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"Posterior lumbar interbody fusion"

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"Posterior lumbar interbody fusion"

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Bone Biology and Osteoporosis Special Issue

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The Combined Effects of RhBMP-2 and Systemic RANKL Inhibitor in Patients With Bone Density Loss Undergoing Posterior Lumbar Interbody Fusion: A Retrospective Observational Analysis With Propensity Score Matching
Neurospine. 2023;20(4):1186-1192.   Published online December 31, 2023
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The Combined Effects of RhBMP-2 and Systemic RANKL Inhibitor in Patients With Bone Density Loss Undergoing Posterior Lumbar Interbody Fusion: A Retrospective Observational Analysis With Propensity Score Matching
Neurospine. 2023;20(4):1186-1192.   Published online December 31, 2023
Close
Objective
The risks of nonunion and subsidence are high in patients with bone density loss undergoing spinal fusion surgery. The internal application of recombinant human bone morphogenic protein 2 (rhBMP-2) in an interbody cage improves spinal fusion; however, related complications have been reported. Denosumab, a human monoclonal antibody targeting the receptor activator of nuclear factor kappa B ligand (RANKL), hinders osteoblast differentiation and function. Therefore, this study aimed to observe the combined effect of the local application of rhBMP-2 in a lumbar cage and systemic RANKL inhibition on postoperative spinal fusion in patients with bone density loss undergoing posterior lumbar interbody fusion (PLIF).
Methods
This retrospective observational study included 251 consecutive patients with spinal stenosis who underwent PLIF at a single center between 2017 and 2021. Clinical outcomes were assessed, and radiographic evaluations included lumbar flexion, extension, range of motion, and subsidence. Statistical analyses were conducted to identify the combined effect of the treatment and the subsidence and spinal fusion status.
Results
One hundred patients were included in the final analysis. Denosumab treatment significantly reduced the rate of osteolysis (p = 0.013). When denosumab was administered in combination with rhBMP-2, the fusion status remained similar; however, the incidences of postoperative osteolysis and postoperative oozing day decreased.
Conclusion
The combined use of rhBMP-2 and RANKL inhibition in patients with bone density loss can enhance bone formation after PLIF with fewer complications than rhBMP-2 alone.

Citations

Citations to this article as recorded by  Crossref logo
  • Postoperative bone loss after posterior lumbar interbody fusion is a risk factor of cage subsidence independently of preoperative CT-derived attenuation: a retrospective study based on hounsfield unit
    Yunsheng Wang, Ruiling Wang, Tong Tong, Dechao Miao, Feng Wang, Linfeng Wang
    BMC Musculoskeletal Disorders.2026;[Epub]     CrossRef
  • Histomorphologic Assessment of Osteoregeneration in a Rabbit Femur Model With Xenograft, Bone Morphogenetic Protein-2, Platelet-Rich Plasma, and Denosumab
    Berik Tuleubayev, Yevgeniy Kamyshanskiy, Yerkin-Dauir Kurmangaliyev, Amina Koshanova, Ivan Avromidi, Yekaterina Kossilova, Daryn Darybayev
    Plastic and Reconstructive Surgery - Global Open.2026; 14(4): e7593.     CrossRef
  • Comparable Fusion Response, but Increased Inflammatory Response, with Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2 in Posterior Lumbar Interbody Fusion Surgery
    Mu Ha Lee, Hyun Jun Jang, Kyung Hyun Kim, Jeong-Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Jae Keun Oh, Bong Ju Moon
    Journal of Clinical Medicine.2026; 15(11): 4026.     CrossRef
  • Comparison of Hounsfield Unit, Vertebral Bone Quality, and Dual-Energy X-Ray Absorptiometry T-Score for Predicting Cage Subsidence After Posterior Lumbar Interbody Fusion
    Yunsheng Wang, Jiali Zhang, Tong Tong, Dechao Miao, Feng Wang, Linfeng Wang
    Global Spine Journal.2025; 15(4): 2226.     CrossRef
  • Antiosteoporosis medication in patients with posterior spine fusion: a systematic review and meta-analysis
    HyungSub Jin, HyungJu Jin, Kyung-Soo Suk, Byung Ho Lee, Si Young Park, Hak-Sun Kim, Seong-Hwan Moon, Sub-Ri Park, Namhoo Kim, Jae Won Shin, Ji-Won Kwon
    The Spine Journal.2025; 25(9): 1877.     CrossRef
  • Impact of Frailty and Other Factors as Estimated by HU to Predict Response to Anabolic Bone Medications
    Abdelrahman M. Hamouda, Zach Pennington, Rahul Kumar, Michael L. Martini, Derrick Obiri-Yeboah, Maria Astudillo Potes, Nicholas Kendall, Anthony L. Mikula, Michelle J. Clarke, William E. Krauss, Ahmad N. Nassr, Brett A. Freedman, Arjun S. Sebastian, Melvi
    Journal of Clinical Medicine.2025; 14(9): 3247.     CrossRef
  • Application of BMP-2 for bone regeneration in osteoporosis
    V.S. Kuznetsova, V.A. Sinelnikova, A.V. Vasilyev
    Stomatology.2025; 104(3): 101.     CrossRef
  • Low-Dose Bone Morphogenetic Protein Use in Spinal Fusion : Rethinking Clinical Efficacy
    Jun Ho Lee, Ji Hyun Youn, Hyun Jung Park, Seung-Jae Hyun
    Journal of Korean Neurosurgical Society.2025; 68(6): 632.     CrossRef
  • Promotion of Bone Formation in a Rat Osteoporotic Vertebral Body Defect Model via Suppression of Osteoclastogenesis by Ectopic Embryonic Calvaria Derived Mesenchymal Stem Cells
    Yerin Yu, Somin Lee, Minsung Bock, Seong Bae An, Hae Eun Shin, Jong Seop Rim, Jun-oh Kwon, Kwang-Sook Park, Inbo Han
    International Journal of Molecular Sciences.2024; 25(15): 8174.     CrossRef
  • The Canal Bone Ratio
    Yunsheng Wang, Tong Tong, Jiali Zhang, Dechao Miao, Feng Wang, Linfeng Wang
    Spine.2024; 49(22): 1570.     CrossRef
  • 7,649 View
  • 190 Download
  • 9 Web of Science
  • 10 Crossref

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Minimally Invasive Spine Surgery With Midline Cortical Bone Trajectory Screw Fixation for Lumbar Degenerative Disease in a Retrospective Study of 200 Patients
Neurospine. 2021;18(2):355-362.   Published online June 30, 2021
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Minimally Invasive Spine Surgery With Midline Cortical Bone Trajectory Screw Fixation for Lumbar Degenerative Disease in a Retrospective Study of 200 Patients
Neurospine. 2021;18(2):355-362.   Published online June 30, 2021
Close
Objective
Midline lumbar interbody fusion is performed for treatment of various lumbar degenerative diseases, with good clinical outcomes and few complications. However, there are no large-scale or long-term studies regarding midline lumbar interbody fusion. Therefore, the purpose of this study was to evaluate the clinical results of midline lumbar interbody fusion and to compare the results according to surgical level.
Methods
Between January 2013 and December 2015, 200 patients with lumbar degenerative disease undergoing midline lumbar interbody fusion surgery were enrolled. The mean patient age was 69.9 ± 15.8 years (range, 40–85 years). The patients were divided into groups according to surgical level: (1) level 1 operation (136 patients), (2) level 2 operation (43 patients), (3) level 3 operation (12 patients), and (4) level 4 or higher (9 patients). Clinical outcomes, fusion rates, and complications were compared among the 4 groups.
Results
All clinical outcomes significantly improved after surgery (measured at 3 years postoperatively) in all groups. Mean fusion rate was 90.5% ± 5.21%. Fusion rate was highest in group I (95.8%) and lowest in group IV (85.2%). There were complications in 17 cases (8.5%). Adjacent segment disease occurred in 16 cases, 5 of which required surgery. Group 1 had 1 case, and group 4 had 4 cases. Screw loosening occurred in 1 case in group 4. There were no cases of infection or mechanical complications.
Conclusion
This large, single‐institution, retrospective study demonstrates favorable clinical outcomes after midline lumbar interbody fusion for lumbar degenerative disease regardless of surgical level.

Citations

Citations to this article as recorded by  Crossref logo
  • Open Midline Decompression with Ligament Reconstruction for Multiple-Level Spinal Stenosis in Elderly Patients
    Shin-Jae Kim, Sang-Ho Lee, Junseok Bae
    NeuroSci.2025; 6(1): 18.     CrossRef
  • Surgical stabilization for degenerative lesions of the lumbar spine in patients with reduced bone mineral density: a systematic literature review
    I. V. Shirokikh, A. I. Vasilyev, Yu. M. Batrak, V. A. Peleganchuk
    Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika).2024; 21(1): 44.     CrossRef
  • Postoperative urinary retention after oblique lumbar interbody fusion under the systematic management protocol
    Joonsoo Lim, Jangyeob Lim, Asfandyar Khan, Chang-Hyun Lee, Jun-Hoe Kim, Sejin Choi, Tae-Shin Kim, Yunhee Choi, Chun Kee Chung, Sangwook T. Yoon, Kyoung-Tae Kim, Chi Heon Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Comparison of Cortical Bone Trajectory to Pedicle-Based Dynamic Stabilization: An Analysis of 291 Patients
    Chih-Chang Chang, Hsuan-Kan Chang, Chin-Chu Ko, Ching-Lan Wu, Yi-Hsuan Kuo, Tsung-Hsi Tu, Wen-Cheng Huang, Jau-Ching Wu
    Neurospine.2023; 20(1): 308.     CrossRef
  • The Fusion Rate of Cortical Bone Trajectory Screw Fixation and Pedicle Screw Fixations in L4‐5 Interbody Fusion: A Retrospective Cohort Study
    Yuhe Lin, Jie Xu, Wu Zheng
    Orthopaedic Surgery.2023; 15(5): 1281.     CrossRef
  • Minimally invasive fusion surgery for patients with degenerative spondylolisthesis and severe lumbar spinal stenosis: a comparative study between MIDLIF and TLIF
    Pedro Santos Silva, Ana Jardim, Joana Pereira, Rita Sousa, Rui Vaz, Paulo Pereira
    European Spine Journal.2023; 32(9): 3210.     CrossRef
  • Cortical bone trajectory screws in the treatment of lumbar degenerative disc disease in patients with osteoporosis
    Song Guo, Kai Zhu, Mei-Jun Yan, Xin-Hua Li, Jun Tan
    World Journal of Clinical Cases.2022; 10(36): 13179.     CrossRef
  • 8,192 View
  • 148 Download
  • 6 Web of Science
  • 7 Crossref

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Vertebral Endplate Cyst Formation in Relation to Properties of Interbody Cages
Neurospine. 2021;18(1):170-176.   Published online March 31, 2021
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Vertebral Endplate Cyst Formation in Relation to Properties of Interbody Cages
Neurospine. 2021;18(1):170-176.   Published online March 31, 2021
Close
Objective
This retrospective study aimed to compare vertebral endplate cyst formation (VECF), an early predictor for pseudoarthrosis, in different types of interbody cages.
Methods
We reviewed 84 cases treated with single-level posterior/transforaminal lumbar interbody fusion. We utilized a polyetheretherketone cage in 20 cases (group P), a titanium cage in 16 cases (group Ti), a titanium-coating polyetheretherketone cage in 13 cases (group TiP) and a porous tantalum cage in 35 cases (group Tn). VECF was evaluated comparing the computed tomography scans taken at day 0 and 6-month postoperation. We defined VECF (+) as enlargement of a pre-existing cyst or de novo formation of a cyst with the diameter over 2 mm. We calculated the adjusted odds ratio (OR) and 95% confidence intervals (CIs) as an indicator of association between different types of cages and VECF using a logistic regression model.
Results
VECF was observed in 13 (65%), 7 (44%), 9 (69%), and 8 (23%) cases in groups P, Ti, TiP and Tn, respectively. VECF correlated with the type of cage (p = 0.04). In comparison with group P, the proportion of VECF (+) cases was lower in group Tn (OR, 0.16; 95% CI, 0.04–0.60) but not different in group Ti (OR, 0.47; 95% CI, 0.10–2.20) and group TiP (OR, 1.06; 95% CI, 0.21–5.28). No patient underwent additional surgery for the fused spinal level during the follow-up periods (average, 37.9 months; range, 6–76 months).
Conclusion
VECF was the least in the porous Tn cage, suggesting its potential superiority for initial stability.

Citations

Citations to this article as recorded by  Crossref logo
  • Comparative Effects of Porous Tantalum and Porous Titanium: A Systematic Review and Meta-Analysis
    Youhao Wang, Zehao Jing, Lu Xu, Xu Yang, Renhua Ni, Hong Cai, Weishi Li
    The Journal of Arthroplasty.2026; 41(5): 1613.     CrossRef
  • Sagittal Alignment and Clinical Outcomes After Biportal Endoscopic Transforaminal Lumbar Interbody Fusion Using a Single Expandable Cage: One Year Follow-up
    Sub-Ri Park, Namhoo Kim, Ji-Won Kwon, Kyung-Soo Suk, Hak-Sun Kim, Seong-Hwan Moon, Si-Young Park, Byung Ho Lee, Jae-Won Shin, Jin-Oh Park
    World Neurosurgery.2026; 205: 124698.     CrossRef
  • Comprehensive Learning Curve, Clinical Outcomes, and Radiological Evaluation of Modified Trans-Kambin Endoscopic Lumbar Interbody Fusion at over 1-Year Follow-Up
    Kai-Ting Chien, Kai Hao Liao, Jian-You Li, Yueh-Ching Liu, Lei-Po Chen, Yu-Ching Huang, Yan-Shiang Lian, Ting-Kuo Chang
    World Neurosurgery.2026; 207: 124818.     CrossRef
  • Lateral parallel insertion of large footprint cages in PLIF promotes early fusion and fewer endplate cysts
    Yuya Kanie, Shota Takenaka, Masayuki Furuya, Takahito Fujimori, Hikari Urakawa, Hiroki Hagizawa, Yuichiro Ukon, Takahiro Makino, Seiji Okada, Takashi Kaito
    European Spine Journal.2026;[Epub]     CrossRef
  • Vertebral Endplate Cavities with Titanium Cages in Posterior Lumbar Interbody Fusion
    Tarek Elfiky, Yaser El Mansy, Martin N. Stienen, Abdelrahman Sa'ed Alabsi, Mahmoud Nafady
    Journal of Neurological Surgery Part A: Central European Neurosurgery.2025; 86(05): 444.     CrossRef
  • Clinical and radiological outcomes of titanium cage versus polyetheretherketone cage in lumbar interbody fusion: a systematic review and meta-analysis
    Haozhong Wang, Hao Zhang, Changming Xiao, Kaiquan Zhang, Lisheng Qi
    Neurosurgical Review.2025;[Epub]     CrossRef
  • Improved Clinical and Radiological Outcomes with Double-Cage Biportal Endoscopic Transforaminal Lumbar Interbody Fusion: A Comparative CT-Based Study
    Yu-Hao Huang, Jwo-Luen Pao
    Diagnostics.2025; 15(20): 2652.     CrossRef
  • The Effectiveness of Tritanium Cages in Preventing Osteolytic Vertebral Endplate Cysts After Lumbar Interbody Fusion
    Shu Takeuchi, Tomoo Inoue, Toshiyuki Takahashi, Ryo Kanematsu, Manabu Minami, Junya Hanakita
    World Neurosurgery.2024; 184: e803.     CrossRef
  • First clinical experience with posterior lumbar interbody fusion using a thermal-sprayed silver-containing hydroxyapatite-coated cage
    Tadatsugu Morimoto, Masatsugu Tsukamoto, Katsuhiro Aita, Nobuyuki Fujita, Masaaki Mawatari
    Journal of Orthopaedic Surgery and Research.2023;[Epub]     CrossRef
  • An update of interbody cages for spine fusion surgeries: from shape design to materials
    Guangshen Li, Lei Yang, Gang Wu, Zhanyang Qian, Haijun Li
    Expert Review of Medical Devices.2022; 19(12): 977.     CrossRef
  • 8,364 View
  • 170 Download
  • 10 Web of Science
  • 10 Crossref

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Robot-Guided Transforaminal Versus Robot-Guided Posterior Lumbar Interbody Fusion for Lumbar Degenerative Disease
Neurospine. 2021;18(1):98-105.   Published online December 14, 2020
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Robot-Guided Transforaminal Versus Robot-Guided Posterior Lumbar Interbody Fusion for Lumbar Degenerative Disease
Neurospine. 2021;18(1):98-105.   Published online December 14, 2020
Close
Objective
There have been no clinical studies comparing different robotic techniques. We compare minimally invasive, robot-guided transforaminal lumbar interbody fusion (RGTLIF) and mini-open robot-guided posterior lumbar interbody fusion (RG-PLIF).
Methods
Using data from a prospective institutional registry, we identified 38 patients who underwent RG-PLIF. Propensity score matching using a nearest-neighbor algorithm was implemented to select RG-TLIF controls. Twelve-month patient-reported outcome measures are presented. A reduction of ≥ 30% from baseline was defined as the minimum clinically important difference (MCID).
Results
Among the 76 included patients, there was no difference between RG-TLIF and RG-PLIF in surgical time (132.3 ± 29.4 minutes vs. 156.5 ± 53.0 minutes, p = 0.162), length of stay (55.9 ± 20.0 hours vs. 57.2 ± 18.8 hours, p = 0.683), and radiation dose area product (310.6 ± 126.1 mGy × cm2 vs. 287.9 ± 90.3 mGy × cm2, p = 0.370). However, while there was no difference among the 2 groups in terms of raw postoperative patient-reported outcome measures scores (all p > 0.05), MCID in leg pain was greater for RG-PLIF (55.3% vs. 78.9%, p = 0.028), and MCID in Oswestry Disability Index was greater for RG-TLIF (92.1% vs. 68.4%, p = 0.009). There was no difference concerning back pain (81.6% vs. 68.4%, p = 0.185).
Conclusion
Our findings suggest that both RG-TLIF and RG-PLIF are viable and equally effective techniques in robotic spine surgery.

Citations

Citations to this article as recorded by  Crossref logo
  • Lumbar spinal stenosis: current concept of management
    Ji-Won Kwon, Kyung-Soo Suk, Seong-Hwan Moon, Si-Young Park, Namhoo Kim, Sub-Ri Park, Jae-Won Shin, Hak-Sun Kim, Byung Ho Lee
    Asian Spine Journal.2026; 20(1): 143.     CrossRef
  • Clinical benefits of robotics in neurosurgery: a systematic review of operative time and recovery outcomes
    Jheremy S. Reyes, Cristian S. Cabezas, Luis M. Navarro-Ramirez, David F. Estupiñan-Pepinosa, Sofia Isabella Leal, Raul F. Vega-Alvear, Juan S. Aguirre-Patiño
    Egyptian Journal of Neurosurgery.2026;[Epub]     CrossRef
  • Real-world data and evidence in pain research: a qualitative systematic review of methods in current practice
    Jan Vollert, Bethea A. Kleykamp, John T. Farrar, Ian Gilron, David Hohenschurz-Schmidt, Robert D. Kerns, Sean Mackey, John D. Markman, Michael P. McDermott, Andrew S.C. Rice, Dennis C. Turk, Ajay D. Wasan, Robert H. Dworkin
    PAIN Reports.2023; 8(2): e1057.     CrossRef
  • Robotics in Cervical Spine Surgery: Feasibility and Safety of Posterior Screw Placement
    Lu-Ping Zhou, Zhi-Gang Zhang, Dui Li, Shu Fang, Rui Sheng, Ren-Jie Zhang, Cai-Liang Shen
    Neurospine.2023; 20(1): 329.     CrossRef
  • Clinical application of spinal robot in cervical spine surgery: safety and accuracy of posterior pedicle screw placement in comparison with conventional freehand methods
    Lu-Ping Zhou, Ren-Jie Zhang, Wen-Kui Zhang, Liang Kang, Kai-Xuan Li, Hua-Qing Zhang, Chong-Yu Jia, Yin-Shun Zhang, Cai-Liang Shen
    Neurosurgical Review.2023;[Epub]     CrossRef
  • Cost-utility analysis of endoscopic lumbar discectomy following a uniform clinical pathway in the Korean national health insurance system
    Chi Heon Kim, Yunhee Choi, Chun Kee Chung, Seung Heon Yang, Chang-Hyun Lee, Sung Bae Park, Keewon Kim, Sun Gun Chung, Sathish Muthu
    PLOS ONE.2023; 18(6): e0287092.     CrossRef
  • Commentary on “Simultaneous Single-Position Lateral Lumbar Interbody Fusion Surgery and Unilateral Percutaneous Pedicle Screw Fixation for Spondylolisthesis”
    Zafer Orkun Toktas
    Neurospine.2023; 20(3): 835.     CrossRef
  • Spine Surgical Robotics: Current Status and Recent Clinical Applications
    Jiangtao Wang, Junxian Miao, Yi Zhan, Yongchao Duan, Yuanshun Wang, Dingjun Hao, Biao Wang
    Neurospine.2023; 20(4): 1256.     CrossRef
  • Narrative Review of Uniportal, Transforaminal Endoscopic Lumbar Discectomy
    Woon Tak Yuh, Chang-Hyun Lee, Chun Kee Chung, Chi Heon Kim
    International journal of Pain.2022; 13(1): 11.     CrossRef
  • Commentary on “Robot-Guided Transforaminal Versus Robot-Guided Posterior Lumbar Interbody Fusion for Lumbar Degenerative Disease”
    Sertac Kirnaz, Branden Medary, Roger Härtl
    Neurospine.2021; 18(1): 106.     CrossRef
  • 7,979 View
  • 193 Download
  • 8 Web of Science
  • 10 Crossref

Clinical Article

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Mid-term Clinical Outcomes of Stand-alone Posterior Interbody Fusion with Rectangular Cages: A 4-year-minimum Follow-up
Korean J Spine. 2013;10(3):126-132.   Published online September 30, 2013
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Mid-term Clinical Outcomes of Stand-alone Posterior Interbody Fusion with Rectangular Cages: A 4-year-minimum Follow-up
Korean J Spine. 2013;10(3):126-132.   Published online September 30, 2013
Close
Objective

We sought to determine minimum 4 years of clinical outcomes including fusion rate, revision rate and complications of patients who underwent placement of rectangular stand-alone cages.

Methods

Thirty-three cases of degenerative spine that had been followed for at least 4-years were reviewed retrospectively. Cages were inserted at L4-L5 level or L5-S1 in 27 or in 6 cases respectively. Visual analogue scale (VAS), Odom's criteria, fusion rate, intervertebral disc height and lumbar lordosis were determined pre- and post-operatively on standing x-rays. Amount of intra- and postoperative blood loss, total volume transfused, duration of surgery and perioperative complications were also evaluated.

Results

The mean VAS score of back pain and sciatica were improved from 8.0 and 7.0 points to 3.4 and 2.4 during 1 years follow-up visit and the scores was raised gradually. Also, during the follow-up, 94% of patients showed excellent or good outcomes by the Odom's criteria. Intervertebral disc height was increased from 8.2±1.4mm to 9.2±1.9mm at the first year of follow-up, however, found to be decreased and stabilized to 8.3±1.8mm after 2 years. The fusion rate was approximately 91% after 4 year postoperative. The segmental angle of lordosis was increased significantly by two years but it was not maintained after four years. A statistically insignificant change in total lumbar lordosis was also observed. Three patients (9%) had experienced perioperative complications.

Conclusion

The use of rectangular stand-alone cages for posterior lumbar interbody fusion (PLIF) resulted in a various degree of subsidence and demonstrate very low complication rate, high functional stability and improved clinical outcomes in patients with degenerative lumbar disc disease.

Citations

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  • Posterior self-expanding stand-alone cage: outcomes in degenerative disc disease
    Nia Atanasova Gecheva, Petar Lyubomirov Ilkov, Konstantin Alexandrov Uzunov
    Folia Medica.2026;[Epub]     CrossRef
  • A Novel Nonpedicular Screw-Based Fixation in Lumbar Spondylolisthesis
    Ming-Hong Chen, Jen-Yuh Chen
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Ten Important Tips in Treating a Patient with Lumbar Disc Herniation
    Farzad Omidi-Kashani, Hamid Hejrati, Shahrara Ariamanesh
    Asian Spine Journal.2016; 10(5): 955.     CrossRef
  • 9,568 View
  • 84 Download
  • 3 Crossref