Neurospine

Neurospine provides spine clinicians and researchers with peer-reviewed articles on basic and clinical investigation of spine and spinal cord to enhance patient management, education, clinical or experimental research, and professionalism.

The journal will consider submissions in areas on craniocervical to lumbosacral spine including the followings: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, rehabilitation of spine, spinal cord and peripheral nerve diseases.

Original Article

June 20, 2023

Spinal Cord Subependymoma: A Subanalysis of the Neurospinal Society of Japan’s Multicenter Study of Intramedullary Spinal Cord Tumors

Takashi Yagi, Masaki Mizuno, Hiroto Kageyama, Kotaro Tatebayashi, Toshiki Endo, Yasuhiro Takeshima, Motoyuki Iwasaki, Ryu Kurokawa, Keisuke Takai, Misao Nishikawa, et al.

Neurospine. 2023;20(3):735-746.

Objective: This study aimed to analyze the clinical characteristics, treatment strategies, and surgical outcomes of subependymoma patients from the 2022 Neurospinal Society of Japan multicenter intramedullary spinal cord tumor study. Methods:...

Original Article

June 20, 2023

Intramedullary Schwannoma of the Spinal Cord: A Nationwide Analysis by the Neurospinal Society of Japan

Takeshi Hara, Masaki Mizuno, Kazutoshi Hida, Toru Sasamori, Yasuyuki Miyoshi, Hisaaki Uchikado, Hiroki Ohashi, Taku Sugawara, Yasuhiro Takeshima, Yukoh Ohara, et al.

Neurospine. 2023;20(3):747-755.

Objective: This study was aimed to report the clinical characteristics of intramedullary schwannomas and discuss imaging findings and treatment strategies. Methods: The inclusion criterion was consecutive patients with intramedullary schwannomas who...

Original Article

June 20, 2023

Comparison of the Recurrence and Surgical Outcome of Spinal Hemangioblastoma in Sporadic and Von Hippel-Lindau Diseases: A Subanalysis of a Nationwide Study by the Neurospinal Society of Japan

Yasuhiro Takeshima, Hirokazu Takami, Toshiki Endo, Masaki Mizuno, Kazutoshi Hida,

Neurospine. 2023;20(3):756-765.

Objective: This study aimed to clarify the relationship between recurrence and the extent of resection in surgery for intramedullary spinal hemangioblastoma (sHB) and its impact on von Hippel-Lindau (vHL) disease. Methods:...

Original Article

September 30, 2023

The Impact of Adjuvant Radiotherapy on Clinical Performance Status in Patients With Grade II Spinal Cord Astrocytoma – A Nationwide Analysis by the Neurospinal Society of Japan

Ryo Kanematsu, Masaki Mizuno, Tomoo Inoue, Toshiyuki Takahashi, Toshiki Endo, Seiji Shigekawa, Jun Muto, Daisuke Umebayashi, Takafumi Mitsuhara, Kazutoshi Hida, et al.

Neurospine. 2023;20(3):766-773.

Objective: The impact of adjuvant radiotherapy on overall survival (OS) and progression-free survival (PFS) of patients with grade II spinal cord astrocytomas remains controversial. Additionally, the relationship between progression and...

Original Article

September 30, 2023

Clinical Characteristics and Long-term Outcomes of Spinal Pilocytic Astrocytomas: A Multicenter Retrospective Study by the Neurospinal Society of Japan

Jun Muto, Hidetoshi Murata, Seiji Shigekawa, Takafumi Mitsuhara, Daisuke Umebayashi, Ryo Kanematsu, Masahiro Joko, Tatsushi Inoue, Tomoo Inoue, Toshiki Endo, et al.

Neurospine. 2023;20(3):774-782.

Objective: The characteristics, imaging features, long-term surgical outcomes, and recurrence rates of primary spinal pilocytic astrocytomas (PAs) have not been clarified owing to their rarity and limited reports. Thus, this...

Original Article

September 30, 2023

Predictors of Cerebrospinal Fluid Leak Following Dural Repair in Spinal Intradural Surgery

Lei Jiang, Alexandru Budu, Muhammad Shuaib Khan, Edward Goacher, Angelos Kolias, Rikin Trivedi, Jibin Francis

Neurospine. 2023;20(3):783-789.

Objective: We aim to compare the effectiveness of dural closure techniques in preventing cerebrospinal fluid (CSF) leaks following surgery for intradural lesions and seek to identify additional factors associated with...

Original Article

September 30, 2023

The Posterior Cranial Vertical Line: A Novel Radiographic Marker for Classifying Global Sagittal Alignment

Paul J. Park, Fthimnir M. Hassan, Xavier E. Ferrer, Cole Morrissette, Nathan J. Lee, Meghan Cerpa, Zeeshan M. Sardar, Michael P. Kelly, Stephane Bourret, Kazuhiro Hasegawa, et al.

Neurospine. 2023;20(3):790-797.

Objective: To define a novel radiographic measurement, the posterior cranial vertical line (PCVL), in an asymptomatic adult population to better understand global sagittal alignment. Methods: We performed a multicenter retrospective review...

Review Article

September 30, 2023

Selection of Optimal Lower Instrumented Vertebra for Adolescent Idiopathic Scoliosis Surgery

Seung-Ho Seo, Seung-Jae Hyun, Jae-Koo Lee, Yong Jae Cho, Dae Jean Jo, Jin Hoon Park, Ki-Jeong Kim,

Neurospine. 2023;20(3):799-807.

Adolescent idiopathic scoliosis (AIS) affects approximately 2% of adolescents across all ethnicities. The objectives of surgery for AIS are to halt curve progression, correct the deformity in 3 dimensions, and...

Original Article

September 30, 2023

Surgical Outcomes of Symptomatic Intramedullary Spinal Cord Cavernous Malformations: Analysis of Consecutive Cases in a Single Center

Zheng Cai, Xinjie Hong, Wei Dai, Zhengwei Zhang, Qiang Liang, Xuehua Ding, Wei Sun

Neurospine. 2023;20(3):810-821.

Objective: Intramedullary spinal cavernous malformations (ISCMs) are rare vascular lesions of the spinal cord with unclear natural history and controversy over treatment. This study aimed to report a series of...

Original Article

September 30, 2023

Simultaneous Single-Position Lateral Lumbar Interbody Fusion Surgery and Unilateral Percutaneous Pedicle Screw Fixation for Spondylolisthesis

Hui Lv, Yu Sheng Yang, Jian Hong Zhou, Yuan Guo, Hui Chen, Fei Luo, Jian Zhong Xu, Zhong Rong Zhang, Ze Hua Zhang

Neurospine. 2023;20(3):824-834.

Objective: To evaluate the clinical and radiological efficacy of a combine of lateral single screw-rod and unilateral percutaneous pedicle screw fixation (LSUP) for lateral lumbar interbody fusion (LLIF) in the...

Original Article

September 30, 2023

Outcomes of Surgical Treatment for Patients With Mild Scoliosis and Age-Appropriate Sagittal Alignment With Minimum 2-Year Follow-up

Justin K. Scheer, Justin S. Smith, Peter G. Passias, Han Jo Kim, Shay Bess, Douglas C. Burton, Eric O. Klineberg, Virginie Lafage, Munish Gupta, Christopher P. Ames, et al.

Neurospine. 2023;20(3):837-848.

Objective: The goal of this study was to determine if patients with mild scoliosis and age-appropriate sagittal alignment have favorable outcomes following surgical correction. Methods: Retrospective review of a prospective, multicenter...

Review Article

September 30, 2023

Risk of Revision After Vertebral Augmentation for Osteoporotic Vertebral Fracture: A Narrative Review

Shinji Takahashi, Hiroyuki Inose, Koji Tamai, Masayoshi Iwamae, Hidetomi Terai, Hiroaki Nakamura

Neurospine. 2023;20(3):852-862.

Osteoporotic vertebral fractures (OVFs) can hinder physical motor function, daily activities, and the quality of life in elderly patients when treated conservatively. Vertebral augmentation, which includes vertebroplasty and balloon kyphoplasty,...

Review Article

September 30, 2023

Proximal Junctional Kyphosis or Failure After Adult Spinal Deformity Surgery - Review of Risk Factors and Its Prevention

Byung-Jou Lee, Sung Soo Bae, Ho Young Choi, Jin Hoon Park, Seung-Jae Hyun, Dae Jean Jo, Yongjae Cho,

Neurospine. 2023;20(3):863-875.

Proximal junction kyphosis (PJK) is a common imaging finding after long-level fusion, and proximal junctional failure (PJF) is an aggravated form of the progressive disease spectrum of PJK. This includes...

Review Article

September 30, 2023

Proximal Junctional Failure in Adult Spinal Deformity Surgery: An In-depth Review

Mitsuru Yagi, Kento Yamanouchi, Naruhito Fujita, Haruki Funao, Shigeto Ebata

Neurospine. 2023;20(3):876-889.

Adult spinal deformity (ASD) surgery aims to correct abnormal spinal curvature in adults, leading to improved functionality and reduced pain. However, this surgery is associated with various complications, one of...

Original Article

September 30, 2023

Severe Obesity Is an Independent Risk Factor of Early Readmission and Nonhome Discharge After Cervical Disc Replacement

Tejas Subramanian, Daniel Shinn, Pratyush Shahi, Izzet Akosman, Troy Amen, Omri Maayan, Eric Zhao, Kasra Araghi, Junho Song, Sidhant Dalal, et al.

Neurospine. 2023;20(3):890-898.

Objective: Despite growing interest in cervical disc replacement (CDR) for conditions such as cervical radiculopathy, limited data exists describing the impact of obesity on early postoperative outcomes and complications. These...

Original Article

September 30, 2023

Risk Factors of Restenosis After Full Endoscopic Foraminotomy for Lumbar Foraminal Stenosis: Case-Control Study

Jong Hun Seo, Chang Il Ju, Seok Won Kim, Seung Myung Lee, Pius Kim

Neurospine. 2023;20(3):899-907.

Objective: To investigate risk factors associated with postoperative restenosis after full endoscopic lumbar foraminotomy (FELF) in patients with lumbar foraminal stenosis (LFS). Methods: A single-center, retrospective case-control study was conducted on...

Original Article

August 7, 2023

The Morphological Evaluation of the Cervical Muscle in Patients With Basilar Invagination: A Magnetic Resonance Imaging-Based Study

Junyu Lin, Panjie Xu, Jianying Zheng, Zhang Zefan, Jingwen Tan, Hang Xiao, Siyan Yu, Qingan Zhu, Wei Ji

Neurospine. 2023;20(3):908-920.

Objective: To investigate the characteristics of functional muscle and muscle size in patients with basilar invagination (BI) and explore the effects of atlantoaxial dislocation. Methods: Eighty BI patients (BI group) and...

Original Article

September 30, 2023

Correlation Between the Severity of Multifidus Fatty Degeneration and the Size of Ossification of Posterior Longitudinal Ligament at Each Spinal Level

Jinyoung Park, Yong Eun Cho, Kyung Hyun Kim, Sanghoon Shin, Sungjun Kim, Chae Hwan Lim, Seok Young Chung, Yoon Ghil Park

Neurospine. 2023;20(3):921-930.

Objective: This study aimed to investigate the correlation between ossification of the posterior longitudinal ligament (OPLL) size and multifidus fatty degeneration (MFD), hypothesizing that larger OPLL sizes are associated with...

Original Article

September 30, 2023

Saving Stabilizing Structure Treatment With Bilateral-Contralateral Decompression for Spinal Stenosis in Degenerative Spondylolisthesis Using Unilateral Biportal Endoscopy

Dong Hyun Lee, Dong-Geun Lee, Choon Keun Park, Jae-Won Jang, Jin Sub Hwang, Jun Yong Kim, Yong-Eun Cho, Sang Won Lee, Dong Chan Lee, Bang Sang Han, et al.

Neurospine. 2023;20(3):931-939.

Objective: This study aimed to evaluate the treatment of spinal stenosis with spondylolisthesis using bilateral-contralateral unilateral biportal endoscopic (UBE) decompression to minimize facet joint damage. Methods: We retrospectively evaluated 42 patients...

Original Article

September 30, 2023

Anterior Transarticular Crossing Screw Fixation for Atlantoaxial Joint Instability: A Biomechanical Study

Hang Xiao, Zhiping Huang, Panjie Xu, Junyu Lin, Qingan Zhu, Wei Ji

Neurospine. 2023;20(3):940-946.

Objective: To evaluate the biomechanical stability of anterior transarticular crossing screw (ATCS) and compare it with anterior transarticular screw (ATS) which may provide basic evidence for clinical application. Methods: Eight human...

Original Article

September 30, 2023

Spatiotemporal Gait Parameters and Gait Asymmetry in Patients With Lumbar Disc Herniation, Treated With Microdiscectomy: A Prospective, Observational Study

Masoud Amir Rashedi Bonab, Suleyman Sener, Tugba Kuru Colak, Mahsa Amirrashedi, Ipek Yeldan, Deniz Konya, Zafer Orkun Toktas

Neurospine. 2023;20(3):947-958.

Objective: The aim of this study was to emphasize on the interaction of spatial and temporal gait parameters and analyse the gait asymmetry in the patients with lumbar disc herniation...

Original Article

September 30, 2023

Relationships Between Skeletal Muscle Mass, Lumbar Lordosis, and Chronic Low Back Pain in the Elderly

Myung Woo Park, Sang Jun Park, Sun Gun Chung

Neurospine. 2023;20(3):959-968.

Objective: Loss of skeletal muscle mass is known to be associated with multiple morbidities. However, there is a dearth of reports on its association with lumbar lordosis and musculoskeletal pain....

Original Article

September 30, 2023

Introduction of a New Radiographic Parameter to Predict Proximal Junctional Kyphosis in Adult Spinal Deformity: UIVPTA (Uppermost Instrumented Vertebra-Pelvic Tilt Angle)

Se-Jun Park, Chong-Suh Lee, Jin-Sung Park, Tae Soo Shin

Neurospine. 2023;20(3):969-980.

Objective: To introduce a new sagittal parameter, uppermost instrumented vertebra-pelvic tilt angle (UIVPTA), and to determine the effects on the proximal junctional kyphosis (PJK) development in adult spinal deformity (ASD)...

Original Article

September 30, 2023

Surgical and Clinical Outcomes Associated With the Use of Barbed Sutures and Self-Adhering Mesh System and Polymeric Glue for Wound Closure in Multilevel or Revision Spinal Surgery: A Matched Cohort Comparative Study With Conventional Wound Closure Procedure

Junho Mun, Seung-Jae Hyun, Jae-Koo Lee, Sungjae An, Ki-Jeong Kim

Neurospine. 2023;20(3):981-988.

Objective: Multilevel or revisional posterior spinal surgery is prone to infection and delayed wound healing, related with the wound closure time and suture strength. Knotless barbed suture is an innovative...

Original Article

September 30, 2023

Long-term Outcomes of Posterior Multilevel Crack Osteotomy: Revisional Surgery for Scoliosis With a Fusion Mass

Mi Hyun Song, Jae Hyuk Yang, Dong-Gune Chang, Yunjin Nam, Seung Woo Suh

Neurospine. 2023;20(3):989-996.

Objective: Osteotomies are required for the mobilization of spinal segments in patients with revisional scoliosis surgery with a fusion mass; however, only a few techniques have shown efficacy and safety,...

Original Article

September 30, 2023

Comparative Efficacy of Clinical Interventions for Sacroiliac Joint Pain: Systematic Review and Network Meta-analysis With Preliminary Design of Treatment Algorithm

Yanting Liu, Siravich Suvithayasiri, Jin-Sung Kim

Neurospine. 2023;20(3):997-1010.

Objective: We aimed to identify the most effective clinical treatment method for sacroiliac joint (SIJ)-related pain based on the systematic review and network meta-analysis (NMA) to evaluate the comparative efficacy...

Original Article

August 7, 2023

Electroacupuncture-Modulated MiR-106b-5p Expression Enhances Autophagy by Targeting Beclin-1 to Promote Motor Function Recovery After Spinal Cord Injury in Rats

Shuhui Guo, Jianmin Chen, Ye Yang, Xiaolu Li, Yun Tang, Yuchang Gui, Jianquan Chen, jianwen Xu

Neurospine. 2023;20(3):1011-1027.

Objective: Electroacupuncture (EA) has a definite effect on the treatment of spinal cord injuries (SCIs), but its underlying molecular mechanism remains unclear. Meanwhile, MiR106b-5p is an autophagy- and apoptosis-related microribonucleic...

Original Article

September 30, 2023

Three-Dimensional Quantitative Assessment of Pedicle Screw Accuracy in Clinical Utilization of a New Robotic System in Spine Surgery: A Multicenter Study

Byeong-Jin Ha, Jong-Min Lee, Seon-Jin Yoon, Byung-Kwan Kim, Junseok Lee, Suhun Lee, Seungjae Ryu, Yongyeob Cha, Sungteac Hwang, Donggi Woo, et al.

Neurospine. 2023;20(3):1028-1039.

Objective: The objective of this study was to evaluate the accuracy of pedicle screw placement in patients undergoing percutaneous pedicle screw fixation with robotic guidance, using a newly developed 3-dimensional...

Original Article

September 30, 2023

Lumbar Endoscopic Unilateral Laminotomy With Bilateral Decompression Surgery in Severe Lumbar Stenosis Under Electrophysiological Monitoring-Focused on Full-Visualized Trephine/Osteotome

Ning-Ning Dou, Hao-lin Wang, Shao-Zhen Hu, Zheng-Nan Huang, Jun Zhong, Shi-Ting Li

Neurospine. 2023;20(3):1040-1046.

Objective: Although endoscopic drill has the advantages in manipulation and hemostasis, whose low efficiency and blurred vision reduce the efficacy of lumbar endoscopic unilateral laminotomy with bilateral decompression (LE-ULBD). The...

Original Article

September 30, 2023

Clinical Effectiveness of Artificial Disc Replacement in Comparison With Anterior Cervical Discectomy and Fusion in the Patients With Cervical Myelopathy: Systematic Review and Meta-analysis

Jung Hwan Lee, Youn Joo Lee, Min Cheol Chang, Jun Ho Lee

Neurospine. 2023;20(3):1047-1060.

Objective: Cervical myelopathy (CM) describes the compressive cervical spinal cord state, often accompanied by serious clinical condition, by herniated disc or hypertrophied spurs or ligament. Anterior cervical discectomy and fusion...

Original Article

September 30, 2023

Traditional Dual Growing Rods With 2 Different Apical Control Techniques in the Treatment of Early-Onset Scoliosis

Shengru Wang, Yiwei Zhao, Guanfeng Lin, You Du, Yang Yang, Jianguo Zhang

Neurospine. 2023;20(3):1061-1072.

Objective: Based on traditional dual growing rods (TDGR), apical control techniques (ACTs) were introduced as adjuvant procedures to improve deformity correction at the apex segment in the treatment of early-onset...

Original Article

September 30, 2023

The Role of Exercise in the Alleviation of Neuropathic Pain Following Traumatic Spinal Cord Injuries: A Systematic Review and Meta-analysis

Amirmohammad Toloui, Hamzah Adel Ramawad, Pantea Gharin, Alexander R. Vaccaro, Hamed Zarei, Mostafa Hosseini, Mahmoud Yousefifard, Vafa Rahimi-Movaghar

Neurospine. 2023;20(3):1073-1087.

Objective: The objective of this systematic review and meta-analysis was to assess the efficacy of exercise in neuropathic pain following traumatic spinal cord injuries. Methods: The search was conducted in MEDLINE,...