Significance of Changes in Erythrocyte Sedimentation Rate and C-Reactive Protein Counts in Pyogenic Spondylitis Treatment |
Ki-Hyun Jeon, M.D., Jin-Young Youm, M.D., Seung-Won Choi, M.D., Hyun-Song Koh, M.D., Shi-Hun Song, M.D. and Youn Kim, M.D. |
Department of Neurosurgery, College of Medicine, Chungnam National University, Daejeon, Korea |
화농성 척추 감염 치료에 따른 적혈구 침강속도, C-반응성 단백질 수치 변화의 중요성 |
전기현, 염진영, 최승원, 고현송, 송시헌, 김 윤 |
충남대학교 의과대학 신경외과학교실 |
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Abstract |
Objective The changes of Erythrocyte Sedimentation Rate(ESR) and C-Reactive Protein(CRP) counts in pyogenic spondylitis patients analyzed to determine the treatment modality, effect and the duration of antibiotics medication.
Methods ESR and CRP counts were examined on 15 pyogenic spondylitis patients from the beginning of hospitalization to normalization, twice per week between January 2001 and December 2003.
Results In all of the 15 pyogenic spondylitis cases, the average ESR(63.8mm/hr) and CRP(7.2mg/dL) counts had risen before the treatment. The operated group is more severe infectious state than non-operated group. The average ESR reduction time down to the 2/3s of the initial level was 2.4 and 1.0 weeks for the operated group and non-operated group respectively. The average CRP counts reduction time was 1.0 and 1.3 weeks correspondingly. The average ESR normalization time was 8.0 and 6.9 weeks for the operated group and non-operated group respectively. The average normalization time of CRP counts was observed as 6.4 and 5.6 weeks correspondingly.
Conclusion Regular examination and follow up ESR and CRP counts are essential in the diagonosis of pyogenic spinal infection and the evaluation of the treatment effect. This study implies that the regular examination of CRP count is necessary for proper usage of antibiotics in the early stage of treatment, and ESR examination is more useful to determine when to terminate antibiotics treatment in the latter stage of treatment.
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Keywords:
Erythrocyte sedimentation rate, C-Reactive protein, Pyogenic spondylitis |
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