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"Cervical discectomy"

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Minimally Invasive Spine Surgery

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Anatomical Importance Between Neural Structure and Bony Landmark in Neuroventral Decompression for Posterior Endoscopic Cervical Discectomy
Neurospine. 2025;22(1):286-296.   Published online March 31, 2025
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Anatomical Importance Between Neural Structure and Bony Landmark in Neuroventral Decompression for Posterior Endoscopic Cervical Discectomy
Neurospine. 2025;22(1):286-296.   Published online March 31, 2025
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Objective
This study aims to investigate the anatomical relationship among the nerve roots, intervertebral space, pedicles, and intradural rootlets of the cervical spine for improving operative outcomes and exploring neuroventral decompression approach in posterior endoscopic cervical discectomy (PECD).
Methods
Cervical computed tomography myelography imaging data from January 2021 to May 2023 were collected, and the RadiAnt DICOM Viewer Software was employed to conduct multiplane reconstruction. The following parameters were recorded: width of nerve root (WN), nerve root-superior pedicle distance (NSPD), nerve root-inferior pedicle distance (NIPD), and the relationship between the intervertebral space and the nerve root (shoulder, anterior, and axillary). Additionally, the descending angles between the spinal cord and the ventral (VRA) and dorsal (DRA) rootlets were measured.
Results
The WN showed a gradual increase from C4 to C7, with measurements notably larger in men compared to women. The NSPD decreased gradually from the C2–3 to the C5–6 levels. However, the NIPD showed an opposite level-related change, notably larger than the NSPD at the C4–5, C5–6, and C7–T1 levels. Furthermore, significant differences in NIPD were observed between different age groups and genders. The incidence of the anterior type exhibited a gradual decrease from the C2–3 to the C5–6 levels. Conversely, the axillary type exhibited an opposite level-related change. Additionally, the VRA and DRA decreased as the level descended, with measurements significantly larger in females.
Conclusion
A prediction of the positional relationship between the intervertebral space and the nerve root is essential for the direct neuroventral decompression in PECD to avoid damaging the neural structures. The axillary route of the nerve root offers a safer and more effective pathway for performing direct neuroventral decompression compared to the shoulder approach.

Citations

Citations to this article as recorded by  Crossref logo
  • Acute Radiculopathy After Anterior Cervical Discectomy and Fusion of Cervical Spondylotic Radiculopathy with Cervical Kyphosis: Causes and Prevention
    Fan He, Zong-xian Feng, Pei-ming Sang, Shi-rong Gu, Bin-hui Chen
    World Neurosurgery.2026; 206: 124767.     CrossRef
  • Bone tunnel approach for cervical spondylotic radiculopathy with uncovertebral osteophytes
    Xin Wang, Tao Hu, Bo Lei, Chaofan Qin, Xiang Tan, Changjun Pi, Mingxin Chen, Qingshuai Yu, Si Cheng, Zhengjian Yan
    European Spine Journal.2025;[Epub]     CrossRef
  • 3,022 View
  • 150 Download
  • 2 Web of Science
  • 2 Crossref

Cervical Spine

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Radiographic Characteristics of Caudal Segment in Multilevel Anterior Cervical Discectomy and Fusion: The Bony Buttress Formation
Neurospine. 2024;21(4):1241-1250.   Published online December 31, 2024
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Radiographic Characteristics of Caudal Segment in Multilevel Anterior Cervical Discectomy and Fusion: The Bony Buttress Formation
Neurospine. 2024;21(4):1241-1250.   Published online December 31, 2024
Close
Objective
Anterior cervical discectomy and fusion (ACDF) with anterior plating is a commonly performed procedure for cervical disc diseases. While the clinical outcomes of most reported multilevel ACDF cases are excellent, symptomatic pseudarthrosis remains a challenge, often requiring revision surgeries. This study aims to present the radiological characteristics of multilevel ACDF constructs, which can be considered during intraoperative management to prevent pseudarthrosis.
Methods
This retrospective cohort study included patients who underwent multilevel (3 or 4 levels) ACDF with anterior plating between June 2010 and August 2022. Patients were regularly followed at 4 months, 12 months, and then annually postoperation. Fusion rates and characteristic radiological patterns, such as the formation of bony buttresses underneath the anterior plate, were graded and evaluated.
Results
A total of 163 patients were included in the study. Overall fusion rates were 26.38%, 64.34%, and 81.58% at 4-month, 1-year, and the final follow-up, respectively. Nonunions at 4-month follow-up with tightly engaged anterior plate with bony buttress formation were more likely to fuse in the later period (Buttress grade 0 vs. 1; p=0.01, odds ratio [OR], 5.70, Buttress grade 1 vs. >2; p<0.01, OR, 12.00).
Conclusion
This study emphasizes the significance of pseudarthrosis following multilevel ACDF. Pseudarthrosis predominantly occurs in the caudal-most segment of the construct, particularly when it terminates at C7. Constructs that are not tightly engaged and lack bony buttress formation in the caudal part of multilevel ACDF are more likely to develop pseudarthrosis.
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Clinical Effectiveness of Artificial Disc Replacement in Comparison With Anterior Cervical Discectomy and Fusion in the Patients With Cervical Myelopathy: Systematic Review and Meta-analysis
Neurospine. 2023;20(3):1047-1060.   Published online September 30, 2023
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Clinical Effectiveness of Artificial Disc Replacement in Comparison With Anterior Cervical Discectomy and Fusion in the Patients With Cervical Myelopathy: Systematic Review and Meta-analysis
Neurospine. 2023;20(3):1047-1060.   Published online September 30, 2023
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Objective
Cervical myelopathy (CM) describes the compressive cervical spinal cord state, often accompanied by serious clinical condition, by herniated disc or hypertrophied spurs or ligament. Anterior cervical discectomy and fusion (ACDF) has been frequently employed as conventional surgical solution for this CM despite its inherent biomechanical handicap. Alternatively, an artificial disc replacement (ADR) preserves cervical motion while still decompressing the spinal canal and neural foramen. This analysis elaborated to clarify the potential benefits of ADR application to CM over ACDF from the conglomerated results of the past references.
Methods
A literature search was performed using MEDLINE, Embase, Cochrane review, and KMbase databases from the studies published until March 2023. Six studies (3 randomized controlled study [RCTs] and 3 non-RCTs) were included in a qualitative and quantitative synthesis. Data were extracted and analyzed using a random effects model to obtain effect size and its statistical significance. Quality assessment and evidence level were established in accordance with the GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology.
Results
Among 6 studies, 2 studies showed that ADR group achieved significantly better clinical improvement than the ACDF group, while the rest 4 studies revealed no significant difference. A meta-analysis showed better clinical outcomes with or without statistical significance. The level of evidence was low because of inconsistency and imprecision.
Conclusion
ADR was superior or at least, not inferior to ACDF in terms of functional recovery. However, its application to the CM patients is merely empowered with weak strength due to low level of evidence.

Citations

Citations to this article as recorded by  Crossref logo
  • ACDF and cervical disc replacement for single-level cervical spine degenerative disease: a frailty driven propensity score-matched comparative analysis
    Nithin Gupta, Omar Sbaih, William DiCiurcio III, Mark Miller, Ruchir Nanavati, Hunter Smith, Blake Delgadillo, Matthew Meade, Aman Singh, Rohin Singh, Christian Bowers
    European Spine Journal.2026;[Epub]     CrossRef
  • Comparison of Hybrid Surgery and Two-Level ACDF in Treating Consecutive Cervical Degenerative Disc Disease: A Systematic Review and Meta-Analysis
    Yihan Yang, Weishi Liang, Duan Sun, Bo Han, Zhangfu Li, Yeqiu Xu, Peng Yin, Xianjun Qu, Yong Hai
    Global Spine Journal.2025; 15(8): 3953.     CrossRef
  • Recent progress in surgical treatment of cervical spine myelopathy – A narrative review
    Jun Ouchida, Hiroaki Nakashima, Sadayuki Ito, Naoki Segi, Ippei Yamauchi, Shiro Imagama
    Journal of Clinical Orthopaedics and Trauma.2025; 68: 103074.     CrossRef
  • Cervical disc replacement versus anterior cervical discectomy and fusion using stand-alone cage for degenerative cervical spondylosis: a systematic review and meta-analysis based on randomized controlled trials
    Yu Zhang, Jidong Ju, Jinchun Wu
    Neurosurgical Review.2025;[Epub]     CrossRef
  • Does the novel artificial cervical joint complex resolve the conflict between stability and mobility after anterior cervical surgery? a finite element study
    Bing Meng, Xiong Zhao, Xin-Li Wang, Jian Wang, Chao Xu, Wei Lei
    Frontiers in Bioengineering and Biotechnology.2024;[Epub]     CrossRef
  • Practical Answers to Frequently Asked Questions in Anterior Cervical Spine Surgery for Degenerative Conditions
    Tejas Subramanian, Austin Kaidi, Pratyush Shahi, Tomoyuki Asada, Takashi Hirase, Avani Vaishnav, Omri Maayan, Troy B. Amen, Kasra Araghi, Chad Z. Simon, Eric Mai, Olivia C. Tuma, Ashley Yeo Eun Kim, Nishtha Singh, Maximillian K. Korsun, Joshua Zhang, Myle
    Journal of the American Academy of Orthopaedic Surgeons.2024; 32(18): e919.     CrossRef
  • Radiographic Characteristics of Caudal Segment in Multilevel Anterior Cervical Discectomy and Fusion: The Bony Buttress Formation
    Chang Hwa Ham, Joo Han Kim, Youn-Kwan Park, Woo-Keun Kwon, Hong Joo Moon
    Neurospine.2024; 21(4): 1241.     CrossRef
  • 13,804 View
  • 239 Download
  • 6 Web of Science
  • 7 Crossref

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Incidence, Risk Factors, and Management of Postoperative Hematoma Following Anterior Cervical Decompression and Fusion for Degenerative Cervical Diseases
Neurospine. 2023;20(2):525-535.   Published online June 30, 2023
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Incidence, Risk Factors, and Management of Postoperative Hematoma Following Anterior Cervical Decompression and Fusion for Degenerative Cervical Diseases
Neurospine. 2023;20(2):525-535.   Published online June 30, 2023
Close
Objective
Studies discussed few risk factors for specific patients, such as duration of disease; or surgical factors, such as duration and time of surgery; or C3 or C7 involvement, which could have led to the formation of hematomas (HTs). To investigate the incidence, risk factors especially the factors mentioned above, and management of postoperative HTs following anterior cervical decompression and fusion (ACF) for degenerative cervical diseases.
Methods
Medical records of 1,150 patients who underwent ACF for degenerative cervical diseases at our hospital between 2013 and 2019 were identified and reviewed. Patients were categorized into the HT group (HT group) or normal group (no-HT group). Demographic, surgical and radiographic data were recorded prospectively to identify risk factors for HT.
Results
Postoperative HT was identified in 11 patients, with an incidence rate of 1.0% (11 of 1,150). HT occurred within 24 hours postoperatively in 5 patients (45.5%), while it occurred at an average of 4 days postoperatively in 6 patients (54.5%). Eight patients (72.7%) underwent HT evacuation; all patients were successfully treated and discharged. Smoking history (odds ratio [OR], 5.193; 95% confidence interval [CI], 1.058–25.493; p = 0.042), preoperative thrombin time (TT) value (OR, 1.643; 95% CI, 1.104–2.446; p = 0.014) and antiplatelet therapy (OR, 15.070; 95% CI, 2.663–85.274; p = 0.002) were independent risk factors for HT. Patients with postoperative HT had longer days of first-degree/intensive nursing (p < 0.001) and greater hospitalization costs (p = 0.038).
Conclusion
Smoking history, preoperative TT value and antiplatelet therapy were independent risk factors for postoperative HT following ACF. High-risk patients should be closely monitored through the perioperative period. Postoperative HT in ACF was associated with longer days of first-degree/intensive nursing and more hospitalization costs.

Citations

Citations to this article as recorded by  Crossref logo
  • Risk factors for symptomatic hematoma following cervical spine surgery: a systematic review and meta-analysis
    ChenGuang Wang, ChengHan Xu, YinGang Zhang
    Journal of Orthopaedic Surgery and Research.2026;[Epub]     CrossRef
  • Clinical characteristics of cervical myelopathy and factors associated with severe disease among patients with cervical disc herniation in a tertiary center in Palestine
    Ahmed Daqour, Heyam Shakarneh, Tala Sharaqa, Ghaya Belih, Batoul Feeno, Iba Hmouz, Shahed Nasser, Abdulsalam Alkaiyat, Ahmad Rjoub, Mohammad Abuawad
    The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2026;[Epub]     CrossRef
  • Novel Risk Factors for Postoperative Hematoma Requiring Reoperation Following Anterior Cervical Discectomy and Fusion
    Dana G. Rowe, Seeley Yoo, Connor Barrett, Emily Luo, Alissa Arango, Matthew Morris, Kerri-Anne Crowell, Russel R. Kahmke, C. Rory Goodwin, Melissa M. Erickson
    Clinical Spine Surgery.2025; 38(5): E234.     CrossRef
  • Incidence, risk factors and airway management of postoperative haematoma following anterior cervical spine surgery: a retrospective nested case-control study
    Yang Tian, Jiao Li, Guangjin Zhou, Mingya Wang, Yinyin Qu, Min Li, Jun Wang, Mao Xu, Shenglin Wang, Xiangyang Guo, Yongzheng Han
    BMJ Open.2025; 15(4): e090547.     CrossRef
  • Assessment of Clinical and Radiologic Outcomes of Biportal Endoscopic Posterior Cervical Inclinatory Foraminotomy : A Retrospective Cohort Study
    Kwan-Su Song, Pius Kim
    Journal of Korean Neurosurgical Society.2025; 68(4): 446.     CrossRef
  • Incidence of Spinal Epidural Hematoma After Anterior Cervical Decompression and Fusion: Systematic Review, Meta-Analysis, and Case Report
    Jerzy Gregorczyk, Negin Fani, Mikołaj Biegański, Jakub Mocarski, Pawel Kowalczyk, Piotr Dąbrowski, Rafał Górski, Mateusz Bielecki
    World Neurosurgery.2025; 203: 124442.     CrossRef
  • Outcome of thyroid surgery by applying a haemostatic agent with and without a drain
    S. M. Asikur Rahat, M. Mahmudul Hasan, M. Aminul I. Joarder, Rokebul H. Mazumdar, Nayeemun Akter, Ferdous Alam, Rajib Chowdhury, M. Shaukat Ali, Emdadul Hoque
    International Surgery Journal.2025; 12(12): 2096.     CrossRef
  • Risk factors and airway management of postoperative retropharyngeal hematoma following anterior cervical spine surgery: a retrospective study
    Yang Tian, Xixi Jia, Gang Li, Yongzheng Han, Xiangyang Guo, Min Li, Yinyin Qu, Mao Xu
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • Screening patients requiring secondary lumbar surgery for degenerative lumbar spine diseases: a nationwide sample cohort study
    Hangeul Park, Juhee Lee, Yunhee Choi, Jun-Hoe Kim, Sum Kim, Young-Rak Kim, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Chi Heon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • The utility of intraoperative ultrasonography for spinal cord surgery
    Hangeul Park, Jun-Hoe Kim, Chang-Hyun Lee, Sum Kim, Young-Rak Kim, Kyung-Tae Kim, Ji-hoon Kim, John M. Rhee, Woo-Young Jo, Hyongmin Oh, Hee-Pyoung Park, Chi Heon Kim, Barry Kweh
    PLOS ONE.2024; 19(7): e0305694.     CrossRef
  • Corticosteroid Effects on Upper Esophageal Sphincter Function in Anterior Cervical Discectomy and Fusion
    Chih-Jun Lai, Jo-Yu Chen, Jing-Rong Jhuang, Ming-Yen Hsiao, Tyng-Guey Wang, Yu-Chang Yeh, Dar-Ming Lai, Fon-Yih Tsuang
    Journal of Bone and Joint Surgery.2024; 106(23): 2241.     CrossRef
  • Limaprost and the Risk of Bleeding: A Self-Controlled Case Series Study
    Eun-Joo Lee, Han Eol Jeong, Yoosoo Chang, Ju-Young Shin
    Neurospine.2023; 20(4): 1490.     CrossRef
  • 8,586 View
  • 215 Download
  • 11 Web of Science
  • 12 Crossref

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Biomechanical Analysis of 3-Level Anterior Cervical Discectomy and Fusion Under Physiologic Loads Using a Finite Element Model
Neurospine. 2022;19(2):385-392.   Published online May 13, 2022
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Biomechanical Analysis of 3-Level Anterior Cervical Discectomy and Fusion Under Physiologic Loads Using a Finite Element Model
Neurospine. 2022;19(2):385-392.   Published online May 13, 2022
Close
Objective
Pseudarthrosis and adjacent segment degeneration (ASD) are 2 common complications after multilevel anterior cervical discectomy and fusion (ACDF). We aim to identify the potential biomechanical factors contributing to pseudarthrosis and ASD following 3-level ACDF using a cervical spine finite element model (FEM).
Methods
A validated cervical spine FEM from C2 to C7 was used to study the biomechanical factors in cervical spine intervention. The FEM model was used to simulate a 3-level ACDF with intervertebral spacers and anterior cervical plating with screw fixation from C4 to C7. The model was then constrained at the inferior nodes of the T1 vertebra, and physiological loads were applied at the top vertebra. The pure moment load of 2 Nm was applied in flexion, extension, and lateral bending. A follower axial force of 75 N was applied to reproduce the weight of the cranium and muscle force, was applied using standard procedures. The motion-controlled hybrid protocol was utilized to comprehend the adjustments in the spinal biomechanics.
Results
Our cervical spine FEM demonstrated that the cranial adjacent level (C3–4) had significantly more increase in range of motion (ROM) (+90.38%) compared to the caudal adjacent level at C7–T1 (+70.18%) after C4–7 ACDF, indicating that the cranial adjacent level has more compensatory increase in ROM than the caudal adjacent level, potentially predisposing it to earlier ASD. Within the C4–7 ACDF construct, the C6–7 level had the least robust fixation during fixation compared to C4–5 and C5–6, as reflected by the smallest reduction in ROM compared to intact spine (-71.30% vs. -76.36% and -77.05%, respectively), which potentially predisposes the C6–7 level to higher risk of pseudarthrosis.
Conclusion
Biomechanical analysis of C4–7 ACDF construct using a validated cervical spine FEM indicated that the C3–4 has more compensatory increase in ROM compared to C7–T1, and C6–7 has the least robust fixation under physiological loads. These findings can help spine surgeons to predicate the areas with higher risks of pseudarthrosis and ASD, and thus developing corresponding strategies to mitigate these risks and provide appropriate preoperative counseling to patients.

Citations

Citations to this article as recorded by  Crossref logo
  • Finite Element Study of Anterior Cervical Discectomy and Fusion Constructs Near Cervicothoracic Junction—Is T2 Modeling Necessary?
    J. A. Febin Chris Asir, D. Davidson Jebaseelan, Aju Bosco, Balaji Harinathan, Narayan Yoganandan
    Journal of Biomechanical Engineering.2026;[Epub]     CrossRef
  • Biomechanical Analysis Comparison of Different Cervical Posterior Screw Fixation Techniques: A Finite Element Study
    Joonoh Seo, Woo-Seok Jung, Tae Hyun Park, Sung-Jae Lee, Ji-Won Kwon, Kyung-Soo Suk, Byung Ho Lee
    Neurospine.2026; 23(1): 187.     CrossRef
  • Approach to assess the effect of sagittal cervical alignment on three-dimensional movement of the cervical spine in spondylosis patients
    Jiangpeng Gu, Xiaoman Wang, Xujing Chen, Zunan Dong, Wei Guo, Wei Feng, Chaoqun Ye, Fei Wang, Xiaomin Liu
    European Spine Journal.2026;[Epub]     CrossRef
  • Evolving trends in anterior cervical spine surgery: a decade-long shift towards standalone constructs
    Nolan M. Reinhart, Jackson P. Tate, Zachary Salas, William F. Sherman, Mathew Cyriac
    Current Orthopaedic Practice.2026;[Epub]     CrossRef
  • MRI after Cervical Spine Decompression and Fusion Surgery: Technical Considerations, Expected Findings, and Complications
    Frederik Abel, Ek T. Tan, Yenpo Lin, J. Levi Chazen, Darren R. Lebl, Darryl B. Sneag
    Radiology.2025;[Epub]     CrossRef
  • Prediction of heterotopic ossification on the cervical spine with offset of the artificial disc – A finite element study
    Balaji Harinathan, Davidson Jebaseelan, Hemkar Sharma, Lenin Babu, Rajasekaran Shanmuganathan, Narayan Yoganandan
    Medical Engineering & Physics.2025; 141: 104356.     CrossRef
  • Fusion Sequence and Risk Factors for Pseudarthrosis in Multilevel Anterior Cervical Discectomy and Fusion
    Hyun Woong Mun, Jong Joo Lee, Hyun Chul Shin, Tae-Hwan Kim, Seok Woo Kim, Jae Keun Oh
    Neurosurgery.2025; 97(5): 1153.     CrossRef
  • A First Step Toward Patient-Specific Cervical Spine Finite Element Modeling Approaches for Military and Civilian Applications
    Narayan Yoganandan, Aditya Vedantam, Balaji Harinathan, Davidson Jebaseelan, Amit Bagchi
    Journal of Engineering and Science in Medical Diagnostics and Therapy.2025;[Epub]     CrossRef
  • Development of a CT-based 3D finite element model of the whole cervical spine with occiput: Insights into sagittal balance, disc pressure, and facet joint forces
    Hu Chen, Lu Cao, Yinghua He, Hao Sun, Qiang Tu
    World Neurosurgery: X.2025; 28: 100543.     CrossRef
  • Does Aspirin Use Influence Rates of Pseudoarthrosis After Anterior Cervical Discectomy and Fusion?
    Kevin T. Kim, Ziam Khan, Joseph Stains, Timothy Chryssikos
    Global Spine Journal.2025;[Epub]     CrossRef
  • Finite element analysis of a new preoperative traction for cervical kyphosis: suspensory traction
    Hongyu Chen, Tianchi Wu, Shengfa Pan, Li Zhang, Yanbin Zhao, Xin Chen, Yu Sun, William W. Lu, Feifei Zhou
    Medical & Biological Engineering & Computing.2024; 62(9): 2867.     CrossRef
  • Biomechanical Analysis of Hybrid Artificial Discs or Zero-Profile Devices for Treating 1-Level Adjacent Segment Degeneration in ACDF Revision Surgery
    Weishi Liang, Yihan Yang, Bo Han, Duan Sun, Peng Yin, Yong Hai
    Neurospine.2024; 21(2): 606.     CrossRef
  • Radiographic Characteristics of Caudal Segment in Multilevel Anterior Cervical Discectomy and Fusion: The Bony Buttress Formation
    Chang Hwa Ham, Joo Han Kim, Youn-Kwan Park, Woo-Keun Kwon, Hong Joo Moon
    Neurospine.2024; 21(4): 1241.     CrossRef
  • Comparing adjacent segment biomechanics between anterior and posterior cervical fusion using patient-specific finite element modeling
    Balaji Harinathan, Davidson Jebaseelan, Narayan Yoganandan, Aditya Vedantam
    Asian Spine Journal.2024; 18(6): 777.     CrossRef
  • Spinal Cord Stress After Anterior Cervical Diskectomy and Fusion: Results from a Patient-Specific Finite Element Model
    Aditya Vedantam, Yuvaraj Purushothaman, Balaji Harinathan, Stephen Scripp, Matthew D. Budde, Narayan Yoganandan
    Annals of Biomedical Engineering.2023; 51(5): 1040.     CrossRef
  • Biomechanik der HWS und ihre anatomischen Grundlagen
    Sebastian Decker, Sabine Roth, Ralph Gaulke, Stephan Sehmisch, Heiko Koller
    Die Wirbelsäule.2023; 07(02): 94.     CrossRef
  • Comparing zero-profile and conventional cage and plate in anterior cervical discectomy and fusion using finite-element modeling
    Chang-Hwan Ahn, Sungwook Kang, Mingoo Cho, Seong-Hun Kim, Chi Heon Kim, Inbo Han, Chul-Hyun Kim, Sung Hyun Noh, Kyoung-Tae Kim, Jong-Moon Hwang
    Scientific Reports.2023;[Epub]     CrossRef
  • 8,948 View
  • 239 Download
  • 18 Web of Science
  • 17 Crossref

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Role of Gender in Improvement of Depressive Symptoms Among Patients Undergoing Cervical Spine Procedures
Neurospine. 2021;18(1):217-225.   Published online March 31, 2021
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Role of Gender in Improvement of Depressive Symptoms Among Patients Undergoing Cervical Spine Procedures
Neurospine. 2021;18(1):217-225.   Published online March 31, 2021
Close
Objective
There is a scarcity of research evaluating gender differences in depressive symptoms among patients undergoing cervical surgery. This study investigated gender differences with regard to depressive symptom severity, measured by Patient Health Questionnaire-9 (PHQ-9), in patients following anterior cervical discectomy and fusion (ACDF) or artificial disc replacement (ADR).
Methods
A prospectively maintained surgical registry was retrospectively reviewed for eligible spine surgeries. Depressive symptom severity was evaluated by PHQ-9 at both preand postoperative timepoints (e.g. , 6 weeks, 12 weeks, 6 months, 1 year, and 2 years). A chi-square test and Student t-test evaluated differences between the gender for demographic and operative variables where appropriate. Differences between the gender subgroup mean PHQ-9 scores were assessed using a t-test pre- and postoperatively (e.g. , 6 weeks, 12 weeks, 6 months, and 1 year) and a paired t-test was used to assess differences from preoperative scores at each postoperative time point.
Results
A total of 170 subjects underwent 125 ACDFs and 45 ADRs. Both pre- and postoperative timepoints demonstrated no significant differences between mean PHQ-9 scores by gender. Female patients demonstrated statistically significant improvement in PHQ-9 scores at 6 weeks, and 12 weeks, but not through 2 years. Male patients demonstrated statistically significant improvement in PHQ-9 scores at 6 weeks, 12 weeks, 6 months, 1 year, and 2 years.
Conclusion
Although there were no significant differences between mean PHQ-9 score between the genders, there was a difference in magnitude of improvement. Females had a significant improvement in depressive symptom severity over baseline at the 6- and 12-week timepoints only, whereas males had significant improvement through 2 years postoperatively.

Citations

Citations to this article as recorded by  Crossref logo
  • Surgical interventions for degenerative cervical disease: Impact on patient quality of life, mental health, pain relief, and spiritual health
    Ching-Ya Huang, Cheng-Shyuan Rau, Jo-Chien Lin, Shiun-Yuan Hsu, Ching-Hua Hsieh
    Heliyon.2025; 11(1): e41555.     CrossRef
  • The use of the Core Yellow Flags Index for the assessment of psychosocial distress in patients undergoing surgery of the cervical spine
    Francine Mariaux, Achim Elfering, Tamás F. Fekete, François Porchet, Daniel Haschtmann, Raluca Reitmeir, Markus Loibl, Dezsö Jeszenszky, Frank S. Kleinstück, Anne F. Mannion
    European Spine Journal.2024; 33(6): 2269.     CrossRef
  • Sex Differences in Patient-Reported Depression Following Vascular Surgery Procedures
    Blake L. Findley, Teryn A. Holeman, Benjamin S. Brooke
    Journal of Surgical Research.2024; 301: 54.     CrossRef
  • Workers compensation patients experiencing depression report meaningful improvement in mental health scores after anterior cervical discectomy and fusion
    Timothy J. Hartman, James W. Nie, Keith R. MacGregor, Omolabake O. Oyetayo, Eileen Zheng, Kern Singh
    Journal of Clinical Orthopaedics and Trauma.2022; 34: 102020.     CrossRef
  • 6,275 View
  • 100 Download
  • 2 Web of Science
  • 4 Crossref

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Patient-Reported Outcomes Measurement Information System Physical Function Validation for Use in Anterior Cervical Discectomy and Fusion: A 2-Year Follow-up Study
Neurospine. 2021;18(1):155-162.   Published online March 31, 2021
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Patient-Reported Outcomes Measurement Information System Physical Function Validation for Use in Anterior Cervical Discectomy and Fusion: A 2-Year Follow-up Study
Neurospine. 2021;18(1):155-162.   Published online March 31, 2021
Close
Objective
Our study aims to evaluate the correlation of Patient-Reported Outcomes Measurement Information System physical function (PROMIS PF) with legacy patient-reported outcome measures (PROMs) among patients undergoing anterior cervical discectomy and fusion (ACDF).
Methods
A prospectively maintained database was retrospectively reviewed for ACDF surgeries performed between May 2015 and September 2017. Inclusion criteria were primary elective, single- or multilevel ACDFs for degenerative spinal pathology. Patients lacking preoperative or 2-year PROMIS PF surveys were excluded. Mean scores were calculated for visual analogue scale (VAS) neck, VAS arm, Neck Disability Index (NDI), 12-Item Short Form Physical Component Score (SF-12 PCS), and PROMIS PF at preoperative and 6-week, 12-week, 6-month, 1-year, and 2-year postoperative timepoints. A t-test and Pearson correlation coefficient were utilized to evaluate score improvement and PROM relationships respectively.
Results
The 50 subject cohort was 60.0% male, 50% obese (body mass index ≥ 30 kg/m2) and had an average age of 50.9 years. Significant improvements were demonstrated for VAS neck and NDI at all postoperative timepoints (p < 0.001) and for SF-12 and PROMIS PF at all timepoints except 6 weeks (p ≤ 0.025). VAS arm improvement was seen up to 1 year (p ≤ 0.016). PROMIS PF demonstrated strong correlations with NDI and SF-12 PCS at all evaluated timepoints and with VAS neck at all postoperative timepoints except 6 weeks (all p < 0.01).
Conclusion
PROMIS PF was strongly correlated with pain, disability, and physical function up to 2 years for patients undergoing ACDF. Our results support the long-term validity of PROMIS PF for measurement of patient-reported physical function among ACDF cohorts.

Citations

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    Cole T. Kwas, Tejas Subramanian, Joshua Zhang, Eric Mai, Annika Heuer, Chad Z. Simon, Nishtha Singh, Tomoyuki Asada, Kasra Araghi, Olivia C. Tuma, Maximilian K. Korsun, Myles R.J. Allen, Eric T. Kim, Avani S. Vaishnav, Evan D. Sheha, James E. Dowdell, Sh
    Clinical Spine Surgery.2026; 39(3): E161.     CrossRef
  • Influence of Preoperative Physical Function Scores on Outcomes After Single-level Cervical Disc Replacement
    Timothy J. Hartman, James W. Nie, Eileen Zheng, Keith R. MacGregor, Omolabake O. Oyetayo, Kern Singh
    Clinical Spine Surgery.2025; 38(7): E376.     CrossRef
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    World Neurosurgery.2025; 196: 123797.     CrossRef
  • Rates of cervical spine surgery and repeat epidural injections after cervical transforaminal epidural steroid injections for patients with cervical radiculopathy utilizing a large national database
    Andrew R. Stephens, Ramzi El-Hassan, Ashley Rogerson
    Interventional Pain Medicine.2025; 4(4): 100651.     CrossRef
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    Dong Hyuck Kim, Do Yun Kwon, Kwang-Ryeol Kim
    Journal of Yeungnam Medical Science.2025; 42: 73.     CrossRef
  • Does Baseline Severity of Arm Pain Influence Outcomes Following Single-Level Anterior Cervical Discectomy and Fusion?
    Madhav R. Patel, Kevin C. Jacob, Frank A. Chavez, Alexander W. Parsons, Nisheka N. Vanjani, Hanna Pawlowski, Michael C. Prabhu, Kern Singh
    Asian Spine Journal.2023; 17(3): 500.     CrossRef
  • Severe Obesity Is an Independent Risk Factor of Early Readmission and Nonhome Discharge After Cervical Disc Replacement
    Tejas Subramanian, Daniel Shinn, Pratyush Shahi, Izzet Akosman, Troy Amen, Omri Maayan, Eric Zhao, Kasra Araghi, Junho Song, Sidhant Dalal, James Dowdell, Sravisht Iyer, Sheeraz Qureshi
    Neurospine.2023; 20(3): 890.     CrossRef
  • The Veterans Rand-12 Physical Composite Score Prognosticates Postoperative Clinical Outcomes in Patients Undergoing Anterior Cervical Discectomy and Fusion
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    World Neurosurgery.2023; 180: e756.     CrossRef
  • Completion Rates for PROMIS Physical Function Surveys Compared with Legacy PROMs in Patients Undergoing Cervical Spine Surgery
    Conor P. Lynch, Elliot D.K. Cha, Kevin C. Jacob, Madhav R. Patel, Cara E. Geoghegan, Hanna Pawlowski, Michael C. Prabhu, Nisheka N. Vanjani, Kern Singh
    Journal of Orthopaedic Experience & Innovation.2023;[Epub]     CrossRef
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    Kevin C. Jacob, Madhav R. Patel, Alexander W. Parsons, Michael C. Prabhu, Max A. Ribot, Hanna Pawlowski, Nisheka N. Vanjani, Kern Singh
    Journal of the American Academy of Orthopaedic Surgeons.2022; 30(17): e1137.     CrossRef
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    James M. Parrish, Nathaniel W. Jenkins, Conor P. Lynch, Elliot D.K. Cha, Thomas S. Brundage, Nadia M. Hrynewycz, Kern Singh
    Clinical Spine Surgery.2021; 34(10): E559.     CrossRef
  • Efficacy for Whitlockite for Augmenting Spinal Fusion
    Su Yeon Kwon, Jung Hee Shim, Yu Ha Kim, Chang Su Lim, Seong Bae An, Inbo Han
    International Journal of Molecular Sciences.2021; 22(23): 12875.     CrossRef
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National Trends and Correlates of Dysphagia After Anterior Cervical Discectomy and Fusion Surgery
Neurospine. 2021;18(1):147-154.   Published online March 31, 2021
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National Trends and Correlates of Dysphagia After Anterior Cervical Discectomy and Fusion Surgery
Neurospine. 2021;18(1):147-154.   Published online March 31, 2021
Close
Objective
Anterior cervical discectomy and fusion (ACDF) is the most common performed surgery in the cervical spine. Dysphagia is one of the most frequent complications following ACDF. Several studies have identified certain demographic and perioperative risk factors associated with increased dysphagia rates, but few have reported recent trends. Our study aims to report current trends and factors associated with the development of inpatient postoperative dysphagia after ACDF.
Methods
The National Inpatient Sample was evaluated from 2004 to 2014 and discharges with International Classification of Diseases procedure codes indicating ACDF were selected. Time trend series plots were created for the yearly treatment trends for each fusion level by dysphagia outcome. Separate univariable followed by multivariable logistic regression analyses were performed to evaluate predictors of dysphagia.
Results
A total of 1,212,475 ACDFs were identified in which 3.3% experienced postoperative dysphagia. A significant increase in annual dysphagia rates was observed from 2004–2014. Frailty, intraoperative neuromonitoring, 4 or more level fusions, African American race, fluid/electrolyte disorders, blood loss, and coagulopathy were all identified as significant independent risk factors for the development of postoperative dysphagia following ACDF.
Conclusion
Postoperative dysphagia is a well-known postsurgical complication associated with ACDF. Our cohort showed a significant increase in the annual dysphagia rates independent of levels fused. We identified several risk factors associated with the development of postoperative dysphagia after ACDF.

Citations

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  • LASSO-based machine learning algorithm for prediction of dysphagia in patients suffering anterior cervical discectomy and fusion
    Bingyu Wang, Jiawei Shi, Zefu Chen, Jingmin Liu, Yongjian Zhu, Zhongmin Zhang, Xin Zheng, Xiaobo Wang
    European Spine Journal.2026; 35(2): 559.     CrossRef
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    Xianxu Zhang, Changlin Zhou, Wenxiang Shen, Lei Huang, Bin Qian, Yuji Zhang, Zhixuan Nian, Rui Li, Shicheng Li, Zhiqiang Luo
    Journal of Clinical Neuroscience.2026; 143: 111768.     CrossRef
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    Jacob M. Gluski, Gabrielle Santangelo, Paul Serrato, Shaila Ghanekar, Ethan DL Brown, Aryaa Karkare, Aladine Elsamadicy, Sheng-fu Larry Lo, Daniel M. Sciubba
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    Hussam Abu Nowar , Wesam Khraisat, Mu'taz Halasah, Laith Alomari, Osama Alabadi, Khalid Abu-Rumman
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    Aditya Mazmudar, Taylor Paziuk, John Mangan, Khoa Tran, Samuel Oh, Sandy Li, Brandon Sherrod, Erica Bisson, Darrel Brodke, Christopher Kepler, Gregory Schroeder, Alexander Vaccaro, Alan Hilibrand, Jeffrey A. Rihn
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    Aaron Lerch, Anthony Minh Tien Chau
    British Journal of Neurosurgery.2024; 38(1): 3.     CrossRef
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    Tomoyuki Asada, Sumedha Singh, Omri Maayan, Pratyush Shahi, Nishtha Singh, Tejas Subramanian, Kasra Araghi, Maximilian Korsun, Olivia Tuma, Anthony Pajak, Amy Lu, Eric Mai, Yeo Eun Kim, James Dowdell, Evan D. Sheha, Sravisht Iyer, Sheeraz A. Qureshi
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    Evan Luther, Ian Ramsay, Vaidya Govindarajan, Chandler N. Berke, Vivien Makhoul, Martin Merenzon, Katherine Berry, Alexis Morell, Daniel Eichberg, Victor M. Lu, Ashish Shah, Ricardo J. Komotar, Michael E. Ivan
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  • 23 Web of Science
  • 25 Crossref

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Synthetic Cages Associated With Increased Rates of Revision Surgery and Higher Costs Compared to Allograft in ACDF in the Nonelderly Patient
Neurospine. 2020;17(4):896-901.   Published online December 31, 2020
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Synthetic Cages Associated With Increased Rates of Revision Surgery and Higher Costs Compared to Allograft in ACDF in the Nonelderly Patient
Neurospine. 2020;17(4):896-901.   Published online December 31, 2020
Close
Objective
The aim of this study was to compare all-cause reoperation rates and costs in nonelderly patients treated with anterior cervical discectomy and fusion (ACDF) with structural allograft versus synthetic cages for degenerative pathology.
Methods
We queried a private claims database to identify adult patients ( ≤ 65 years) who underwent single-level ACDF in a hospital setting using either structural allograft or a synthetic cage (polyetheretherketone, metal, or hybrid device), from 2010 to 2016. The rate of all-cause reoperations at 2 years were compared between the 2 groups. Index hospitalization costs and 90-day complication rates were also compared. Significance was set at p < 0.05.
Results
A total of 26,754 patients were included in the study. 11,514 patients (43%) underwent ACDF with structural allograft and 15,240 (57%) underwent ACDF with a synthetic cage. The patients in the allograft group were younger and more likely to be male. There was no significant difference between the 2 groups with respect to 90-day complications including: wound dehiscence, dysphagia, dysphonia, and hematoma/seroma. In the 2-year postoperative period, the synthetic cage group had a significantly higher rate of allcause reoperation compared to the allograft group (9.1% vs. 8.0%, p = 0.002). Index hospitalization costs were significantly higher in the synthetic cage group compared to those in the allograft group ($23,475 vs. $20,836, p < 0.001).
Conclusion
Structural allograft is associated with lower all-cause reoperation rates and lower index costs in nonelderly patients undergoing ACDF surgery for degenerative pathology. It is important to understand this data as we transition toward value-based care.

Citations

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  • Revision Surgery after Single Level Anterior Cervical Discectomy and Fusion With Plate vs Stand-Alone Cage over 2 to 5 Year Follow-Up
    Wesley M. Durand, Rajan Khanna, Gabriel I. Nazario-Ferrer, Sang H. Lee, Richard L. Skolasky, Amit Jain
    Global Spine Journal.2025; 15(4): 2014.     CrossRef
  • Considering the Effects of Age and Patient Factors on Subsidence and Implant Selection in Anterior Cervical Discectomy and Fusion
    Jeffrey B. Weinreb, Jake Carbone, Hershil Patel, Amit Ratanpal, Rohan I. Suresh, Tyler J. Pease, Ryan A. Smith, Joseph Blommer, Anthony K. Chiu, Idris Amin, Louis J. Bivona, Julio J. Jauregui, Daniel L. Cavanaugh, Eugene Y. Koh, Charles A. Sansur, Steven
    Clinical Spine Surgery.2025;[Epub]     CrossRef
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    Adeesya Gausper, Andrew M. Miller, Vivien Chan, Suhas K. Etigunta, Andy M. Liu, David Skaggs, Tiffany Perry, Corey Walker, Alexander Tuchman
    Clinical Spine Surgery.2025;[Epub]     CrossRef
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    Andrew Y. Powers, Darren Z. Nin, Ya-Wen Chen, Ruijia Niu, David H. Kim, David C. Chang, Raymond W. Hwang
    Operative Neurosurgery.2024; 26(1): 16.     CrossRef
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    Lucas Kim, Jonathan N. Grauer
    North American Spine Society Journal (NASSJ).2024; 17: 100310.     CrossRef
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    Ji-Won Kwon, Yong Ho Lee, Byung Ho Lee, Jae Hong Kim, Kyung Soo Suk
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    Tu Thai Bao Nguyen, Nguyen Anh Duy Tran, Huu Dat Nguyen, Khai Duy Lam, Thanh Tan Nguyen, Yi-Jie Kuo, Yu-Pin Chen
    World Neurosurgery.2024; 191: e730.     CrossRef
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    Micheal Raad, Amy L. Xu, Carlos Ortiz-Babilonia, Majd Marrache, Wesley M. Durand, Marc Greenberg, Amit Jain
    Spine.2023; 48(5): 330.     CrossRef
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    Adrian John Rodrigues, Kunal Varshneya, Martin Nikolaus Stienen, Ethan Schonfeld, Khoi Duc Than, Anand Veeravagu
    Asian Spine Journal.2023; 17(4): 620.     CrossRef
  • Comparing zero-profile and conventional cage and plate in anterior cervical discectomy and fusion using finite-element modeling
    Chang-Hwan Ahn, Sungwook Kang, Mingoo Cho, Seong-Hun Kim, Chi Heon Kim, Inbo Han, Chul-Hyun Kim, Sung Hyun Noh, Kyoung-Tae Kim, Jong-Moon Hwang
    Scientific Reports.2023;[Epub]     CrossRef
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    Alan T. Villavicencio, E. Lee Nelson, Sharad Rajpal, Kara Beasley, Sigita Burneikiene
    Spine.2022; 47(15): 1043.     CrossRef
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    Elahe Jalilvand, Nabiolah Abollfathi, Mohsen Khajehzhadeh, Mojtaba Hassani-Gangaraj
    Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.2022; 236(11): 1613.     CrossRef
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    Hyun Jun Jang, Kyung Hyun Kim, Jeong Yoon Park, Keun Su Kim, Yong Eun Cho, Dong Kyu Chin
    Acta Neurochirurgica.2022; 164(12): 3173.     CrossRef
  • The Effect of Subsidence on Segmental and Global Lordosis at Long-term Follow-up After Anterior Cervical Discectomy and Fusion
    Akiro H. Duey, Christopher Gonzalez, Eric A. Geng, Pierce J. Ferriter Jr, Ashley M. Rosenberg, Ula N. Isleem, Bashar Zaidat, Paul M. Al-Attar, Jonathan S. Markowitz, Jun S. Kim, Samuel K. Cho
    Neurospine.2022; 19(4): 927.     CrossRef
  • 8,318 View
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  • 14 Crossref

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Perioperative Outcomes in 17,947 Patients Undergoing 2-Level Anterior Cervical Discectomy and Fusion Versus 1-Level Anterior Cervical Corpectomy for Treatment of Cervical Degenerative Conditions: A Propensity Score Matched National Surgical Quality Improvement Program Analysis
Neurospine. 2020;17(4):871-878.   Published online December 31, 2020
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Perioperative Outcomes in 17,947 Patients Undergoing 2-Level Anterior Cervical Discectomy and Fusion Versus 1-Level Anterior Cervical Corpectomy for Treatment of Cervical Degenerative Conditions: A Propensity Score Matched National Surgical Quality Improvement Program Analysis
Neurospine. 2020;17(4):871-878.   Published online December 31, 2020
Close
Objective
To compare the perioperative morbidity of 2-level anterior cervical discectomy and fusion (ACDF) with that of 1-level anterior cervical corpectomy and fusion (ACCF) for the treatment of cervical degenerative conditions.
Methods
A retrospective study of the 2005–2016 National Surgical Quality Improvement Program database for patients undergoing 2-level ACDF and 1-level ACCF was performed. Patient data included: age, sex, body mass index (BMI), functional status, and American Society of Anesthesiologists (ASA) physical status (PS) classification. Hospital data included: operative time and length of hospital stay (LOS). Thirty-day outcome data included: any, serious, and minor adverse events, return to the operating room, readmission, and mortality. After propensity matching for age, sex, ASA PS classification, functional status, and BMI, multivariate logistic regression analysis was used to compare outcomes between the 2 propensity-matched subcohorts. Finally, multivariate logistic regression that additionally controlled for operative time was performed to compare the 2 propensity-matched subcohorts.
Results
A total of 17,497 cases were identified, with 90.20% undergoing 2-level ACDF and 9.80% undergoing 1-level ACCF. Patients undergoing 2-level ACDF were younger, more likely to be female, had higher functional status, and had shorter operative time and LOS (p < 0.001). After propensity score matching, cases undergoing 1-level ACCF had a statistically significant higher rate of serious adverse events (p = 0.005). This difference was no longer significant after controlling for operative time.
Conclusion
While there was noted to be additional morbidity in 1-level ACCF cases relative to 2-level ACDF cases, the lack of difference once controlling for the surgical time supports using the procedure that best accomplishes the surgical objectives.

Citations

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  • A Meta-Analysis of Surgical Outcomes in 25727 Patients Undergoing Anterior Cervical Discectomy and Fusion or Anterior Cervical Corpectomy and Fusion for Cervical Deformity
    Karma Barot, Miguel A. Ruiz-Cardozo, Som Singh, Gabriel Trevino, Michael R. Kann, Samuel Brehm, Tim Bui, Karan Joseph, Rujvee Patel, Angela Hardi, Alexander T. Yahanda, Julio J. Jauregui, Magalie Cadieux, Brenton Pennicooke, Camilo A. Molina
    Global Spine Journal.2025; 15(2): 1390.     CrossRef
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Case Report

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Cervical Arthroplasty in the Treatment of Cervical Angina: Case Report and Review of the Literature
Neurospine. 2020;17(4):929-938.   Published online December 31, 2020
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Cervical Arthroplasty in the Treatment of Cervical Angina: Case Report and Review of the Literature
Neurospine. 2020;17(4):929-938.   Published online December 31, 2020
Close
Cervical angina is an often-overlooked etiology of noncardiac chest pain that may mimic true angina pectoris but is due to cervical spine disease. Diagnosis can be difficult, and treatment ranges from conservative therapy to surgical management. However, of patient’s refractory to conservative therapy, approximately ninety percent experience postoperative relief of angina symptoms. Here, we present a case report on cervical angina and performed a systematic review of the literature. A 34-year-old male with prior surgery for thoracic outlet syndrome presented with persistent anterior neck and chest pain as well as posterior left scapular and upper lateral arm pain. The pain was refractory to 12 months of conservative therapy. Cardiac workup was negative and cervical spine imaging revealed a C6–7 herniation with neuroforaminal stenosis. A systematic literature search was conducted in PubMed, Web of Science, and Cochrane databases from database inception to April 2020. Studies reporting cervical level, average symptom duration, location of pain, and postoperative pain improvement were included. The patient's atypical symptoms were completely resolved after C6–7 anterior cervical discectomy and arthroplasty. To our knowledge, this is the first study which reports on the use of arthroplasty in the treatment of cervical angina. The systematic review included 11 articles from 1989–2020 consisting of 1,186 total patients and 109 patients (age range, 36–84 years; 60.7% male) meeting inclusion criteria. Symptom duration range was 2 days to 90 months, with the most common location of pain being localized to the anterior chest wall (66.7% of patients). All patients (100%) had postoperative resolution of their pain symptoms. The most common herniation level was C6–7 (87.3% of patients). We conclude that a broad and multidisciplinary approach is necessary for the diagnosis and management of noncardiac chest pain. When cervical disease is identified as the underlying cause for the angina-like pain, conservative therapy should be sought. Refractory cases should be treated surgically depending on the cervical pathology.

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  • The Underdiagnosed, Understudied Complexity of Pseudoangina: Should Clinicians Take a Neurosurgical Approach in Diagnosing Unexplained Visceral Pain?
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  • 16,046 View
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Original Article

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Effects of Body Mass Index on Perioperative Outcomes in Patients Undergoing Anterior Cervical Discectomy and Fusion Surgery
Neurospine. 2021;18(1):79-86.   Published online November 17, 2020
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Effects of Body Mass Index on Perioperative Outcomes in Patients Undergoing Anterior Cervical Discectomy and Fusion Surgery
Neurospine. 2021;18(1):79-86.   Published online November 17, 2020
Close
Objective
Obesity has become a public health crisis and continues to be on the rise. An elevated body mass index has been linked to higher rates of spinal degenerative disease requiring surgical intervention. Limited studies exist that evaluate the effects of obesity on perioperative complications in patients undergoing anterior cervical discectomy and fusion (ACDF). Our study aims to determine the incidence of obesity in the ACDF population and the effects it may have on postoperative inpatient complications.
Methods
The National Inpatient Sample was evaluated from 2004 to 2014 and discharges with International Classification of Diseases procedure codes indicating ACDF were identified. This cohort was stratified into patients with diagnosis codes indicating obesity. Separate univariable followed by multivariable logistic regression analysis were performed for the likelihood of perioperative inpatient outcomes among the patients with obesity.
Results
From 2004 to 2014, estimated 1,212,475 ACDFs were identified in which 9.2% of the patients were obese. The incidence of obesity amongst ACDF patients has risen dramatically during those years from 5.8% to 13.4%. Obese ACDF patients had higher inpatient likelihood of dysphagia, neurological, respiratory, and hematologic complications as well as pulmonary emboli, and intraoperative durotomy.
Conclusion
Obesity is a well-established modifiable comorbidity that leads to increased perioperative complications in various surgical specialties. We present one of the largest retrospective analyses evaluating the effects of obesity on inpatient complications following ACDF. Our data suggest that the number of obese patients undergoing ACDF is steadily increasing and had a higher inpatient likelihood of developing perioperative complications.

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Review Article

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Anterior Reconstruction Techniques for Cervical Spine Deformity
Neurospine. 2020;17(3):534-542.   Published online September 30, 2020
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Anterior Reconstruction Techniques for Cervical Spine Deformity
Neurospine. 2020;17(3):534-542.   Published online September 30, 2020
Close
Cervical spine deformity is an uncommon yet severely debilitating condition marked by its heterogeneity. Anterior reconstruction techniques represent a familiar approach with a range of invasiveness and correction potential—including global or focal realignment in the sagittal and coronal planes. Meticulous preoperative planning is required to improve or prevent neurologic deterioration and obtain satisfactory global spinal harmony. The ability to perform anterior only reconstruction requires mobility of the opposite column to achieve correction, unless a combined approach is planned. Anterior cervical discectomy and fusion has limited focal correction, but when applied over multiple levels there is a cumulative effect with a correction of approximately 6° per level. Partial or complete corpectomy has the ability to correct sagittal deformity as well as decompress the spinal canal when there is anterior compression behind the vertebral body. If pathoanatomy permits, a hybrid discectomy-corpectomy construct is favored over multilevel corpectomies. The anterior cervical osteotomy with bilateral complete uncinectomy may be necessary for angular correction of fixed cervical kyphosis, and is particularly useful in the midcervical spine. A detailed understanding of the patient’s local anatomy, careful attention to positioning, and avoiding long periods of retraction time will help prevent complications and iatrogenic injury.

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Review and Technical Note

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Posterior Endoscopic Cervical Decompression: Review and Technical Note
Neurospine. 2020;17(Suppl 1):S74-S80.   Published online July 31, 2020
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Posterior Endoscopic Cervical Decompression: Review and Technical Note
Neurospine. 2020;17(Suppl 1):S74-S80.   Published online July 31, 2020
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Endoscopic spine surgery for the treatment of degenerative spinal diseases from lumbar to cervical spine has accelerated over the past 2 decades. Posterior endoscopic cervical discectomy (PECD) has been described as a safe, effective, and minimally invasive procedure for cervical radiculopathy or even part of the myelopathy. This procedure also has been validated with comparable outcomes to open and microscopic surgery. Radiculopathy due to foraminal disc herniation or foraminal stenosis should be the optimum indications of this procedure. Intraoperative 3-dimensional navigation can help surgeons to get quick and great quality guidance for endoscopic surgeons. In this review, we will focus on the technical details and evidence-based results of PECD which is a promising procedure for cervical radiculopathy with the advantages of a minimally invasive method.

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Original Article

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Effect of the Presence and Type of Plate Augmentation on Postoperative Dysphagia Among Adult Patients Undergoing Elective Anterior Cervical Discectomy and Fusion for Spondylosis: A Randomized Trial
Neurospine. 2020;17(1):174-183.   Published online March 31, 2020
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Effect of the Presence and Type of Plate Augmentation on Postoperative Dysphagia Among Adult Patients Undergoing Elective Anterior Cervical Discectomy and Fusion for Spondylosis: A Randomized Trial
Neurospine. 2020;17(1):174-183.   Published online March 31, 2020
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Objective
To determine the effect of anterior plating on postoperative dysphagia (POD) among adult patients undergoing elective anterior cervical discectomy and fusion (ACDF) for cervical spondylosis and determine the potential role of demographic and clinical characteristics in the development of POD.
Methods
Consecutive adults undergoing an elective, single-level, ACDF were randomly assigned to receive a stand-alone CoRoent Cage or a CoRoent Cage with a Helix, or HelixMini plate. Patients with a history of cervical spine surgery were excluded. M. D. Anderson Dysphagia Inventory and Bazaz questionnaires were completed at regular intervals for 12 months postoperatively.
Results
Twenty-five patients were recruited over a 2-year period, with 8 allocated to receive a stand-alone cage, 5 to receive a cage and Helix Mini plate, and 12 to receive a cage and Helix plate. The POD rate was 68% at 48 hours, before falling to 16% at 6 and 12 months. A longer retraction time was observed in the Helix plate group compared to the stand-alone cage group (7.88; 95% confidence interval, 0.12–15.63; p = 0.046), although there was no difference in the incidence or severity of dysphagia between cohorts at any timepoint. With the exception of body mass index, there was no difference in patients with and without dysphagia, and each of the interventions was equally efficacious with respect to clinical and radiological endpoints.
Conclusion
Dysphagia is a common consequence of ACDF and, while the placement of a large plate results in longer retraction time, it was not associated with higher rates of dysphagia. Further research is required to identify both patient-specific and surgical contributors to this complication.

Citations

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    European Spine Journal.2023; 32(7): 2448.     CrossRef
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  • 8,900 View
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  • 2 Web of Science
  • 3 Crossref