Neurospine

Neurospine provides spine clinicians and researchers with peer-reviewed articles on both basic and clinical investigations of the spine and spinal cord, aimed at enhancing patient management, education, research, and professionalism.

The journal welcomes submissions covering the entire spine, from the craniocervical to the lumbosacral regions, including the following areas: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, and rehabilitation of spinal, spinal cord and peripheral nerve diseases.

Original Article

September 30, 2024

An Experimental Model for Fluid Dynamics and Pressures During Endoscopic Lumbar Discectomy

Mazda Farshad, Alexandra Stauffer, Carl Moritz Zipser, Najmeh Kheram, José Miguel Spirig, Jonas Widmer, Vincent Hagel, Jana Felicitas Schader

Neurospine. 2024;21(3):745-752.

Objective: Endoscopic spine surgery is an emerging technique of minimally invasive spine surgery. However, headache, seizure, and autonomic dysreflexia are possible irrigation-related complications following full-endoscopic lumbar discectomy (FELD). Pressure elevation...

Review Article

September 30, 2024

Intraoperative Management of Iatrogenic Durotomy in Endoscopic Spine Surgery: A Systematic Review

Warayos Trathitephun, Akarawit Asawasaksakul, Khananut Jaruwanneechai, Boonserm Pakdeenit, Abhirat Suebsing, Yanting Liu, Jin-Sung Kim, Siravich Suvithayasiri

Neurospine. 2024;21(3):756-766.

This review aims to systematically evaluate the incidence, management strategies, and clinical outcomes of iatrogenic durotomy (ID) in endoscopic spine surgery and to propose a management flowchart based on the...

Review Article

September 30, 2024

Complications in Minimally Invasive Spine Surgery in the Last 10 Years: A Narrative Review

Blake I. Boadi, Chibuikem Anthony Ikwuegbuenyi, Sean Inzerillo, Gabrielle Dykhouse, Rachel Bratescu, Mazin Omer, Osama N. Kashlan, Galal Elsayed, Roger Härtl

Neurospine. 2024;21(3):770-803.

Objective: Minimally invasive spine surgery (MISS) employs small incisions and advanced techniques to minimize tissue damage while achieving similar outcomes to open surgery. MISS offers benefits such as reduced blood...

Original Article

September 30, 2024

Clinical Outcomes and Complications of Unilateral Biportal Endoscopic Posterior Cervical Foraminotomy: A Systematic Review and Meta-Analysis With a Comparison to Full-Endoscopic Posterior Cervical Foraminotomy

Sang Hyub Lee, Junghan Seo, Dain Jeong, Jin Seop Hwang, Jae-Won Jang, Yong Eun Cho, Dong-Geun Lee, Choon Keun Park

Neurospine. 2024;21(3):807-819.

Objective: The unilateral biportal endoscopic posterior cervical foraminotomy (UBE-PCF) has been recently adopted for unilateral radiating arm pain due to cervical herniated intervertebral disc or foraminal stenosis. We systematically meta-analyzed...

Original Article

September 30, 2024

Incidence and Risk Factors for Lumbar Sympathetic Chain Injury After Oblique Lumbar Interbody Fusion

Weerasak Singhatanadgige, Thanadol Tangdamrongtham, Worawat Limthongkul, Wicharn Yingsakmongkol, Stephen J. Kerr, Teerachat Tanasansomboon, Vit Kotheeranurak

Neurospine. 2024;21(3):820-832.

Objective: Oblique lumbar interbody fusion (OLIF), performed using a retroperitoneal approach, can lead to complications related to the approach, such as lumbar sympathetic chain injury (LSCI). Although LSCI is a...

Original Article

September 30, 2024

Artificial Intelligence Detection of Cervical Spine Fractures Using Convolutional Neural Network Models

Wongthawat Liawrungrueang, Inbo Han, Watcharaporn Cholamjiak, Peem Sarasombath, K. Daniel Riew

Neurospine. 2024;21(3):833-841.

Objective: To develop and evaluate a technique using convolutional neural networks (CNNs) for the computer-assisted diagnosis of cervical spine fractures from radiographic x-ray images. By leveraging deep learning techniques, the...

Original Article

September 30, 2024

Risk Factors of Unsatisfactory Outcomes Requiring Additional Intervention Following Oblique Lateral Interbody Fusion

Worawat Limthongkul, Bandid Chaiwongwattana, Stephen J. Kerr, Teerachat Tanasansomboon, Vit Kotheeranurak, Wicharn Yingsakmongkol, Weerasak Singhatanadgige

Neurospine. 2024;21(3):845-855.

Objective: Oblique lateral interbody fusion (OLIF) is a minimally invasive procedure for stabilizing the spine and indirectly decompressing the neural elements. There is sparse data on unsatisfactory outcomes that require...

Original Article

September 30, 2024

Distal Junctional Failure After Fusion Stopping at L5 in Patients With Adult Spinal Deformity: Incidence, Risk Factors, and Radiographic Criteria

Sung Ho Do, Sungsoo Bae, Dae Jean Jo, Ho Yong Choi

Neurospine. 2024;21(3):856-864.

Objective: To identify risk factors and establish radiographic criteria for distal junctional failure (DJF) in patients with adult spinal deformity (ASD), who underwent fusion surgery stopping at L5. Methods: This retrospective...

Review Article

September 30, 2024

Human-Robot Interaction and Social Robot: The Emerging Field of Healthcare Robotics and Current and Future Perspectives for Spinal Care

In Ho Han, Dong Hwan Kim, Kyoung Hyup Nam, Jae Il Lee, Kye-Hyung Kim, Jong-Hwan Park, Ho Seok Ahn

Neurospine. 2024;21(3):868-877.

Recent advances in robotics technology and artificial intelligence (AI) have sparked increased interest in humanoid robots that resemble humans and social robots capable of interacting socially. Alongside this trend, a...

Original Article

September 30, 2024

Modulation of the LIMK Pathway by Myricetin: A Protective Strategy Against Neurological Impairments in Spinal Cord Injury

Abhishek Roy, Santimoy Sen, Rudradip Das, Amit Shard, Hemant Kumar

Neurospine. 2024;21(3):878-889.

Objective: Spinal cord injury (SCI), one of the major disabilities concerning central nervous system injury, results in permanent tissue loss and neurological impairment. The existing therapeutic options for SCI are...

Original Article

September 30, 2024

Spinal Schwannoma Classification Based on the Presumed Origin With Preoperative Magnetic Resonance Images

Tae-Shin Kim, Jae Hee Kuh, Junhoe Kim, Woon Tak Yuh, Junghoon Han, Chang-Hyun Lee, Chi Heon Kim, Chun Kee Chung

Neurospine. 2024;21(3):890-902.

Objective: Classification guides the surgical approach and predicts prognosis. However, existing classifications of spinal schwannomas often result in a high ‘unclassified’ rate. Here, we aim to develop a new comprehensive...

Original Article

September 30, 2024

Postoperative Coronal Imbalance in Lenke 5C Adolescent Idiopathic Scoliosis: Evolution, Risk Factors, and Clinical Implications

Yinyu Fang, Jie Li, Zongshan Hu, Zezhang Zhu, Yong Qiu, Zhen Liu

Neurospine. 2024;21(3):903-912.

Objective: To explore the changes in coronal imbalance (CIB) in Lenke 5C adolescent idiopathic scoliosis (AIS) after posterior selective fusion surgery and determine their implications for surgical decision-making. Methods: One hundred...

Original Article

September 30, 2024

Magnetic Resonance Imaging-Based Vertebral Bone Quality Score for Prediction of Cage Subsidence and Screw Loosening in Patients Undergoing Degenerative Lumbar Surgery: A Meta-analysis

Fangke Hu, Lu Xue, Dong Zhao, Chao Chen, Feng Jing, Qiang Yang

Neurospine. 2024;21(3):913-924.

Objective: Poor bone quality is a risk factor for postoperative complications after degenerative lumbar fusion surgery. The magnetic resonance imaging-based vertebral bone quality (VBQ) score is a good tool for...

Original Article

September 30, 2024

STM2457 Inhibits METTL3-Mediated m6A Modification of miR-30c to Alleviate Spinal Cord Injury by Inducing the ATG5-Mediated Autophagy

Gang Chen, Zhitao Shangguan, Xiaoqing Ye, Zhi Chen, Jiandong Li, Wenge Liu

Neurospine. 2024;21(3):925-941.

Objective: The study aimed to investigate the role of N6-methyladenosine (m6A) modification in spinal cord injury (SCI) and its underlying mechanism, focusing on the interplay between m6A methyltransferase-like 3 (METTL3),...

Original Article

September 30, 2024

The Clinical Outcomes of Cervical Spine Chordoma: A Nationwide Multicenter Retrospective Study

Hangeul Park, Yunhee Choi, Sungjoon Lee, Sun-Ho Lee, Eun-Sang Kim, Sun Woo Jang, Jin Hoon Park, Yunseong Cho, Giwuk Jang, Yoon Ha, et al.

Neurospine. 2024;21(3):942-953.

Objective: Chordoma, a rare malignant tumor originating from embryonal notochord remnants, exhibits high resistance to conventional treatments, making surgical resection imperative. However, the factors influencing prognosis specifically for cervical spine...

Original Article

September 30, 2024

Comparison of Clinical Outcomes of Posterior-Only Transforaminal Debridement and Interbody Fusion With Preservation of Posterior Ligamentous Complex Versus Conventional Posterior-Only Debridement and Interbody Fusion for Thoracic Spine Tuberculosis: A Prospective, Randomized, Controlled, Clinical Trial - A Pilot Study

Yuxiang Wang, Shuntian Xiao, Guohui Zeng, Hongqi Zhang, Emmanuel Alonge, Zhuocheng Yang

Neurospine. 2024;21(3):954-965.

Objective: The main objective of this study was to analyze the efficacy and feasibility of surgical management for patients with thoracic spinal tuberculous spondylitis (STB) by using posterior-only transforaminal debridement...

Original Article

September 30, 2024

Utility of Radiographic Parameter in Assessing Bone Density and Subsequent Fractures in Patients With Osteoporotic Vertebral Compression Fracture

Yunsheng Wang, Mei Dong, Jiali Zhang, Dechao Miao, Feng Wang, Tong Tong, Linfeng Wang

Neurospine. 2024;21(3):966-972.

Objective: To investigate the ability of radiological parameter canal bone ratio (CBR) to assess bone mineral density and to differentiate between patients with primary and multiple osteoporotic vertebral compression fracture...

Original Article

September 30, 2024

Effect of Cage Material and Size on Fusion Rate and Subsidence Following Biportal Endoscopic Transforaminal Lumbar Interbody Fusion

Ki-Han You, Samuel K. Cho, Jae-Yeun Hwang, Sun-Ho Cha, Min-Seok Kang, Sang-Min Park, Hyun-Jin Park

Neurospine. 2024;21(3):973-983.

Objective: Biportal endoscopic transforaminal lumbar interbody fusion (BE-TLIF) is an emerging, minimally invasive technique performed under biportal endoscopic guidance. However, concerns regarding cage subsidence and sufficient fusion during BE-TLIF necessitate...

Original Article

September 30, 2024

A Self-Developed Mobility Augmented Reality System Versus Conventional X-rays for Spine Positioning in Intraspinal Tumor Surgery: A Case-Control Study

Wenyao Hong, Xiaohua Huang, Tian Li, Juntao Luo, Yuqing Liu, Shengyue Huang, Zhongyi Chen, Bingwei He, Yuxing Wen, Yuanxiang Lin

Neurospine. 2024;21(3):984-993.

Objective: To evaluate the efficacy of a self-developed mobile augmented reality navigation system (MARNS) in guiding spinal level positioning during intraspinal tumor surgery based on a dual-error theory. Methods: This retrospective...

Original Article

September 30, 2024

Application of the “Klotski Technique” in Cervical Ossification of the Posterior Longitudinal Ligament With En Bloc Type Dura Ossification

Jian Guan, Kang Li, Chenghua Yuan, Wanru Duan, Kai Wang, Zhenlei Liu, Zuowei Wang, Xingwen Wang, Hao Wu, Fengzeng Jian, et al.

Neurospine. 2024;21(3):994-1003.

Objective: The anterior controllable antedisplacement and fusion (ACAF) technique is a new procedure for the treatment of cervical ossification of the posterior longitudinal ligament (OPLL) that requires management of the...

Original Article

April 4, 2024

Evaluating the Efficacy and Safety of Hemofence (Thorombin Cross-Linked Sodium Hyaluronate Gel Matrix) in Hemostasis for Intractable Exudative Bleeding in Spinal Surgery: A Multicenter, Randomized, Phase III Clinical Trial

Sungjae An, Woo-Keun Kwon, Il Choi, Jang-Bo Lee, Joohyun Kim, Junseok W. Hur

Neurospine. 2024;21(3):1004-1013.

Objective: To demonstrate the noninferiority of the novel hemostatic agent, Hemofence (BMI Korea Co., Ltd., thrombin cross-linked sodium hyaluronate gel matrix) compared to the established agent, Floseal Hemostatic Matrix (Baxter,...

Original Article

September 30, 2024

Biomechanical Study of Atlanto-occipital Instability in Type II Basilar Invagination: A Finite Element Analysis

Junhua Ye, Qinguo Huang, Qiang Zhou, Hong Li, Lin Peng, Songtao Qi, Yuntao Lu

Neurospine. 2024;21(3):1014-1028.

Objective: Recent studies indicate that 3 morphological types of atlanto-occipital joint (AOJ) exist in the craniovertebral junction and are associated with type II basilar invagination (BI) and atlanto-occipital instability. However,...

Original Article

September 30, 2024

Different Degeneration Patterns of Paraspinal Muscles Between Double-Level and Single-Level Lumbar Spondylolisthesis: An Magnetic Resonance Imaging Analysis of 140 Patients

Yi Li, Ruiling Wang, Junjun Li, Linfeng Wang, Yong Shen

Neurospine. 2024;21(3):1029-1039.

Objective: To evaluate the degeneration patterns of paraspinal muscles in double-level degenerative lumbar spondylolisthesis (dl-DLS) versus single-level degenerative lumbar spondylolisthesis (sl-DLS). Methods: A total of 67 dl-DLS and 73 sl-DLS patients...

Original Article

September 30, 2024

Clinical and Radiographic Outcomes of Cervical Disc Replacement Versus Posterior Endoscopic Cervical Decompression: A Matched-Pair Comparison Analysis

Vit Kotheeranurak, Khanathip Jitpakdee, Kai-Uwe Lewandrowski, Guang-Xun Lin, Weerasak Singhatanadgige, Worawat Limthongkul, Wicharn Yingsakmongkol, Jin-Sung Kim, Wongthawat Liawrungrueang

Neurospine. 2024;21(3):1040-1050.

Objective: To compare clinical and radiographic outcomes between 2 motion preservation surgeries, cervical disc replacement (CDR) and posterior endoscopic cervical decompression (PECD), for unilateral cervical radiculopathy. Methods: Between February 2018 and...

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