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"Ossification of posterior longitudinal ligament"

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Long-term Outcomes of Multilevel Anterior Cervical Osteotomy and Posterior Instrumentation for OPLL-Induced Myelopathy With Cervical Kyphosis
Neurospine. 2025;22(3):623-630.   Published online September 30, 2025
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Long-term Outcomes of Multilevel Anterior Cervical Osteotomy and Posterior Instrumentation for OPLL-Induced Myelopathy With Cervical Kyphosis
Neurospine. 2025;22(3):623-630.   Published online September 30, 2025
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Objective
To analyze long-term clinical and radiological outcomes after multilevel anterior osteotomy with posterior instrumentation in patients with ossification of posterior longitudinal ligament (OPLL)-induced myelopathy and cervical kyphosis.
Methods
Patients who underwent multilevel anterior osteotomy with posterior instrumentation for OPLL-induced myelopathy and cervical kyphosis and had a minimum of 5-year follow-up were included. Clinical outcomes (Japanese Orthopaedic Association score system for cervical myelopathy [C-JOA], 12-item Short Form health survey [SF-12], Neck Disability Index [NDI]) and radiological parameters (C2–7 lordosis, center of gravity of the head [CGH]-C7 sagittal vertical axis [SVA], T1 slope) were analyzed at the preoperative, immediate postoperative, and latest follow-up timepoints.
Results
Twenty-eight patients were included. The average follow-up period was 66.4 months. All clinical outcome parameters showed significant improvement. C-JOA, SF-12, and NDI showed significant improvement at latest follow-up (p<0.001). C2–7 lordosis increased significantly immediately postoperatively (-6.0°±10.4°) compared to preoperatively (+9.2°±9.6°), and was largely maintained at latest follow-up (-5.7°±9.4°). T1 slope significantly increased between the immediate postoperative timepoint (21.9°±7.7°) and latest follow-up (24.2°±9.5°) (p=0.046). CGH-C7 SVA significantly increased between the immediate postoperative timepoint (22.7±14.8 mm) and latest follow-up (32.2±22.6 mm) (p=0.046).
Conclusion
Multilevel anterior osteotomy with posterior instrumentation is a safe and effective surgical option for OPLL-induced myelopathy with kyphotic cervical alignment. Future studies are required to investigate the forward tilting of cervical spine over time after surgery.
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Cervical Spine

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Predicting Neck Dysfunction After Open-Door Cervical Laminoplasty — A Prospective Cohort Patient-Reported Outcome Measurement Study
Neurospine. 2024;21(4):1053-1065.   Published online December 31, 2024
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Predicting Neck Dysfunction After Open-Door Cervical Laminoplasty — A Prospective Cohort Patient-Reported Outcome Measurement Study
Neurospine. 2024;21(4):1053-1065.   Published online December 31, 2024
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Objective
To analyze the predictive factors for neck pain and cervical spine function after laminoplasty for degenerative cervical myelopathy (DCM) using K-means for longitudinal data (KML).
Methods
In this prospective cohort study, we collected clinical and radiographic data from patients with DCM who underwent cervical laminoplasty. A novel index of surgical outcome, “neck function,” which comprises neck pain and cervical spine function according to the Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire, was proposed. We treated surgical outcomes as longitudinal rather than cross-sectional data and used KML for analysis. Patients were categorized as having good or poor outcomes based on the KML graph of neck pain and cervical spine function.
Results
From 2016 to 2020, 104 patients underwent laminoplasty for DCM; however, 35 patients were excluded because of loss to follow-up or incomplete data. The authors found that central canal stenosis (odds ratio [OR], 17.93; 95% confidence interval [CI], 1.26–254.73; p=0.03) and preoperative neck pain (OR per 1 point increase=1.49; 95% CI, 1.12–1.99; p=0.006) were 2 negative predictive factors and that a positive K-line during flexion was a positive predictive factor (OR, 0.11; 95% CI, 0.01–0.87; p=0.036) for neck function after laminoplasty.
Conclusion
Central canal stenosis, preoperative neck pain and a K-line during flexion were found to be predictive of postoperative neck pain and cervical spine function after laminoplasty. To achieve better surgical outcomes for neck function, the authors suggest the utilization of these determinants as a guiding framework for the selection of surgical approaches for DCM.

Citations

Citations to this article as recorded by  Crossref logo
  • Predictive value of preoperative T1 slope minus cervical lordosis for clinical outcomes after standalone laminectomy in elderly degenerative cervical myelopathy
    Ahmed Mohammed Ragab, Mahmoud M. Taha, Mansour Abdel Mageed Makkia, Ayman M. Ismail
    Scientific Reports.2026;[Epub]     CrossRef
  • Evaluating the predictive value of K-line conversion in surgical outcomes for K-line negative cervical ossification of the posterior longitudinal ligament (OPLL): laminectomy with fusion versus laminoplasty
    San Kim, Sehan Park, Chang Ju Hwang, Jae Hwan Cho, Dong-Ho Lee
    The Spine Journal.2025; 25(12): 2620.     CrossRef
  • From the Editor-in-Chief: Featured Articles in the December 2024 Issue
    Inbo Han
    Neurospine.2024; 21(4): 1051.     CrossRef
  • A Commentary on “Predicting Neck Dysfunction After Open-Door Cervical Laminoplasty — A Prospective Cohort Patient-Reported Outcome Measurement Study”
    Nobuyuki Shimokawa
    Neurospine.2024; 21(4): 1066.     CrossRef
  • 6,759 View
  • 178 Download
  • 4 Web of Science
  • 4 Crossref

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Management of Cerebrospinal Fluid Leakage by Pump-Regulated Volumetric Continuous Lumbar Drainage Following Anterior Cervical Decompression and Fusion for Ossification of the Posterior Longitudinal Ligament
Neurospine. 2023;20(4):1421-1430.   Published online December 31, 2023
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Management of Cerebrospinal Fluid Leakage by Pump-Regulated Volumetric Continuous Lumbar Drainage Following Anterior Cervical Decompression and Fusion for Ossification of the Posterior Longitudinal Ligament
Neurospine. 2023;20(4):1421-1430.   Published online December 31, 2023
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Objective
Cerebrospinal fluid (CSF) leakage is a major concern related to anterior cervical decompression and fusion for ossification of the posterior longitudinal ligament (OPLL). We propose a management algorithm for CSF leakage following anterior cervical decompression and fusion for OPLL involving the use of pump-regulated volumetric continuous lumbar drainage.
Methods
We retrospectively reviewed patients who underwent anterior cervical decompression and fusion for OPLL and were managed with the proposed algorithm between March 2018 and July 2022. The proposed management algorithm for CSF leakage by pump-regulated volumetric continuous lumbar drainage was as follows. On exposure of the arachnoid membrane with or without CSF leakage, a dural sealant patch was applied to manage the dural defect. In case of persistent CSF leakage despite application of the dural sealant patch, patients underwent pump-regulated volumetric continuous lumbar drainage.
Results
Fifty-one patients were included in the study. CSF leakage occurred in 14 patients. Of these 14 patients, 9 patients underwent lumbar drain insertion according to the proposed management algorithm. Successful resolution of CSF leakage was observed in 8 of the 9 patients who underwent lumbar drainage. All patients were encouraged to ambulate without concern of CSF overdrainage due to gravity, because it could be avoided with pump-regulated volumetric continuous CSF drainage. Therefore, complications associated with absolute bed rest or CSF overdrainage were not observed.
Conclusion
The proposed management algorithm with pump-regulated volumetric continuous lumbar drainage showed safety and efficacy for management of CSF leakage following anterior decompression and fusion for OPLL.

Citations

Citations to this article as recorded by  Crossref logo
  • Enhanced indirect sealing of cerebrospinal fluid leaks in anterior cervical surgery using plate mechanical pressure
    Dong Liu, Leisheng Wang, Xiaoguang Fan
    Journal of Radiation Research and Applied Sciences.2026; 19(1): 102196.     CrossRef
  • Delayed myelopathy caused by cerebrospinal fluid pseudocyst following decompression for thoracic ossification of the ligamentum flavum: a case report and literature review
    Shuxin Zheng, Jianzhi Wang, Junhu Li, Linnan Wang, Lei Wang, Yueming Song
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • External lumbar drain for fistula leakage in posterior fossa and spinal surgery: a systematic review with meta-analysis
    Luciano Falcão, João Pedro Fernandes Gonçalves, Maianna Sancho do Lago, Maria Clara Nery Cardoso, Judson Carlos S. N. Júnior, Lucas Piason, Jean G. de Oliveira, José Carlos Esteves Veiga
    Neurosurgical Review.2025;[Epub]     CrossRef
  • Dural Tear and Cerebrospinal Fluid Leakage in Anterior Cervical Spine Surgery: Pathophysiology, Management, and Evolving Repair Techniques
    Jae Jun Yang, Jiwon Park, Jong-Beom Park, Suo Kim
    Journal of Clinical Medicine.2025; 14(23): 8478.     CrossRef
  • Review/Perspective: Incidence and treatment of CSF leaks/dural tears (DT) occurring during anterior cervical surgery
    Nancy E. Epstein, Marc A. Agulnick
    Surgical Neurology International.2024; 15: 401.     CrossRef
  • The drainage volume control by elevation of drainage height versus head down tilt in supine position for management of cerebrospinal fluid leakage following lumbar posterior surgery
    Ping Dong, Jing Huang, Xu Deng, Hongli Yang, Chunmei Luo
    BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
  • 8,364 View
  • 219 Download
  • 4 Web of Science
  • 6 Crossref

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Correlation Between the Severity of Multifidus Fatty Degeneration and the Size of Ossification of Posterior Longitudinal Ligament at Each Spinal Level
Neurospine. 2023;20(3):921-930.   Published online September 30, 2023
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Correlation Between the Severity of Multifidus Fatty Degeneration and the Size of Ossification of Posterior Longitudinal Ligament at Each Spinal Level
Neurospine. 2023;20(3):921-930.   Published online September 30, 2023
Close
Objective
This study aimed to investigate the correlation between ossification of the posterior longitudinal ligament (OPLL) size and multifidus fatty degeneration (MFD), hypothesizing that larger OPLL sizes are associated with worse MFD.
Methods
One hundred four patients with cervical OPLL who underwent surgery were screened. OPLL occupying diameter and area ratios, the severity of MFD using the Goutallier classification, and range of motion (ROM) of cervical flexion-extension (ΔCobb) were measured. Correlation analyses between OPLL size, MFD severity, and ΔCobb were conducted. MFD severity was compared for each OPLL type using one-way analysis of variance.
Results
The final clinical data from 100 patients were analyzed. The average Goutallier grade of C2–7 significantly correlated with the average OPLL diameter and area occupying ratios, and OPLL involved vertebral level (r = 0.58, p < 0.01; r = 0.40, p < 0.01; r = 0.47, p < 0.01, respectively). The OPLL size at each cervical level significantly correlated with MFD of the same or 1–3 adjacent levels. ΔCobb angle was negatively correlated with the average Goutallier grade (r = -0.31, p < 0.01) and average OPLL occupying diameter and area ratios (r = -0.31, p < 0.01; r = -0.35, p < 0.01, respectively). Patients with continuous OPLL exhibited worse MFD than those with segmental OPLL (p < 0.01).
Conclusion
OPLL size is clinically correlated with MFD and cervical ROM. OPLL at one spinal level affects MFD at the same and 1–3 adjacent spinal levels. The worsening severity of MFD is associated with the longitudinal continuity of OPLL.

Citations

Citations to this article as recorded by  Crossref logo
  • The Impact of Cervical Multifidus Sarcopenia on Outcomes After Laminoplasty for Cervical Ossification of the Posterior Longitudinal Ligament
    Yiwei Zhao, Ye Tian, Dihan Sun, Jianguo Zhang, Siyi Cai
    Journal of Bone and Joint Surgery.2026; 108(5): 370.     CrossRef
  • Degenerative characteristics of the subaxial cervical spine in patients with degenerative lateral atlantoaxial osteoarthritis: A propensity score-matched study based on computed tomography imaging
    Shun Han, Yuliang Wu, Haotian Tian, Bo Sun, Songbo Gao, Weitao Han, Zhengqi Huang, Xiaohe Zhang, Yan Peng, Youxi Lin, Wei Ye
    Journal of Craniovertebral Junction and Spine.2026; 17(2): 125.     CrossRef
  • Cervical facet joint angle and deep extensor degeneration are correlated with laterally deviated type ossification of the posterior longitudinal ligament
    Hao Zhou, Tianyu Yao, Tenghui Zhang, Fazhi Zang, Xiaodong Wu, Lei Liang, Huajiang Chen
    European Journal of Medical Research.2026;[Epub]     CrossRef
  • The role of paraspinal muscle degeneration in cervical spondylosis
    Zhifei Li, Yisheng Zhang, Yuanfang Lin, Chunyu Fan, Yin Yang, Yueli Sun, Zhihua Wu, Ziyang Liang
    European Spine Journal.2025; 34(3): 1187.     CrossRef
  • Association between Congestive Heart Failure and Ossification of the Posterior Longitudinal Ligament in Korea: A Nationwide Longitudinal Cohort Study
    Dong Soon Jang, Hakyung Kim, Seung Hun Sheen, Inbo Han, Soo Hyun Lee, Woo Seok Choi, Je Beom Hong, Min Jai Cho, Seil Sohn
    The Nerve.2024; 10(1): 19.     CrossRef
  • 5,154 View
  • 180 Download
  • 3 Web of Science
  • 5 Crossref

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Vertebral Body Sliding Osteotomy as a Surgical Strategy for the Treatment of Cervical Myelopathy: Complications and Pitfalls
Neurospine. 2023;20(2):669-677.   Published online June 30, 2023
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Vertebral Body Sliding Osteotomy as a Surgical Strategy for the Treatment of Cervical Myelopathy: Complications and Pitfalls
Neurospine. 2023;20(2):669-677.   Published online June 30, 2023
Close
Objective
This retrospective cohort study has been aimed at evaluating the incidence of complications after vertebral body sliding osteotomy (VBSO) and analyzing some cases. Furthermore, the complications of VBSO were compared with those of anterior cervical corpectomy and fusion (ACCF).
Methods
This study included 154 patients who underwent VBSO (n = 109) or ACCF (n = 45) for cervical myelopathy and were followed up for > 2 years. Surgical complications, clinical and radiological outcomes were analyzed.
Results
The most common surgical complications after VBSO were dysphagia (n = 8, 7.3%) and significant subsidence (n = 6, 5.5%). There were 5 cases of C5 palsy (4.6%), followed by dysphonia (n = 4, 3.7%), implant failure (n = 3, 2.8%), pseudoarthrosis (n = 3, 2.8%), dural tears (n = 2, 1.8%), and reoperation (n = 2, 1.8%). C5 palsy and dysphagia did not require additional treatment and spontaneously resolved. The rates of reoperation (VBSO, 1.8%; ACCF, 11.1%; p = 0.02) and subsidence (VBSO, 5.5%; ACCF, 40%; p < 0.01) were significantly lower in VBSO than in ACCF. VBSO restored more C2–7 lordosis (VBSO, 13.9° ± 7.5°; ACCF, 10.1° ± 8.0°; p = 0.02) and segmental lordosis (VBSO, 15.7° ± 7.1°; ACCF, 6.6° ± 10.2°; p < 0.01) than ACCF. The clinical outcomes did not significantly differ between both groups.
Conclusion
VBSO has advantages over ACCF in terms of low rate of surgical complications related to reoperation and significant subsidence. However, dural tears may still occur despite the lessened need for ossified posterior longitudinal ligament lesion manipulation in VBSO; hence, caution is warranted.

Citations

Citations to this article as recorded by  Crossref logo
  • Comparative efficacy and safety of ACAF, ACCF, and laminoplasty for multilevel cervical OPLL: A network meta-analysis of observational studies
    Wei Wang, Cheng-Hao Xiang, Dan Li, Xian-Zao Wang, Xin-Hua Xu
    Journal of Orthopaedic Surgery.2026;[Epub]     CrossRef
  • The number of fusion levels as a potential factor influencing long-term complications of anterior controllable antedisplacement fusion: a biomechanical analysis
    Gaole He, Haopeng Li, Liang Yan, Zhongkai Liu, Teng Lu
    Frontiers in Surgery.2026;[Epub]     CrossRef
  • Vertebral body sliding osteotomy as a less invasive alternative to 540° surgery for cervical myelopathy with rigid kyphosis
    Dong-Ho Lee, Sung Tan Cho, Chang Ju Hwang, Jae Hwan Cho, Sehan Park, Jin Hwan Kim, Wongthawat Liawrungrueang
    European Spine Journal.2026;[Epub]     CrossRef
  • Anterior Controllable Antedisplacement Fusion (ACAF) in Revision Surgery for Iatrogenic Cervical Kyphosis: Technical Note and Case Series
    Zhenlei Liu, Yaobin Wang, Lei Zhang, Shanhang Jia, He Wang, Lei Cheng, Fengzeng Jian, Kai Wang, Hao Wu
    Orthopaedic Surgery.2025; 17(4): 1265.     CrossRef
  • Novel radiologic parameter for assessing decompression adequacy in anterior cervical decompression surgery: the V-line
    Dong-Ho Lee, Sung Tan Cho, Chang Ju Hwang, Jae Hwan Cho, Sehan Park, Jin Hwan Kim, Wongthawat Liawrungrueang
    The Spine Journal.2025; 25(9): 1928.     CrossRef
  • A narrative review of surgical approaches in cervical degenerative myelopathy and update of the algorithm for decision making
    Majid Reza Farrokhi, Seyed Reza Mousavi, Abbas Khosravifarsani, Jaloliddin Mavlonov, Mohammadhadi Amir Shahpari Motlagh, Seyed Bahram Seif, Armin Akbarzadeh
    Egyptian Journal of Neurosurgery.2025;[Epub]     CrossRef
  • Management of Cerebrospinal Fluid Leakage by Pump-Regulated Volumetric Continuous Lumbar Drainage Following Anterior Cervical Decompression and Fusion for Ossification of the Posterior Longitudinal Ligament
    Sun Woo Jang, Sang Hyub Lee, Hong Kyung Shin, Sang Ryong Jeon, Sung Woo Roh, Jin Hoon Park
    Neurospine.2023; 20(4): 1421.     CrossRef
  • 6,402 View
  • 250 Download
  • 7 Web of Science
  • 7 Crossref

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Genetic Odyssey to Ossification of the Posterior Longitudinal Ligament in the Cervical Spine: A Systematic Review
Neurospine. 2022;19(2):299-306.   Published online June 30, 2022
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Genetic Odyssey to Ossification of the Posterior Longitudinal Ligament in the Cervical Spine: A Systematic Review
Neurospine. 2022;19(2):299-306.   Published online June 30, 2022
Close
Despite numerous studies, the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) is still unclear. Previous genetic studies proposed variations in genes related to bone and collagen as a cause of OPLL. It is unclear whether the upregulations of those genes are the cause of OPLL or an intermediate result of endochondral ossification process. Causal variations may be in the inflammation-related genes supported by clinical and updated genomic studies. OPLL demonstrates features of genetic diseases but can also be induced by mechanical stress by itself. OPLL may be a combination of various diseases that share ossification as a common pathway and can be divided into genetic and idiopathic. The phenotype of OPLL can be divided into continuous (including mixed) and segmental (including localized) based on the histopathology, prognosis, and appearance. Continuous OPLL shows substantial overexpression of osteoblast-specific genes, frequent upper cervical involvement, common progression, and need for surgery, whereas segmental OPLL shows moderate-to-high expression of these genes and is often clinically silent. Genetic OPLL seems to share clinical features with the continuous type, while idiopathic OPLL shares features with the segmental type. Further genomic studies are needed to elucidate the relationship between genetic OPLL and phenotype of OPLL.

Citations

Citations to this article as recorded by  Crossref logo
  • The Impact of Cervical Multifidus Sarcopenia on Outcomes After Laminoplasty for Cervical Ossification of the Posterior Longitudinal Ligament
    Yiwei Zhao, Ye Tian, Dihan Sun, Jianguo Zhang, Siyi Cai
    Journal of Bone and Joint Surgery.2026; 108(5): 370.     CrossRef
  • Comparative Analysis of Outcomes and Kyphotic Risk Factors After Cervical Laminoplasty in 2 Different Ossification of the Posterior Longitudinal Ligament Groups and Cervical Spondylotic Myelopathy
    Hyun Woong Mun, Jong Joo Lee, Hyun Chul Shin, Tae-Hwan Kim, Seok Woo Kim, Jae Keun Oh
    Neurosurgery.2025; 97(2): 320.     CrossRef
  • Correlation Between Facet Tropism and Ossification of the Posterior Longitudinal Ligament in the Cervical Spine
    Hao Zhou, Jianxi Wang, Wenyu Zhang, Chenfei Gao, Bo Hu, Genjiang Zhen, Xingyu Li, Hui Wang, Wen Yuan, Huajiang Chen, Lei Liang
    Global Spine Journal.2025; 15(6): 2947.     CrossRef
  • Ossification of the Posterior Longitudinal Ligament in the Cervical Spine: Etiology, Clinical Presentation, and Management
    Christopher P. Bellaire, Ambika E. Paulson, Chinonso F. Ani, Lancelot Benn, Austin H. Carroll, Addisu Mesfin
    JBJS Reviews.2025;[Epub]     CrossRef
  • Spinal hypermobility accelerates ossification in posterior longitudinal ligaments: insights from an in vivo mouse model
    Tao Tang, Zhengya Zhu, Zhongyuan He, Fuan Wang, Lin Chen, Jianfeng Li, Hongkun Chen, Jiaxiang Zhou, Jianmin Wang, Shaoyu Liu, Yunfeng Yao, Xizhe Liu, Zhiyu Zhou
    Frontiers in Physiology.2025;[Epub]     CrossRef
  • X-ray Diagnostics of Degenerative Spinal Canal Stenosis at the Cervical Level (Literature Review)
    V. S. Petrova, P. V. Seliverstov, V. A. Sorokovikov, S. N. Larionov
    Radiology - Practice.2025; (2): 28.     CrossRef
  • Factors Associated With Repeat Surgery in Cervical Ossification of the Posterior Longitudinal Ligaments
    Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho
    Clinical Spine Surgery.2024; 37(4): 131.     CrossRef
  • Association between Congestive Heart Failure and Ossification of the Posterior Longitudinal Ligament in Korea: A Nationwide Longitudinal Cohort Study
    Dong Soon Jang, Hakyung Kim, Seung Hun Sheen, Inbo Han, Soo Hyun Lee, Woo Seok Choi, Je Beom Hong, Min Jai Cho, Seil Sohn
    The Nerve.2024; 10(1): 19.     CrossRef
  • Integrin αVβ3 antagonist-c(RGDyk) peptide attenuates the progression of ossification of the posterior longitudinal ligament by inhibiting osteogenesis and angiogenesis
    Xiangwu Geng, Yifan Tang, Changjiang Gu, Junkai Zeng, Yin Zhao, Quanwei Zhou, Lianshun Jia, Shengyuan Zhou, Xiongsheng Chen
    Molecular Medicine.2024;[Epub]     CrossRef
  • Is the Ossification of the Posterior Longitudinal Ligament a Positive Factor for the Fusion after Posterior Cervical Fusion and Decompression?
    Jun-Woo Ha, Bong Ju Moon, Kwang-Ryeol Kim, Kyung Hyun Kim, Jeong Yoon Park, Dong Kyu Chin, Yong Eun Cho, Keun Su Kim, Hyun Jun Jang
    The Nerve.2024; 10(2): 89.     CrossRef
  • Concentration-Dependent Efficacy of Recombinant Human Bone Morphogenetic Protein-2 Using a HA/β-TCP Hydrogel Carrier in a Mini-Pig Vertebral Oblique Lateral Interbody Fusion Model
    Hye-Yeong Lee, Ji-In Kang, Hye-Lan Lee, Gwang-Yong Hwang, Keung-Nyun Kim, Yoon Ha
    International Journal of Molecular Sciences.2023; 24(1): 892.     CrossRef
  • Comparison of the outcome after anterior cervical ossified posterior longitudinal ligament en bloc resection versus posterior total laminectomy and fusion in patients with ossification of the cervical posterior longitudinal ligament: a prospective randomi
    Bing Cao, Jingxuan Chen, Bo Yuan, Yanqing Sun, Shengyuan Zhou, Yin Zhao, Zheng Xu, Yifan Tang, Xiongsheng Chen
    The Bone & Joint Journal.2023; 105-B(4): 412.     CrossRef
  • Assessment of Cervical Myelopathy Risk in Ossification of the Posterior Longitudinal Ligament Patients With Spinal Cord Compression Based on Segmental Dynamic Versus Static Factors
    Zhongyuan He, Nguyen Tran Canh Tung, Hiroto Makino, Taketoshi Yasuda, Shoji Seki, Kayo Suzuki, Kenta Watanabe, Hayato Futakawa, Katsuhiko Kamei, Yoshiharu Kawaguchi
    Neurospine.2023; 20(2): 651.     CrossRef
  • Correlation Between the Severity of Multifidus Fatty Degeneration and the Size of Ossification of Posterior Longitudinal Ligament at Each Spinal Level
    Jinyoung Park, Yong Eun Cho, Kyung Hyun Kim, Sanghoon Shin, Sungjun Kim, Chae Hwan Lim, Seok Young Chung, Yoon Ghil Park
    Neurospine.2023; 20(3): 921.     CrossRef
  • 10,987 View
  • 252 Download
  • 12 Web of Science
  • 14 Crossref

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Review of Radiological Parameters, Imaging Characteristics, and Their Effect on Optimal Treatment Approaches and Surgical Outcomes for Cervical Ossification of the Posterior Longitudinal Ligament
Neurospine. 2019;16(3):506-516.   Published online September 30, 2019
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Review of Radiological Parameters, Imaging Characteristics, and Their Effect on Optimal Treatment Approaches and Surgical Outcomes for Cervical Ossification of the Posterior Longitudinal Ligament
Neurospine. 2019;16(3):506-516.   Published online September 30, 2019
Close
Determining the optimal surgical method for cervical ossification of the posterior longitudinal ligament (OPLL) is challenging. The surgical indication should be made based on not only radiological findings, but also the patient’s age, preoperative neurological findings, social background, activities of daily life, and the presence or absence of comorbid diseases. Anterior resection for OPLL with or without wide corpectomy and fusion, posterior decompression with or without relatively long fusion, or anterior and posterior combined surgery may be considered. When evaluating the clinical condition of patients with cervical OPLL before surgery, various radiological parameters should be carefully considered, including the number of spinal segments involved, the cervical alignment or tilt angle, the relationship between OPLL and the C2–7 line (termed the “K-line”), the occupying ratio of OPLL, and the involvement of dural ossification. The objective of this article is to review the radiological parameters in current use for deciding upon the optimal surgical strategy and for predicting surgical outcomes, focusing on cervical OPLL.

Citations

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  • C2-Involving Cervical Ossification of the Posterior Longitudinal Ligament (OPLL): Dome-like Laminoplasty Versus Laminectomy With Fusion
    Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Joongkyum Shin, Yoon Ha
    Global Spine Journal.2026;[Epub]     CrossRef
  • Comparative Analysis of Outcomes and Kyphotic Risk Factors After Cervical Laminoplasty in 2 Different Ossification of the Posterior Longitudinal Ligament Groups and Cervical Spondylotic Myelopathy
    Hyun Woong Mun, Jong Joo Lee, Hyun Chul Shin, Tae-Hwan Kim, Seok Woo Kim, Jae Keun Oh
    Neurosurgery.2025; 97(2): 320.     CrossRef
  • Evaluating the predictive value of K-line conversion in surgical outcomes for K-line negative cervical ossification of the posterior longitudinal ligament (OPLL): laminectomy with fusion versus laminoplasty
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    The Spine Journal.2025; 25(12): 2620.     CrossRef
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Ossification of the Posterior Longitudinal Ligament: Surgical Approaches and Associated Complications
Neurospine. 2019;16(3):517-529.   Published online September 30, 2019
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Ossification of the Posterior Longitudinal Ligament: Surgical Approaches and Associated Complications
Neurospine. 2019;16(3):517-529.   Published online September 30, 2019
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Ossification of the posterior longitudinal ligament (OPLL) is a rare but potentially devastating cause of degenerative cervical myelopathy (DCM). Decompressive surgery is the standard of care for OPLL and can be achieved through anterior, posterior, or combined approaches to the cervical spine. Surgical correction of OPLL via any approach is associated with higher rates of complications and the presence of OPLL is considered a significant risk factor for perioperative complications in DCM surgeries. Potential complications include dural tear (DT) and subsequent cerebrospinal fluid leak, C5 palsy, hematoma, hardware failure, surgical site infections, and other neurological deficits. Anterior approaches are technically more demanding and associated with higher rates of DT but offer greater access to ventral OPLL pathology. Posterior approaches are associated with lower rates of complications but may allow for continued disease progression. Therefore, the decision to pursue either an anterior or posterior approach to surgical decompression may be critically influenced by complications associated with each procedure. The authors critically review anterior and posterior approaches to surgical decompression of OPLL with particular focus on the complications associated with each approach. We also review the recent work in developing new surgical treatments for OPLL that aim to reduce complication incidence.

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Ossification of the Posterior Longitudinal Ligament in Cervical Spine: Prevalence, Management, and Prognosis
Neurospine. 2018;15(1):33-41.   Published online March 28, 2018
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Ossification of the Posterior Longitudinal Ligament in Cervical Spine: Prevalence, Management, and Prognosis
Neurospine. 2018;15(1):33-41.   Published online March 28, 2018
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Ossification of the posterior longitudinal ligament (OPLL) in the cervical spine and related neurological complications are not uncommon in East Asian countries. The estimated prevalence of cervical OPLL-related hospitalization is 7.7 per 100,000 person-years in Taiwan, and higher incidence rates have been observed in elderly and male patients. Although cervical OPLL is frequently insidious, it can eventually cause myelopathy and predispose patients to spinal cord injury (SCI). There are multiple options for managing cervical OPLL, ranging from observation to many kinds of surgical procedures, including posterior laminoplasty, laminectomy with or without fusion, anterior corpectomy with or without instrumentation, and circumferential decompression and fusion. None of these surgical approaches is free of complications. However, to date, there is still a lack of consensus regarding the choice of the surgical approach and the timing of surgical intervention. Cervical SCI and related neurological disabilities are more likely to occur in OPLL patients, who should therefore be cautioned regarding the possibility of a subsequent SCI if treated without surgery. This article aimed to review the prevalence, management strategies, and prognosis of cervical OPLL.

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Clinical Articles

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Increased Prevalence of Ossification of Posterior Longitudinal Ligament and Increased Bone Mineral Density in Patients with Ossification of Nuchal Ligament
Korean J Spine. 2016;13(3):139-143.   Published online September 30, 2016
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Increased Prevalence of Ossification of Posterior Longitudinal Ligament and Increased Bone Mineral Density in Patients with Ossification of Nuchal Ligament
Korean J Spine. 2016;13(3):139-143.   Published online September 30, 2016
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Objective

There are also few studies demonstrating the relationship between ossification of nuchal ligament (ONL) and ossification of posterior longitudinal ligament (OPLL). We compared the prevalence, location, and type of OPLL between patients with ONL and matched patients without ONL.We also compared the bone mineral densities (BMDs) between the 2 groups.

Methods

total of 124 cervical ONL patients were enrolled in this study. The control group of 124 patients was matched with 124 patients with ONL by age and sex on a 1:1 basis to minimize confounding factors. We reviewed the prevalence, location, and type of OPLL in both groups.

Results

The prevalence of OPLL was almost 2.5 times greater in patients with ONL than those without ONL. The mean value of BMD in patients with ONL was greater at the lumbar spine (L1-L4) than in patients without ONL. The mean T score of the lumbar spine was 0.25±1.68 in the patients with ONL and -0.73±1.64 in the patients without ONL.

Conclusion

The prevalence of OPLL in patients with ONL was significantly higher than in patients without ONL. Because ONL is innocuous and may be seen more readily than OPLL on simple cervical radiographs, clinicians should consider the possibility of coexisting OPLL when ONL, especially extensive ONL, is detected in patients with neck pain, radiculopathy, or myelopathy, to facilitate proper treatment.

Citations

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  • Anatomical variability, morphofunctional characteristics, and clinical relevance of accessory ossicles of the back: implications for spinal pathophysiology and differential diagnosis
    Eren Ogut
    Journal of Orthopaedic Surgery and Research.2025;[Epub]     CrossRef
  • The impact of nuchal ligament ossification resection on cervical stability after modified laminoplasty: a long-term follow-up study
    Chong Chen, Wenlin Ye, Tao Yu, Xing Cheng, Lutong Wang, Xingchen Zhao, Xiang Long, Jun Ouyang, Yunbing Chang, Xiaoqing Zheng
    BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
  • Is the Ossification of the Posterior Longitudinal Ligament a Positive Factor for the Fusion after Posterior Cervical Fusion and Decompression?
    Jun-Woo Ha, Bong Ju Moon, Kwang-Ryeol Kim, Kyung Hyun Kim, Jeong Yoon Park, Dong Kyu Chin, Yong Eun Cho, Keun Su Kim, Hyun Jun Jang
    The Nerve.2024; 10(2): 89.     CrossRef
  • Potential Link between Ossification of Nuchal Ligament and the Risk of Cervical Ossification of Posterior Longitudinal Ligament: Evidence and Clinical Implication from a Meta‐Analysis of 8429 Participants
    Baoliang Zhang, Guanghui Chen, Xingshuai Gao, Zhongqiang Chen
    Orthopaedic Surgery.2021; 13(3): 1055.     CrossRef
  • Surgery for cervical ossification of posterior longitudinal ligament (OPLL) via posterior laminoplasty
    Xiaoqing Chen, Jie Hao, Ting Fu, Rongqin Qin, Feng Zhang
    Interdisciplinary Neurosurgery.2020; 19: 100562.     CrossRef
  • Factors associated with bone metabolism in patients with cervical ossification of the posterior longitudinal ligament accompanied with diffuse idiopathic skeletal hyperostosis
    Shinji Horie, Yasunobu Sawaji, Kenji Endo, Hidekazu Suzuki, Yuji Matsuoka, Hirosuke Nishimura, Takeshi Seki, Kengo Yamamoto
    SICOT-J.2018; 4: 7.     CrossRef
  • Radiographic Features and Correlation Analysis of Location of Ossification in Patients with Cervical Ossification of the Posterior Longitudinal Ligament Combined with Ossification of the Nuchal Ligament
    Bo Yuan, Zhiwei Wang, Yin Zhao, Guofeng Xu, Shengyuan Zhou, Xiongsheng Chen, Lianshun Jia
    World Neurosurgery.2018; 116: e929.     CrossRef
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Modified Open-door Laminoplasty Using Hydroxyapatite Spacers and Miniplates
Korean J Spine. 2014;11(3):188-194.   Published online September 30, 2014
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Modified Open-door Laminoplasty Using Hydroxyapatite Spacers and Miniplates
Korean J Spine. 2014;11(3):188-194.   Published online September 30, 2014
Close
Objective

Cervical laminoplasty has been widely accepted as one of the major treatments for cervical myelopathy and various modifications and supplementary procedures have been devised to achieve both proper decompression and stability of the cervical spine. We present the retrospectively analyzed results of a modified unilateral open-door laminoplasty using hydroxyapatite (HA) spacers and malleable titanium miniplates.

Methods

From June 2008 to May 2012, among patients diagnosed with cervical spondylotic myelopathy and ossification of posterior longitudinal ligament, the patients who received laminoplasty were reviewed. Clinical outcome was assessed using Frankel grade and Japanese Orthopaedic Association score. The radiologic parameters were obtained from plain films, 3-dimensional computed tomography and magnetic resonance images.

Results

A total of 125 cervical laminae were operated in 38 patients. 11 patients received 4-level laminoplasty and 27 patients received 3-level laminoplasty. Postoperatively, the mean Frankel grade and JOA score were significantly improved from 3.97 to 4.55 and from 12.76 to 14.63, respectively (p<0.001). Radiologically, cervical curvature was worsened from 19.09 to 15.60 (p=0.025). The percentage of range of motion preservation was 73.32±22.39%. The axial dimension of the operated spinal canal was increased from 1.75 to 2.70 cm2 (p<0.001).

Conclusion

In the presenting study, unilateral open-door laminoplasty using HA spacers and miniplates appears to be a safe, rapid and easy procedure to obtain an immediate and rigid stabilization of the posterior elements of the cervical spine. This modified laminoplasty method showed effective expansion of the spinal canal and favorable clinical outcomes.

Citations

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  • Delayed Surgical Site Infection with Progressive Myelopathy Following Hydroxyapatite Spacer Dislodgement in Double-Door Laminoplasty
    Pranavakumar Palaninathan, Karthik Ramachandran, Niventhiran Kuppusamy, Ajoy Prasad Shetty, Shanmuganathan Rajasekaran
    JBJS Case Connector.2026;[Epub]     CrossRef
  • Laminoplasty in Motion: Evolving Techniques and Complications
    Ian M. Singleton, Amit S. Piple, Ben Crawford, Ashish Mittal, Alexander A. Rosinski, Dimitriy G. Kondrashov
    Journal of Neurological Surgery Part A: Central European Neurosurgery.2024; 85(02): 171.     CrossRef
  • Optimal Treatment of C3 Lamina in Cervical Laminoplasty
    Hidenori Matsuoka, So Ohashi, Michihisa Narikiyo, Ryo Nogami, Keita Hashimoto, Minami Wade, Hirokazu Nagasaki, Yoshifumi Tsuboi
    World Neurosurgery.2023; 180: e618.     CrossRef
  • Spinal Adhesive Arachnoiditis Treated with Lift-up Laminoplasty―A Case Report―
    Daichi Kawamura, Hiroki Ohashi, Keisuke Hatano, Yuichi Murayama, Satoshi Tani
    Spinal Surgery.2021; 35(2): 188.     CrossRef
  • Clinical outcome and radiological findings after cervical open door laminoplasty with titanium basket
    Hidenori Matsuoka, Yukoh Ohara, Takaoki Kimura, Nahoko Kikuchi, Yasuhiro Nakajima, Junichi Mizuno
    Journal of Clinical Neuroscience.2020; 73: 140.     CrossRef
  • Posteriore Dekompressionstechniken an der Halswirbelsäule bei spondylogener zervikaler Myelopathie
    G. Schmeiser, R. Kothe
    Die Wirbelsäule.2020; 04(04): 275.     CrossRef
  • Posterior Surgical Techniques for Cervical Spondylotic Myelopathy: WFNS Spine Committee Recommendations
    Abdul Hafid Bajamal, Se-Hoon Kim, Mohammad Reza Arifianto, Muhammad Faris, Eko Agus Subagio, Ben Roitberg, Inyang Udo-Inyang, Jonathan Belding, Mehmet Zileli, Jutty K.B.C. Parthiban
    Neurospine.2019; 16(3): 421.     CrossRef
  • A Comparison of Implants Used in Double Door Laminoplasty : Allogeneic Bone Spacer versus Hydroxyapatite Spacer
    Dong Yoon Lee, Chang Kyu Lee, In-Soo Kim
    Journal of Korean Neurosurgical Society.2016; 59(6): 604.     CrossRef
  • Safety and efficacy of cervical laminoplasty using a piezosurgery device compared with a high-speed drill
    Kunpeng Li, Wen Zhang, Bin Li, Hui Xu, Zhong Li, Dawei Luo, Jingtao Zhang, Jinzhu Ma
    Medicine.2016; 95(37): e4913.     CrossRef
  • Predictors of Outcome in Patients with Cervical Spondylotic Myelopathy Undergoing Unilateral Open-Door Laminoplasty
    Ji-Won Shin, Sung-Won Jin, Se-Hoon Kim, Jong-Il Choi, Bum-Joon Kim, Sang-Dae Kim, Dong-Jun Lim
    Korean Journal of Spine.2015; 12(4): 261.     CrossRef
  • Expansive Open-Door Cervical Laminoplasty
    Zhaohui Cheng, Weishan Chen, Shigui Yan, Wanli Li, Shengjun Qian
    Medicine.2015; 94(28): e1171.     CrossRef
  • 11,245 View
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Is the Cross-sectional Area after Unilateral Open Door Laminoplasty Wider than that after Midline Splitting Laminoplasty ? : Mathematical Approach
Korean J Spine. 2013;10(4):237-241.   Published online December 31, 2013
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Is the Cross-sectional Area after Unilateral Open Door Laminoplasty Wider than that after Midline Splitting Laminoplasty ? : Mathematical Approach
Korean J Spine. 2013;10(4):237-241.   Published online December 31, 2013
Close
Objective

The aim of this study was to compare geometrically cross-sectional areas of two different laminoplasty techniques in same opening size.

Some investigators have studied the expanded areas of the two different techniques using imaging study. Although it is unclear that postoperative spinal canal is correlated with the surgical outcome we just focused on mathematical and geometrical correlation of the expandable area with surgical opening size in different laminoplasty techniques.

Methods

To predict the expandable area by a midline splitting technique and a unilateral open door technique, we placed an imaginary isosceles triangle in the spinal canal and drew graphs for the equation of the expandable areas in same opening size using the Pythagorean theorem and mathematical program. To substitute the constant figures of mathematical formula we estimated the normal cervical spine CT scans of 50 Korean adults.

Results

We subtracted the imaginary triangle from the spinal canal and were left with the remaining area of the spinal canal that was not changed before and after surgery. In same opening size the expandable area by the midline splitting technique was same but slightly wider than the unilateral open door technique, irrespective of the triangular shape. For a normal isosceles triangle the results were the same.

Conclusion

Using mathematical proof, the expandable area after the midline splitting technique was same but slightly larger than that after the unilateral open door technique, irrespective of the size of the lamina opening.

Citations

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  • Expansion of Spinal Canal with Lift‐Open Laminoplasty: A New Method for Compression Cervical Myelopathy
    Huan Wang, Lei Zhang
    Orthopaedic Surgery.2021; 13(5): 1673.     CrossRef
  • Cervical Sagittal Imbalance after Cervical Laminoplasty in Elderly Patients
    Hyun Woong Mun, Chang Duk Yuk, Tae Hwan Kim, Moon Soo Park, Seok Woo Kim, Ji Hee Kim, Jun Hyong Ahn, In Bok Chang, Joon Ho Song, Jae Keun Oh, Andrea Lovato
    BioMed Research International.2020;[Epub]     CrossRef
  • CERVICAL SPINOLAMINOPLASTY WITH NEWLY DESIGNED TITANIUM MINI-PLATES
    CAN YALDIZ, TOLGA TOLUNAY, ARSLAN KAĞAN ARSLAN, ONUR YAMAN, TEYFIK DEMIR
    Journal of Mechanics in Medicine and Biology.2016; 16(04): 1650050.     CrossRef
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  • 3 Crossref

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Diagnosis of Cervical OPLL in Lateral Radiograph and MRI: Is it Reliable?
Korean J Spine. 2012;9(3):205-208.   Published online September 30, 2012
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Diagnosis of Cervical OPLL in Lateral Radiograph and MRI: Is it Reliable?
Korean J Spine. 2012;9(3):205-208.   Published online September 30, 2012
Close
Objective

Cervical OPLL is a relatively common cause of developing cervical myelopathy or radiculopathy in Asians. Cervical OPLL is sometimes missed in lateral radiography or MRI. In the present study, we analyzed the diagnostic accuracy of cervical OPLL in lateral radiography and MRI compared to CT scan.

Methods

This is a retrospective study of forty-six patients who underwent decompressive surgery anteriorly or posteriorly in our institute. All patients were diagnosed with cervical OPLL by CT scan. The patients were grouped into continuous type, segmental type, mixed type, and localized type. We then evaluated lateral radiographs and MRI compared to CT scans. The diagnostic accuracy and false negative rates in lateral radiograph and MRI were evaluated.

Results

In a total of 46 patients diagnosed with cervical OPLL in CT scans, diagnostic accuracy using lateral radiograph and MRI were 52.2%(24/46) and 58.7%(27/46), respectively. In the continuous type group, diagnostic accuracy using lateral radiograph and MRI were 85.7%(6/7) and 100.0%(7/7). In the segmental type group, diagnostic accuracy using lateral radiograph and MRI were 27.3%(6/22) and 31.8%(7/22). In the mixed type group, diagnostic accuracy was 91.7%(11/12) in lateral radiograph and 83.3%(10/12) in MRI. In the localized group, diagnostic accuracy was 20.0%(1/5) in lateral radiograph and 60.0%(3/5) in MRI.

Conclusion

The diagnostic accuracy of cervical OPLL using lateral radiograph and MRI was less than using CT scan. For the best treatment plan, preoperative CT scan should be performed to detect conditions of ossifications such as cervical OPLL.

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    Journal of Clinical Neuroscience.2025; 140: 111515.     CrossRef
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  • 147 Download
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