Neurospine

Neurospine provides spine clinicians and researchers with peer-reviewed articles on both basic and clinical investigations of the spine and spinal cord, aimed at enhancing patient management, education, research, and professionalism.

The journal welcomes submissions covering the entire spine, from the craniocervical to the lumbosacral regions, including the following areas: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, and rehabilitation of spinal, spinal cord and peripheral nerve diseases.

Original Article

December 31, 2025

Romosozumab Enhances Implant Stability in Glucocorticoid-Induced Osteoporotic Bone: A Rabbit Model Study

Ji-Won Kwon, Seong-Hwan Moon, Kyung-Soo Suk, Si Young Park, Hak-Sun Kim, Sub-Ri Park, Namhoo Kim, Byung Ho Lee

Neurospine. 2025;22(4):880-890.

Objective: Implant fixation in osteoporotic bone presents substantial challenges due to reduced bone mass and compromised microarchitecture. This study investigated whether romosozumab, a sclerostin inhibitor, improves osseointegration and mechanical stability...

Original Article

December 31, 2025

Radiographic Analysis of Endplate Coverage of a 3-Dimensional-Expandable Transforaminal Lumbar Interbody Fusion (TLIF) Implant Compared to Static TLIF and Anterior Lumbar Interbody Fusion Implants

Jacob Mazza, Manhal Siddiqi, John Paul G. Kolcun, Dominick Richards, Richard G. Fessler

Neurospine. 2025;22(4):891-901.

Objective: Transforaminal lumbar interbody fusion (TLIF) has become a mainstay technique for interbody fusion, allowing for large contact area between implant and endplate, and providing increased stability and greater area...

Original Article

December 31, 2025

Epidemiology and Screening of Traumatic Vertebral Artery Injuries at a Large Scandinavian Level 1 Trauma Center

Paulina Cewe, Victor E. Staartjes, Victor Gabriel El-Hajj, Ihab Ahmad Al-Rikabi, Basel Musmar, Joana M Roy, Dennis Troung, Mats Beckman, Marcus Ohlsson, Pascal Jabbour, et al.

Neurospine. 2025;22(4):905-915.

Objective: Traumatic vertebral artery injuries (tVAIs) are uncommon but potentially devastating if missed. While computed tomography angiography (CTA) is routinely used for diagnosis, data on the number needed to image...

Original Article

December 31, 2025

Magnetic Resonance Spectroscopy Lipids Peak May Serve as a Potential Biomarker for Back Pain in Intervertebral Disc Degeneration: An Integrative Metabolomics and Proteomics Study Investigating the Role of the Lipid Droplets-Interleukin-17 Inflammatory Axis

Xi Chen, Jiang Jiang, Yijun Dong, Shuangshuang Tu, Chuanfu Li, Wenzhi Zhang, Yongjin Li, Jun Hu

Neurospine. 2025;22(4):918-933.

Objective: To explore and validate clinical magnetic resonance spectroscopy (MRS) biomarkers associated with patient-reported symptoms in intervertebral disc degeneration, and to further elucidate the pathogenic mechanisms linking these symptoms to...

Original Article

December 31, 2025

Flexion K-Line Status Predicts Surgical Strategy in Multilevel Cervical Ossification of the Posterior Longitudinal Ligament: A Multicenter Comparison of Laminoplasty and Laminectomy With Fusion

Jun Jae Shin, Sun Joon Yoo, Se Jun Park, Dong Kyu Kim, Hyun Jun Jang, Bong Ju Moon, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, et al.

Neurospine. 2025;22(4):937-948.