Neurospine

Neurospine provides spine clinicians and researchers with peer-reviewed articles on basic and clinical investigation of spine and spinal cord to enhance patient management, education, clinical or experimental research, and professionalism.

The journal will consider submissions in areas on craniocervical to lumbosacral spine including the followings: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, rehabilitation of spine, spinal cord and peripheral nerve diseases.

Review Article

September 30, 2021

Emerging Technologies in the Treatment of Adult Spinal Deformity

Akshar V. Patel, Christopher A. White, John T. Schwartz, Nicholas L. Pitaro, Kush C. Shah, Sirjanhar Singh, Varun Arvind, Jun S. Kim, Samuel K. Cho

Neurospine. 2021;18(3):417-427.

Outcomes for adult spinal deformity continue to improve as new technologies become integrated into clinical practice. Machine learning, robot-guided spinal surgery, and patientspecific rods are tools that are being used...

Review Article

September 30, 2021

Intraoperative Neuromonitoring During Lateral Lumbar Interbody Fusion

Ram Alluri, Jung Kee Mok, Avani Vaishnav, Tara Shelby, Ahilan Sivaganesan, Raymond Hah, Sheeraz A. Qureshi

Neurospine. 2021;18(3):430-436.

Objective: To review the evidence for the use of electromyography (EMG), motor-evoked potentials (MEPs), and somatosensory-evoked potentials (SSEPs) intraoperative neuromonitoring (IONM) strategies during lateral lumbar interbody fusion (LLIF), as well...

Original Article

September 30, 2021

The Effect of Brace Treatment on Large Curves of 40° to 55° in Adolescents With Idiopathic Scoliosis Who Have Avoided Surgery: A Retrospective Cohort Study

Reza Razeghinezhad, Mojtaba Kamyab, Taher Babaee, Mohammad Saleh Ganjavian, Shahrbanoo Bidari

Neurospine. 2021;18(3):437-444.

Objective: To evaluate the effect of Milwaukee brace treatment on adolescents with idiopathic scoliosis (AIS) with large curves (40° to 55°) who refuse to do surgery. Methods: In this retrospective cohort...

Original Article

September 30, 2021

Characteristics and Risk Factors of Rod Fracture Following Adult Spinal Deformity Surgery: A Systematic Review and Meta-Analysis

Sung Hyun Noh, Kyung Hyun Kim, Jeong Yoon Park, Sung Uk Kuh, Keun Su Kim, Yong Eun Cho, Dong Kyu Chin

Neurospine. 2021;18(3):447-454.

Objective: The aim of study is to investigate the features and risk factors of rod fracture (RF) following adult spinal deformity (ASD) surgery. Methods: We searched the PubMed, Embase, Web of...

Original Article

April 12, 2021

The Incidence of Adding-On or Distal Junctional Kyphosis in Adolescent Idiopathic Scoliosis Treated by Anterior Spinal Fusion to L3 Was Significantly Higher Than by Posterior Spinal Fusion to L3

Seung-Jae Hyun, Lawrence G. Lenke, Yongjung Kim, Keith H. Bridwell, Meghan Cerpa, Kathy M. Blanke

Neurospine. 2021;18(3):457-463.

Objective: To compare and identify risk factors for distal adding-on (AO) or distal junctional kyphosis (DJK) in adolescent idiopathic scoliosis (AIS) treated by anterior- (ASF) and posterior spinal fusion (PSF)...

Original Article

September 30, 2021

Thoracolumbar Slope Is Useful Parameter for Evaluating HealthRelated Quality of Life and Sagittal Imbalance Aggravation in Adult Spinal Deformity: A Prospective Observational Cohort Study

Bong Ju Moon, Moon-Soo Han, Jae-Young Kim, Jung-Kil Lee

Neurospine. 2021;18(3):467-474.

Objective: The purpose of the present study was to evaluate the natural course of primary degenerative sagittal imbalance (PDSI), its aggravating factors, and health-related quality of life (HRQoL) associated with...

Original Article

September 30, 2021

Obeid-Coronal Malalignment Classification Is Age Related and Independently Associated to Personal Reported Outcome Measurement Scores in the Nonfused Spine

David Christopher Kieser, Louis Boissiere, Anouar Bourghli, Kazunori Hayashi, Derek Cawley, Caglar Yilgor, Ahmet Alanay, Emre Acaroglu, Frank Kleinstueck, Javier Pizones, et al.

Neurospine. 2021;18(3):475-480.

Objective: To evaluate Obeid-coronal malalignment (O-CM) modifiers according to age, sagittal alignment, and patient-reported outcome measures (PROMs), in the mobile spine. Methods: Retrospective review of a prospective multicenter adult spinal deformity...

Original Article

September 30, 2021

Modified Global Alignment and Proportion Scoring With Body Mass Index and Bone Mineral Density Analysis in Global Alignment and Proportion Score of Each 3 Categories for Predicting Mechanical Complications After Adult Spinal Deformity Surgery

Sung Hyun Noh, Yoon Ha, Jeong Yoon Park, Sung Uk Kuh, Dong Kyu Chin, Keun Su Kim, Yong Eun Cho, Hye Sun Lee, Kyung Hyun Kim

Neurospine. 2021;18(3):484-491.

Objective: This study aimed to analyze the prediction rate of the modified Global Alignment and Proportion (GAP) scoring system with body mass index and bone mineral density (GAPB) in each...

Original Article

September 30, 2021

Correlation of Paraspinal Muscle Mass With Decompensation of Sagittal Adult Spinal Deformity After Setting of Fatigue Post 10-Minute Walk

Junseok Bae, Ashwin Sathe, Shih-Min Lee, Alexander A. Theologis, Vedat Deviren, Sang-Ho Lee

Neurospine. 2021;18(3):495-503.

Objective: The purpose of this study was to investigate the changes in spinopelvic parameters before and after the setting of muscle fatigue along with its correlation with pre-existing paraspinal and...

Original Article

September 30, 2021

Prioritization of Realignment Associated With Superior Clinical Outcomes for Cervical Deformity Patients

Katherine E. Pierce, Peter G. Passias, Avery E. Brown, Cole A. Bortz, Haddy Alas, Lara Passfall, Oscar Krol, Nicholas Kummer, Renaud Lafage, Dean Chou, et al.

Neurospine. 2021;18(3):506-514.

Objective: To prioritize the cervical parameter targets for alignment. Methods: Included: cervical deformity (CD) patients (C2–7 Cobb angle > 10°, cervical lordosis > 10°, cervical sagittal vertical axis [cSVA] > 4...

Original Article

September 30, 2021

Incidence of Chronic Periscapular Pain After Adult Thoracolumbar Deformity Correction and Impact on Outcomes

Alexander F. Haddad, Justin K. Scheer, Marissa T. Fury, Justin S. Smith, Vedat Deviren, Christopher P. Ames

Neurospine. 2021;18(3):515-523.

Objective: Extension of the posterior upper-most instrumented vertebra (UIV) into the upper thoracic (UT) spine allows for greater deformity correction and reduced incidence of proximal junction kyphosis (PJK) in adult...

Original Article

March 22, 2021

A Comparison of Mortality and Morbidity Between Complex and Degenerative Spine Surgery in Prospectively Collected Data From 2,280 Procedures

Stian Solumsmoen, Tanvir Johanning Bari, Sarah Woldu, Oliver Bremerskov Zielinski, Martin Gehrchen, Benny Dahl, Rachid Bech-Azeddine

Neurospine. 2021;18(3):524-532.

Objective: The reported incidence of complications and/or adverse events (AEs) following spine surgery varies greatly. A validated, systematic, reproducible reporting system to quantify AEs was used in 2 prospective cohorts,...

Original Article

May 18, 2021

Association of Spinal Alignment Correction With Patient-Reported Outcomes in Adult Cervical Deformity: Review of the Literature

Elie Massaad, Muhamed Hadzipasic, Ali Kiapour, Asad M. Lak, Ganesh Shankar, Hasan A. Zaidi, Stuart H. Hershman, John H. Shin

Neurospine. 2021;18(3):533-542.

Objective: Adult cervical deformity (ACD) is a debilitating spinal condition that causes significant pain, neurologic dysfunction, and functional impairment. Surgery is often performed to correct cervical alignment, but the optimal...

Original Article

September 30, 2021

Lordosis Distribution Index in Short-Segment Lumbar Spine Fusion – Can Ideal Lordosis Reduce Revision Surgery and Iatrogenic Deformity?

Tanvir Johanning Bari, Martin Heegaard, Rachid Bech-Azeddine, Benny Dahl, Martin Gehrchen

Neurospine. 2021;18(3):543-553.

Objective: The demand for spinal fusion is increasing, with concurrent reports of iatrogenic adult spinal deformity (flatback deformity) possibly due to inappropriate lordosis distribution. This distribution is assessed using the...

Original Article

September 30, 2021

Utilization of S1 Foraminal Hooks for Augmentation of S1 Screws in Adult Spinal Deformity Surgery: Comparative Study With Iliac Screws

Ho Yong Choi, Dae Jean Jo

Neurospine. 2021;18(3):554-561.

Objective: To compare the outcomes of S1 foraminal hooks and iliac screws regarding fusion rate at the lumbosacral junction and protective effects on S1 screws. Methods: From January 2017 to December...

Original Article

September 30, 2021

Outcomes of Posterior Lumbar Hemivertebra Resection and Short Fusion in Patients With Severe Sacral Tilt

Shengru Wang, Jianguo Zhang, Yanbin Zhang, You Du, Yang Yang, Guanfeng Lin

Neurospine. 2021;18(3):562-569.

Objective: To introduce surgical strategies to restore coronal balance during limited fusion for early lumbar hemivertebra resection in patients with severe sacral tilt. Methods: Sacral tilt was defined as a sacral...

Original Article

September 30, 2021

Be Prepared: Preoperative Coronal Malalignment Often Leads to More Extensive Surgery Than Sagittal Malalignment During Adult Spinal Deformity Surgery

Scott L. Zuckerman, Christopher S. Lai, Yong Shen, Mena G. Kerolus, Alex S. Ha, Ian A. Buchanan, Nathan J. Lee, Eric Leung, Meghan Cerpa, Ronald A. Lehman, et al.

Neurospine. 2021;18(3):570-579.

Objective: To evaluate the effect of coronal alignment on: (1) surgical invasiveness and operative complexity and (2) postoperative complications. Methods: A retrospective, cohort study of adult spinal deformity patients was conducted....

Original Article

September 30, 2021

Ligament Augmentation With Mersilene Tape Reduces the Rates of Proximal Junctional Kyphosis and Failure in Adult Spinal Deformity

Pope Rodnoi, Hai Le, Luke Hiatt, Joseph Wick, Joshua Barber, Yashar Javidan, Rolando Roberto, Eric O. Klineberg

Neurospine. 2021;18(3):580-586.

Objective: To investigate prevention of proximal junctional kyphosis (PJK) and failure (PJF) following adult spinal deformity (ASD) surgery utilizing a novel technique of posterior ligament augmentation with polyester fiber tether. Methods:...

Original Article

September 30, 2021

A Comparative Biomechanical Analysis of Various Rod Configurations Following Anterior Column Realignment and Pedicle Subtraction Osteotomy

Muzammil Mumtaz, Justin Mendoza, Ardalan Seyed Vosoughi, Anthony S. Unger, Vijay K. Goel

Neurospine. 2021;18(3):587-596.

Objective: The objective of this study was to compare the biomechanical differences of different rod configurations following anterior column realignment (ACR) and pedicle subtraction osteotomy (PSO) for an optimal correction...

Original Article

September 30, 2021

Which Is More Predictive Value for Mechanical Complications: Fixed Thoracolumbar Alignment (T1 Pelvic Angle) Versus Dynamic Global Balance Parameter (Odontoid-Hip Axis Angle)

Kwang-Ryeol Kim, Jean-Charles Le Huec, Hyun-Jun Jang, Sung-Hyun Noh, Jeong-Yoon Park, Yoon Ha, Sung-Uk Kuh, Dong-Kyu Chin, Keun-Su Kim, Byung-Ho Jin, et al.

Neurospine. 2021;18(3):597-607.

Objective: In this study, we investigate about relationship between postoperative global sagittal imbalance and occurrence of mechanical complications after adult spinal deformity (ASD) surgery. In global sagittal balance parameters, odontoid-hip...

Original Article

September 30, 2021

Clinical, Radiographic, and Genetic Analyses in a Population-Based Cohort of Adult Spinal Deformity in the Older Population

Jun Jae Shin, Byeongwoo Kim, Juwon Kang, Junjeong Choi, Bong Ju Moon, Dal Sung Ryu, Seung Hwan Yoon, Dong Kyu Chin, Jung-Kil Lee, Keung Nyun Kim, et al.

Neurospine. 2021;18(3):608-617.

Objective: This study aimed to identify the sagittal parameters associated with health-related quality of life and genetic variations that increase the risk of adult spinal deformity (ASD) onset in the...

Original Article

September 30, 2021

The Relationship Between Preoperative Cervical Sagittal Balance and Clinical Outcome of Patients With Hirayama Disease Treated With Anterior Cervical Discectomy and Fusion

Xiao Lu, Guang-Yu Xu, Cong Nie, Yu Xuan Zhang, Jian Song, Jian-Yuan Jiang

Neurospine. 2021;18(3):618-627.

Objective: Anterior cervical discectomy and fusion (ACDF) is a common surgical method used to treat patients with Hirayama disease. And sagittal balance indexes have been revealed to be predictors of...

Original Article

September 30, 2021

Impact of Myelopathy Severity and Degree of Deformity on Postoperative Outcomes in Cervical Spinal Deformity Patients

Peter G. Passias, Katherine E. Pierce, Nicholas Kummer, Oscar Krol, Lara Passfall, M. Burhan Janjua, Daniel Sciubba, Waleed Ahmad, Sara Naessig, Bassel Diebo

Neurospine. 2021;18(3):628-634.

Objective: Malalignment of the cervical spine can result in cord compression, leading to a myelopathy diagnosis. Whether deformity or myelopathy severity is stronger predictors of surgical outcomes is understudied. Methods: Surgical...

Original Article

September 30, 2021

Influence of Lumbar Lordosis on Posterior Rod Strain in Long-Segment Construct During Biomechanical Loading: A Cadaveric Study

Bernardo de Andrada Pereira, Anna G.U. Sawa, Jakub Godzik, Jennifer N. Lehrman, Juan S. Uribe, Jay D. Turner, Brian P. Kelly

Neurospine. 2021;18(3):635-643.

Objective: The lordotic shape of the lumbar spine differs substantially between individuals. Measuring and recording strain during spinal biomechanical tests is an effective method to infer stresses on spinal implants...