Neurospine

Neurospine provides spine clinicians and researchers with peer-reviewed articles on basic and clinical investigation of spine and spinal cord to enhance patient management, education, clinical or experimental research, and professionalism.

The journal will consider submissions in areas on craniocervical to lumbosacral spine including the followings: neuroscience and pain research, bone and mineral research, disc and joint research, bio and industrial technology, pathophysiology, risk factors, symptomatology, imaging, treatment, rehabilitation of spine, spinal cord and peripheral nerve diseases.

Review Article

September 30, 2022

History and Evolution of the Minimally Invasive Transforaminal Lumbar Interbody Fusion

Michael C. Prabhu, Kevin C. Jacob, Madhav R. Patel, Hanna Pawlowski, Nisheka N. Vanjani, Kern Singh

Neurospine. 2022;19(3):479-491.

The minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a popular surgical technique for lumbar arthrodesis, widely considered to hold great efficacy while conferring an impressive safety profile through the...

Original Article

May 13, 2022

The Change of Spinal Canal According to Oblique Lumbar Interbody Fusion in Degenerative Spondylolisthesis: A Prospective Observational Study

Young-Seok Lee, Dong-Hyun Lee, Dae-Chul Cho, Inbo Han, Chi Heon Kim, Heum-Dai Kwon, Kyoung-Tae Kim

Neurospine. 2022;19(3):492-500.

Objective: Oblique lumbar interbody fusion (OLIF) involves inserting large cages into the interbody disc space. This expands the spinal canal and neural foramen by stretching the ligament flavum and releasing...

Original Article

September 30, 2022

Safety and Feasibility of Augmented Reality Assistance in Minimally Invasive and Open Resection of Benign Intradural Extramedullary Tumors

Fabian Sommer, Ibrahim Hussain, Sertac Kirnaz, Jacob Goldberg, Lynn McGrath, Rodrigo Navarro-Ramirez, Francois Waterkeyn, Franziska Schmidt, Pravesh Shankar Gadjradj, Roger Härtl

Neurospine. 2022;19(3):501-512.

Objective: Surgical resection of benign intradural extramedullary tumors (BIETs) is effective for appropriately selected patients. Minimally invasive surgical (MIS) techniques have been described for successful resection of BIET while minimizing...

Original Article

May 16, 2022

Comparison of the Clinical Efficacy of Transforaminal Endoscopy and Microtubular Technology for the Treatment of Lumbar Dumbbell-Shaped Tumors

Rui Wang, Ze Yan Liang, Yan Chen, Chun Mei Chen

Neurospine. 2022;19(3):513-523.

Objective: To analyze differences in feasibility and efficacy between the paravertebral approach and microtubular tumorectomy (PAMT) or percutaneous transforaminal endoscopic tumorectomy (PTET) for the treatment of lumbar dumbbell-shaped tumors. Methods: Clinical...

Original Article

September 30, 2022

Comparison Between 3-Dimensional-Printed Titanium and Polyetheretherketone Cages: 1-Year Outcome After Minimally Invasive Transforaminal Interbody Fusion

Do-Yeon Kim, O-Hyuk Kwon, Jeong-Yoon Park

Neurospine. 2022;19(3):524-532.

Objective: Three-dimensional (3D)-printed titanium implants have been developed recently, but the utility is not yet proven. The aim of this study was to compare 3D-printed titanium and polyetheretherketone (PEEK) implants...

Original Article

January 2, 2022

Higher American Society of Anesthesiologists Classification Does Not Limit Safety or Improvement Following Minimally Invasive Transforaminal Lumbar Interbody Fusion

Conor P. Lynch, Elliot D.K. Cha, Cara E. Geoghegan, Caroline N. Jadczak, Shruthi Mohan, Kern Singh

Neurospine. 2022;19(3):533-543.

Objective: The American Society of Anesthesiologists (ASA) physical status classification has been used to risk stratify surgical candidates. Our study compares outcomes of minimally invasive transforaminal lumbar interbody fusion (MIS...

Original Article

September 30, 2022

Indirect Decompression Using Oblique Lumbar Interbody Fusion Revision Surgery Following Previous Posterior Decompression: Comparison of Clinical and Radiologic Outcomes Between Direct and Indirect Decompression Revision Surgery

Sang-Jin Park, Jong-Moon Hwang, Dae-Chul Cho, Subum Lee, Chi Heon Kim, Inbo Han, Dae-Won Park, Heum-Dai Kwon, Kyoung-Tae Kim

Neurospine. 2022;19(3):544-554.

Objective: This study compared the radiological and clinical outcomes with transforaminal lumbar interbody fusion (TLIF) to evaluate the effect of indirect decompression through oblique lumbar interbody fusion (OLIF) as revision...

Original Article

September 30, 2022

Comparative Analysis of Transforaminal Endoscopic Thoracic Discectomy and Microscopic Discectomy for Symptomatic Thoracic Disc Herniation

Junseok Bae, Jisang Kim, Sang-Ho Lee, Jin-Sung Kim

Neurospine. 2022;19(3):555-562.

Objective: To evaluate the clinical outcomes of transforaminal endoscopic thoracic discectomy (TETD) and microscopic discectomy (MD) for the treatment of symptomatic thoracic disc herniation (TDH). Methods: Seventy-seven patients (mean, 55.9 years;...

Original Article

September 30, 2022

Assessing the Learning Process of Transforaminal Endoscopic Discectomy for Sciatica

Pravesh Shankar Gadjradj, Pieter Schutte, Arnold Vreeling, Paul Depauw, Biswadjiet S. Harhangi

Neurospine. 2022;19(3):563-570.

Objective: Percutaneous transforaminal endoscopic discectomy (PTED) is gaining popularity by both surgeons and patients as a less invasive treatment option for sciatica. Concerns, however, exist for its learning curve. No...

Original Article

September 30, 2022

Augmented Reality to Improve Surgical Workflow in Minimally Invasive Transforaminal Lumbar Interbody Fusion – A Feasibility Study With Case Series

Fabian Sommer, Ibrahim Hussain, Sertac Kirnaz, Jacob L. Goldberg, Rodrigo Navarro-Ramirez, Lynn B. McGrath Jr, Franziska A. Schmidt, Branden Medary, Pravesh Shankar Gadjradj, Roger Härtl

Neurospine. 2022;19(3):574-585.

Objective: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is a highly reproducible procedure for the fusion of spinal segments. We recently introduced the concept of “total navigation” to improve workflow...

Original Article

September 30, 2022

Posterior Apophyseal Ring Fracture in Adult Lumbar Disc Herniation: An 8-Year Experience in Minimally Invasive Surgical Management of 48 Cases

Shuo Yuan, Qichao Wu, Lei Zang, Ning Fan, Peng Du, Aobo Wang, Tianyi Wang, Fangda Si, Jian Li, Xiaochuan Kong

Neurospine. 2022;19(3):586-593.

Objective: Posterior apophyseal ring fracture (PARF) is an uncommon disorder that is usually accompanied by lumbar disc herniation (LDH). The aim of this study to describe the 8-year experience of...

Original Article

September 30, 2022

Surgeons Learning Curve of Transforaminal Endoscopic Discectomy for Sciatica

Pravesh S. Gadjradj, Arnold Vreeling, Paul R. Depauw, Pieter J. Schutte, Biswadjiet S. Harhangi,

Neurospine. 2022;19(3):594-602.

Objective: Full-endoscopic spine surgery is gaining interest as a less-invasive alternative to treat sciatica caused by a lumbar disc herniation. Concerns, however, exist with the learning curve as percutaneous transforaminal...

Original Article

September 30, 2022

Comparative Analysis With Modified Inclined Technique for Posterior Endoscopic Cervical Foraminotomy in Treating Cervical Osseous Foraminal Stenosis: Radiological and Midterm Clinical Outcomes

Ji Yeon Kim, Dong Hwa Heo, Dong Chan Lee, Tae Hyun Kim, Choon Keun Park

Neurospine. 2022;19(3):603-615.

Objective: We compared the midterm clinical and radiological outcomes between 2 types of full endoscopic posterior cervical foraminotomy, including conventional posterior endoscopic cervical foraminotomy (PECF) and modified inclined technique for...

Review Article

September 30, 2022

Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells

Yuan-huan Ma, Qing-yue Liang, Ying Ding, Inbo Han, Xiang Zeng

Neurospine. 2022;19(3):616-629.

Spinal cord injury (SCI) is a result of a devastating injury to the central nervous system. Currently, there is no effective treatment available for these patients. The possible use of...

Review Article

September 30, 2022

Extra Cellular Matrix Remodeling: An Adjunctive Target for Spinal Cord Injury and Intervertebral Disc Degeneration

Ashish Kumar, Neeraj Kumar, Zarna Pathak, Hemant Kumar

Neurospine. 2022;19(3):632-645.

The extracellular matrix (ECM) is a protein-and-carbohydrate meshwork that supports a variety of biological structures and processes, from tissue development and elasticity to the preservation of organ structures. ECM composition...

Review Article

September 30, 2022

Spinal Cord Injury Provoked Neuropathic Pain and Spasticity, and Their GABAergic Connection

Ankita Bhagwani, Manjeet Chopra, Hemant Kumar

Neurospine. 2022;19(3):646-668.

Traumatic spinal cord injury (SCI) is the devastating neurological damage to the spinal cord that becomes more complicated in the secondary phase. The secondary injury comes with inevitable long-lasting complications,...

Review Article

September 30, 2022

Effect of Acute Physical Interventions on Pathophysiology and Recovery After Spinal Cord Injury: A Comprehensive Review of the Literature

Nicholle E. Lewis, Troy Q. Tabarestani, Brianna R. Cellini, Nina Zhang, Eric J. Marrotte, Haichen Wang, Daniel T. Laskowitz, Muhammad M. Abd-El-Barr, Timothy D. Faw

Neurospine. 2022;19(3):671-686.

Physical rehabilitation is essential for enhancing recovery in individuals with spinal cord injury (SCI); however, aside from early surgical intervention and hemodynamic management, there are no proven interventions for promoting...

Review Article

September 30, 2022

Surgical Considerations to Improve Recovery in Acute Spinal Cord Injury

Troy Q. Tabarestani, Nicholle E. Lewis, Margot Kelly-Hedrick, Nina Zhang, Brianna R. Cellini, Eric J. Marrotte, Theresa Williamson, Haichen Wang, Daniel T. Laskowitz, Timothy D. Faw, et al.

Neurospine. 2022;19(3):689-702.

Acute traumatic spinal cord injury (SCI) can be a devastating and costly event for individuals, their families, and the health system as a whole. Prognosis is heavily dependent on the...

Review Article

September 30, 2022

A Review of Functional Restoration From Spinal Cord Stimulation in Patients With Spinal Cord Injury

Alice Lin, Elias Shaaya, Jonathan S. Calvert, Samuel R. Parker, David A. Borton, Jared S. Fridley

Neurospine. 2022;19(3):703-734.

Traumatic spinal cord injury often leads to loss of sensory, motor, and autonomic function below the level of injury. Recent advancements in spinal cord electrical stimulation (SCS) for spinal cord...

Original Article

September 30, 2022

Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury

Dongwoo Yu, Seul Ah Mun, Sang Woo Kim, Dae-Chul Cho, Chi Heon Kim, Inbo Han, Subum Lee, Sang-Woo Lee, Kyoung-Tae Kim

Neurospine. 2022;19(3):737-747.

Objective: Neuropathic pain is a common secondary complication of spinal cord injury (SCI). N-methyl-D-aspartate (NMDA) receptor activation is critical for hypersensitivity in neuropathic pain. This activation requires the binding of...

Original Article

September 30, 2022

Meta-Analysis on the Effect of Hypothermia in Acute Spinal Cord Injury

Hong Kyung Shin, Jin Hoon Park, Sung Woo Roh, Sang Ryong Jeon

Neurospine. 2022;19(3):748-756.

Objective: Acute spinal cord injury (SCI) can result in debilitating motor, sensory, and autonomic dysfunction. As a treatment option, therapeutic hypothermia has been researched to inadequate pharmaceutical treatment, except for...

Original Article

September 30, 2022

Transcription Profiling of a Revealed the Potential Molecular Mechanism of Governor Vessel Electroacupuncture for Spinal Cord Injury in Rats

Xingru Xiao, Qingwen Deng, Xiang Zeng, Bi-Qin Lai, Yuan-Huan Ma, Ge Li, Yuan-Shan Zeng, Ying Ding

Neurospine. 2022;19(3):757-769.

Objective: This study aimed to identify differentially expressed genes (DEGs) by transcriptome analysis to elucidate a potential mechanism by which governor vessel electroacupuncture (GV-EA) promotes neuronal survival, axonal regeneration, and...

Review Article

September 30, 2022

Minimally Invasive Posterior Facet Decortication and Fusion Using Navigated Robotic Guidance: Feasibility and Workflow Optimization

Christopher R. Good, Lindsay D. Orosz, Ronald A. Lehman, Jeffrey L. Gum, Douglas Fox, Isador H. Lieberman

Neurospine. 2022;19(3):773-779.

Minimally invasive spine surgery reduces tissue dissection and retraction, decreasing the morbidity associated with traditional open spine surgery by decreasing blood loss, blood transfusion, complications, and pain. One of the...

Review Article

September 30, 2022

Pathological Classification of the Intramedullary Spinal Cord Tumors According to 2021 World Health Organization Classification of Central Nervous System Tumors, a Single-Institute Experience

Sung-Hye Park, Jae Kyung Won, Chi Heon Kim, Ji Hoon Phi, Seung-Ki Kim, Seung Hong Choi, Chun Kee Chung

Neurospine. 2022;19(3):780-791.

According to the new 2021 World Health Organization (WHO) classification of tumors of the central nervous system (CNS) the classification of the primary intramedullary spinal cord tumors (IM-SCT) follows that...

Original Article

August 15, 2022

Learning Curve and Complications of Unilateral Biportal Endoscopy: Cumulative Sum and Risk-Adjusted Cumulative Sum Analysis

Jinchao Xu, Dong Wang, Jidan Liu, Chengyue Zhu, Jianhang Bao, Wenshuo Gao, Wei Zhang, Hao Pan

Neurospine. 2022;19(3):792-804.

Objective: The purpose of this study was to investigate the learning curve and complications of unilateral biportal endoscopy (UBE) in the treatment of lumbar disc herniation (LDH) and lumbar spinal...

Original Article

August 10, 2022

Successful Criteria for Indirect Decompression With Lateral Lumbar Interbody Fusion

Wicharn Yingsakmongkol, Khanathip Jitpakdee, Stephen Kerr, Worawat Limthongkul, Vit Kotheeranurak, Weerasak Singhatanadgige

Neurospine. 2022;19(3):805-815.

Objective: No consensus criteria have been established regarding ideal candidates for indirect decompression with lateral lumbar interbody fusion (LLIF), and contributing factors of indirect decompression failure were rarely reported. We...

Original Article

September 30, 2022

Phenotypes and Prognostic Factors of Syringomyelia in Single-Center Patients With Chiari I Malformation: Moniliform Type as a Special Configuration

Chunli Lu, Longbing Ma, Chenghua Yuan, Lei Cheng, Xinyu Wang, Wanru Duan, Kai Wang, Zan Chen, Hao Wu, Gao Zeng, et al.

Neurospine. 2022;19(3):816-827.

Objective: The specific association between morphometric characteristics of the syrinx and the prognosis of Chiari malformation type I (CM-I) with syringomyelia following surgical procedure seems to have not been fully...

Original Article

September 30, 2022

Biomechanical Effects of Proximal Polyetheretherketone Rod Extension on the Upper Instrumented and Adjacent Levels in a Human Long-Segment Construct: A Cadaveric Model

Bernardo de Andrada Pereira, Jennifer N. Lehrman, Anna G.U. Sawa, Piyanat Wangsawatwong, Jakub Godzik, David S. Xu, Jay D. Turner, Brian P. Kelly, Juan S. Uribe

Neurospine. 2022;19(3):828-837.

Objective: The high mechanical stress zone at the sudden transition from a rigid to flexible region is involved in proximal junctional kyphosis (PJK) physiopathology. We evaluated the biomechanical performance of...

Original Article

September 30, 2022

Safety and Efficacy of Recombinant Human Bone Morphogenetic Protein-2 in Multilevel Posterolateral Lumbar Fusion in a Prospective, Randomized, Controlled Trial

Ho Yong Choi, Seung-Jae Hyun, Chang Hyun Lee, Ji Hyun Youn, Mi Young Ryu, Ki-Jeong Kim

Neurospine. 2022;19(3):838-846.

Objective: This study is an investigator-initiated, prospective, randomized, controlled study to evaluate the efficacy and safety of the combined use of recombinant human BMP-2 (rhBMP-2) and a hydroxyapatite (HA) carrier...