The authors describe a patient with multiple myeloma who was treated for an acute cervical vertebra body fracture by percutaneous vertebroplasty. A 48-year-old female patient presented a severe neck pain without neurologic deficit. A myelomatous pathologic fracture of C4 was diagnosed, and percutaneous vertebroplasty was performed successfully through a left anterolateral approach. Her posterior neck pain was immediately relieved with vertebroplasty and no instability was observed over 18 months of follow-up.