle strength. Emergency magnetic resonance imaging revealed that the lumbar catheter was tangled and wedged into the ventral spinal cord at T11, causing severe spinal cord compression. In the operating room under general anesthesia, the lumbar catheter was removed through a right T12 hemilaminectomy. Postoperatively, her neurological function was fully restored. Although LPS placement is frequently indicated for idiopathic normal-pressure hydrocephalus, recognition of this rare complication is important for proper LPS management.
Citations
Citations to this article as recorded by
Fluoroscopic Spinal Catheter Tip Guidance in Lumboperitoneal Shunting: Mechanistic Basis for Preventing Radicular Pain Yukihiro Goto, Masayuki Yamagishi, Takuro Inoue Operative Neurosurgery.2026;[Epub] CrossRef
Progress in Surgical Treatment of Traffic Hydrocephalus 飞 张 Advances in Clinical Medicine.2021; 11(09): 3942. CrossRef
Development of a Lumbar Extradural Arachnoid Cyst Associated with a Lumbar Catheter of Lumboperitoneal Shunt: A Case Report Daisuke KITA, Yuya YOSHIDA, Fumihide ENKAKU NMC Case Report Journal.2021; 8(1): 811. CrossRef
First
Prev
