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Neurospine provides spine clinicians and researchers with peer-reviewed articles on basic and clinical investigation of spine and spinal cord to enhance patient management, education, clinical or experimental research, and professionalism.
The journal will consider submissions in areas on craniocervical to lumbosacral spine including the followings: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, rehabilitation of spine, spinal cord and peripheral nerve diseases.

Review Article

March 31, 2022


Hemostats in Spine Surgery: Literature Review and Expert Panel Recommendations
J.C. Le Huec, S. AlEissa, A.J. Bowey, B. Debono, A. El-Shawarbi, N. Fernández-Baillo, K.S. Han, A. Martin-Benlloch, R. Pflugmacher, P. Sabatier, et al.
Neurospine. 2022;19(1):1-12.

Bleeding in spine surgery is a common occurrence but when bleeding is uncontrolled the consequences can be severe due to the potential for spinal cord compression and damage to the...

Review Article

February 2, 2022


Glioma Immunotherapy: Advances and Challenges for Spinal Cord Gliomas
Clare Grady, Kaitlyn Melnick, Ken Porche, Farhad Dastmalchi, Daniel J. Hoh, Maryam Rahman, Ashley Ghiaseddin
Neurospine. 2022;19(1):13-29.

Spinal cord gliomas are rare entities that often have limited surgical options. Immunotherapy has shown promise in intracranial gliomas with some research suggesting benefit for spinal cord gliomas. A focused...

Original Article

January 30, 2022


Remnant Tumor Margin as Predictive Factor for Its Growth After Incomplete Resection of Cervical Dumbbell-Shaped Schwannomas
Kazuya Kitamura, Narihito Nagoshi, Osahiko Tsuji, Satoshi Suzuki, Satoshi Nori, Eijiro Okada, Mitsuru Yagi, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
Neurospine. 2022;19(1):32-40.

Objective: The purpose of our study was to investigate the risk factors of remnant tumor growth after incomplete resection (IR) of cervical dumbbell-shaped schwannomas (DS). Methods: Twenty-one patients with IR of...

Original Article

January 30, 2022


Steroids in the Management of Preoperative Neurological Deficits in Metastatic Spine Disease: Results From the EPOSO Study
Anne L. Versteeg, Lior M. Elkaim, Arjun Sahgal, Laurence D. Rhines, Daniel M. Sciubba, James M. Schuster, Michael G. Fehlings, Aron Lazary, Michelle J. Clarke, Paul M. Arnold, et al.
Neurospine. 2022;19(1):43-50.

Objective: Patients presenting with neurological deficit secondary to metastatic epidural spinal cord compression (MESCC) are often treated with surgery in combination with high-dose corticosteroids. Despite steroids being commonly used, the...

Original Article

February 2, 2022


Frailty Status Is a More Robust Predictor Than Age of Spinal Tumor Surgery Outcomes: A NSQIP Analysis of 4,662 Patients
Syed Faraz Kazim, Alis J. Dicpinigaitis, Christian A. Bowers, Smit Shah, William T. Couldwell, Rachel Thommen, Daniel J. Alvarez-Crespo, Matthew Conlon, Omar H. Tarawneh, John Vellek, et al.
Neurospine. 2022;19(1):53-62.

Objective: The present study aimed to evaluate the effect of baseline frailty status (as measured by modified frailty index-5 [mFI-5]) versus age on postoperative outcomes of patients undergoing surgery for...

Original Article

February 3, 2022


Clinical Features, Treatments, and Prognosis of Intramedullary Spinal Cord Metastases From Lung Cancer: A Case Series and Systematic Review
Liang Wu, Li'ao Wang, Jun Yang, Wenqing Jia, Yulun Xu
Neurospine. 2022;19(1):65-76.

Objective: Intramedullary spinal cord metastasis from lung cancer (ISCM-LC) are increasing in prevalence. We aim to investigate its clinical features, treatments and prognosis. Methods: We reported 6 ISCM-LC cases and conducted...

Original Article

January 17, 2022


Recovery Potential of Spinal Meningioma Patients With Preoperative Loss of Walking Ability Following Surgery – A Retrospective Single-Center Study
Ville Vasankari, Roel Haeren, Mika Niemelä, Miikka Korja
Neurospine. 2022;19(1):77-83.

Objective: Spinal meningiomas are neurosurgical rarities that manifest with progressive paraor tetraparesis. The effect of timing of surgery on the recovery after the loss of walking ability is poorly known....

Original Article

March 31, 2022


Hardware Failure in Spinal Tumor Surgery: A Hallmark of Longer Survival?
Nikita Zaborovskii, Adam Schlauch, Dmitrii Ptashnikov, Dmitrii Mikaylov, Sergei Masevnin, Oleg Smekalenkov, John Shapton, Dimitriy Kondrashov
Neurospine. 2022;19(1):84-95.

Objective: Instrumentation failure in spine tumor surgery is a common reason for revision operation. Increases in patient survival demand a better understanding of the hardware longevity. The study objective was...

Original Article

March 31, 2022


Functional Outcome After Spinal Meningioma Surgery. A Nationwide Population-Based Study
Charles Champeaux-Depond, Nicolas Penet, Joconde Weller, Jean-Charles Le Huec, Vincent Jecko
Neurospine. 2022;19(1):96-107.

Objective: To describe and analysed the functional outcome (FO) after spinal meningioma (SM) surgery. Methods: We processed the système national des données de santé (SNDS) i.e. , the French national administrative...

Original Article

March 31, 2022


Intramedullary Spinal Cord Lesions: A Single-Center Experience
Vincent Jecko, Paul Roblot, Lorenzo Mongardi, Morgan Ollivier, Natalia Delgado Piccoli, Thomas Charleux, Thomas Wavasseur, Edouard Gimbert, Dominique Liguoro, Guillaume Chotard, et al.
Neurospine. 2022;19(1):108-117.

Objective: Spinal cord tumors constitute a small part of spinal surgery owing to their rarity. This retrospective study describes their current management. Methods: Forty-eight patients were treated for an intramedullary tumor...

Original Article

March 31, 2022


Long-term Neurologic Outcome After Spinal Ependymoma Resection With Multimodal Intraoperative Electrophysiological Recording: Cohort Study and Review of the Literature
Grégoire P. Chatain, Michael W. Kortz, Stephanie Serva, Keshari Shrestha, Patrick Hosokawa, Timothy H. Ung, Michael Finn
Neurospine. 2022;19(1):118-132.

Objective: To evaluate how multimodal intraoperative neuromonitoring (IONM) changes during spinal ependymoma (SE) resection correlate with long-term neuro-functional outcomes. Methods: A retrospective analysis of patients aged 18 years or older who...

Original Article

March 31, 2022


Prediction of Discharge Status and Readmissions after Resection of Intradural Spinal Tumors
Michael C. Jin, Allen L. Ho, Austin Y. Feng, Zachary A. Medress, Arjun V. Pendharkar, Paymon Rezaii, John K. Ratliff, Atman M. Desai
Neurospine. 2022;19(1):133-145.

Objective: Intradural spinal tumors are uncommon and while associations between clinical characteristics and surgical outcomes have been explored, there remains a paucity of literature unifying diverse predictors into an integrated...

Original Article

March 31, 2022


Mechanical Failure After Total En Bloc Spondylectomy and Salvage Surgery
Shin Won Kwon, Chun Kee Chung, Young Il Won, Woon Tak Yuh, Sung Bae Park, Seung Heon Yang, Chang Hyun Lee, John M. Rhee, Kyoung-Tae Kim, Chi Heon Kim
Neurospine. 2022;19(1):146-154.

Objective: Total en bloc spondylectomy (TES) is a curative surgical method for spinal tumors. After resecting the 3 spinal columns, reconstruction is of paramount importance. We present cases of mechanical...

Review Article

March 31, 2022


Pearls and Pitfalls of Oblique Lateral Interbody Fusion: A Comprehensive Narrative Review
Hyoungmin Kim, Bong-Soon Chang, Sam Yeol Chang
Neurospine. 2022;19(1):163-176.

Lumbar degenerative disease is a common problem in an aging society. Oblique lateral interbody fusion (OLIF) is a minimally invasive surgical (MIS) technique that utilizes a retroperitoneal antepsoas corridor to...

Review Article

January 29, 2022


Clinical Issues in Indication, Correction, and Outcomes of the Surgery for Neuromuscular Scoliosis: Narrative Review in Pedicle Screw Era
Hak Sun Kim, Ji Won Kwon, Kun-Bo Park
Neurospine. 2022;19(1):177-187.

Surgical treatment for neuromuscular scoliosis has evolved with pedicle screw instrumentation and the improvement of perioperative management. We aimed to review recent papers related to posterior surgical correction with a...

Original Article

January 2, 2022


Location Distribution of Fistulas and Surgical Strategies for Spinal Extradural Meningeal Cysts: A Retrospective Analysis of 30 Cases at a Single Center
Qiang Jian, Gang Song, Zhenlei Liu, Wanru Duan, Jian Guan, Fengzeng Jian, Zan Chen
Neurospine. 2022;19(1):188-201.

Objective: This study aimed to illustrate the features of fistula location distribution, surgical strategies, and outcomes in spinal epidural meningeal cysts (SEMCs). Methods: The authors searched and reviewed the medical records...

Original Article

February 2, 2022


Reconstruction of the Cervical Lateral Mass Using 3-Dimensional-Printed Prostheses
Qiang Jian, Zhenlei Liu, Wanru Duan, Jian Guan, Fengzeng Jian, Zan Chen
Neurospine. 2022;19(1):202-211.

Objective: This study aimed to investigate the outcome of using 3-dimensional (3D)-printed prostheses to reconstruct a cervical lateral mass to maintain cervical stability. Methods: We retrospectively analyzed data of 7 patients...

Original Article

February 2, 2022


Comparative Analysis of 3 Types of Minimally Invasive Posterior Cervical Foraminotomy for Foraminal Stenosis, Uniportal-, Biportal Endoscopy, and Microsurgery: Radiologic and Midterm Clinical Outcomes
Ji Yeon Kim, Hyun Jin Hong, Dong Chan Lee, Tae Hyun Kim, Jin Seob Hwang, Choon Keun Park
Neurospine. 2022;19(1):212-223.

Objective: The aim of this study was to compare the clinical and radiologic outcomes of 3 types of minimally invasive posterior cervical foraminotomy (PCF): uniportal endoscopic surgery, biportal endoscopic surgery,...

Original Article

March 31, 2022


Risk Factors for Poor Outcomes Following Minimally Invasive Discectomy: A Post Hoc Subgroup Analysis of 2-Year Follow-up Prospective Data
Zihao Chen, Lei He, Lijun Huang, Zhongyu Liu, Jianwen Dong, Bin Liu, Ruiqiang Chen, Liangming Zhang, Peigen Xie, Limin Rong
Neurospine. 2022;19(1):224-235.

Objective: A post hoc subgroup analysis of prospectively collected data from a randomized controlled trial was conducted to identify risk factors related to poor outcomes in patients who underwent minimally...

Original Article

March 31, 2022


The Last Touched Vertebra on Supine Radiographs Can Be the Optimal Lower Instrumented Vertebra in Adolescent Idiopathic Scoliosis Patients
Do-Hyoung Kim, Seung-Jae Hyun, Chang-Hyun Lee, Ki-Jeong Kim
Neurospine. 2022;19(1):236-243.

Objective: To determine whether the last touched vertebra (LTV) on supine radiographs is suitable for the lower instrumented vertebra (LIV) in adolescent idiopathic scoliosis (AIS) correction surgery. Methods: In total, 57...
Current Issue
Volume 19(1); Mar 2022
Biomaterials in Spinal Implants: A Review
Andrew Warburton, Steven J. Girdler, Christopher M. Mikhail, Amy Ahn, Samuel K. Cho
Neurospine. 2020;17(1):101-110.

Review Article

November 4, 2019
Telerobotic Spinal Surgery Based on 5G Network: The First 12 Cases  
Wei Tian, Mingxing Fan, Cheng Zeng, Yajun Liu, Da He, Qi Zhang
Neurospine. 2020;17(1):114-120.

Original Article

March 31, 2020
Robotic Spine Surgery and Augmented Reality Systems: A State of the Art
Gianluca Vadalà, Sergio De Salvatore, Luca Ambrosio, Fabrizio Russo, Rocco Papalia, Vincenzo Denaro
Neurospine. 2020;17(1):88-100.

Review Article

March 31, 2020
Less Opioid Consumption With Enhanced Recovery After Surgery Transforaminal Lumbar Interbody Fusion (TLIF): A Comparison to Standard Minimally-Invasive TLIF
Hsuan-Kan Chang, Meng Huang, Jau-Ching Wu, Wen-Cheng Huang, Michael Y. Wang
Neurospine. 2020;17(1):228-236.

Original Article

March 31, 2020
Gene Therapy Approach for Intervertebral Disc Degeneration: An Update
Yoshiki Takeoka, Takashi Yurube, Kotaro Nishida
Neurospine. 2020;17(1):3-14.

Review Article

March 31, 2020
Bicortical Screw Purchase at Upper Instrumented Vertebra (UIV) Can Cause UIV Fracture After Adult Spinal Deformity Surgery: A Finite Element Analysis Study
Seong-Hyun Wui, Seung-Jae Hyun, Bokku Kang, Ki-Jeong Kim, Tae-Ahn Jahng, Hyun Jib Kim
Neurospine. 2020;17(2):377-383.

Original Article

July 11, 2019
Technique of Biportal Endoscopic Transforaminal Lumbar Interbody Fusion  
Dong Hwa Heo, Young Ho Hong, Dong Chan Lee, Hun Jae Chung, Choon Keun Park
Neurospine. 2020;17(Suppl 1):S129-S137.

Review and Technical Note

July 31, 2020
Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature
Elie Massaad, Nida Fatima, Ali Kiapour, Muhamed Hadzipasic, Ganesh M. Shankar, John H. Shin
Neurospine. 2020;17(1):125-135.Correction in: Neurospine 2020;17(2):473

Original Article

March 31, 2020
A Narrative Review of Development of Full-Endoscopic Lumbar Spine Surgery
Pang Hung Wu, Hyeun-Sung Kim, Il-Tae Jang
Neurospine. 2020;17(Suppl 1):S20-S33.

Review Article

July 31, 2020
Opioids and Spinal Cord Stimulators: Pre- and Postoperative Opioid Use Patterns and Predictors of Prolonged Postoperative Opioid Use
Lawal Labaran, Jomar N.A. Aryee, Joshua Bell, Nikhil Jain, Varun Puvanesarajah, Micheal Raad, Amit Jain, Jonathan Carmouche, Hamid Hassanzadeh
Neurospine. 2020;17(1):246-253.

Original Article

March 31, 2020
Dual S2 Alar-Iliac Screw Technique With a Multirod Construct Across the Lumbosacral Junction: Obtaining Adequate Stability at the Lumbosacral Junction in Spinal Deformity Surgery
Paul J. Park, James D. Lin, Melvin C. Makhni, Meghan Cerpa, Ronald A. Lehman, Lawrence G. Lenke
Neurospine. 2020;17(2):466-470.

Case Report

November 4, 2019
Lower Extremity Motor Deficits Are Underappreciated in Patient-Reported Outcome Measures: Added Value of Objective Outcome Measures
Martin Nikolaus Stienen, Nicolai Maldaner, Marketa Sosnova, Holger Joswig, Marco Vincenzo Corniola, Luca Regli, Gerhard Hildebrandt, Karl Schaller, Oliver Pascal Gautschi
Neurospine. 2020;17(1):270-280.

Original Article

January 26, 2020
The Navigated Oblique Lumbar Interbody Fusion: Accuracy Rate, Effect on Surgical Time, and Complications
Zhuo Xi, Dean Chou, Praveen V. Mummaneni, Shane Burch
Neurospine. 2020;17(1):260-267.

Original Article

February 5, 2020
Global Neurosurgery in the Time of COVID-19
Kee B. Park, Ulrick Sidney Kanmounye, Jean Wilguens Lartigue
Neurospine. 2020;17(2):348-350.

Editorial

May 18, 2020
Lumbar Endoscopic Unilateral Laminotomy for Bilateral Decompression Outside-In Approach: A Proctorship Guideline With 12 Steps of Effectiveness and Safety  
Hyeun-Sung Kim, Pang Hung Wu, Il-Tae Jang
Neurospine. 2020;17(Suppl 1):S99-S109.

Review and Technical Note

July 31, 2020
Surgical Impact on Global Sagittal Alignment and Health-Related Quality of Life Following Cervical Kyphosis Correction Surgery: Systematic Review
Chang-Wook Kim, Seung-Jae Hyun, Ki-Jeong Kim
Neurospine. 2020;17(3):497-504.

Review Article

September 30, 2020
Smartphone-Based Self-Assessment of Objective Functional Impairment (6-Minute Walking Test) in Patients Undergoing Epidural Steroid Injection
Anna Maria Zeitlberger, Marketa Sosnova, Michal Ziga, Valentin Steinsiepe, Oliver P. Gautschi, Martin N. Stienen, Nicolai Maldaner
Neurospine. 2020;17(1):136-142.

Case Report

March 31, 2020
Use of Opioids and Other Analgesics Before and After Primary Surgery for Adult Spinal Deformity: A 10-Year Nationwide Study
Frederik Taylor Pitter, Matt Sikora, Martin Lindberg-Larsen, Alma Becic Pedersen, Benny Dahl, Martin Gehrchen
Neurospine. 2020;17(1):237-245.

Original Article

July 24, 2019
The Eclipse of Degenerative Spine Pathology During COVID-19 Pandemic
Carlo Brembilla, Pierlorenzo Veiceschi, Andrea Fanti, Emanuele Costi, Maurizio Passoni, Angelo Mirco Sicignano, Claudio Bernucci
Neurospine. 2020;17(2):354-356.

Editorial

May 18, 2020
Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma
Shanmuganathan Rajasekaran, Chitraa Tangavel, Dilip Chand Raja Soundararajan, Sharon Miracle Nayagam, Monica Steffi Matchado, Raveendran Muthurajan, K.S. Sri Vijay Anand, Sunmathi Rajendran, Ajoy Prasad Shetty, Rishi Mugesh Kanna, et al.
Neurospine. 2020;17(2):426-442.

Original Article

June 30, 2020
Cervical Sagittal Alignment: Literature Review and Future Directions
Sang Hun Lee, Seung-Jae Hyun, Amit Jain
Neurospine. 2020;17(3):478-496.

Review Article

September 30, 2020
Effects of Body Mass Index on Perioperative Outcomes in Patients Undergoing Anterior Cervical Discectomy and Fusion Surgery
Roberto J. Perez-Roman, David McCarthy, Evan M. Luther, Julian G. Lugo-Pico, Roberto Leon-Correa, Wendy Gaztanaga, Karthik Madhavan, Steven Vanni
Neurospine. 2021;18(1):79-86.

Original Article

November 17, 2020
Perioperative Outcomes in 17,947 Patients Undergoing 2-Level Anterior Cervical Discectomy and Fusion Versus 1-Level Anterior Cervical Corpectomy for Treatment of Cervical Degenerative Conditions: A Propensity Score Matched National Surgical Quality Improvement Program Analysis
Anoop R. Galivanche, Raj Gala, Preetpaul S. Bagi, Arianne J. Boylan, Christopher M. Dussik, Pedro D. Coutinho, Jonathan N. Grauer, Arya G. Varthi
Neurospine. 2020;17(4):871-878.

Original Article

December 31, 2020
Pharmacologic and Regenerative Cell Therapy for Spinal Cord Injury: WFNS Spine Committee Recommendations
Toshihiro Takami, Nobuyuki Shimokawa, Jutty Parthiban, Mehmet Zileli, Sheena Ali
Neurospine. 2020;17(4):785-796.

Review Article

December 31, 2020
Degenerative Cervical Myelopathy: A 7-Letter Coding System That Supports Decision-Making for the Surgical Approach
Luca Papavero, Gregor Schmeiser, Ralph Kothe, Bronek Boszczyk, Oliver Heese, Yoshiharu Kawaguchi, Anna MacDowall, Claes Olerud, Nikolaos Paidakakos, Anastasios Panagiotou, et al.
Neurospine. 2020;17(1):164-171.

Original Article

July 9, 2019
Comparison of the Safety and Effectiveness of Percutaneous Endoscopic Lumbar Discectomy for Treating Lumbar Disc Herniation Under Epidural Anesthesia and General Anesthesia
Zhiqiang Ren, Shenghua He, Jiao Li, Yeguang Wang, Juyi Lai, Zhitao Sun, Hualong Feng, Jian Wang
Neurospine. 2020;17(1):254-259.

Original Article

February 1, 2020
Direct and Intervertebral Disc-Mediated Sensitization of Dorsal Root Ganglion Neurons by Hypoxia and Low pH  
Junxuan Ma, Despina Stefanoska, Sibylle Grad, Mauro Alini, Marianna Peroglio
Neurospine. 2020;17(1):42-59.

Original Article

March 31, 2020
The Biportal Endoscopic Posterior Cervical Inclinatory Foraminotomy for Cervical Radiculopathy: Technical Report and Preliminary Results  
Kwan-Su Song, Chul-Woo Lee
Neurospine. 2020;17(Suppl 1):S145-S153.

Case Report: Technical Note

July 31, 2020
Metabolic Syndrome is a Predisposing Factor for Diffuse Idiopathic Skeletal Hyperostosis
Eijiro Okada, Shinichi Ishihara, Koichiro Azuma, Takehiro Michikawa, Satoshi Suzuki, Osahiko Tsuji, Satoshi Nori, Narihito Nagoshi, Mitsuru Yagi, Michiyo Takayama, et al.
Neurospine. 2021;18(1):109-116.

Original Article

November 17, 2020
Longitudinal Evaluation of Patient-Reported Outcomes Measurement Information System for Back and Leg Pain in Minimally Invasive Transforaminal Lumbar Interbody Fusion
Nathaniel W. Jenkins, James M. Parrish, Nadia M. Hrynewycz, Thomas S. Brundage, Kern Singh
Neurospine. 2020;17(4):862-870.

Original Article

December 31, 2020
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