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Review Article

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Clinical Outcomes and Patient Perspectives in Full Endoscopic Cervical Surgery: A Systematic Review
Neurospine. 2025;22(1):81-104.   Published online March 31, 2025
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Clinical Outcomes and Patient Perspectives in Full Endoscopic Cervical Surgery: A Systematic Review
Neurospine. 2025;22(1):81-104.   Published online March 31, 2025
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Objective
Full endoscopic cervical surgery (FECS) is an evolving minimally invasive approach for treating cervical spine disorders. This systematic review synthesizes current evidence on the clinical outcomes and patient perspectives associated with FECS, specifically evaluating its safety, efficacy, and overall patient satisfaction.
Methods
A systematic search of the PubMed/MEDLINE, Cochrane Library, Embase, and Web of Science databases was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies published between January 2000 and September 2024 that reported on clinical outcomes or patient perspectives related to FECS were included. Risk of bias was assessed using the ROBINS-I (Risk Of Bias In Non-randomized Studies - of Interventions) tool and the Cochrane Risk of Bias tool. Inclusion criteria encompassed randomized controlled trials, prospective cohort studies, retrospective studies, and observational studies focused on adult populations undergoing FECS for cervical spine surgery.
Results
The final synthesis included 30 studies. FECS was associated with significant reductions in both cervical and radicular pain, as well as meaningful functional improvements, measured by standardized clinical scales such as the Neck Disability Index and visual analogue scale. Patient satisfaction rates were consistently high, with most studies reporting satisfaction exceeding 85%. Complication rates were low, primarily involving transient neurological deficits that were typically resolved without the need for further intervention. Nonrandomized studies generally presented a moderate risk of bias due to confounding and selection, whereas randomized controlled trials exhibited a low risk of bias.
Conclusion
FECS is a safe and effective minimally invasive surgical option for cervical spine disorders associated with substantial pain relief, functional improvement and high levels of patient satisfaction.

Citations

Citations to this article as recorded by  Crossref logo
  • Response to the letter to the editor: Inconsistencies in obesity criteria: implications for systematic reviews on endoscopic spine surgery
    Wongthawat Liawrungrueang, Watcharaporn Cholamjiak, Peem Sarasombath, Yudha Mathan Sakti, Pang Hung Wu, Meng-Huang Wu, Yu-Jen Lu, Lo Cho Yau, Zenya Ito, Sung Tan Cho, Dong-Gune Chang, Kang Taek Lim
    Asian Spine Journal.2026; 20(1): 211.     CrossRef
  • Full-Endoscopic Posterior Cervical Foraminotomy and Discectomy for Cervical Disc Hernia With Unilateral Radiculopathy
    Idris Gurpinar, Mehmet Yigit Akgun, Furkan Almas, Ozkan Ates
    Journal of Minimally Invasive Spine Surgery and Technique.2026; 11(1): 149.     CrossRef
  • Clinical and Functional Outcomes of Posterior Endoscopic Decompression for Symptomatic Cervical Disc Herniation
    Adam Mahendra Teja, Muhammed Anzar, Cheol Wung Park
    Cureus.2026;[Epub]     CrossRef
  • Ultrasound-guided brachial plexus hydrodissection combined with acupotomy release for the treatment of cervical spondylotic radiculopathy: a multicenter retrospective study
    Xiang Shang, Guo-Rui Luan, Yang-Chun Song, Fen Zhang, San-Bing Wu, Kai Geng, Hou-Shan Fang, Wei Wei, Zhen-Ya Wang, Han-Qing Zhao, Yong-Hui Yang, De-Hong Meng
    Frontiers in Aging Neuroscience.2026;[Epub]     CrossRef
  • Current Trends and Future Directions in Lumbar Spine Surgery: A Review of Emerging Techniques and Evolving Management Paradigms
    Gianluca Galieri, Vittorio Orlando, Roberto Altieri, Manlio Barbarisi, Alessandro Olivi, Giovanni Sabatino, Giuseppe La Rocca
    Journal of Clinical Medicine.2025; 14(10): 3390.     CrossRef
  • Navigated Minimally Invasive Cervical and Cervicothoracic Fixation: A Technical Note on Surgical Technique and Proposed Classification
    Spyridon Komaitis, Konstantinos Zygogiannis, Sotirios Karatzoglou, Dimitrios Klitsinikos, Dritan Pasku, Khalid Salem
    Cureus.2025;[Epub]     CrossRef
  • 14,778 View
  • 224 Download
  • 5 Web of Science
  • 6 Crossref

Original Article

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A Prospective, Single-Blinded, Bicentric Study, and Literature Review to Assess the Need of C2-Ganglion Preservation - SAVIOUR’s Criteria
Neurospine. 2021;18(1):87-95.   Published online November 17, 2020
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A Prospective, Single-Blinded, Bicentric Study, and Literature Review to Assess the Need of C2-Ganglion Preservation - SAVIOUR’s Criteria
Neurospine. 2021;18(1):87-95.   Published online November 17, 2020
Close
Objective
Joint manipulation for craniovertebral junction instability is often hindered by the C2-ganglion (C2G). Our study aims to compare the surgical outcome among patients with or without C2G preservation and discuss the technical nuances.
Methods
We did a prospective, bicentric study and included all the operated patients with craniovertebral junction anomaly. The outcome was assessed by the Pain Numeric Rating Scale, Patient Satisfactions Score, and Stony Brook Scar Evaluation Scale. The fusion was assessed using Lenke fusion grade.
Results
One hundred seventy-one patients (88 in group A and 83 in group B) were included. The most common symptom was spastic quadriparesis (n = 165, 96.5%) with median Nurick grade 3.3. Thirteen patients had suboccipital numbness and 12 patients had paraesthesia. Mean blood loss in group A was 490 ± 96.2 mL and group B was 525 ± 45.7 mL; median operative time was 217.9 and 162.2 minutes in the groups A and B, respectively (p < 0.05). At the follow-up (median, 46.8 months), Lenke fusion grade A was achieved in 92.4% and grade B in 7.6%. A trend suggesting better functional outcomes (numbness, parestheisa, scar outcome, and postoperative ulcer formation) in group A was seen with all 6 patients, who underwent O-C2 fixation, developed pressure sore.
Conclusion
Our results support ganglion preservation, especially in the subset of patients where occipital plating is required. Although the study fails to show any statistical significance, we suggest that one should always start with an ‘intent’ of preservation as the functional outcome is better.

Citations

Citations to this article as recorded by  Crossref logo
  • Cutting the Cord: Risks, Rewards, and Techniques of C2 Nerve Ligation
    Arun K. Movva, Kaitlyn L. Hurka, Julia Kaniuk, Rushmin Khazanchi, William B. Marcus, Jake A. Morales, Joshua M. Tennyson, Daniel E. Herrera, Mark A. Plantz, Jason Tegethoff, Tyler Compton, Henry Hilow, Parth Desai, Srikanth N. Divi, Wellington K. Hsu, Alp
    Contemporary Spine Surgery.2025; 26(11): 1.     CrossRef
  • An institutional study on accuracy of freehand cervical C1 C2 screws placement by knock and drill technique in craniovertebral anomalous bony anatomy: An evaluation of more than 600 screws based on SGPGI screw accuracy criteria
    Sudhir Bisan Sasapardhi, Pawan Kumar Verma, Arun Kumar Srivastava, Kuntal Kanti Das, Ashutosh Kumar, Priyadarshi Dikshit, Ved Prakash Maurya, Kamlesh Singh Bhaisora, Anant Mehrotra, Awadhesh Kumar Jaiswal, Prabhaker Mishra, Sanjay Behari, Raj Kumar, Harsh
    Journal of Craniovertebral Junction and Spine.2024; 15(1): 83.     CrossRef
  • Safety and efficacy of the new modified technique for c2 nerve root resection in 3d fluoroscopy navigated instrumentation in the cranio-cervical junction
    Lukas Bobinski, Linda Sandberg, Frida Bylander, Hampus Hållberg, Anders Berglund, John M. Duff
    Acta Neurochirurgica.2024;[Epub]     CrossRef
  • C2 Nerve Root Preservation During Posterior Fixation for Instability Secondary to Congenital Craniovertebral Junction Anomalies: Feasibility Factors and Related Outcomes
    Shivanna Puneeth, Madhivanan Karthigeyan, Pravin Salunke, Chirag Panchal, Mandeep Singh Kataria
    World Neurosurgery.2022; 157: e94.     CrossRef
  • Surgical Versus Conservative Management for Treating Unstable Atlas Fractures: A Multicenter Study
    Jun Jae Shin, Kwang-Ryeol Kim, Joongkyum Shin, Jiin Kang, Ho Jin Lee, Tae Woo Kim, Jae Taek Hong, Sang-Woo Kim, Yoon Ha
    Neurospine.2022; 19(4): 1013.     CrossRef
  • Prophylaxis of occipital pressure sores in patients after elective spinal surgery in a pandemic condition
    Piotr Tederko, Victoria Perovic-Kaczmarek, Robert Gasik, Beata Tarnacka
    Rheumatology.2022; 60(2): 153.     CrossRef
  • Commentary on “A Prospective, Single-Blinded, Bicentric Study, and Literature Review to Assess the Need of C2-Ganglion Preservation - SAVIOUR’s Criteria”
    James S. Harrop
    Neurospine.2021; 18(1): 96.     CrossRef
  • 7,517 View
  • 147 Download
  • 7 Crossref